diethylnitrosamine has been researched along with Disease Exacerbation in 70 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 8.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 7.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 7.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 5.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| " However, the bioavailability of ABZ is very poor." | 5.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 5.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 5.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 5.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 4.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice." | 3.85 | Role of insulin receptor substrates in the progression of hepatocellular carcinoma. ( Aihara, M; Hayashi, T; Iwamoto, M; Kadowaki, T; Kubota, N; Kubota, T; Nishihara, H; Obata, A; Sakurai, Y; Takamoto, I, 2017) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 3.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)." | 3.79 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. ( Chung, RT; Mueller, T; Nahmias, A; Scaiewicz, V; Shibolet, O; Tirosh, B, 2013) |
| "To induce chronic cholestasis, Balb/c mice were given 2 weekly intraperitoneal injections of diethylnitrosamine (DEN); 2 weeks later, some mice also received left and median bile duct ligation (LMBDL) and, then 1 week later, were fed DEN, in corn oil, weekly by oral gavage (DLD)." | 3.77 | A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. ( Aller, MA; Ko, KS; Li, TW; Peng, J; Tang, X; Xia, M; Yang, H, 2011) |
| " To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma." | 3.75 | Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009) |
| " Glutathione S-transferase placental (GST-P)-negative hepatocellular altered foci (HAF), hepatocellular adenoma (HCA), and hepatocellular carcinoma (HCC) were generated by two initiation-promotion models with N-nitrosodiethylamine (NDEN) and peroxisome proliferators, Wy-14,643 and clofibrate." | 3.72 | alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. ( Fukushima, S; Kikuchi, K; Kushida, M; Mikami, N; Morimura, K; Oeda, K; Okuno, Y; Ozaki, K; Saito, K; Sukata, T; Sumida, K; Uwagawa, S, 2004) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 1.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| " As a competitor of SHBG-androgen binding, EE2 could bind with SHBG and increase the bioavailability of androgen." | 1.62 | Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin. ( Heo, JH; Hong, EJ; Jeong, SH; Jo, SL; Ko, JW; Kwun, HJ; Lee, SR, 2021) |
| "Phenobarbital treated mice showed damped corticosterone levels and a less stable 24 hours activity rhythm as well as an increase in activity during the light phase, reminiscent of sleep disruption." | 1.62 | Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. ( Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M, 2021) |
| " However, the bioavailability of ABZ is very poor." | 1.62 | Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression. ( Amin, NA; Batiha, GE; El-Ahwany, E; El-Rous, MA; Elagamy, HI; Elewa, YHA; Elsergany, RN; Girgis, S; Gobba, NA; Hafez, AM; Kaddah, MMY; Kamal, I; Khodir, AE; Mahmoud, MH; Mourad, AAE; Nasr, M; Saad, AS; Saber, S; Shata, A, 2021) |
| "Pioglitazone treatment started at the first signs of fibrosis in both models." | 1.51 | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019) |
| "In the NAFLD pigs, hepatic histology of nonalcoholic steatohepatitis (NASH) was observed at 36 weeks, and HCC developed at 60 weeks." | 1.51 | Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. ( Aizawa, N; Hatano, E; Iguchi, K; Iijima, H; Ikegawa, M; Kawaguchi, H; Nakamura, N; Nishiguchi, S; Ohtsu, I; Okuda, Y; Sakurai, T; Sato, M; Seo, S; Taura, K; Tomono, T; Uemoto, S; Wada, S, 2019) |
| "However, the change of 5 hmC level in hepatocellular carcinoma (HCC) and association with clinical outcome were not well defined." | 1.39 | Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1. ( Bian, XW; Bie, P; Chen, X; Cui, Y; Liu, C; Liu, L; Qian, C; Shan, J; Shen, J; Wu, L; Xia, F; Xu, Y; Yang, Z, 2013) |
| "Decreased KLF6 expression in human hepatocellular carcinoma (HCC) correlates with increased mortality, but the contribution of increased SV1 is unknown." | 1.38 | Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing. ( Cohen-Naftaly, M; Friedman, SL; Hannivoort, R; Kocabayoglu, P; Lee, YA; M Llovet, J; Narla, G; Thung, SN; Vetter, D; Villanueva, A, 2012) |
| "Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels." | 1.38 | Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. ( Chen, HY; Dai, RY; He, YQ; Li, YQ; Li, Z; Lin, Y; Liu, Q; Qiu, BJ; Shan, L; Tan, YX; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, H; Yan, HX; Yang, W; Yu, LX; Zhai, B; Zhang, HL; Zheng, LY, 2012) |
| "Phosphorylated STAT3 was found in human hepatocellular carcinoma tissue samples and was expressed in tumor cells and also in monocytes." | 1.37 | STAT3 activation in monocytes accelerates liver cancer progression. ( Li, J; Meng, XL; Wu, WY; Wu, ZS; Zhang, CL, 2011) |
| "Mean DeltaR2* decreased during liver fibrosis progression, from 19." | 1.36 | Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis. ( Chadashvili, T; Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; Yang, GY; Zhang, Y; Zhang, Z, 2010) |
| "Recently, human non-alcholic steatohepatitis (NASH) has been focused of attention regarding hepatocellular carcinoma." | 1.34 | High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice. ( Fukushima, S; Hagihara, A; Iwai, S; Makino, S; Min, W; Mori, S; Morimura, K; Murai, T; Seki, S, 2007) |
| "Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative." | 1.30 | Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (11.43) | 18.2507 |
| 2000's | 17 (24.29) | 29.6817 |
| 2010's | 38 (54.29) | 24.3611 |
| 2020's | 7 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chun, HJ | 1 |
| Shim, YJ | 1 |
| Kwon, YH | 1 |
| Lee, SR | 1 |
| Jeong, SH | 1 |
| Heo, JH | 1 |
| Jo, SL | 1 |
| Ko, JW | 1 |
| Kwun, HJ | 1 |
| Hong, EJ | 1 |
| Guerrero-Escalera, D | 1 |
| Alarcón-Sánchez, BR | 1 |
| Arellanes-Robledo, J | 1 |
| Cruz-Rangel, A | 1 |
| Del Pozo-Yauner, L | 1 |
| Chagoya de Sánchez, V | 1 |
| Resendis-Antonio, O | 1 |
| Villa-Treviño, S | 1 |
| Torres-Mena, JE | 1 |
| Pérez-Carreón, JI | 1 |
| Mello, T | 1 |
| Materozzi, M | 1 |
| Zanieri, F | 1 |
| Simeone, I | 1 |
| Ceni, E | 1 |
| Bereshchenko, O | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Marroncini, G | 1 |
| Nerlov, C | 1 |
| Guasti, D | 1 |
| Bani, D | 1 |
| Pinzani, M | 1 |
| Galli, A | 1 |
| Hassan, SA | 1 |
| Ali, AAH | 1 |
| Yassine, M | 1 |
| Sohn, D | 1 |
| Pfeffer, M | 1 |
| Jänicke, RU | 1 |
| Korf, HW | 1 |
| von Gall, C | 1 |
| Raffaele, M | 1 |
| Kovacovicova, K | 1 |
| Frohlich, J | 1 |
| Lo Re, O | 1 |
| Giallongo, S | 1 |
| Oben, JA | 1 |
| Faldyna, M | 1 |
| Leva, L | 1 |
| Giannone, AG | 1 |
| Cabibi, D | 1 |
| Vinciguerra, M | 1 |
| Saber, S | 1 |
| Nasr, M | 1 |
| Saad, AS | 1 |
| Mourad, AAE | 1 |
| Gobba, NA | 1 |
| Shata, A | 1 |
| Hafez, AM | 1 |
| Elsergany, RN | 1 |
| Elagamy, HI | 1 |
| El-Ahwany, E | 1 |
| Amin, NA | 1 |
| Girgis, S | 1 |
| Elewa, YHA | 1 |
| Mahmoud, MH | 1 |
| Batiha, GE | 1 |
| El-Rous, MA | 1 |
| Kamal, I | 1 |
| Kaddah, MMY | 1 |
| Khodir, AE | 1 |
| Yan, G | 1 |
| Wang, X | 3 |
| Sun, C | 1 |
| Zheng, X | 1 |
| Wei, H | 1 |
| Tian, Z | 1 |
| Sun, R | 1 |
| Sakurai, Y | 1 |
| Kubota, N | 1 |
| Takamoto, I | 1 |
| Obata, A | 1 |
| Iwamoto, M | 1 |
| Hayashi, T | 1 |
| Aihara, M | 1 |
| Kubota, T | 1 |
| Nishihara, H | 1 |
| Kadowaki, T | 1 |
| Moreno-Marín, N | 1 |
| Barrasa, E | 1 |
| Morales-Hernández, A | 1 |
| Paniagua, B | 1 |
| Blanco-Fernández, G | 1 |
| Merino, JM | 1 |
| Fernández-Salguero, PM | 1 |
| Guo, X | 1 |
| Noguchi, H | 1 |
| Ishii, N | 1 |
| Homma, T | 1 |
| Hamada, T | 1 |
| Hiraki, T | 1 |
| Zhang, J | 2 |
| Matsuo, K | 1 |
| Yokoyama, S | 1 |
| Ishibashi, H | 1 |
| Fukushige, T | 1 |
| Kanekura, T | 1 |
| Fujii, J | 1 |
| Uramoto, H | 1 |
| Tanimoto, A | 1 |
| Yamada, S | 2 |
| Li, S | 1 |
| Ghoshal, S | 1 |
| Sojoodi, M | 1 |
| Arora, G | 1 |
| Masia, R | 1 |
| Erstad, DJ | 1 |
| Lanuti, M | 2 |
| Hoshida, Y | 2 |
| Baumert, TF | 1 |
| Tanabe, KK | 2 |
| Fuchs, BC | 2 |
| Kaltenecker, D | 1 |
| Themanns, M | 1 |
| Mueller, KM | 1 |
| Spirk, K | 1 |
| Golob-Schwarzl, N | 1 |
| Friedbichler, K | 1 |
| Kenner, L | 1 |
| Haybaeck, J | 1 |
| Moriggl, R | 1 |
| Cho, W | 1 |
| Jin, X | 1 |
| Pang, J | 1 |
| Wang, Y | 2 |
| Mivechi, NF | 1 |
| Moskophidis, D | 1 |
| Nakamura, N | 2 |
| Hatano, E | 1 |
| Iguchi, K | 1 |
| Sato, M | 1 |
| Kawaguchi, H | 1 |
| Ohtsu, I | 1 |
| Sakurai, T | 1 |
| Aizawa, N | 1 |
| Iijima, H | 1 |
| Nishiguchi, S | 1 |
| Tomono, T | 1 |
| Okuda, Y | 1 |
| Wada, S | 1 |
| Seo, S | 1 |
| Taura, K | 1 |
| Uemoto, S | 1 |
| Ikegawa, M | 1 |
| Casagrande, V | 1 |
| Mauriello, A | 1 |
| Anemona, L | 1 |
| Mavilio, M | 1 |
| Iuliani, G | 1 |
| De Angelis, L | 1 |
| D'Onofrio, M | 1 |
| Arisi, I | 1 |
| Federici, M | 1 |
| Menghini, R | 1 |
| Liu, C | 1 |
| Liu, L | 1 |
| Chen, X | 2 |
| Shen, J | 1 |
| Shan, J | 1 |
| Xu, Y | 1 |
| Yang, Z | 1 |
| Wu, L | 1 |
| Xia, F | 1 |
| Bie, P | 1 |
| Cui, Y | 1 |
| Bian, XW | 1 |
| Qian, C | 1 |
| Lin, H | 3 |
| Liu, XB | 1 |
| Yu, JJ | 1 |
| Hua, F | 3 |
| Hu, ZW | 3 |
| Scaiewicz, V | 1 |
| Nahmias, A | 1 |
| Chung, RT | 1 |
| Mueller, T | 1 |
| Tirosh, B | 1 |
| Shibolet, O | 1 |
| Fujii, T | 1 |
| Wei, L | 2 |
| Lauwers, GY | 1 |
| McGinn, CM | 1 |
| DePeralta, DK | 1 |
| Kuroda, T | 1 |
| Schmitt, AD | 1 |
| Gupta, S | 1 |
| Crenshaw, A | 1 |
| Onofrio, R | 1 |
| Taylor, B | 1 |
| Winckler, W | 1 |
| Bardeesy, N | 1 |
| Caravan, P | 1 |
| Golub, TR | 1 |
| Mukhopadhyay, B | 1 |
| Schuebel, K | 1 |
| Mukhopadhyay, P | 1 |
| Cinar, R | 1 |
| Godlewski, G | 1 |
| Xiong, K | 1 |
| Mackie, K | 1 |
| Lizak, M | 1 |
| Yuan, Q | 1 |
| Goldman, D | 1 |
| Kunos, G | 1 |
| Shen, Y | 1 |
| Wei, Y | 1 |
| Wang, Z | 3 |
| Jing, Y | 1 |
| He, H | 1 |
| Yuan, J | 1 |
| Li, R | 1 |
| Zhao, Q | 1 |
| Yang, T | 1 |
| Lu, J | 1 |
| Fujisawa, K | 1 |
| Terai, S | 1 |
| Matsumoto, T | 1 |
| Takami, T | 1 |
| Yamamoto, N | 1 |
| Nishina, H | 1 |
| Furutani-Seiki, M | 1 |
| Sakaida, I | 1 |
| Shibata, Y | 1 |
| Hara, T | 1 |
| Nagano, J | 1 |
| Ohno, T | 1 |
| Ninomiya, S | 1 |
| Ito, H | 2 |
| Tanaka, T | 1 |
| Saito, K | 2 |
| Seishima, M | 1 |
| Shimizu, M | 1 |
| Moriwaki, H | 1 |
| Tsurumi, H | 1 |
| Kowalik, MA | 1 |
| Perra, A | 1 |
| Ledda-Columbano, GM | 1 |
| Ippolito, G | 1 |
| Piacentini, M | 1 |
| Columbano, A | 1 |
| Falasca, L | 1 |
| Mercer, KE | 1 |
| Pulliam, C | 1 |
| Hennings, L | 1 |
| Lai, K | 1 |
| Cleves, M | 1 |
| Jones, E | 1 |
| Drake, RR | 1 |
| Ronis, M | 1 |
| Wei, T | 1 |
| Chen, W | 1 |
| Wen, L | 1 |
| Zhang, Q | 1 |
| Yang, J | 1 |
| Liu, H | 3 |
| Chen, BW | 1 |
| Zhou, Y | 1 |
| Feng, X | 1 |
| Yang, Q | 1 |
| Bai, X | 1 |
| Liang, T | 1 |
| Chi, HC | 1 |
| Chen, SL | 1 |
| Tsai, CY | 1 |
| Chuang, WY | 1 |
| Huang, YH | 1 |
| Tsai, MM | 1 |
| Wu, SM | 1 |
| Sun, CP | 1 |
| Yeh, CT | 1 |
| Lin, KH | 1 |
| Sheppard, S | 1 |
| Guedes, J | 1 |
| Mroz, A | 1 |
| Zavitsanou, AM | 1 |
| Kudo, H | 1 |
| Rothery, SM | 1 |
| Angelopoulos, P | 1 |
| Goldin, R | 1 |
| Guerra, N | 1 |
| Ding, YF | 1 |
| Wu, ZH | 1 |
| Wei, YJ | 1 |
| Shu, L | 1 |
| Peng, YR | 1 |
| Kaji, K | 1 |
| Yoshiji, H | 1 |
| Kitade, M | 1 |
| Ikenaka, Y | 1 |
| Noguchi, R | 1 |
| Yoshii, J | 1 |
| Yanase, K | 1 |
| Namisaki, T | 1 |
| Yamazaki, M | 1 |
| Moriya, K | 1 |
| Tsujimoto, T | 1 |
| Kawaratani, H | 1 |
| Akahane, T | 1 |
| Uemura, M | 1 |
| Fukui, H | 1 |
| Furtado, KS | 1 |
| Pires, PW | 1 |
| Justulin, LA | 1 |
| Rodrigues, MA | 1 |
| Felisbino, SL | 1 |
| Barbisan, LF | 2 |
| Al-Rejaie, SS | 1 |
| Aleisa, AM | 1 |
| Al-Yahya, AA | 1 |
| Bakheet, SA | 1 |
| Alsheikh, A | 1 |
| Fatani, AG | 1 |
| Al-Shabanah, OA | 1 |
| Sayed-Ahmed, MM | 1 |
| Ishii, Y | 1 |
| Sakamoto, T | 1 |
| Ito, R | 1 |
| Yanaga, K | 1 |
| Liu, YF | 1 |
| Zha, BS | 1 |
| Zhang, HL | 2 |
| Zhu, XJ | 1 |
| Li, YH | 1 |
| Zhu, J | 1 |
| Guan, XH | 1 |
| Feng, ZQ | 1 |
| Zhang, JP | 1 |
| Jin, N | 1 |
| Deng, J | 1 |
| Chadashvili, T | 1 |
| Zhang, Y | 1 |
| Guo, Y | 1 |
| Zhang, Z | 1 |
| Yang, GY | 1 |
| Omary, RA | 1 |
| Larson, AC | 1 |
| Lu, X | 1 |
| Guo, H | 1 |
| Molter, J | 1 |
| Miao, H | 1 |
| Gerber, L | 1 |
| Hu, Y | 1 |
| Barnes, EL | 1 |
| Vogel, H | 1 |
| Lee, Z | 1 |
| Luo, G | 1 |
| Wang, B | 1 |
| Yang, H | 2 |
| Li, TW | 1 |
| Peng, J | 1 |
| Tang, X | 1 |
| Ko, KS | 1 |
| Xia, M | 1 |
| Aller, MA | 1 |
| Park, O | 1 |
| Wang, H | 1 |
| Weng, H | 1 |
| Feigenbaum, L | 1 |
| Li, H | 1 |
| Yin, S | 1 |
| Ki, SH | 1 |
| Yoo, SH | 1 |
| Dooley, S | 1 |
| Wang, FS | 1 |
| Young, HA | 1 |
| Gao, B | 1 |
| Wu, WY | 1 |
| Li, J | 1 |
| Wu, ZS | 1 |
| Zhang, CL | 1 |
| Meng, XL | 1 |
| Xu, CS | 1 |
| Wang, GP | 1 |
| Zhang, LX | 1 |
| Chang, CF | 1 |
| Zhi, J | 2 |
| Hao, YP | 1 |
| Schneider, C | 1 |
| Teufel, A | 1 |
| Yevsa, T | 1 |
| Staib, F | 1 |
| Hohmeyer, A | 1 |
| Walenda, G | 1 |
| Zimmermann, HW | 1 |
| Vucur, M | 1 |
| Huss, S | 1 |
| Gassler, N | 1 |
| Wasmuth, HE | 1 |
| Lira, SA | 1 |
| Zender, L | 1 |
| Luedde, T | 1 |
| Trautwein, C | 1 |
| Tacke, F | 1 |
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2 reviews available for diethylnitrosamine and Disease Exacerbation
| Article | Year |
|---|---|
The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: transforming growth factor alpha expression as a marker for the stage of progression.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Count; Cell Transformation, Neoplastic; | 1995 |
Genetic analysis of multistage hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Disease | 1996 |
68 other studies available for diethylnitrosamine and Disease Exacerbation
| Article | Year |
|---|---|
Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet.
Topics: Amino Acids; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cholesterol; Cholesterol, Dietary; | 2022 |
Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin.
Topics: Androgens; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Disease P | 2021 |
Comparative subcellular localization of NRF2 and KEAP1 during the hepatocellular carcinoma development in vivo.
Topics: Actin Cytoskeleton; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cyclooxygenase 1; Diethylnitro | 2022 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Ci | 2021 |
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
Topics: Aging; Animals; Dasatinib; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Disease Progr | 2021 |
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.
Topics: Albendazole; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biological Availability; Carci | 2021 |
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances.
Topics: Alcohol Drinking; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Pr | 2017 |
Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2017 |
Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethy | 2017 |
The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma.
Topics: Aged; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cohort St | 2019 |
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High- | 2019 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Pro | 2019 |
Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.
Topics: Acute-Phase Proteins; Adolescent; Adult; Aged; Animals; Biomarkers; Blood Proteins; Carcinogens; Car | 2019 |
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Topics: Animals; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; Disease Progression; Fatty L | 2019 |
Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.
Topics: 5-Methylcytosine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytosine; | 2013 |
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethyl | 2013 |
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.
Topics: Active Transport, Cell Nucleus; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nucleus; Di | 2013 |
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul | 2014 |
Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progression; Endocannabinoids; Forkh | 2015 |
TGF-β regulates hepatocellular carcinoma progression by inducing Treg cell polarization.
Topics: Animals; Azabicyclo Compounds; Carcinoma, Hepatocellular; Cell Differentiation; Cell Polarity; Cell | 2015 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Topics: Adenoma; Animals; CD8 Antigens; Cyclooxygenase 2; Diethylnitrosamine; Disease Progression; Forkhead | 2016 |
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules.
Topics: Alkylating Agents; Animals; Autophagy; Carcinogenesis; Diethylnitrosamine; Disease Progression; Gene | 2016 |
Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice.
Topics: Adenoma; Alkylating Agents; Animals; Blotting, Western; Carcinoma, Hepatocellular; Diet; Diethylnitr | 2016 |
G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis.
Topics: Animals; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethylnitrosamine | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Immunological; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proli | 2017 |
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Progression; Hepatitis; | 2017 |
Impact of insulin resistance on the progression of chronic liver diseases.
Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu | 2008 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Bilirubin; Carnitine; Catalase; Dietary Supplem | 2009 |
Anti-angiogenic therapy on hepatocellular carcinoma development and progression.
Topics: alpha-Fetoproteins; Angiogenesis Inhibitors; Animals; Diethylnitrosamine; Disease Progression; Inter | 2010 |
Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model.
Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Progression; Gene Ex | 2009 |
Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Diethylnitrosamine; Disease Progression; Image Proces | 2010 |
Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Female | 2011 |
A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic Helix-Loop-Helix Transcr | 2011 |
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury, Chronic; Concanavalin A; Diethylnitr | 2011 |
STAT3 activation in monocytes accelerates liver cancer progression.
Topics: Aminosalicylic Acids; Analysis of Variance; Animals; Apoptosis; Benzenesulfonates; Carcinogens; Carc | 2011 |
Correlation between liver cancer occurrence and gene expression profiles in rat liver tissue.
Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Gene Expression Profiling; | 2011 |
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Chemo | 2012 |
Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.
Topics: Analysis of Variance; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal | 2012 |
Gene expression profiles reveal significant differences between rat liver cancer and liver regeneration.
Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Proliferation; Diethylnitrosamine; Disease P | 2012 |
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Bifidobacterium; Carcinoma, Hepatocellular; Cytok | 2012 |
Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progr | 2013 |
Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice.
Topics: Alkylating Agents; Animals; Autophagy; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; C | 2013 |
Toll-like receptor 4 activity protects against hepatocellular tumorigenesis and progression by regulating expression of DNA repair protein Ku70 in mice.
Topics: Animals; Antigens, Nuclear; Apoptosis; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; D | 2013 |
Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Progression; Gen | 2013 |
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III.
Topics: Acetylglucosamine; Animals; Apoptosis; Carbohydrate Sequence; Carcinogens; Cell Division; Diethylnit | 2003 |
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Topics: Adenoma; Alkylating Agents; alpha-Macroglobulins; Animals; Anticholesteremic Agents; Biomarkers, Tum | 2004 |
Effect of proapoptosis protein on hepatocarcinogenesis.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cell Proliferati | 2005 |
Increased lung metastasis in transgenic NM23-Null/SV40 mice with hepatocellular carcinoma.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral, Tumor; Biomarkers, Tumor; Blotting, Western; Chi-Squar | 2005 |
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemokine CCL3; Chemokine CCL4; Diethylnitros | 2006 |
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: comparison to C3H and C57 mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Deoxyguanosine; Diethylnitrosamine; Disease | 2007 |
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cyclin D1; Diethylnitrosamine; Disease Progression; | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors.
Topics: Animals; Base Sequence; Carcinogens; CpG Islands; Diethylnitrosamine; Disease Models, Animal; Diseas | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Correlation of repressed transcription of alpha-tocopherol transfer protein with serum alpha-tocopherol during hepatocarcinogenesis.
Topics: Aged; Animals; Carcinogens; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Diethylnitrosa | 1997 |
Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression.
Topics: Acetylglucosamine; Animals; Carcinogens; Diethylnitrosamine; Disease Progression; Female; Genetic Ve | 1998 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt | 1998 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitro | 1999 |
Oral administration of cholic acid promotes growth of liver tumors initiated by diethylnitrosamine in rats.
Topics: Administration, Oral; Animals; Apoptosis; Carcinogens; Cell Division; Cholic Acid; Diethylnitrosamin | 1999 |
Effects of dietary iron overload on progression in chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Ch | 1999 |
Diet restriction increases ubiquinone contents and inhibits progression of hepatocellular carcinoma in the rat.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Apoptosis; Carcinogens; Cell Division; Diethylnitrosam | 2000 |
New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice.
Topics: Alleles; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Diethylnitrosamine; Dis | 2000 |
Effects of fasting and intermittent fasting on rat hepatocarcinogenesis induced by diethylnitrosamine.
Topics: Alkylating Agents; Animals; Basophils; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2002 |