diethylnitrosamine has been researched along with Condition, Preneoplastic in 451 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 7.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 5.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| " Here, hyperpolyploidization of hepatocytes around the centrilobular (CL) region is demonstrated to be closely linked with the development of HCC cells after diethylnitrosamine treatment." | 4.02 | Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver. ( Chao, HW; Chen, H; Chen, HW; Doi, M; Fustin, JM; Hou, HS; Huang, YS; King, PC; Lai, HH; Lee, YL; Lin, H; Lin, SH; Young, PY, 2021) |
| " The chemically-induced mouse model of diethylnitrosamine (DEN) provides useful insight into liver carcinogenesis, namely HCC." | 3.80 | The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. ( Colaço, A; Da Costa, RM; Lopes, C; Oliveira, PA; Paula-Santos, N; Rocha, AF, 2014) |
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| ") injection of 200 mg/kg body weight diethylnitrosamine (DEN)." | 3.73 | Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Panayappan, L; Srivastawa, S, 2006) |
| "0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice." | 3.66 | Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. ( Goldfarb, S; He, YZ; Koen, H; Pugh, TD, 1983) |
| "Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat." | 3.66 | Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. ( Farber, E; Sarma, DS; Ying, TS, 1981) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Carcinomas developed in the mucosa of the esophagus in BUF strain rats ingesting diethylnitrosamine in the diet." | 3.65 | Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine. ( Reuber, MD, 1977) |
| " Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation." | 1.56 | Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020) |
| "The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood." | 1.43 | TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. ( Bohner, A; Dapito, DH; Lammert, F; Schwabe, RF; Weber, SN, 2016) |
| "Diethylnitrosamine (DEN) was adopted to induce hepatic precancerous model in mice through intraperitoneal injection, and prevention efficacy of TMPZ at a dose of 162 mg/kg was examined by liver histological analysis and activities of serum marker enzymes." | 1.40 | Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects. ( Cai, D; Feng, L; Jiao, Y; Liu, X; Mao, W; Wang, X; Wang, Y; Zhang, D; Zhang, J; Zhao, X, 2014) |
| "Pinocembrin was neither mutagenic nor carcinogenic in rat liver, and neither inhibited nor prevented micronucleus formation as well as GST-P positive foci formation induced by diethylnitrosamine." | 1.38 | Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis. ( Fukushima, S; Pompimon, W; Punvittayagul, C; Wanibuchi, H; Wongpoomchai, R, 2012) |
| " At day 0, the fertilized eggs of the dosed groups were injected with 1 (LD) or 4 (HD) mg/egg (about 12." | 1.37 | Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine. ( Brunnemann, KD; Enzmann, HG; Iatropoulos, MJ; Smart, DJ; Williams, GM, 2011) |
| "Quercetin is an antioxidant flavonoid, found ubiquitously in nature and extensively used in herbal medicines and food additives." | 1.37 | Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats. ( Gupta, C; Jena, GB; Ramarao, P; Tripathi, DN; Vikram, A, 2011) |
| " In the present study, the authors treated C57BL/6 mice with 25, 50, and 75 mg/kg of diethylnitrosamine (DEN) for 4 or 8 weeks by intraperitoneal injection to investigate the dose-response pattern of preneoplastic and neoplastic lesion formation in the liver." | 1.37 | Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice. ( Kamendulis, LM; Klaunig, JE; Kushida, M; Peat, TJ, 2011) |
| " Using this model, we investigated the efficacy of an equivalent dosage of dietary LY from either a pure compound or a tomato extract (TE) against NASH-promoted hepatocarcinogenesis." | 1.36 | Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. ( Ausman, LM; Greenberg, AS; Russell, RM; Wang, XD; Wang, Y, 2010) |
| "Embelin treatment significantly prevented NDEA or CCl4 induced increase in biochemical marker enzymes: glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, glutathione-S-transferase, lipid peroxidase as well as hypoproteinemia, hypoalbuminuria and glutathione depletion." | 1.36 | Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver. ( Bhagwat, S; Gupta, S; Khade, B; Maru, G; Poojari, R, 2010) |
| " Our results showed a resistance to the toxic effects of EA since viability and cellular integrity values were significantly higher than control." | 1.34 | Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. ( Alvarez, Mde L; Carnovale, C; Carrillo, MC; Francés, D; Parody, JP; Quiroga, A; Ronco, MT, 2007) |
| "Cyclohexanol is a basic industrial chemical widely used because of its versatility as an industrial solvent." | 1.34 | Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model. ( Alemán-Lazarini, L; Arce-Popoca, E; Cabrales-Romero, Mdel P; Carrasco-Legleu, CE; Fatel-Fazenda, S; Márquez-Rosado, L; Sierra-Santoyo, A; Trejo-Solís, C; Villa-Treviño, S, 2007) |
| "Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms." | 1.34 | Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007) |
| " Two reports recorded the appearance of tumors after treatment with NDEA, although one used a different dosing schedule that included phenobarbital promotion." | 1.33 | Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine. ( Fukushima, S; Waddell, WJ; Williams, GM, 2006) |
| "N-diethylnitrosamine is an important carcinogen used in liver cancer animal models." | 1.33 | Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis. ( Alemán-Lazarini, L; Carrasco-Legleu, C; García-Cuellar, C; Hernández-García, S; Pérez-Carreón, J; Salcido-Neyoy, M; Sánchez-Pérez, Y; Villa-Treviño, S, 2005) |
| "05 ppm, caused significant reduction, showing a J-shape dose-response curve." | 1.33 | Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes. ( Fukushima, S; Funae, Y; Kinoshita, A; Mitsuru, F; Morimura, K; Oka, M; Puatanachokchai, R; Wanibuchi, H; Yamaguchi, S, 2006) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "As tumors progressed to hepatocellular carcinomas, the additional Tg FoxM1B protein had no effect on cell proliferation, and there was no increase in tumor burden compared to wild-type animals." | 1.32 | Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions. ( Adami, GR; Costa, RH; Kalinin, SA; Kalinina, OA; Mikaelian, I; Panda, S; Polack, EW, 2003) |
| " Two weeks later, daily dosing of 0." | 1.32 | Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. ( Andersen, ME; Chubb, LS; Conolly, RB; Dobrev, ID; Gustafson, DL; Lapidot, SA; Long, ME; Ou, YC; Thomas, RS; Xu, Y; Yang, RS, 2003) |
| "In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development." | 1.31 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002) |
| " These rats had been treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) under different dosing regimens, but we used the same administered biweekly dose of 1." | 1.31 | Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. ( Lucier, GW; Portier, CJ; Sills, RC; Tritscher, AM; Walker, NJ, 2000) |
| "Hepatocellular carcinomas were induced with the decreased Bcl-x protein expression." | 1.31 | Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. ( Ashida, H; Danno Gi, G; Hashizume, K; Hatanaka, Y; Kamihara, Y; Kinoshita, N; Konishi, Y; Mutai, M; Nakae, D; Ohta, S; Tani, Y, 2001) |
| "Vanadium (V) has recently been found to possess potent anti-neoplastic activity in rat hepatocarcinogenesis." | 1.31 | Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3). ( Basak, R; Chatterjee, M; Saha, BK, 2000) |
| "Diethylnitrosamine-treated TT mice developed both preneoplastic and neoplastic lesions in the liver." | 1.31 | Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene. ( Altavilla, G; Barbanti-Brodano, G; Caputo, A; Corallini, A; Lanfredi, M; Piola, C, 2000) |
| "Melatonin treatment were performed only during the night (between 18:00 to 09:00) in order to maintain their circadian rhythm, since serum melatonin levels are high at midnight." | 1.31 | Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. ( Asamoto, M; Futakuchi, M; Hagiwara, A; Imaida, K; Ogawa, K; Sano, M; Shirai, T; Tamano, S; Yoshino, H, 2000) |
| "Diethylnitrosamine (DEN) was administered at the age of 8 weeks." | 1.30 | Chronic liver injury promotes hepatocarcinogenesis of the LEC rat. ( Enomoto, K; Hattori, A; Mori, M; Sawada, N; Sawaki, M; Sugawara, N; Tsuzuki, N, 1998) |
| "Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative." | 1.30 | Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998) |
| "Histologically, the tumors were hepatocellular carcinomas (HCCs) of trabecular, (pseudo)glandular and solid types with or without cholangiocellular involvement." | 1.30 | Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine. ( Ahn, B; Han, BS; Kim, DJ; Ohshima, H, 1999) |
| "Determining both the mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) acts as a tumor promoter and the shape of the dose-response curve at low doses remains an important goal of risk-assessment-directed research." | 1.30 | Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. ( Dragan, YP; Goldsworthy, T; Pitot, HC; Singh, J; Teeguarden, JG; Vaughan, J; Xu, YH, 1999) |
| "A stable and sensitive early marker of liver cancer--GST-Pi positive foci or nodule was measured by a immunohistochemical method." | 1.30 | [Inhibitory effects of tea polyphenols and tea pigments on liver precancerous lesions in rats]. ( Chen, J; Gong, Y; Han, C, 1999) |
| "Diethylnitrosamine (DEN) was administered to rats as a single dose, which is known not to give rise to liver tumours without subsequent promotion." | 1.30 | Iron promotes DEN initiated GST-P foci in rat liver. ( Carthew, P; Edwards, RE; Nolan, BM; Smith, AG, 1997) |
| " Because the dose-response curves were considered non-linear for most nitrosamines, synergistic effects were not apparent for the 1/4 mixture." | 1.29 | Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat. ( Futakuchi, M; Hasegawa, R; Hirose, M; Ito, N; Lijinsky, W; Shirai, T, 1996) |
| " In Experiment 2, a total of 45 female SD rats were dosed with DEN (100 mg/kg, i." | 1.29 | Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. ( Ahn, B; Bae, JH; Han, BS; Jang, JJ; Kim, DJ; Lee, KK, 1994) |
| "The dose-response characteristics of initiation of hepatocarcinogenesis by diethylnitrosamine (DEN) was investigated in the neonatal female rat by means of the quantitative stereologic estimation of altered hepatic foci (AHF) expressing multiple markers." | 1.29 | The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats. ( Dragan, YP; Pitot, HC; Xu, YH, 1993) |
| "HAM-6 was also slightly reactive to rat hepatocellular carcinoma, but not to normal or fetal rat liver, other normal rat organs, human hepatocellular carcinoma, or human liver cirrhosis." | 1.29 | Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens. ( Kurokawa, F, 1994) |
| "Hydroquinone (HQ) treatment 24 or 48 h after diethylnitrosamine (DEN) initiation reduced the number of glutathione S-transferase-P (GST-P)-positive hepatocytes in situ." | 1.29 | Selective toxicity in putative preneoplastic hepatocytes: a comparison of hydroquinone and duroquinone. ( Högberg, J; Stenius, U; Warholm, M, 1993) |
| " We conclude that long term intake of BC could reduce cancer risk by preventing hepatic lipid peroxidation and RBC membrane protein damage due to its antioxidant actions." | 1.29 | Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. ( Bishayee, A; Chatterjee, M; Sarkar, A, 1995) |
| " In contrast, the dose-response curve observed for DEN-treated rats 18 weeks after carcinogen administration was similar to that observed 2 weeks after carcinogen treatment for both phenobarbital- and non-phenobarbital-treated rats." | 1.29 | Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats. ( Baker, K; Campbell, HA; Dragan, YP; Mass, M; Pitot, HC; Vaughan, J, 1994) |
| "Propranolol is a lipophilic non-selective beta-blocker mainly eliminated via the liver; atenolol is a hydrophilic beta 1-selective blocking agent, mainly eliminated via the kidney." | 1.29 | Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats. ( Ameri, L; Arias, E; Girotti, P; Mazzoleni, G; Presta, M; Radaelli, G; Ragnotti, G; Zavanella, T, 1994) |
| "Deferoxamine (DFO) is an iron chelating agent and has been known to have an antiproliferative effect in various malignant cells including hepatocellular carcinoma and the effect seems to be related to depletion of iron." | 1.29 | The effect of deferoxamine on the preneoplastic lesions in the chemically induced hepatocarcinogenesis. ( Jung, WH; Park, C; Park, YN, 1994) |
| " The slope of the dose-response curve was rather steep." | 1.29 | Dose dependence of diethylnitrosamine-induced nuclear enlargement in embryonal turkey liver. ( Bannasch, P; Enzmann, H; Kühlem, C; Löser, E, 1995) |
| " We report here that the bioassay can rapidly detect carcinogenic doses of HCB and that there is a clear dose-response relationship." | 1.29 | Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene. ( Cabral, R; Hakoi, K; Hasegawa, R; Hoshiya, T; Ito, N, 1996) |
| " In the present study we examined the dose-response effect of dieldrin (at several doses) on focal lesion growth (tumor promotion), hepatocyte apoptosis and DNA synthesis in rat and mouse liver." | 1.29 | Selective dieldrin promotion of hepatic focal lesions in mice. ( Klaunig, JE; Kolaja, KL; Stevenson, DE; Walborg, EF, 1996) |
| "5." | 1.28 | Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine. ( Pulga, VB; Sulakhe, SJ; Tran, ST, 1992) |
| "d-Limonene treatment alone caused a significant increase in the number of atypical tubules and atypical hyperplasias in F344 rats when compared with the F344 vehicle control." | 1.28 | The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. ( Dietrich, DR; Swenberg, JA, 1991) |
| "One of the critical issues in risk assessment for chemical carcinogens is the evaluation of dose-response relationships for tumor promoters." | 1.28 | Dose-response relationships in promotion of rat hepatocarcinogenesis by 17 alpha-ethinylestradiol. ( Campen, D; Lucier, G; Maronpot, R, 1990) |
| " Dose-response experiments showed that the hepatocarcinogenic effects of long-term chlordecone administration became undetectable at concentrations in non-initiated rat liver in the same range as those measured in human biopsies taken from exposed workers who exhibited no liver effects." | 1.28 | Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. ( Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL, 1989) |
| " In this model HQ could be shown to be selectively toxic to GGT-negative cells in the presence of extracellular GSH." | 1.28 | The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci. ( Högberg, J; Lundberg, I; Rannug, A; Stenius, U; Walles, S; Warholm, M, 1989) |
| "Tfm (testicular feminization) mutant mice lack functional androgen receptors." | 1.28 | Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous. ( Drinkwater, NR; Kemp, CJ; Leary, CN, 1989) |
| "Phenobarbital (PB) promotes hepatic tumorigenesis when chronically administered to male B6C3F1 mice after initiation with diethylnitrosamine (DENA) at 30 days of age." | 1.28 | Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender. ( Klaunig, JE; Weghorst, CM, 1989) |
| "Diethylnitrosamine was injected to Sprague-Dawley rats after a partial hepatectomy, and enzyme histochemistry analysis was made after 35 weeks in the preneoplastic liver." | 1.27 | [Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine]. ( Domingo, J; Estadella, MD; Pujol, MJ, 1983) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "Thiourea (TU) fails to enhance the incidence of foci deficient in adenosine-5'-triphosphatase (ATPase) either by initiation or by promotion in a rat liver foci bioassay." | 1.27 | Lack of initiating and promoting activity of thiourea in rat liver foci bioassay. ( Deml, E; Oesterle, D, 1988) |
| " The dose levels in the individual dose-response experiments ranged from the lowest concentrations of previous experiments (NDEA, 0." | 1.27 | Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats. ( Berger, MR; Schmähl, D; Zerban, H, 1987) |
| "When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA." | 1.26 | Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver. ( Britt, AL; Herren, SL; Khoury, MM; Pereira, MA, 1982) |
| " Dose-response relationships measured with diethylnitrosamine, the carcinogen with the lowest toxicity as compared with the carcinogenic action, indicated that island formation is due to a one-hit process, i." | 1.26 | Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. ( Emmelot, P; Scherer, E, 1976) |
| "The chronic administration of diethylnitrosamine in drinking water induces liver tumors in the rat." | 1.26 | [Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)]. ( Barbason, H; Betz, EH; Fridman-Manduzio, A, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 171 (37.92) | 18.7374 |
| 1990's | 149 (33.04) | 18.2507 |
| 2000's | 83 (18.40) | 29.6817 |
| 2010's | 45 (9.98) | 24.3611 |
| 2020's | 3 (0.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sojoodi, M | 1 |
| Wei, L | 1 |
| Erstad, DJ | 1 |
| Yamada, S | 1 |
| Fujii, T | 1 |
| Hirschfield, H | 1 |
| Kim, RS | 1 |
| Lauwers, GY | 1 |
| Lanuti, M | 1 |
| Hoshida, Y | 1 |
| Tanabe, KK | 1 |
| Fuchs, BC | 1 |
| Takasu, S | 1 |
| Ishii, Y | 3 |
| Kijima, A | 1 |
| Ogawa, K | 8 |
| Nakane, S | 1 |
| Umemura, T | 3 |
| Lin, H | 1 |
| Huang, YS | 1 |
| Fustin, JM | 1 |
| Doi, M | 1 |
| Chen, H | 1 |
| Lai, HH | 1 |
| Lin, SH | 1 |
| Lee, YL | 1 |
| King, PC | 1 |
| Hou, HS | 1 |
| Chen, HW | 1 |
| Young, PY | 1 |
| Chao, HW | 1 |
| Kumar, V | 1 |
| Bhatt, PC | 1 |
| Rahman, M | 1 |
| Al-Abbasi, FA | 1 |
| Anwar, F | 1 |
| Verma, A | 1 |
| Horng, CT | 1 |
| Huang, CW | 1 |
| Yang, MY | 1 |
| Chen, TH | 1 |
| Chang, YC | 1 |
| Wang, CJ | 1 |
| Ito, Y | 1 |
| Nakajima, K | 1 |
| Masubuchi, Y | 1 |
| Kikuchi, S | 1 |
| Saito, F | 1 |
| Akahori, Y | 1 |
| Jin, M | 6 |
| Yoshida, T | 3 |
| Shibutani, M | 6 |
| Matboli, M | 1 |
| ElGwad, AA | 1 |
| Hasanin, AH | 1 |
| El-Tawdi, A | 1 |
| Habib, EK | 1 |
| Elmansy, RA | 1 |
| Ibrahim, D | 1 |
| Shehata, H | 1 |
| Tash, F | 1 |
| Feng, L | 1 |
| Mao, W | 1 |
| Zhang, J | 1 |
| Liu, X | 1 |
| Jiao, Y | 1 |
| Zhao, X | 1 |
| Wang, X | 2 |
| Zhang, D | 1 |
| Cai, D | 1 |
| Wang, Y | 3 |
| Kumamoto, R | 1 |
| Uto, H | 1 |
| Oda, K | 1 |
| Ibusuki, R | 1 |
| Tanoue, S | 1 |
| Arima, S | 1 |
| Mawatari, S | 1 |
| Kumagai, K | 1 |
| Numata, M | 1 |
| Tamai, T | 1 |
| Moriuchi, A | 1 |
| Fujita, H | 1 |
| Oketani, M | 1 |
| Ido, A | 1 |
| Tsubouchi, H | 1 |
| Shen, T | 1 |
| Khor, SC | 1 |
| Zhou, F | 1 |
| Duan, T | 1 |
| Xu, YY | 1 |
| Zheng, YF | 1 |
| Hsu, S | 1 |
| DE Stefano, J | 1 |
| Yang, J | 1 |
| Xu, LH | 1 |
| Zhu, XQ | 1 |
| Hara, S | 1 |
| Morita, R | 3 |
| Ogawa, T | 1 |
| Segawa, R | 1 |
| Takimoto, N | 1 |
| Suzuki, K | 3 |
| Hamadate, N | 1 |
| Hayashi, SM | 2 |
| Odachi, A | 1 |
| Ogiwara, I | 1 |
| Shibusawa, S | 1 |
| Santos, NP | 1 |
| Oliveira, PA | 2 |
| Arantes-Rodrigues, R | 1 |
| Faustino-Rocha, AI | 1 |
| Colaço, A | 2 |
| Lopes, C | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Urinary Excretion of Acetylamantadine by Cancer Patients[NCT02277938] | 120 participants (Anticipated) | Observational | 2013-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for diethylnitrosamine and Condition, Preneoplastic
| Article | Year |
|---|---|
[Early histochemical markers of hepatocarcinogenesis].
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; alpha-Fetoproteins; Animals; Diethylnitrosamine; g | 1984 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Genetic analysis of multistage hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Disease | 1996 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Trends in pathobiochemical studies of tumour development and progression.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Diethylnitrosamine; DNA; Homeostasis; Humans; L | 1986 |
446 other studies available for diethylnitrosamine and Condition, Preneoplastic
| Article | Year |
|---|---|
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescen | 2020 |
Furan Induced Characteristic Glutathione
Topics: Animals; Diethylnitrosamine; Female; Furans; Gene Expression; Glutathione Transferase; Kinetics; Liv | 2020 |
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosa | 2021 |
Umbelliferon-α-d-glucopyranosyl-(2
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Cytok | 2017 |
Nelumbo nucifera leaf extract treatment attenuated preneoplastic lesions and oxidative stress in the livers of diethylnitrosamine-treated rats.
Topics: Alanine Transaminase; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Aspartate Aminotrans | 2017 |
Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens.
Topics: Animals; Cadherins; Carbon Tetrachloride; Cell Proliferation; Cell Transformation, Neoplastic; Dieth | 2019 |
Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 2019 |
Pharmacokinetic variations of tetramethylpyrazine phosphate after oral administration in hepatic precancerous mice and its hepatoprotective effects.
Topics: Administration, Oral; Animals; Area Under Curve; Diethylnitrosamine; Liver; Liver Neoplasms, Experim | 2014 |
Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Biomarkers; Body Weight; Deoxyguanosine; | 2013 |
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; | 2014 |
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cocarcinogenesis; Diethylnitrosamin | 2014 |
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2014 |
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniqu | 2014 |
The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine | 2014 |
Chemopreventive effects of pequi oil (Caryocar brasiliense Camb.) on preneoplastic lesions in a mouse model of hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ericales; Liver Neoplasms, Experim | 2016 |
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Topics: alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers, Tumor; Carbon Tetrachloride; Carcinogens; Cell | 2015 |
Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats.
Topics: Animals; Antioxidants; Blueberry Plants; Catalase; Diethylnitrosamine; Glutathione; Lipid Peroxidati | 2016 |
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Topics: Adenoma; Animals; CD8 Antigens; Cyclooxygenase 2; Diethylnitrosamine; Disease Progression; Forkhead | 2016 |
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules.
Topics: Alkylating Agents; Animals; Autophagy; Carcinogenesis; Diethylnitrosamine; Disease Progression; Gene | 2016 |
Recurrent acute thermal lesion induces esophageal hyperproliferative premalignant lesions in mice esophagus.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Drinking Water; Esophagus; Female; Hot Temperature; | 2016 |
TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Hepatic preneoplasia induction in male Wistar rats: histological studies up to five months post treatment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver; Liver Neoplasms | 2016 |
Photothermal therapy mediated by gum Arabic-conjugated gold nanoparticles suppresses liver preneoplastic lesions in mice.
Topics: Animals; Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; Glutathione | 2016 |
Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogenicity Tests; Deoxyguanosine; Diethylnitrosamine; DNA | 2009 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype.
Topics: Animals; Apoptosis; Cell Differentiation; Choline Deficiency; Diethylnitrosamine; Glutathione Transf | 2009 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D | 2009 |
Effect of antisense oligomer in controlling c-raf.1 overexpression during diethylnitrosamine-induced hepatocarcinogenesis in rat.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Transformation, Neoplastic; Cytochrome P-45 | 2010 |
Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats.
Topics: Animals; Blotting, Western; Carcinogens; Carotenoids; Cell Transformation, Neoplastic; Chromatograph | 2010 |
Absence of chemopreventive influence of propolis on the rat liver altered foci development.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Brazil; Cocarcinogenesis; Diethylnitrosamine; Glutath | 2010 |
[Differentially expressed proteins in the precancerous stage of rat hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferase | 2009 |
Sida rhombifolia ssp. retusa seed extract inhibits DEN induced murine hepatic preneoplasia and carbon tetrachloride hepatotoxicity.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferase, Mitochondrial; Carbon Tetrachloride; Chem | 2009 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Immunohistochemical analyses at the late stage of tumor promotion by oxfendazole in a rat hepatocarcinogenesis model.
Topics: Adenoma, Liver Cell; Animals; Anthelmintics; Apoptosis; Benzimidazoles; Carcinogens; Cell Cycle Prot | 2011 |
Genotoxic and carcinogenic risks associated with the dietary consumption of repeatedly heated coconut oil.
Topics: Animals; Antioxidants; Biomarkers; Carcinogens; Chromosome Aberrations; Coconut Oil; Cocos; Cooking; | 2010 |
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry; | 2011 |
Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Base Sequence; Carcinogens; Cell Cycle Proteins; Diethylnitrosamine; DNA Primers; DNA Repai | 2011 |
Production of liver preneoplasia and gallbladder agenesis in turkey fetuses administered diethylnitrosamine.
Topics: Animals; Biological Assay; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response | 2011 |
Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver.
Topics: Adult Stem Cells; Animals; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Diethylnitrosam | 2011 |
Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzoquinones; Carbon Tetrachloride; Chemical and Dr | 2010 |
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arrestins; beta-Arrestin | 2011 |
Quercetin inhibits diethylnitrosamine-induced hepatic preneoplastic lesions in rats.
Topics: Analysis of Variance; Animals; Biological Assay; Diethylnitrosamine; Glutathione Transferase; Hepate | 2011 |
Alpha-fetoprotein-thymidine kinase-luciferase knockin mice: a novel model for dual modality longitudinal imaging of tumorigenesis in liver.
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Disease Models, Animal; Disease Progression; Female | 2011 |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy | 2011 |
Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Carcinogens; Deoxyguanosine; Diethylnitrosamine; | 2011 |
Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Ca | 2011 |
Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice.
Topics: Animals; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationsh | 2011 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Biomarkers; Carcinogens; Carcinoma, Hepatocellular; Chemo | 2012 |
Effect of prolyl hydroxylase domain-2 haplodeficiency on the hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular | 2012 |
The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cel | 2012 |
Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Flavanones; Glutathione S-Transfera | 2012 |
Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Apoptosis; Carcinogens; Cell Line, Tumor; Deoxyguanosine; Diet | 2013 |
The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Acetanilides; Animals; Anticarcinogenic Agents; Antioxidants; Caffeic Acids; | 2013 |
Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Diethylnitrosa | 2002 |
Anomalous elevation of glutathione S-transferase P-form (GST-P) in the elementary process of epigenetic initiation of chemical hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Cell Nucleus; Cell Size; Cells, Cultured; Diethylnitrosamine; Electrolyt | 2002 |
Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 17beta-estradiol in male Sprague-Dawley rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Cytochrome P-450 CYP1A1; Diethylnitrosam | 2002 |
[Effect of Boschniakia rossica extract on antioxidative activities in rat hepatic preneoplasia induced by diethylnitrosamine].
Topics: Animals; Antioxidants; Diethylnitrosamine; Drugs, Chinese Herbal; Glutathione Peroxidase; Glutathion | 1999 |
In ovo carcinogenicity assay (IOCA): evaluation of mannitol, caprolactam and nitrosoproline.
Topics: Animals; Caprolactam; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Diethylnitrosamine; Dose- | 2002 |
High vascular endothelial growth factor (VEGF) expression in chemically-induced hepatic microcancers in mice.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Endothelial Growth Factors; | 2002 |
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione | 2002 |
Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Astragalus Plant; Astragalus propinquus; Blotting, Northern; Blottin | 2003 |
Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia.
Topics: Animals; Animals, Newborn; Body Weight; Carcinogens; Diethylnitrosamine; Gene Expression Regulation; | 2003 |
Chemopreventive effect of orange oil on the development of hepatic preneoplastic lesions induced by N-nitrosodiethylamine in rats: an ultrastructural study.
Topics: Animals; Carcinogens; Diethylnitrosamine; Gap Junctions; Liver; Liver Neoplasms, Experimental; Male; | 2002 |
Enhancing effects of mustard oil on preneoplastic hepatic foci development in Wistar rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; gamma-Glutamyltransferase; Glutathione Tra | 2003 |
Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay.
Topics: Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Chlorobenzenes; Clone Cells; Comp | 2003 |
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Brazil; Bromodeoxyuridine; | 2003 |
[Inhibitory effects of tea polyphenols and tea pigments on liver precancerous lesions in rats].
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Glutathione Transferase; | 1999 |
[Effect of tea polyphenols and tea pigments on inducing the activity of phase II detoxicating enzymes and on the chemoprevention of liver precancerous lesions].
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Glutathione Transferase; | 2000 |
Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Eati | 2003 |
Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; DNA-Binding Prot | 2003 |
Characterizing the role of MDM2 in diethylnitrosamine induced acute liver damage and development of pre-neoplastic lesions.
Topics: Animals; Blotting, Western; Diethylnitrosamine; Female; In Situ Hybridization; Liver; Liver Neoplasm | 2004 |
Diethylnitrosamine may induce esophageal dysplasia after local intramural administration.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Esophageal Neoplasms; Injections; Male; Models, Anim | 2003 |
Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Hepatocellular; Diethyl | 2004 |
Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Animals; Antineoplastic Agents; Ardisia; Carcinogens; Ca | 2004 |
Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cycl | 2004 |
Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Biomarkers, Tumor; | 2004 |
Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Diethylnitrosamine; | 2004 |
[Effect of Sorbaria Sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine].
Topics: Animals; Antioxidants; Diethylnitrosamine; Drugs, Chinese Herbal; Glutathione; Glutathione Peroxidas | 2003 |
Induction of preneoplastic rat liver lesions with an attenuated p53 response by low doses of diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glutathione S-Transferase pi; | 2004 |
Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Antioxidants; Diethylnitrosamine; Ethylnitrosourea; gamma-Glutamyltransf | 2005 |
Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Diethylnitrosamine; g | 2004 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
Topics: Adenoma; Alkylating Agents; Amaranthaceae; Animals; Diethylnitrosamine; Disease Models, Animal; Fema | 2005 |
Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Diethylnitrosamine; Down-Regulation; Female; Gene Expression | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cytochrome | 2006 |
Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relation | 2006 |
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepat | 2006 |
Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; DNA Damage; gamma-Glutamyltransfe | 2006 |
Chemoprevention of bicyclol against hepatic preneoplastic lesions.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Cell Transformation, Neoplastic; Chemoprevention | 2006 |
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; DN | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; | 2007 |
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocytes; I | 2007 |
Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; ATP-Binding Cassette Transporters; Carcinogens; C | 2007 |
Co-carcinogenic effect of cyclohexanol on the development of preneoplastic lesions in a rat hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cyclohexanols; Diet | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis; | 2007 |
The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats.
Topics: Administration, Oral; Alkylating Agents; Animals; Body Weight; Carcinogens, Environmental; Cell Prol | 2007 |
Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Liver | 2007 |
beta-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; beta-Naphthoflavone; Blotting, Western; Cell Proliferation; De | 2008 |
Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine.
Topics: Animals; Catalase; Cysteine; Diethylnitrosamine; Glutathione; Glutathione Peroxidase; Glutathione Tr | 2008 |
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Body Weight; Carcinogens; Deoxyguanosine; D | 2008 |
Anti-tumor effect of pegylated interferon in the rat hepatocarcinogenesis model.
Topics: 2-Acetylaminofluorene; Algorithms; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethy | 2008 |
Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver.
Topics: Animals; Cell Line, Tumor; Diethylnitrosamine; Enzyme Activation; Glucosephosphate Dehydrogenase; Im | 2008 |
Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Chemopreventio | 2008 |
Enzyme pattern and growth rate of liver preneoplastic clones during carcinogenesis by diethylnitrosamine.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Clone Cells; Diethylnitrosamine; Glucose-6-Phos | 1984 |
[Enzymatic phenotype of preneoplastic islands induced in the rat liver by diethylnitrosamine].
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1983 |
Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.
Topics: Adenoma; Animals; Body Weight; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Diet; Diethyln | 1980 |
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
Topics: Animals; Cell Division; Diethylnitrosamine; Ditiocarb; gamma-Glutamyltransferase; Hepatectomy; Histo | 1981 |
Purification and transplantation of hepatocytes from livers of carcinogen-treated rats.
Topics: Animals; Cell Separation; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver; Li | 1982 |
Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA; gamma-Glutamyltransferase; Hepatectomy; Injec | 1982 |
Dose and sex dependent effects of 2-acetylaminofluorene, 3'-methyl-4-dimethylaminoazobenzene and DL-ethionine in induction of gamma-glutamyl transpeptidase-positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; E | 1983 |
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, E | 1984 |
Accelerated regression of carcinogen-induced preneoplastic hepatocyte foci by peroxisome proliferators, BR931, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio (N-B-hydroxyethyl)acetamide, and di-(2-ethylhexyl)phthalate.
Topics: Animals; Cell Division; Choline Deficiency; Diethylhexyl Phthalate; Diethylnitrosamine; gamma-Glutam | 1984 |
Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocytochem | 1984 |
Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver.
Topics: Animals; Chlorobenzenes; Diet; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransfera | 1982 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Nuclear morphology in preneoplastic lesions of rat liver.
Topics: Animals; Cell Nucleus; Cytological Techniques; Diethylnitrosamine; Female; Histocytochemistry; Liver | 1983 |
Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins | 1984 |
[Evolution of hyperplastic foci in the rat liver induced by diethylnitrosamine].
Topics: alpha-Fetoproteins; Animals; Diethylnitrosamine; Glutathione Transferase; Hyperplasia; Immunoenzyme | 1984 |
Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Live | 1982 |
Effect of ethanol on early stages in nitrosamine carcinogenesis in rat liver.
Topics: Adenosine Triphosphatases; Alcoholism; Animals; Carcinogens; Diethylnitrosamine; Female; Humans; Liv | 1983 |
Isolation and culture of adult rat hepatocytes and preneoplastic nodules from diethylnitrosamine treated livers: glucose-6-phosphatase distribution, albumin synthesis and hepatic binding protein activity.
Topics: Albumins; Animals; Asialoglycoprotein Receptor; Carrier Proteins; Cells, Cultured; Diethylnitrosamin | 1980 |
Liver cell control after discontinuation of DENA feeding in hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Growth Inhibitors; Homeostasis; Liver; | 1981 |
Carcinogenesis studies on guppies.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Fishes; Liver Neoplasms; Liver Regeneration; Male; | 1984 |
Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl-nitrosamine carcinogenesis in rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Endoplasmic | 1984 |
Initiation-promotion-initiation. Induction of neoplastic foci within islands of precancerous liver cells in the rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Ethylnitrosourea; Female; Hepatectomy; Liver; Li | 1984 |
Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.
Topics: Animals; Body Weight; Diet; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Interactions; Enzyme In | 1983 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Diethylnitrosamine; Female; Fetus; Glutathione Transferase; | 1984 |
Scanning electron microscopy of experimentally induced sequential alterations of rat liver hyperplastic nodules.
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Microscopy, El | 1984 |
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture.
Topics: Adult; Aflatoxin B1; Aflatoxins; Animals; Biological Evolution; Carcinogens; Carcinogens, Environmen | 1982 |
Properties of the increased glutathione S-transferase A form in rat preneoplastic hepatic lesions induced by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Immunochem | 1983 |
Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Fluorescein; Fluoresceins; Liver; Liver Circulat | 1983 |
Sequential observations on the appearance of neoplastic lesions in the liver and kidney after treatment with N-ethyl-N-hydroxyethylnitrosamine followed by partial hepatectomy and unilateral nephrectomy.
Topics: Animals; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neoplasms; Liver Neoplasms; Male; Neop | 1983 |
Centrilobular distribution of diethylnitrosamine-induced hepatocellular foci in the mouse.
Topics: Animals; Diethylnitrosamine; Hepatic Veins; Liver Neoplasms, Experimental; Male; Mice; Portal Vein; | 1983 |
Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Cell Division; Diethylnitrosamine; Liver Neopla | 1983 |
Immunohistochemical study of epoxide hydrolase during experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Epoxide Hydrolases; Histocytochemistry; Immunoen | 1981 |
[Action of N-dinitrosopiperazine and N-nitrosodiethylamine on aquarium guppies].
Topics: Animals; Diethylnitrosamine; Female; Fish Diseases; Fishes; Male; Neoplasms, Experimental; Nitrosami | 1982 |
Induction of preneoplastic and neoplastic lesions in rats treated N-nitroso compounds.
Topics: Animals; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relati | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
Short term induction of preneoplastic nodules in the rat liver. I. The role of 2-AAF as selecting agent.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1980 |
The effects of various chemicals on the development of hyperplastic liver nodules in hepatectomized rats treated with N-nitrosodiethylamine or N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Drug Evaluation, Preclinical; Enzyme Induction; | 1980 |
Proliferation of preneoplastic lesions after discontinuation of chronic DEN feeding in the development of hepatomas in rat.
Topics: Animals; Cell Count; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; Live | 1981 |
Invasiveness of hyperplastic nodule cells from diethylnitrosamine-treated rat liver.
Topics: Animals; Cell Adhesion; Diethylnitrosamine; Liver; Nitrosamines; Precancerous Conditions; Rats | 1981 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liv | 1980 |
SEM study of adult rat hepatocytes from preneoplastic and hyperplastic foci induced in the liver by diethylnitrosamine.
Topics: Animals; Cell Membrane; Diethylnitrosamine; Disease Models, Animal; Female; Hyperplasia; Liver; Live | 1980 |
Cytosolic levels and distribution of cadmium, copper and zinc in pretumorous livers from diethylnitrosamine-exposed mice and in non-cancerous kidneys cancer patients.
Topics: Animals; Cadmium; Copper; Cytosol; Diethylnitrosamine; Female; Humans; Kidney; Liver Neoplasms; Male | 1980 |
Membrane and cytosolic protein phosphorylation patterns in the early stages of DEN-induced hepatocarcinogenesis in rats fed a high or low protein diet.
Topics: Animals; Dietary Proteins; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Membrane Protein | 1995 |
Modifying influence of prior treatment with toxic agents on induction of preneoplastic and neoplastic lesions in a medium-term multi-organ carcinogenesis bioassay.
Topics: Aniline Compounds; Animals; Bleomycin; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Galac | 1993 |
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Glutathione | 1995 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
GST-P-positive hepatocytes isolated from rats bearing enzyme-altered foci show no signs of p53 protein induction and replicate even when their DNA contains strand breaks.
Topics: Animals; Cells, Cultured; Diethylnitrosamine; DNA Damage; DNA Replication; Female; Glutathione Trans | 1995 |
Identification of clastogenic and/or aneugenic events during the preneoplastic stages of experimental rat hepatocarcinogenesis by fluorescence in situ hybridization.
Topics: Aneuploidy; Animals; Carbon Tetrachloride; Chromosome Aberrations; Diethylnitrosamine; In Situ Hybri | 1995 |
The enhancing effect of fasting/refeeding on the growth of nodules selectable by the resistant hepatocyte model in rat liver.
Topics: Animals; Diethylnitrosamine; Energy Intake; Fasting; Glutathione Transferase; Liver; Liver Neoplasms | 1995 |
Lack of significant promoting activity by benzene in the rat liver model of carcinogenesis.
Topics: Animals; Benzene; Diethylnitrosamine; Disease Models, Animal; Drug Interactions; Liver Neoplasms, Ex | 1995 |
Demonstration of initiation potential of carcinogens by induction of preneoplastic glutathione S-transferase P-form-positive liver cell foci: possible in vivo assay system for environmental carcinogens.
Topics: Animals; Captan; Carcinogenicity Tests; Carcinogens, Environmental; Cyclohexenes; Diethylnitrosamine | 1993 |
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenoma; Administration, Oral; Alpha-Globulins; Animals; Body Weight; Carcinoma, Renal Cell; Catecho | 1993 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-G | 1995 |
Dose dependence of diethylnitrosamine-induced nuclear enlargement in embryonal turkey liver.
Topics: Animals; Cell Nucleus; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver; Precancerous Con | 1995 |
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Diterpenes; Drug Interact | 1995 |
The effect of deferoxamine on the preneoplastic lesions in the chemically induced hepatocarcinogenesis.
Topics: Animals; Deferoxamine; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Precancerous Conditi | 1994 |
Localization of oxidative damage by a glutathione-gamma-glutamyl transpeptidase system in preneoplastic lesions in sections of livers from carcinogen-treated rats.
Topics: Animals; Carcinogens; Catalase; Cell Membrane; Diethylnitrosamine; Female; Free Radical Scavengers; | 1994 |
[Inhibition of the protein kinase C-alpha gene overexpression in rat preneoplastic liver by selenium].
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Huma | 1993 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice: comparison with the expression of pi-class glutathione S-transferase.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression; Genes, jun; Glutathione Transferase; Immunohis | 1994 |
Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats.
Topics: Animals; Atenolol; Body Weight; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1994 |
Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Fem | 1994 |
Dose related promoter effect of metanil yellow on the development of hepatic pre-neoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Azo Compounds; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Food Colo | 1994 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Enhanced neoplastic lesion development with adenine-induced experimental multicystic nephropathy by adenine--a model system for the analysis of renal tumor generation in long-term hemodialysis patients.
Topics: Adenine; Adenoma; Animals; Diethylnitrosamine; Epithelium; Hyperplasia; Kidney Diseases; Kidney Neop | 1994 |
Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Enzyme Inducti | 1994 |
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1993 |
Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms; | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Estradiol; Estrogen Antagonists; Estrog | 1994 |
[Promotive action of sodium fluoride on precancerous lesions of hepatocellular carcinoma induced by diethylnitrosamine (DEN) in rats--stereologic study of enzyme histochemistry].
Topics: Animals; Diethylnitrosamine; Fluoride Poisoning; Liver Neoplasms, Experimental; Male; Precancerous C | 1993 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver.
Topics: Allium; Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Drug Synergism; Garlic; Glutathio | 1994 |
Immunohistochemical characterization of a monoclonal antibody to hyperplastic nodules induced in rat liver by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Hepatocellula | 1994 |
Promotion of preneoplastic lesions and induction of CYP2B by unleaded gasoline vapor in female B6C3F1 mouse liver.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Inducti | 1993 |
[The expression of C-myc, N-ras mRNA and its relations to the differentiation of preneoplastic altered hepatocytes].
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Differentiation; Diethylnitrosam | 1993 |
Tissue protein turnover during liver carcinogenesis.
Topics: Animals; Cell Division; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Neoplasm Pro | 1993 |
Modifying effects of chemicals on the development of liver preneoplastic placental glutathione S-transferase positive foci in analbuminemic and Sprague-Dawley rats.
Topics: Acetylglucosaminidase; Animals; Butylated Hydroxyanisole; Carcinogens; Clofibrate; Diethylnitrosamin | 1993 |
Increased yield in GST-P-positive liver pre-neoplastic foci induced by DENA or ENU in rats pre-treated with estradiol or tamoxifen.
Topics: Animals; Cell Division; Diethylnitrosamine; Estradiol; Ethylnitrosourea; Female; Glutathione Transfe | 1993 |
Chemopreventive effects of dietary D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, on initiation and postinitiation stages of diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Drug Screening Assays, Antitumor; Eflornithine; Glutathione Transferase | 1993 |
Selective toxicity in putative preneoplastic hepatocytes: a comparison of hydroquinone and duroquinone.
Topics: Animals; Benzoquinones; Cells, Cultured; Diethylnitrosamine; Drug Synergism; Enzyme Induction; Femal | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 1993 |
Increased expression of the female-predominant cytochrome P4502C12 in liver nodules from male Wistar rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; | 1993 |
Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Sche | 1993 |
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
Topics: Animals; Body Weight; Captan; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Diethylnitrosami | 1993 |
Expression of hepatocyte growth factor and c-met mRNAs during rat chemically induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Hepatocyte | 1996 |
Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Liver Ne | 1996 |
Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; beta Carotene; Carcinogens; Carotenoids; Cytosol; Di | 1995 |
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Pesticide | 1995 |
Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Humans; Iodine Radioisotope | 1996 |
Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dose-Response Relation | 1996 |
Strain dependent effects of sex hormones on hepatocarcinogenesis in mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Female; Glucose-6-Phosphatase; Liver Neoplasms, Experiment | 1996 |
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Ne | 1996 |
Modeling the number and size of hepatic focal lesions following exposure to 2,3,7,8-TCDD.
Topics: Adenosine Triphosphate; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Respo | 1996 |
Selective dieldrin promotion of hepatic focal lesions in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diethylnitrosamine; DNA, Neop | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; G | 1996 |
[Expression of PCNA and protooncogenes during experimental hepatocarcinogenesis in rats].
Topics: Animals; Cell Count; Diethylnitrosamine; Gene Expression; Genes, ras; Liver Neoplasms, Experimental; | 1996 |
Cell proliferation and regulation of negative growth factors in mouse liver foci.
Topics: Air Pollutants; Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Diet; Diethylnitrosamine; Et | 1996 |
No evidence for an inhibitory effect of beta-carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat.
Topics: Animals; Anticarcinogenic Agents; beta Carotene; Canthaxanthin; Carcinogens; Diet; Diethylnitrosamin | 1996 |
Inhibition of aflatoxin B1- and N-nitrosodiethylamine-induced liver preneoplastic foci in rats fed naturally occurring allyl sulfides.
Topics: Aflatoxin B1; Allyl Compounds; Animals; Anticarcinogenic Agents; Diet; Diethylnitrosamine; Disulfide | 1996 |
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Glutathione Transferase; Liver Neopla | 1996 |
Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats.
Topics: Animals; Carcinogens; Diazinon; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Organothiop | 1995 |
c-myc amplification in pre-malignant and malignant lesions induced in rat liver by the resistant hepatocyte model.
Topics: Adenoma; Animals; Blotting, Northern; Blotting, Southern; Carcinoma, Hepatocellular; Deoxyribonuclea | 1996 |
Selective colocalization of lipid peroxidation and protein thiol loss in chemically induced hepatic preneoplastic lesions: the role of gamma-glutamyltranspeptidase activity.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; gamma-Glutamyltr | 1996 |
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays, | 1996 |
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosa | 1996 |
Decreased connexin32 and a characteristic enzyme phenotype in clofibrate-induced preneoplastic lesions not shared with spontaneously occurring lesions in the rat liver.
Topics: Animals; Carcinogens; Clofibrate; Connexins; Diethylnitrosamine; gamma-Glutamyltransferase; Gap Junc | 1996 |
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Topics: Aminobiphenyl Compounds; Animals; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Carcino | 1997 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Iron promotes DEN initiated GST-P foci in rat liver.
Topics: Animals; Biomarkers; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitros | 1997 |
Monoclonal and polyclonal development of digestive tract tumors in chimeric mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carrier Proteins; Chimera; Colonic Neoplasms; Diethylni | 1997 |
Inhibition by green tea extract of diethylnitrosamine-initiated but not choline-deficient, L-amino acid-defined diet-associated development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in rat liver.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Diet; Diethylnitrosamine; DNA; Glutathione Transf | 1997 |
Sparse distribution of hepatocyte growth factor-producing cells inside hepatocellular foci in rats treated with hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Hepatocyte | 1997 |
Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticarcinogenic Agents; Antioxidants; beta Car | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Diethylnitrosamine; Liver Neoplasms; Lyc | 1997 |
Chronic liver injury promotes hepatocarcinogenesis of the LEC rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Copper; Dieth | 1998 |
Initiation and promotion of altered hepatic foci in female rats and inhibition of cell-cell communication by the imidazole fungicide prochloraz.
Topics: Animals; Body Weight; Carcinogens; Cell Communication; Cell Line; Diethylnitrosamine; Epithelial Cel | 1998 |
Wild-type p53 expression in liver tissue and in enzyme-altered foci: an in vivo investigation on diethylnitrosamine-treated rats.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA; DNA Damage; Female; Glutathione Transferase; Immunohi | 1998 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt | 1998 |
Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis.
Topics: 2-Acetylaminofluorene; Actins; Animals; beta Carotene; Bile Ducts, Intrahepatic; Collagen; Diethylni | 1998 |
Prevention by 1'-acetoxychavicol acetate of the induction but not growth of putative preneoplastic, glutathione S-transferase placental form-positive, focal lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet.
Topics: Amino Acids; Animals; Anticarcinogenic Agents; Benzyl Alcohols; Carcinogens; Choline; Diet; Diethyln | 1998 |
Medium-term bioassays for carcinogenicity of chemical mixtures.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dr | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene.
Topics: Animals; Animals, Genetically Modified; Choline Deficiency; Diet; Diethylnitrosamine; Glutathione Tr | 1998 |
Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats.
Topics: Aflatoxin B1; Animals; Bacterial Toxins; Biomarkers; Chemical and Drug Induced Liver Injury; Diethyl | 1999 |
Correlation of c-myc overexpression and amplification with progression of preneoplastic liver lesions to malignancy in the poorly susceptible Wistar rat strain.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Cell Transformation, Neoplastic; Chloroform; Diethylnitro | 1999 |
Resistance to the promotion of glutathione S-transferase 7-7-positive liver lesions in Copenhagen rats.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Glu | 1999 |
Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine.
Topics: Adenoma, Bile Duct; Animals; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; Immunohistoch | 1999 |
The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains.
Topics: Animals; Carcinogenicity Tests; Connexins; Crosses, Genetic; Diethylnitrosamine; Gap Junction beta-1 | 1999 |
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
Topics: Animals; Blotting, Northern; Body Weight; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA; | 1999 |
Development of resistance during the early stages of experimental liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Diethylnitrosamine; Drug Resistan | 1999 |
Elevation of metallothionein level in preneoplastic lesions during chemical hepatocarcinogenesis of the Fischer 344 rat.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Glutathione Transferase; Liver Neoplasms; Liver | 1999 |
Regulation of selection of liver nodules initiated with N-nitrosodiethylamine and promoted with nodularin injections in fischer 344 male rats by reciprocal expression of transforming growth factor-beta1 and its receptors.
Topics: Alkylating Agents; Animals; Blotting, Northern; Diethylnitrosamine; Gene Expression Regulation, Neop | 1999 |
Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Femal | 1999 |
Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices.
Topics: Animals; Carcinogenicity Tests; Chlorobenzenes; Cytochrome P-450 Enzyme System; Diethylnitrosamine; | 2000 |
Fas-mediated apoptosis is attenuated in preneoplastic GST-P-positive hepatocytes isolated from diethylnitrosamine-treated rats.
Topics: Animals; Animals, Newborn; Antibodies; Apoptosis; Biomarkers, Tumor; Carcinogens; Cells, Cultured; D | 1999 |
Implication of Bcl-2 family genes in basal and D-amphetamine-induced apoptosis in preneoplastic and neoplastic rat liver lesions.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Coloring Agents; Dextroamphetamine; Diethylnitrosami | 2000 |
[The expression of mutant p53 (mp53) protein in rat hepatic preneoplastic lesions induced by diethylnitrosamine (DEN)].
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms, Experim | 1997 |
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Fe | 2000 |
Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Azoxymethane; Colon; Colonic Neoplas | 2000 |
Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Administration Schedule; Female; | 2000 |
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Animals; Biological Assay; Body Weight; Bromodeoxyur | 2000 |
Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green.
Topics: Animals; Azo Compounds; Cyclins; Diethylnitrosamine; Food Coloring Agents; G1 Phase; Liver Neoplasms | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Enhancement of chemical hepatocarcinogenesis by the HIV-1 tat gene.
Topics: Adenoma, Liver Cell; Animals; Basophils; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; | 2000 |
Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3).
Topics: Animals; Antineoplastic Agents; Calcitriol; Chromosome Aberrations; Diethylnitrosamine; DNA Damage; | 2000 |
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female | 2000 |
Presence of a no-observed effect level for enhancing effects of development of the alpha-isomer of benzene hexachloride (alpha-BHC) on diethylnitrosamine-initiated hepatic foci in rats.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrom | 2001 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions.
Topics: Animals; Blotting, Western; Cell Division; Diethylnitrosamine; DNA; DNA Damage; DNA Mutational Analy | 2001 |
A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.
Topics: Animals; Biological Assay; Body Weight; Calibration; Carcinogens; Cell Count; Cell Division; Chlorob | 2001 |
Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.
Topics: Animals; Animals, Newborn; Apoptosis; Bromodeoxyuridine; Cell Division; Diethylnitrosamine; Female; | 2001 |
Further experiments on lipid peroxidation in transplanted and experimental hepatomas.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Cytosol; Diethylnit | 1984 |
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, Hepatocellular; C | 2001 |
Matrix metalloproteinases-2 and 9 do not play a role in the growth of preneoplastic liver lesions in F344 rats.
Topics: Alkylating Agents; Animals; Densitometry; Diethylnitrosamine; Glutathione Transferase; Liver; Liver | 2001 |
[Inhibitory effect of methanol extract of Boschniakia rossica Fedtsch. et Flerov on rat hepatic preneoplastic lesions induced by diethylnitrosamine].
Topics: Animals; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnitrosamine; Drugs, Chinese Herbal; | 1998 |
Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats.
Topics: Alkylating Agents; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cell Division; Chol | 2001 |
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Topics: Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Carcin | 2001 |
Effect of metanil yellow and malachite green on DNA synthesis in N-nitrosodiethylamine induced preneoplastic rat livers.
Topics: Animals; Azo Compounds; Blotting, Western; Cell Division; Coloring Agents; Cyclins; Diethylnitrosami | 2001 |
Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells.
Topics: Animals; Butylated Hydroxyanisole; Diethylnitrosamine; DNA-Binding Proteins; Female; Gene Expression | 2002 |
Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice.
Topics: Animals; Carcinogens; Connexins; Diethylnitrosamine; Gap Junction beta-1 Protein; Liver Neoplasms, E | 2002 |
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D | 2002 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Diethylnitrosam | 1978 |
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Diethylnitrosamine; Enzyme Induction; | 1978 |
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver.
Topics: Animals; Diethylnitrosamine; Fetus; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1979 |
Differences in serum alpha-fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetylaminofluorene.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Diethylnitrosamine; Fluorenes; Liver Neoplasms, | 1979 |
Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine | 1975 |
Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Diethylnitrosamine; DNA Nucleotidyltransferases; Do | 1976 |
Variations of liver cell control during diethylnitrosamine carcinogenesis.
Topics: Animals; Circadian Rhythm; Diethylnitrosamine; Growth Inhibitors; Hepatectomy; Liver; Liver Extracts | 1977 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe | 1978 |
Cell kinetics of hepatocytes during the preneoplastic period of diethylnitrosamine-induced liver carcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Cell Division; Diethylnitrosamine; Kinetics; Liver Neoplasms, Ex | 1979 |
Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Count; Diethylnitrosamine; Dose- | 1975 |
[Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)].
Topics: Animals; Circadian Rhythm; Diethylnitrosamine; Liver; Liver Glycogen; Liver Neoplasms; Male; Mitosis | 1976 |
Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose-6-Phospha | 1976 |
[Hyperplastic foci in chemical carcinogenesis].
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethyln | 1976 |
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Hyperplasia; Liver Neoplasms; Lung; Male; Mi | 1977 |
Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Nitrosamines; Precancerous Conditi | 1979 |
The effect of antilymphocytic and normal horse serum on growth of precancerous foci and development of tumours induced by diethylnitrosamine in rat liver.
Topics: Animals; Antilymphocyte Serum; Diethylnitrosamine; Female; Immunosuppression Therapy; Liver Neoplasm | 1976 |
Quantitative autoradiographic studies on the competition of diethylnitrosamine (DENA) and 9,10-dimethyl-1,2-benzanthracene (DMBA) in the liver cell of CBA-mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Autoradiography; Benz(a)Anthracenes; Cell Nucleus; Diethy | 1975 |
Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.
Topics: Animals; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diethylnitrosamine; Esophageal | 1977 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
Activation of intracisternal A particles in mouse liver by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Inclusion Bodies, Viral; Liver; Male; Mice; Mice, Inbred A; Mice, Inbre | 1977 |
Newer insights into the pathogenesis of liver cancer.
Topics: Aflatoxins; Animals; Cell Division; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylnit | 1977 |
Effect of age and sex on lesions of the esophagus in Buffalo strain rats ingesting diethylnitrosamine.
Topics: Age Factors; Animals; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Neopl | 1976 |
Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine-induced lung carcinogenesis in hamsters.
Topics: Animals; Cell Division; Cricetinae; Diethylnitrosamine; Epithelial Cells; Epithelium; Lung Neoplasms | 1976 |
mRNA levels of catalytic subunits of protein phosphatases 1, 2A, and 2C in hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Ph | 1992 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine.
Topics: Aging; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Precanc | 1992 |
[Characteristics and biologic significance of changes in DNA content of rat liver cells during hepatocarcinogenesis].
Topics: Aneuploidy; Animals; Diethylnitrosamine; Diploidy; DNA; DNA, Neoplasm; Flow Cytometry; Liver; Liver | 1992 |
Enhancing effects of harman and norharman on induction of preneoplastic and neoplastic kidney lesions in rats initiated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Carbolines; Carcinogens; Carcinoma, Renal Cell; Diethylnitrosamine; Harmine; Kidney Neoplas | 1992 |
Transforming growth factor-alpha expression in rat experimental hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; Ethinyl Estradiol; Female; Immunohistochemistry; Liver Neoplasms, Exper | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Topics: Animals; Antioxidants; Benzodioxoles; Body Weight; Bromodeoxyuridine; Butylated Hydroxyanisole; Cate | 1992 |
Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE).
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Electropho | 1992 |
Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.
Topics: Animals; Cell Division; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Estrogens; Female; gamma | 1991 |
Aneuploidy and progression in promoted preneoplastic foci during chemical hepatocarcinogenesis in the rat.
Topics: Aneuploidy; Animals; Biomarkers, Tumor; Diethylnitrosamine; DNA; DNA, Neoplasm; gamma-Glutamyltransf | 1991 |
Enhancing effect of malachite green on the development of hepatic pre-neoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Glycogen; Liver; Liver Neo | 1991 |
Effect of dietary fat on the initiation of hepatocarcinogenesis by diethylnitrosamine or 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Dietary Fats; Diethylnitrosamine; Female; | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Reversal by 5-azacytidine of the S-adenosyl-L-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis.
Topics: Adenosine; Animals; Azacitidine; Biomarkers, Tumor; Deoxyadenosines; Diethylnitrosamine; gamma-Gluta | 1991 |
The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.
Topics: Adenoma; Alpha-Globulins; Animals; Body Weight; Carcinogens; Cell Division; Cyclohexenes; Diethylnit | 1991 |
Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Diethylnitrosamine; gamma-Glutamyltransferase; Ker | 1991 |
Effect of FK 506 on experimental liver carcinogenesis.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver N | 1991 |
[Comparative study on the inhibitory effect of green tea, coffee and levamisole on the hepatocarcinogenic action of diethylnitrosamine].
Topics: Animals; Coffee; Diethylnitrosamine; Levamisole; Liver Neoplasms; Male; Precancerous Conditions; Rat | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
[Immunohistochemical observation on the proliferative activity of rat liver in early hepatocarcinogenesis].
Topics: Animals; Antibodies, Monoclonal; Bromodeoxyuridine; Diethylnitrosamine; Female; Hyperplasia; Immunoh | 1991 |
Specific gain of chromosome 19 in preneoplastic mouse liver cells after diethylnitrosamine treatment.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Diethylnitrosamine; Karyotyping; | 1991 |
Dose-dependent enhancing effects of quinacrine on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in male F344 rats.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Enzyme Induct | 1991 |
Expression of a 65-kDa tumor-associated protein and persistence of altered hepatic foci.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Cell Division; Choline Deficiency; Diethylnitrosamin | 1991 |
Molecular genetic analysis of preneoplastic and neoplastic liver lesions in the mouse.
Topics: Animals; Diethylnitrosamine; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Liver Neoplasms, Ex | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Dose-response relationships in promotion of rat hepatocarcinogenesis by 17 alpha-ethinylestradiol.
Topics: Animals; Cholesterol; Diethylnitrosamine; Dose-Response Relationship, Drug; Ethinyl Estradiol; Femal | 1990 |
Diamine oxidase activity in a model of multistep hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Amine Oxidase (Copper-Containing); Animals; Diethylnitrosamine; gamma-Glutamy | 1990 |
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosou | 1990 |
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1990 |
Modulation by estrogen of the incidence of diethylnitrosamine-induced gamma-glutamyltranspeptidase-positive foci in rat liver.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Estrogens; Female; gamma-Glutamyltransferase; Liver; | 1990 |
Promotion of hepatocellular foci in female rats by chenodeoxycholic acid.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Diethylnitrosamine; Female; Glutathione Transf | 1991 |
Mutational activation of the c-Ha-ras gene in liver tumors of different rodent strains: correlation with susceptibility to hepatocarcinogenesis.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Ethylnitrosourea; Gene Expression Regulation, Neo | 1991 |
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Diethylnitrosamine; Hepatectomy; Liver; Liver Ne | 1991 |
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Exper | 1991 |
Expression of p53 mutant protein(s) in diethylnitrosamine-induced foci of enzyme-altered hepatocytes in male Fischer-344 rats.
Topics: Animals; Diethylnitrosamine; Genes, p53; Glutathione Transferase; Immunoblotting; Immunohistochemist | 1991 |
Tumor promoting potential in male F344 rats and mutagenicity in Salmonella typhimurium of dipyrone.
Topics: Animals; Body Weight; Diethylnitrosamine; Dipyrone; Dose-Response Relationship, Drug; Drinking; Kidn | 1991 |
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerou | 1990 |
Immunohistochemical detection of c-myc and c-erbA products in diethylnitrosamine-induced preneoplastic and neoplastic liver lesions in rats.
Topics: Animals; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Precancerous Conditions; Proto-O | 1990 |
Modulation by indomethacin of diethylnitrosamine-induced early changes in c-myc and c-ras expression and late incidence of preneoplastic lesions in rat liver.
Topics: Animals; Diethylnitrosamine; Female; Gene Expression; Genes, ras; Indomethacin; Liver Neoplasms, Exp | 1990 |
The enhancing effect of ethanol on the development of glutatione S-transferase placental form-positive foci induced by diethylnitrosamine in F344 rat.
Topics: Animals; Diethylnitrosamine; Ethanol; Glutathione Transferase; Immune Sera; Liver Cirrhosis, Alcohol | 1990 |
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver.
Topics: Animals; Body Weight; Choline Deficiency; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, Ex | 1990 |
Hepatocellular cancer development in spleen of syngenic rats after transfer of potential precursor hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Glutathione Transferase; Hepatect | 1990 |
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immuno | 1990 |
Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats.
Topics: Animals; Diethylnitrosamine; DNA; Glucosinolates; Indoles; Liver Neoplasms, Experimental; Male; Prec | 1990 |
Histochemical changes in livers from portacaval-shunted rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Eosine Yellowish-(YS); gamma-Glutamyltransferase; Glu | 1986 |
Diethylnitrosamine-induced pancreatic neoplasms in the fish Rivulus ocellatus marmoratus.
Topics: Adenocarcinoma; Adenoma; Animals; Cystadenoma; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1986 |
In situ hybridization studies on expression of albumin and alpha-fetoprotein during the early stage of neoplastic transformation in rat liver.
Topics: Albumins; alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Gene Exp | 1987 |
Adenine nucleotides and carbohydrates in subpopulations of hepatic nodules with normal and compromised microcirculation.
Topics: Adenine Nucleotides; Animals; Carbohydrate Metabolism; Dextrans; Diethylnitrosamine; Fluorescein-5-i | 1989 |
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticid | 1989 |
Protooncogene methylation and expression in regenerating liver and preneoplastic liver nodules induced in the rat by diethylnitrosamine: effect of variations of S-adenosylmethionine:S-adenosylhomocysteine ratio.
Topics: Animals; Diethylnitrosamine; Genes, ras; Homocysteine; Immunoblotting; Liver; Liver Neoplasms, Exper | 1989 |
Production of monoclonal antibodies to preneoplastic liver cell populations induced by chemical carcinogens in rats and to transplantable Morris hepatomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Diethylnitrosamine; Enzy | 1989 |
Different lineages of chemically induced hepatocellular carcinoma in rats defined by monoclonal antibodies.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Antibodies, Monoclonal; Diethylnitrosamine; gamm | 1989 |
Expression of N-acetylglucosaminyltransferase III in hepatic nodules generated by different models of rat liver carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Glucosyltransferases; Intracellular Me | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci.
Topics: Animals; Benzoquinones; Diethylnitrosamine; DNA Damage; gamma-Glutamyltransferase; Glutathione; Hydr | 1989 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma | 1989 |
[A histochemical study of diethylnitrosamine-induced altered liver cells in rats].
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Histocyto | 1989 |
Lack of modifying effects of 2,2'-[(4-aminophenyl) imino] bisethanol sulfate on induction of preneoplastic gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Eating; gamma-Glutamyltransferase; Hair | 1989 |
Comparison of three rat liver foci bioassays--incidence of preneoplastic foci initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Diethylnitrosamine; Fe | 1989 |
Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations.
Topics: 2-Acetylaminofluorene; Adenoma; Aflatoxin B1; Aflatoxins; Animals; Biomarkers, Tumor; Diethylnitrosa | 1989 |
Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker.
Topics: Animals; Biomarkers, Tumor; Carcinogenicity Tests; Diethylnitrosamine; Gene Expression Regulation, E | 1989 |
[Inhibitory effects of jian pi li qi Chinese medicinal herbs on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in rats].
Topics: Animals; Diethylnitrosamine; Drugs, Chinese Herbal; Gene Expression Regulation; Genes, ras; Liver Ne | 1989 |
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; M | 1989 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Identification of the putative first cellular step of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Biomarkers, Tumor; Bromodeoxyuridine; Cell Division; | 1989 |
Immunocytochemical detection of the onco-developmental protein oncomodulin in pre-neoplastic and neoplastic hepatocellular lesions during hepatocarcinogenesis in rats.
Topics: Animals; Calcium-Binding Proteins; Diethylnitrosamine; Female; Hepatectomy; Immunohistochemistry; Li | 1989 |
Chromosomal analysis of a diethylnitrosamine-induced tumorigenic and a nontumorigenic rat liver cell line.
Topics: Animals; Cell Line; Chromosome Aberrations; Diethylnitrosamine; Karyotyping; Liver Neoplasms, Experi | 1989 |
Oxidative metabolism of 4-hydroxy-2,3-nonenal during diethyl-nitrosamine-induced carcinogenesis in rat liver.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Diethylnitrosamine; Lipid Peroxides; Liver; Liver Neopla | 1989 |
Focal impairment of growth in hepatocellular neoplasms of C57BL/6 mice: a possible explanation for the strain's resistance to hepatocarcinogenesis.
Topics: Animals; Diethylnitrosamine; DNA Replication; Immunity, Innate; Liver Neoplasms, Experimental; Lung | 1989 |
Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous.
Topics: Aging; Androgen-Insensitivity Syndrome; Animals; Diethylnitrosamine; Disease Susceptibility; Female; | 1989 |
Transient induction of single GST-P positive hepatocytes by DEN.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione Transfe | 1989 |
Genetic control of susceptibility to diethylnitrosamine carcinogenesis in inbred ACP (grc+) and R16 (grc) rats.
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Major Histocompa | 1989 |
Cell phenotype instability in preneoplastic foci of rat liver.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1988 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase.
Topics: Animals; Anisoles; Body Weight; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Diethylnitrosami | 1985 |
Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; gamma-Glutamyltransferase; Li | 1985 |
Diethylnitrosamine induced enzyme altered areas in the rat liver: effect of partial hepatectomy.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experim | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Dose-dependent promoting activity of chloroform in rat liver foci bioassay.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Chloroform; Cocarcinogenesis; Diethylnitrosamine; F | 1985 |
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitr | 1985 |
Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenoma; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehyd | 1985 |
Synergistic induction of altered hepatocyte foci by combined gamma radiation and diethylnitrosamine administered to neonatal rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Female; Gamma Rays; gamma-Glutamyltransferase; Iron; | 1986 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Female; gamma-Glutamy | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Influence of the nature and the dose of the initiator on the development of premalignant and malignant lesions in rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, | 1986 |
Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1986 |
Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion.
Topics: Animals; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental | 1986 |
Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines.
Topics: Animals; Carcinogens; Diethylnitrosamine; Glycolysis; Kidney; Kidney Neoplasms; Male; Nitrosamines; | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
Persistent effect of a low dose of preadministered diethylnitrosamine on the induction of enzyme-altered foci in rat liver.
Topics: Animals; Diethylnitrosamine; DNA Repair; gamma-Glutamyltransferase; Glutathione Transferase; Hepatec | 1987 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma- | 1987 |
The clonal nature of carcinogen-induced altered foci of gamma-glutamyl transpeptidase expression in rat liver.
Topics: Animals; Chimera; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimenta | 1987 |
Effects of separate and combined treatments with gamma radiation and diethylnitrosamine in neonatal rats on the induction of altered hepatocyte foci and hepatic tumors.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; DNA Damage; Female; Gamma Rays; gamma-Glutamyltransfe | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Variations of ornithine decarboxylase activity and S-adenosyl-L-methionine and 5'-methylthioadenosine contents during the development of diethylnitrosamine-induced liver hyperplastic nodules and hepatocellular carcinoma.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Deoxyadenosines; Diethylnitrosamine; DNA; gamma-Glutamylt | 1987 |
Influence of level of dietary protein on tryptophan-induced promotional activity in induction of gamma-glutamyl transpeptidase-positive foci of rat liver.
Topics: Animals; Body Weight; Dietary Proteins; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; | 1987 |
Effect of vitamin E on the induction and evolution of enzyme-altered foci in the liver of rats treated with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glutathione Transferase; Hematoxylin; Hyperp | 1987 |
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; L | 1988 |
Cancer promoting potential of different strains of Fusarium moniliforme in a short-term cancer initiation/promotion assay.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Ducks; Fusarium; gamma-Glutamyltransfera | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
[Stimulation, by acute inflammation, of the proliferation in preneoplastic hepatocyte foci expressing the gamma glutamyl transpeptidase, induced by diethylnitrosamine in adult rats].
Topics: Acute Disease; Animals; Caseins; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Infla | 1988 |
Quantitative morphometric comparison between the expression of two different "marker enzymes" in preneoplastic liver lesions induced in rats with low doses of N-nitrosodiethanolamine.
Topics: Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver Neopla | 1988 |
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; | 1989 |
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Diploidy; DNA, Neoplasm; Liver Neoplasms, Experi | 1989 |
[A preliminary study on the development of altered cells in different liver cell subpopulations of diethylnitrosamine-treated rats].
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; Female; Liver; Liver Neoplasms, Experimental; Male; | 1986 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Lack of initiating and promoting activity of thiourea in rat liver foci bioassay.
Topics: Animals; Biological Assay; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Precance | 1988 |
Inhibitory effect of tamoxifen on diethylstilbestrol-promoted hepatic tumorigenesis in male rats and its possible mechanism of action.
Topics: Animals; Diethylnitrosamine; Diethylstilbestrol; Liver Neoplasms, Experimental; Male; Precancerous C | 1988 |
Immunohistochemical detection of c-Ha-ras oncogene p21 product in pre-neoplastic and neoplastic lesions during hepatocarcinogenesis in rats.
Topics: Animals; Diethylnitrosamine; DNA Replication; Female; Genes, ras; Immunohistochemistry; Liver Neopla | 1988 |
Reactivity of monoclonal antibodies to oncoproteins with normal rat liver, carcinogen-induced tumours, and premalignant liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Monoclonal; Diethylnitrosamine; Immunoenzyme Techniques; | 1988 |
Immunocytochemical studies on the formation and repair of O6-alkylguanine in rat tissues.
Topics: Animals; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Guanine; Immunohisto | 1987 |
Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system.
Topics: Animals; Biological Assay; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver Neop | 1988 |
Dose-time relationship of the development of preneoplastic liver lesions induced in rats with low doses of N-nitrosodiethanolamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Kinetics; Liver; Liver N | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Shift from polyploidizing to nonpolyploidizing growth in carcinogen-treated rat liver.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Flow Cytometry; Liver; Liver Neoplasms, Experime | 1988 |
Tyrosine protein kinase in preneoplastic and neoplastic rat liver.
Topics: Affinity Labels; Animals; Antibodies; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Methy | 1988 |
Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: influence of subsequent butylated hydroxyanisole treatment.
Topics: Animals; Butylated Hydroxyanisole; Cricetinae; Diethylnitrosamine; Dimethylhydrazines; Glutathione T | 1987 |
N-nitrosodiethylamine-induced hepatocarcinogenesis in estuarine sheepshead minnow (Cyprinodon variegatus): neoplasms and related lesions compared with mammalian lesions.
Topics: Animals; Bile Ducts; Cyprinidae; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Fish Diseases | 1987 |
Coordinate polypeptide expression during hepatocarcinogenesis in male F-344 rats: comparison of the Solt-Farber and Reddy models.
Topics: Animals; Clofibric Acid; Computers; Cytosol; Diethylnitrosamine; Dihydrolipoamide Dehydrogenase; Dis | 1987 |
HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth.
Topics: Animals; Cell Division; Cholesterol; Diabetes Mellitus, Experimental; Diethylnitrosamine; Fasting; G | 1987 |
Induction of a novel Ca2+-dependent serine protease in rat liver treated with various promoters of liver carcinogenesis.
Topics: Animals; Calcium; Carcinogens; Diethylnitrosamine; Endopeptidases; Enzyme Induction; Liver Neoplasms | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Immunohistochemically demonstrated altered expression of cytochrome P-450 molecular forms and epoxide hydrolase in N-ethyl-N-hydroxyethylnitrosamine-induced rat kidney and liver lesions.
Topics: Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Epoxide Hydrolases; Glutathione Transfe | 1987 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn | 1987 |
Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrini infection in Syrian golden hamsters.
Topics: Animals; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Liver Neoplasms, Experimental; Mesocricet | 1987 |
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug C | 1987 |
Invasiveness, proliferative activity and ultrastructural phenotypes of hepatocytes from diethylnitrosamine-induced neoplastic nodules and hepacarcinomas in vitro.
Topics: Animals; Autoradiography; Cell Division; Chick Embryo; Diethylnitrosamine; In Vitro Techniques; Live | 1987 |
Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic foci in rats.
Topics: Animals; Calcium; Diet; Diethylnitrosamine; Female; Glucaric Acid; Glucuronidase; Liver Neoplasms, E | 1987 |
[Early morphofunctional changes in the liver after administration of nitrosodiethylamine].
Topics: Animals; Diethylnitrosamine; Hyperplasia; Liver; Liver Neoplasms; Male; Precancerous Conditions; Rat | 1986 |
Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice.
Topics: Alleles; Animals; Body Weight; Crosses, Genetic; Diethylnitrosamine; DNA; Female; Liver Neoplasms, E | 1986 |
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index; | 1986 |
Changes in nucleolar transcriptional activity and nuclear DNA content during the first steps of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Cell Nucleolus; Diethylnitrosamine; | 1987 |
New data on kinetics of lipid peroxidation in experimental hepatomas and preneoplastic nodules.
Topics: Alcohol Dehydrogenase; Animals; Chromatography, High Pressure Liquid; Diethylnitrosamine; Glutathion | 1986 |
[Immunosuppressive effect and promotor activity for hepatic carcinogenesis of thiobenzamide].
Topics: Amides; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; Hemolytic Plaque Techniq | 1985 |
Sequential analysis of chemically induced hepatoma development in rats by two dimensional electrophoresis.
Topics: Albumins; Aldehyde Dehydrogenase; Animals; Cytosol; Diethylnitrosamine; Electrophoresis, Polyacrylam | 1986 |
Evidence for growth heterogeneity among foci with different phenotypes in the population of altered hepatocyte foci induced by a single neonatal treatment with carcinogen.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Phenotype; | 1986 |
Dehydrogenase histochemistry of N-ethyl-N-hydroxyethylnitrosamine-induced focal liver lesions in the rat--increase in NADPH-generating capacity.
Topics: Animals; Diethylnitrosamine; Fatty Acids; Histocytochemistry; Liver Neoplasms, Experimental; Male; N | 1986 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |
Promotion of preneoplastic changes in liver by coal-derived organic mixtures applied to skin.
Topics: Administration, Topical; Animals; Benzo(a)pyrene; Coal; Diethylnitrosamine; Female; Liver Neoplasms, | 1985 |