diethylnitrosamine has been researched along with Cocarcinogenesis in 177 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals." | 3.77 | Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Sakai, H; Shimizu, M; Tanaka, T; Terakura, D; Tsurumi, H; Yasuda, Y, 2011) |
| "In previous studies, we found that male D2B6F1 mice fed phenobarbital (PB) for 53 weeks following N-nitrosodiethylamine (NDEA) initiation developed a high (70-80%) incidence of malignant hepatoblastomas." | 3.69 | Further evidence for promoter-dependent development of hepatoblastoma in the mouse. ( Diwan, BA; Henneman, JR; Rice, JM, 1995) |
| " When administered 1 or 3 days after N-diethylnitrosamine initiation and partial hepatectomy, colchicine increased the mitotic index of regenerating hepatocytes at days 4-6 without evidence of liver cell necrosis." | 3.69 | Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats. ( Kobitsu, K; Konishi, Y; Mori, Y; Nakajima, Y; Nakano, H; Ohashi, K; Okajima, E; Takahashi, M; Tsujiuchi, T; Tsutsumi, M, 1996) |
| " injection of diethylnitrosamine (DEN) (25-mg/kg body weight)." | 3.67 | Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine. ( Jirtle, RL; Michalopoulos, G; Novicki, DL; Novotny, A; Rosenberg, MR, 1985) |
| "After 4 or 13 weeks of IMA treatment, liver hypertrophy was observed at the tumor-inducible dose without differences among genotypes or durations." | 1.43 | A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice. ( Inoue, K; Kodama, Y; Matsuo, S; Takahashi, M; Tamura, K; Yoshida, M, 2016) |
| "An increased number of chromosomal aberrations were observed after pre-treatment with PB." | 1.37 | N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF, 2011) |
| "Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms." | 1.34 | Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat. ( Boitier, E; Desdouets, C; Isaacs, KR; Michel, C; Roberts, RA; Slaoui, M, 2007) |
| " The better correlation between 8-oxodG formation and tumor response indicates that dose-response information from the female rat would be much more relevant to human risk assessment." | 1.33 | Etiology of bromate-induced cancer and possible modes of action-studies in Japan. ( Kurokawa, Y; Umemura, T, 2006) |
| " At dosage levels equimolar to 500 ppm PB, none of the three compounds promoted development of hepatocellular adenomas or carcinomas, in contrast to PB." | 1.28 | Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat. ( Diwan, BA; Henneman, JR; Lubet, RA; Nims, RW; Rice, JM; Ward, JM, 1992) |
| " Although no toxicity-related hepatocyte lesions were found, severe renal toxic tubular lesions and regeneration were evident." | 1.28 | Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman. ( Hagiwara, A; Ito, N; Kato, T; Kurata, Y; Tanaka, H; Tsuda, H, 1990) |
| "Tracheal papillomas were not seen in untreated hamsters or in those not given NDEA and fed diets containing PBB." | 1.28 | Promoting effect of polybrominated biphenyls on tracheal papillomas in Syrian golden hamsters. ( Sleight, SD, 1989) |
| "Nafenopin treatment suppressed the development of foci at all time points, such that less hepatic lesions were seen than in animals which received only diethylnitrosamine." | 1.27 | Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver. ( Bentley, P; Bieri, F; Fröhlich, E; Stäubli, W; Waechter, F, 1984) |
| " Chronic administration of dose levels of PB below 0." | 1.27 | The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. ( Campbell, HA; Goldsworthy, T; Pitot, HC, 1984) |
| ") at 4 weeks of age with N-nitrosodiethylamine (DEN) at a dosage of 80 mg/kg." | 1.27 | Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. ( Lynch, P; Ohshima, M; Riggs, C; Ward, JM, 1984) |
| "The phenobarbital treatment became unnecessary when neoplastic nodules were present." | 1.27 | Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect. ( Barbason, H; Betz, EH; Rassenfosse, C, 1983) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| " The dose levels in the individual dose-response experiments ranged from the lowest concentrations of previous experiments (NDEA, 0." | 1.27 | Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats. ( Berger, MR; Schmähl, D; Zerban, H, 1987) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| "The dose-response relationship was determined in rats for the enhancement by phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular carcinomas." | 1.27 | Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver. ( Herren-Freund, SL; Long, RE; Pereira, MA, 1986) |
| " A simple two-stage model of rat hepatocarcinogenesis with a single ip dose of diethylnitrosamine (DEN) as the initiator and sodium phenobarbitone or ethanol given in the drinking-water for 12-18 months as the promoter was used to investigate dose-response relationships for initiation and promotion." | 1.27 | Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol. ( Driver, HE; McLean, AE, 1986) |
| "Diethylnitrosamine failed to transform RLC-1 cells with or without tetradecanoylphorbol acetate (TPA) promotion." | 1.27 | 12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells. ( Higgins, PJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 92 (51.98) | 18.7374 |
| 1990's | 49 (27.68) | 18.2507 |
| 2000's | 19 (10.73) | 29.6817 |
| 2010's | 17 (9.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, P | 1 |
| Cai, X | 1 |
| Guo, Y | 1 |
| Xu, M | 1 |
| Tian, J | 1 |
| Locker, J | 1 |
| Xie, W | 1 |
| Rignall, B | 2 |
| Grote, K | 1 |
| Gavrilov, A | 1 |
| Weimer, M | 1 |
| Kopp-Schneider, A | 1 |
| Krause, E | 1 |
| Appel, KE | 1 |
| Buchmann, A | 4 |
| Robertson, LW | 3 |
| Lehmler, HJ | 1 |
| Kania-Korwel, I | 1 |
| Chahoud, I | 1 |
| Schwarz, M | 5 |
| Fujii, Y | 2 |
| Segawa, R | 2 |
| Kimura, M | 3 |
| Wang, L | 1 |
| Ishii, Y | 2 |
| Yamamoto, R | 2 |
| Morita, R | 3 |
| Mitsumori, K | 7 |
| Shibutani, M | 5 |
| Hara, S | 1 |
| Ogawa, T | 1 |
| Takimoto, N | 1 |
| Suzuki, K | 2 |
| Hamadate, N | 1 |
| Hayashi, SM | 1 |
| Odachi, A | 1 |
| Ogiwara, I | 1 |
| Shibusawa, S | 1 |
| Yoshida, T | 2 |
| Kennedy, GD | 1 |
| Nukaya, M | 1 |
| Moran, SM | 1 |
| Glover, E | 1 |
| Weinberg, S | 1 |
| Balbo, S | 1 |
| Hecht, SS | 3 |
| Pitot, HC | 13 |
| Drinkwater, NR | 3 |
| Bradfield, CA | 1 |
| Parzefall, W | 1 |
| Freiler, C | 1 |
| Lorenz, O | 1 |
| Koudelka, H | 1 |
| Riegler, T | 1 |
| Nejabat, M | 1 |
| Kainzbauer, E | 1 |
| Grasl-Kraupp, B | 2 |
| Schulte-Hermann, R | 2 |
| Maeda, J | 1 |
| Inoue, K | 2 |
| Ichimura, R | 1 |
| Takahashi, M | 6 |
| Kodama, Y | 3 |
| Saito, N | 1 |
| Yoshida, M | 2 |
| Mu, X | 1 |
| Español-Suñer, R | 1 |
| Mederacke, I | 1 |
| Affò, S | 1 |
| Manco, R | 1 |
| Sempoux, C | 1 |
| Lemaigre, FP | 1 |
| Adili, A | 1 |
| Yuan, D | 1 |
| Weber, A | 1 |
| Unger, K | 1 |
| Heikenwälder, M | 1 |
| Leclercq, IA | 1 |
| Schwabe, RF | 1 |
| Mizukami, S | 1 |
| Watanabe, Y | 1 |
| Onda, N | 1 |
| Tamura, K | 1 |
| Matsuo, S | 1 |
| Liu, WB | 1 |
| Liu, JY | 1 |
| Ao, L | 1 |
| Zhou, ZY | 1 |
| Zhou, YH | 1 |
| Cui, ZH | 1 |
| Yang, H | 1 |
| Cao, J | 1 |
| Said, RA | 1 |
| Grassi, TF | 1 |
| Scolastici, C | 1 |
| Alves de Lima, RO | 1 |
| Darros, BR | 1 |
| Barbisan, LF | 1 |
| de Camargo, JL | 1 |
| Dewa, Y | 1 |
| Nishimura, J | 1 |
| Jin, M | 2 |
| Kawai, M | 1 |
| Saegusa, Y | 1 |
| Kenmochi, S | 1 |
| Shimamoto, K | 2 |
| Harada, T | 1 |
| Khan, TH | 1 |
| Sultana, S | 1 |
| Shimizu, M | 1 |
| Yasuda, Y | 1 |
| Sakai, H | 1 |
| Kubota, M | 1 |
| Terakura, D | 1 |
| Baba, A | 1 |
| Ohno, T | 1 |
| Kochi, T | 1 |
| Tsurumi, H | 1 |
| Tanaka, T | 2 |
| Moriwaki, H | 1 |
| Aiub, CA | 1 |
| Gadermaier, G | 1 |
| Oliveira, I | 1 |
| Felzenszwalb, I | 1 |
| Ferreira, F | 1 |
| Ribeiro Pinto, LF | 1 |
| Eckl, P | 1 |
| Schmid, A | 1 |
| Pichler, BJ | 1 |
| Hemmings, SJ | 1 |
| Strickland, J | 1 |
| Ito, N | 11 |
| Tamano, S | 3 |
| Shirai, T | 6 |
| Bursch, W | 1 |
| Chabicovsky, M | 1 |
| Wastl, U | 1 |
| Bukowska, K | 1 |
| Taper, H | 1 |
| Liu, LL | 1 |
| Gong, LK | 1 |
| Qi, XM | 1 |
| Cai, Y | 1 |
| Wang, H | 1 |
| Wu, XF | 1 |
| Xiao, Y | 1 |
| Ren, J | 1 |
| Hokaiwado, N | 1 |
| Asamoto, M | 2 |
| Ogawa, K | 2 |
| Umemura, T | 1 |
| Kurokawa, Y | 3 |
| Moto, M | 1 |
| Okamura, M | 1 |
| Muguruma, M | 1 |
| Ito, T | 1 |
| Kashida, Y | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Michel, C | 1 |
| Desdouets, C | 1 |
| Slaoui, M | 1 |
| Isaacs, KR | 1 |
| Roberts, RA | 1 |
| Boitier, E | 1 |
| Takami, T | 1 |
| Kaposi-Novak, P | 1 |
| Uchida, K | 1 |
| Gomez-Quiroz, LE | 1 |
| Conner, EA | 1 |
| Factor, VM | 1 |
| Thorgeirsson, SS | 2 |
| Marx-Stoelting, P | 1 |
| Mahr, J | 1 |
| Knorpp, T | 1 |
| Schreiber, S | 1 |
| Templin, MF | 1 |
| Ott, T | 2 |
| Shinozuka, H | 2 |
| Lombardi, B | 3 |
| Pereira, MA | 5 |
| Savage, RE | 1 |
| Herren, SL | 2 |
| Guion, CW | 1 |
| Britt, AL | 1 |
| Khoury, MM | 1 |
| Novicki, DL | 2 |
| Jirtle, RL | 3 |
| Michalopoulos, G | 2 |
| Abanobi, SE | 1 |
| Stäubli, W | 1 |
| Bentley, P | 1 |
| Bieri, F | 1 |
| Fröhlich, E | 1 |
| Waechter, F | 1 |
| Goldsworthy, T | 2 |
| Campbell, HA | 1 |
| Tsuda, H | 7 |
| Hasegawa, R | 5 |
| Imaida, K | 2 |
| Solt, DB | 1 |
| Cayama, E | 1 |
| Enomoto, K | 1 |
| Lee, G | 1 |
| Farber, E | 2 |
| Ding, L | 1 |
| Zou, DY | 1 |
| Chen, JY | 1 |
| Wang, JT | 1 |
| Wang, YB | 1 |
| Pan, SR | 1 |
| Wand, SH | 1 |
| Hoffmann, D | 2 |
| Wynder, EL | 2 |
| Ward, JM | 7 |
| Ohshima, M | 4 |
| Lynch, P | 1 |
| Riggs, C | 1 |
| Furukawa, F | 3 |
| Toyoda, K | 2 |
| Kokubo, T | 1 |
| Hayashi, Y | 4 |
| Swann, PF | 1 |
| Gurkalo, VK | 1 |
| Zabezhinski, MA | 1 |
| Malvaldi, G | 4 |
| Chieli, E | 1 |
| Saviozzi, M | 4 |
| Newberne, PM | 1 |
| Connor, M | 1 |
| Preston, BD | 1 |
| Van Miller, JP | 1 |
| Moore, RW | 1 |
| Allen, JR | 1 |
| Moran, S | 2 |
| Sirica, AE | 1 |
| Weeks, J | 1 |
| Barbason, H | 1 |
| Rassenfosse, C | 1 |
| Betz, EH | 1 |
| Mochizuki, Y | 2 |
| Furukawa, K | 2 |
| Sawada, N | 2 |
| Hiasa, Y | 1 |
| Kitahori, Y | 1 |
| Konishi, N | 1 |
| Fujita, T | 1 |
| Yuasa, T | 1 |
| Kunz, W | 2 |
| Schaude, G | 1 |
| Tennekes, H | 1 |
| Pool, BL | 1 |
| Bertram, B | 1 |
| Wiessler, M | 1 |
| Vesselinovitch, SD | 1 |
| Mihailovich, N | 1 |
| Rao, KV | 2 |
| Goldfarb, S | 1 |
| Küng-Vösamäe, A | 1 |
| Vinkmann, F | 1 |
| Yaono, M | 1 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Nakamura, T | 1 |
| Deguchi, T | 1 |
| Lin, YZ | 1 |
| Brunt, EM | 1 |
| Bowling, W | 1 |
| Hafenrichter, DG | 1 |
| Kennedy, SC | 1 |
| Flye, MW | 1 |
| Ponder, KP | 1 |
| Takada, N | 1 |
| Kitano, M | 1 |
| Chen, T | 1 |
| Yano, Y | 1 |
| Otani, S | 1 |
| Fukushima, S | 3 |
| Berberian, I | 1 |
| Chen, LC | 1 |
| Robinson, FR | 1 |
| Glauert, HP | 4 |
| Chow, CK | 1 |
| Diwan, BA | 6 |
| Henneman, JR | 2 |
| Rice, JM | 5 |
| Maisin, JR | 2 |
| Vankerkom, J | 1 |
| De Saint-Georges, L | 2 |
| Janowski, M | 2 |
| Lambiet-Collier, M | 2 |
| Mattelin, G | 2 |
| Wambersie, A | 1 |
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| Dragan, YP | 1 |
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| Godin, CS | 1 |
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| Boonyaphiphat, P | 1 |
| Tritscher, AM | 1 |
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| Sutter, TR | 1 |
| Lucier, GW | 4 |
| Russell, WE | 1 |
| Kaufmann, WK | 1 |
| Sitaric, S | 1 |
| Luetteke, NC | 1 |
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| Hallstrom, IP | 1 |
| Liao, DZ | 1 |
| Assefaw-Redda, Y | 1 |
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| Sahlin, L | 1 |
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| Eriksson, LC | 1 |
| Gustafsson, JA | 1 |
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| Chiaverotti, TA | 1 |
| Carabeo, RA | 1 |
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| Ichinose, M | 1 |
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| Yanai, T | 1 |
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| Tatematsu, M | 2 |
| Okada, N | 1 |
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| Kawabata, M | 1 |
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| Sato, A | 1 |
| Hendrich, S | 3 |
| Leveston, AO | 1 |
| Nims, RW | 2 |
| Lubet, RA | 2 |
| Armstrong, D | 1 |
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| Fernandes, C | 1 |
| Lalitha, VS | 1 |
| Mufti, SI | 2 |
| Sipes, IG | 1 |
| Wada, S | 1 |
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| Cho, KJ | 1 |
| Bae, JH | 1 |
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| Maronpot, R | 1 |
| Beer, DG | 1 |
| Neveu, MJ | 1 |
| Hagiwara, A | 4 |
| Yamada, M | 1 |
| Kurata, Y | 1 |
| Kato, T | 2 |
| Kemp, CJ | 1 |
| Evarts, RP | 1 |
| Raab, M | 1 |
| Marsden, E | 1 |
| Masuko, T | 1 |
| Hashimoto, Y | 1 |
| Nagase, S | 1 |
| Sleight, SD | 1 |
| Goodspeed, D | 1 |
| Dunn, T | 1 |
| Maronpot, RR | 1 |
| Shibata, M | 1 |
| Arai, M | 1 |
| Krasil'schikov, DG | 1 |
| Barauskaĭte, SV | 1 |
| Lee, MS | 1 |
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| van Schalkwyk, DJ | 1 |
| Kroese, ED | 1 |
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| Mulder, GJ | 1 |
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| Gao, FM | 1 |
| Yu, YN | 1 |
| Schechtman, LM | 1 |
| Hatch, GG | 1 |
| Anderson, TM | 1 |
| Putman, DL | 1 |
| Kouri, RE | 1 |
| Cameron, JW | 1 |
| Spalding, JW | 1 |
| Tennant, RW | 1 |
| Wolf, CR | 1 |
| Oesch, F | 1 |
| Rosenberg, MR | 1 |
| Novotny, A | 1 |
| Bartsch, H | 1 |
| Préat, V | 2 |
| Aitio, A | 1 |
| Cabral, JR | 1 |
| Roberfroid, M | 2 |
| Ruch, RJ | 1 |
| Weghorst, CM | 2 |
| Takamura, N | 2 |
| Matushima, Y | 1 |
| Flodström, S | 1 |
| Warngård, L | 1 |
| Hemming, H | 1 |
| Ahlborg, UG | 1 |
| Kononenko, LI | 1 |
| Grabovaia, AR | 1 |
| Bykorez, AI | 2 |
| Williams, GM | 1 |
| Maruyama, H | 1 |
| Pieracci, D | 1 |
| Thamavit, W | 1 |
| Ngamying, M | 1 |
| Boonpucknavig, V | 1 |
| Boonpucknavig, S | 1 |
| Moore, MA | 1 |
| Berger, MR | 2 |
| Zerban, H | 1 |
| Osipova, LA | 1 |
| Vinarchuk, MP | 1 |
| Khranovskaia, LN | 1 |
| Ikawa, E | 1 |
| Sakata, T | 1 |
| Satoh, K | 1 |
| Sato, K | 1 |
| Dragani, TA | 2 |
| Manenti, G | 2 |
| Della Porta, G | 2 |
| Shivapurkar, N | 1 |
| Hoover, KL | 1 |
| Herren-Freund, SL | 1 |
| Long, RE | 1 |
| de Gerlache, J | 2 |
| Lans, M | 2 |
| Pasquinelli, P | 1 |
| Bruschi, F | 1 |
| Aoki, S | 1 |
| Matsushima, Y | 1 |
| Driver, HE | 1 |
| McLean, AE | 1 |
| Galliani, G | 1 |
| Deleener, A | 1 |
| Kirsch-Volders, M | 1 |
| Higgins, PJ | 1 |
| Timchalk, C | 1 |
| Charles, AK | 1 |
| Abraham, R | 1 |
| Sons, HU | 1 |
| Borchard, F | 1 |
| Müller-Jäh, K | 1 |
| Sandmann, H | 1 |
| Litvinov, NN | 1 |
| Voronin, VM | 1 |
| Kazachkov, VI | 1 |
10 reviews available for diethylnitrosamine and Cocarcinogenesis
| Article | Year |
|---|---|
A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Biological Assay; Biomarkers, Tumor; Carcino | 2003 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepate | 1982 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Receptor-mediated toxicity and implications for risk assessment.
Topics: Animals; Cell Division; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; D | 1994 |
Genetic analysis of multistage hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Disease | 1996 |
Experimental data concerning the question of the synergic action of the influenza virus and of some chemical carcinogens in the pathogenesis of lung cancer.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Humans; Influenza, Human; Lung Neoplasms | 1979 |
Model studies in tobacco carcinogenesis with the Syrian golden hamster.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Disease Models, | 1979 |
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F | 1990 |
[Modified effect of ethanol on blastomogenesis induced by carcinogenic substances].
Topics: Alcoholic Beverages; Animals; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Ethanol; Humans; | 1989 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
167 other studies available for diethylnitrosamine and Cocarcinogenesis
| Article | Year |
|---|---|
Constitutive Activation of the Human Aryl Hydrocarbon Receptor in Mice Promotes Hepatocarcinogenesis Independent of Its Coactivator Gadd45b.
Topics: Animals; Antigens, Differentiation; Basic Helix-Loop-Helix Transcription Factors; Cocarcinogenesis; | 2019 |
Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cocarcinogenesis; Cytochrome P-450 CYP1A1 | 2013 |
Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Cocarcinogene | 2013 |
Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Proliferation; Cocarcinogenesis; Diethylnitrosamin | 2014 |
Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.
Topics: Animals; Caprylates; Cocarcinogenesis; Diethylnitrosamine; Dioxins; Liver Neoplasms, Experimental; M | 2014 |
Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Female; Liver; Liver Neoplasms, Experimental | 2015 |
Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis.
Topics: Adenoma, Liver Cell; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cocarcinogenesis; Constitu | 2015 |
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
Topics: alpha-Fetoproteins; Animals; Bile Ducts; Biomarkers, Tumor; Carbon Tetrachloride; Carcinogens; Cell | 2015 |
Aberrant cell cycle regulation in rat liver cells induced by post-initiation treatment with hepatocarcinogens/hepatocarcinogenic tumor promoters.
Topics: Acetaminophen; Animals; Apoptosis; beta-Naphthoflavone; Carbadox; Carcinogens; Cell Proliferation; C | 2016 |
A crucial role of constitutive androstane receptor (CAR) in liver tumor development by imazalil in mice.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cocarcinogenesis; Constitutive | 2016 |
Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine.
Topics: Animals; Azacitidine; Cell Line; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dep | 2009 |
Absence of chemopreventive influence of propolis on the rat liver altered foci development.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Brazil; Cocarcinogenesis; Diethylnitrosamine; Glutath | 2010 |
Immunohistochemical analyses at the late stage of tumor promotion by oxfendazole in a rat hepatocarcinogenesis model.
Topics: Adenoma, Liver Cell; Animals; Anthelmintics; Apoptosis; Benzimidazoles; Carcinogens; Cell Cycle Prot | 2011 |
Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study.
Topics: 2-Acetylaminofluorene; Aegle; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinogens; | 2011 |
Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-Associated Death Protein; Cocarc | 2011 |
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrat | 2011 |
Quantitative analysis of the growth kinetics of chemically induced mouse liver tumors by magnetic resonance imaging.
Topics: Animal Use Alternatives; Animals; Cocarcinogenesis; Diethylnitrosamine; Early Detection of Cancer; I | 2012 |
Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Indole | 2013 |
Administration of diethylnitrosamine in the immediate postnatal period coupled with exposure to a choline deficient diet accelerates hepatocarcinogenesis in the rat.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Glucose; Choline Deficiency; Cocarcinogenesis | 2002 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
Etiology of bromate-induced cancer and possible modes of action-studies in Japan.
Topics: Administration, Oral; Alpha-Globulins; Animals; Bromates; Carcinogens, Environmental; Carcinoma, Ren | 2006 |
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; DN | 2006 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Anticholesteremic Agents; Carcinogens; Clofibric Acid; Cocarcinogenesis; | 2007 |
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Topics: Acetylcysteine; Animals; Antioxidants; Cocarcinogenesis; Diethylnitrosamine; Gene Expression Regulat | 2007 |
Tumor promotion in liver of mice with a conditional Cx26 knockout.
Topics: Animals; Apoptosis; Carcinogens; Cocarcinogenesis; Connexin 26; Connexins; Diethylnitrosamine; Femal | 2008 |
Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
Topics: Animals; Body Weight; Choline; Cocarcinogenesis; Diet; Diethylnitrosamine; gamma-Glutamyltransferase | 1980 |
Diazepam and tumour promotion.
Topics: Animals; Cocarcinogenesis; Diazepam; Diethylnitrosamine; Female; Humans; Neoplasms; Neoplasms, Exper | 1981 |
Comparison of enhancement of GGTase-positive foci and induction of ornithine decarboxylase in rat liver by barbiturates.
Topics: Animals; Barbiturates; Biotransformation; Carboxy-Lyases; Cocarcinogenesis; Diethylnitrosamine; Enzy | 1982 |
Promotion by polychlorinated biphenyls of enzyme-altered foci in rat liver.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cocarcinogenesis; Diethylnitrosamine; Drug Adminis | 1982 |
Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol.
Topics: Animals; Cell Line; Cell Separation; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase | 1983 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver; | 1984 |
The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1984 |
Comparison of the promoting effects of various agents in induction of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Rel | 1983 |
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachl | 1983 |
A histological study of the promotive effect of diethylstilbestrol on diethylnitrosamine initiated carcinogenesis of liver in rat.
Topics: Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; Diethylstilbestrol; Female | 1984 |
Tumor promoters and cocarcinogens in tobacco carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acids; Animals; Benzopyrenes; Cocarcinogenesis; Cricetinae; Diethy | 1983 |
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Topics: Animals; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; | 1984 |
[Establishment of test methods for examining promoters of hepatocarcinogenesis--promoting effects of phenobarbital, butylated hydroxytoluene and barbital].
Topics: Animals; Barbital; Barbiturates; Butylated Hydroxytoluene; Cocarcinogenesis; Diethylnitrosamine; Liv | 1984 |
Effect of ethanol on nitrosamine metabolism and distribution. Implications for the role of nitrosamines in human cancer and for the influence of alcohol consumption on cancer incidence.
Topics: Alcohol Drinking; Animals; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Ethanol; Human | 1984 |
The role of central dopaminergic processes in chemical carcinogenesis.
Topics: Animals; Apomorphine; Autonomic Nervous System; Behavior, Animal; Cocarcinogenesis; Diethylnitrosami | 1984 |
Promotive effects of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobar | 1983 |
Effects of sequential exposure to aflatoxin B1 and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Diethylnitrosamine; H | 1980 |
Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat.
Topics: Animals; Aroclors; Benzofurans; Body Weight; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinoge | 1981 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver N | 1983 |
Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.
Topics: Animals; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver N | 1983 |
beta-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; beta-Cyclodextrins; Body Weight; Carcinogens; Cocarcinogenesis; Cyclodextrins; Dextrins; Di | 1982 |
Mutagenicity and synthesis of alpha-substituted N-nitrosamines: derivatives with dithiocarbamic acid.
Topics: Chemical Phenomena; Chemistry; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Disulfiram | 1982 |
Relevance of basophilic foci to promoting effect of sex hormones on hepatocarcinogenesis.
Topics: Animals; Castration; Cocarcinogenesis; Diethylnitrosamine; Female; Gonadal Steroid Hormones; Kinetic | 1982 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Combined carcinogenic action of chrysotile asbestos dust and N-nitrosodiethylamine on the respiratory tract of Syrian golden hamsters.
Topics: Animals; Asbestos; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Dust; Mesocricetus; Nitrosamine | 1980 |
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Glutathione | 1995 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
Ras-transduced diethylnitrosamine-treated hepatocytes develop into cancers of mixed phenotype in vivo.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Gene Transfer Techniques; Genes, ras; Hematopoiesis; | 1995 |
Enhancing effects of organosulfur compounds from garlic and onions on hepatocarcinogenesis in rats: association with increased cell proliferation and elevated ornithine decarboxylase activity.
Topics: Acetyltransferases; Allium; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Garlic; Gl | 1994 |
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Diterpenes; Drug Interact | 1995 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental | 1995 |
Effect of neutrons alone or combined with diethylnitrosamine on tumor induction in the livers of infant C57BL mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Ma | 1995 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transfe | 1994 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 1994 |
[Use of a foreign body as a promotor for detecting the ability of various chemical substances to initiate carcinogenesis in connective tissue].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dimethylhydrazine | 1994 |
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplast | 1994 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Evaluation of the promotion potential of chlorotrifluoroethylene trimer acid in male Sprague-Dawley rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Fatty Acids; gamma-Gluta | 1993 |
Enhancing effect of ethanol on esophageal tumor development in rats by initiation of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Esophageal Neoplasms; Esophagus; Ethanol; Hyperplasia | 1993 |
Modulation of N-nitrosodiethylamine-induced hamster lung tumors by ozone.
Topics: Administration, Inhalation; Animals; Body Weight; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; | 1993 |
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
Topics: Animals; Body Weight; Captan; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Diethylnitrosami | 1993 |
Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Deoxyguanosine; Diethylnitrosamine; DNA; DNA Damage; Estradi | 1996 |
Liver regeneration and hepatocarcinogenesis in transforming growth factor-alpha-targeted mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Humans; Iodine Radioisotope | 1996 |
Disturbance of the cell cycle with colchicine enhances the growth advantage of diethylnitrosamine-initiated hepatocytes in rats.
Topics: Animals; Cell Cycle; Cell Division; Cocarcinogenesis; Colchicine; Diethylnitrosamine; Dose-Response | 1996 |
Promotion potential of tamoxifen on hepatocarcinogenesis in female SD or F344 rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1996 |
Estrogen receptor levels and occupancy in hepatic sinusoidal endothelial and Kupffer cells are enhanced by initiation with diethylnitrosamine and promotion with 17alpha-ethinylestradiol in rats.
Topics: Animals; Carcinogens; Cell Nucleus; Cocarcinogenesis; Diethylnitrosamine; Endothelium; ErbB Receptor | 1996 |
Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis caused by a colchicine-induced cell cycle disturbance in partially hepatectomized rats.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Cocarcinogenesis; Colchicine; Diethylnitrosamine; g | 1996 |
Role of the pituitary in tumor promotion with ethinyl estradiol in rat liver.
Topics: Animals; Body Weight; Bromocriptine; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Estradiol Co | 1996 |
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Cyclophosph | 1996 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; DNA; Drug Synergism; Lac Op | 1997 |
Liver tumour-promoting effects of oxfendazole in rats.
Topics: Administration, Oral; Animals; Anthelmintics; Benzimidazoles; Carcinogens; Cell Count; Cocarcinogene | 1997 |
Changes in drug-metabolizing enzymes of rats in ciprofibrate-induced hepatic nodules.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Carcinogens; Clofibric Acid; Cocarcinogen | 1997 |
Liver cancer is induced by a subnecrogenic dose of DENA when associated with fasting/refeeding: role of glutathione-transferase and lipid peroxidation.
Topics: Animals; Antioxidants; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Eating; Fasting; Fatty Aci | 1999 |
[Genotoxic effect on human mucous membrane biopsies of the upper aerodigestive tract].
Topics: Adult; Benzo(a)pyrene; Carcinogenicity Tests; Chromates; Cocarcinogenesis; Diethylnitrosamine; Envir | 1999 |
Toxicity of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in diethylnitrosamine-initiated ovariectomized rats implanted with subcutaneous 17 beta-estradiol pellets.
Topics: Animals; Body Weight; Clinical Chemistry Tests; Cocarcinogenesis; Diethylnitrosamine; Drug Implants; | 2000 |
Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenocarcinoma; Adenoma; Adrenal Glands; Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitros | 2000 |
Mouse strain susceptibility to diethylnitrosamine induced hepatocarcinogenesis is cell autonomous whereas sex-susceptibility Is due to the micro-environment: analysis with C3H <--> BALB / c sexually chimeric mice.
Topics: Animals; Antibodies; Carcinogens; Chimera; Cocarcinogenesis; Diethylnitrosamine; Female; Genetic Mar | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci
Topics: Animals; Base Sequence; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Ki | 2001 |
Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cocarcinogenesis; Deoxyguanosine; Diethylnitrosam | 2001 |
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; | 2001 |
interactions of ionizing radiation, nitrosamines, sulfonoxyalkanes and antioxidants as they affect carcinogenesis and survival in mice.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Carcinogens; Cocarcinogenesis; Cresols; Diethylnitr | 1978 |
Inhibition of the multiplication of herpes simplex virus by aliphatic nitrosamines.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Transformation, Neoplastic; Cells, C | 1978 |
Effects of exposure to acetaldehyde in syrian hamsters simultaneously treated with benzo(a)pyrene or diethylnitrosamine.
Topics: Acetaldehyde; Animals; Benzopyrenes; Body Weight; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; | 1979 |
Effects of exposure to furfural vapour in hamsters simultaneously treated with benzo[alpha] pyrene or diethylnitrosamine.
Topics: Adenoma; Animals; Benzopyrenes; Body Weight; Carcinoma; Cocarcinogenesis; Cricetinae; Diethylnitrosa | 1978 |
Combination effects in chemical carcinogenesis (experimental results).
Topics: Animals; Carcinogens; Cocarcinogenesis; Cyclamates; Diethylnitrosamine; Disease Models, Animal; Dose | 1976 |
The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA Pro | 1992 |
Ethanol ingestion combined with lowered carbohydrate intake enhances the initiation of diethylnitrosamine liver carcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cocarcinogenesis; Dietary Carbohydrates; | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.
Topics: Animals; Barbiturates; Body Weight; Cocarcinogenesis; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzy | 1992 |
Comparison of liver cancer and nodules induced in rats by deoxycholic acid diet with or without prior initiation.
Topics: Animals; Cocarcinogenesis; Deoxycholic Acid; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Gl | 1991 |
Enhancing effect of malachite green on the development of hepatic pre-neoplastic lesions induced by N-nitrosodiethylamine in rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Glycogen; Liver; Liver Neo | 1991 |
A reduction in mixed function oxidases and in tumor promoting effects of ethanol in a NDEA-initiated hepatocarcinogenesis model.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; gamma-Glutamyltransferase; Liver Neoplasms, | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neopla | 1991 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Proto-oncogene and gap-junction protein expression in rodent liver neoplasms.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gene Expression Re | 1990 |
Free radicals generated in ethanol metabolism may be responsible for tumor promoting effects of ethanol.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasm | 1991 |
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione | 1990 |
Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.
Topics: Alkaloids; Animals; Body Weight; Carbolines; Cocarcinogenesis; Diethylnitrosamine; Glutathione Trans | 1990 |
The androgen receptor and liver tumor development in mice.
Topics: Androgen-Insensitivity Syndrome; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hyperplasia; | 1990 |
Histochemical changes in livers from portacaval-shunted rats.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Eosine Yellowish-(YS); gamma-Glutamyltransferase; Glu | 1986 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Promoting effect of polybrominated biphenyls on tracheal papillomas in Syrian golden hamsters.
Topics: Adenoma; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Cricetinae; Diet; Diethylnitrosamine; | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
Lack of modifying effects of 2,2'-[(4-aminophenyl) imino] bisethanol sulfate on induction of preneoplastic gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Eating; gamma-Glutamyltransferase; Hair | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyl | 1985 |
Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransf | 1985 |
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Dose-dependent promoting activity of chloroform in rat liver foci bioassay.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Chloroform; Cocarcinogenesis; Diethylnitrosamine; F | 1985 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Enhancing effect of co-administration of polychlorinated biphenyls and diethylnitrosamine on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
Investigations on the carcinogenicity of fusarin C--a mutagenic metabolite of Fusarium moniliforme.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Fusarium; gamma-Glutamyltransferase; Liver Ne | 1986 |
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
Topics: Animals; Chick Embryo; Chlorophenols; Cocarcinogenesis; Diethylnitrosamine; Dioxoles; Female; gamma- | 1987 |
Rat renal carcinogenesis after chronic simultaneous exposure to lead acetate and N-nitrosodiethylamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Kidney Neoplasms; Male; Organometallic Compounds; Rat | 1987 |
Cancer promoting potential of different strains of Fusarium moniliforme in a short-term cancer initiation/promotion assay.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Ducks; Fusarium; gamma-Glutamyltransfera | 1988 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamylt | 1988 |
[Induction of lung tumors in mice by low doses of ionizing radiation and diethylnitrosamine].
Topics: Animals; Cocarcinogenesis; Cystadenocarcinoma; Diethylnitrosamine; Gamma Rays; Lung Neoplasms; Male; | 1987 |
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Ade | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Fem | 1986 |
Modifying effects of butylated hydroxyanisole, di(2-ethylhexyl)phthalate or indomethacin on mouse hepatocarcinogenesis initiated by N-nitrosodiethylamine.
Topics: Adenoma; Animals; Butylated Hydroxyanisole; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosa | 1986 |
Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Kidney Neoplasms; Kidney Tubules; Male; | 1985 |
Partial hepatectomy of rats ten weeks before carcinogen administration can enhance liver carcinogenesis: preliminary observations.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver Neoplasms, Experimental; Male; Rat | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis.
Topics: Animals; Clofibrate; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Kidney Neoplasms; | 1988 |
Chlorobenzilate-induced effects on enzyme-altered foci in rat liver and intercellular communication in rat liver WB-F344 epithelial cells.
Topics: Animals; Benzilates; Cell Communication; Cell Line; Cocarcinogenesis; Cricetinae; Diethylnitrosamine | 1988 |
[The use of a primary culture of liver cells from rat embryos subjected to transplacental exposure to N-nitrosodiethylamine for the study of hepatocarcinogenesis promoters].
Topics: Animals; Carcinogens; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Ne | 1987 |
Effect of X-rays alone or combined with diethylnitrosamine on cancer induction in mouse liver.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Mice; Neoplasms, Radiat | 1987 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Effects of an initiation-promotion-initiation protocol on the liver carcinogenesis in the one day old rat.
Topics: Amides; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Exper | 1987 |
[The initiation-promotion-initiation protocol in experimental liver carcinogenesis].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Rats; Rats, In | 1987 |
Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrini infection in Syrian golden hamsters.
Topics: Animals; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; Liver Neoplasms, Experimental; Mesocricet | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
Combination experiments with very low doses of three genotoxic N-nitrosamines with similar organotropic carcinogenicity in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug C | 1987 |
Syncarcinogenesis at low exposure levels of three nitrosamines with a common target of carcinogenic action: preliminary results.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; N-Nitrosopyrroli | 1987 |
[Characteristics of hepatocarcinogenesis after single exposure of synchronized cells of the regenerating liver to N-nitrosodiethylamine and subsequent administration of phenobarbital].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regenerat | 1987 |
Modification potentials of ethyl alcohol and acetaldehyde on development of preneoplastic glutathione S-transferase P-form-positive liver cell foci initiated by diethylnitrosamine in the rat.
Topics: Acetaldehyde; Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Glutathione Transferase; Hepat | 1986 |
Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms, | 1986 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Ex | 1986 |
Promoting effect of oxazepam in rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamin | 1987 |
[Immunosuppressive effect and promotor activity for hepatic carcinogenesis of thiobenzamide].
Topics: Amides; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; Hemolytic Plaque Techniq | 1985 |
Dose-related enhancing effect of potassium bromate on renal tumorigenesis in rats initiated with N-ethyl-N-hydroxyethyl-nitrosamine.
Topics: Animals; Bromates; Bromine; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relatio | 1985 |
An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Butylated Hydroxyanisole; Carcinogens; | 1985 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |
Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; E | 1986 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
12-O-Tetradecanoylphorbol-13-acetate promotion of carcinogen-treated rat liver endothelial cells.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |
Accelerated tumor induction by distal esophageal constriction in the rat under the influence of N-ethyl-N-butyl-nitrosamine.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Esophageal Neoplasms; Esophageal Stenosi | 1985 |
[Experimental study of the effect of combinations of chemical water pollutants on carcinogenesis].
Topics: Animals; Benzene; Cadmium; Carbon Tetrachloride; Cocarcinogenesis; Diethylnitrosamine; Female; Mice; | 1985 |