Compounds > diethylnitrosamine
Page last updated: 2024-11-08

diethylnitrosamine and Cirrhosis, Liver

diethylnitrosamine has been researched along with Cirrhosis, Liver in 84 studies

Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.

Research Excerpts

ExcerptRelevanceReference
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease."8.12ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022)
"To investigate whether hepatic oval cells are activated in diethylnitrosamine (DEN)-induced rat liver cirrhosis, and to explore its mechanism."7.76Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis. ( Deng, JJ; Ge, W; Song, QB; Wu, YG; Xu, XM; Yuan, GJ, 2010)
" To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma."7.75Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009)
" Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation."5.56Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020)
"Pioglitazone treatment started at the first signs of fibrosis in both models."5.51Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"These findings demonstrated that ADSC-derived exosomes could efficiently alleviate hepatic fibrosis by suppressing HSCs activation and remodeling glutamine and ammonia metabolism mediated by hepatocellular glutamine synthetase, which might be a novel and promising anti-fibrotic therapeutics for hepatic fibrosis disease."4.12ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis. ( Feng, J; Fu, Q; Guo, J; Ling, B; Ning, K; Wang, J; Wu, B; Xiu, G; Xu, J, 2022)
" We observed that FUN14 domain-containing 1 (FUNDC1), a previously characterized mitophagy receptor, accumulates in most human hepatocellular carcinomas (HCCs), and we thus explored the role of FUNDC1-mediated mitophagy in HCC initiation and progression in a mouse model in which HCC is induced by the chemical carcinogen, diethylnitrosamine (DEN)."3.91FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice. ( Chen, Q; Du, L; Fan, Y; Huang, X; Jin, H; Li, W; Li, Y; Liu, L; Siraj, S; Wang, J; Wang, X; Yang, X, 2019)
"To investigate whether hepatic oval cells are activated in diethylnitrosamine (DEN)-induced rat liver cirrhosis, and to explore its mechanism."3.76Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis. ( Deng, JJ; Ge, W; Song, QB; Wu, YG; Xu, XM; Yuan, GJ, 2010)
" To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma."3.75Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009)
"Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC."3.75Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. ( Bian, J; Guo, DM; Liu, SF; Qiu, TS; Wang, CZ, 2009)
"Hepatocellular carcinoma (HCC) was induced by diethylnitrosamine in 70 treated rats with 20 normal rats used as controls."3.73In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model. ( Li, X; Xie, JX; Xu, H; Yang, ZH, 2006)
"Autophagy plays a dual role in liver cancer, as it suppresses tumor initiation and promotes tumor progression."1.72Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022)
"Liver fibrosis is a complex process characterized by the excessive accumulation of extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of chronic liver diseases such as cirrhosis, hepatocellular carcinoma (HCC) and liver failure."1.62Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation. ( González, DR; Herrera Vielma, F; Rodríguez, MJ; Sabaj, M; Tolosa, G; Zúñiga, MJ; Zúñiga-Hernández, J, 2021)
"TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner."1.62TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. ( Agirre-Lizaso, A; Andersen, JB; Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Elortza, F; Esparza-Baquer, A; Hijona, E; Jimenez-Agüero, R; Knapp, S; La Casta, A; Labiano, I; Landa, A; Mann, DA; Munoz-Garrido, P; O'Rourke, CJ; Oakley, F; Perugorria, MJ; Riaño, I; Rodrigues, PM; Schabbauer, G; Sharif, O; Vogel, A; Zaki, MYW; Zhuravleva, E, 2021)
"The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells."1.62Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021)
"The DEN-induced liver cirrhosis could develop into three time zone of fibrosis, cirrhosis and cancer, and the histological patterns in the model are similar to those described in humans."1.56Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis. ( Bai, L; Chen, Q; Jiang, S; Lai, J; Yang, W; You, X; Zhang, H, 2020)
" Clinically achievable dosing of EGCG was well-tolerated in diethylnitrosamine-injured rats and was associated with improved serum liver markers including alanine transaminase, aspartate transaminase, and total bilirubin, and reduced HCC tumor formation."1.56Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma. ( Erstad, DJ; Fuchs, BC; Fujii, T; Hirschfield, H; Hoshida, Y; Kim, RS; Lanuti, M; Lauwers, GY; Sojoodi, M; Tanabe, KK; Wei, L; Yamada, S, 2020)
"Liver fibrosis is a complex process associated to most types of chronic liver disease, which is characterized by a disturbance of hepatic tissue architecture and the excessive accumulation of extracellular matrix."1.56Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation. ( Castillo, I; Donoso, W; González, DR; Herrera, F; Orrego, R; Rodríguez, MJ; Zúñiga-Hernández, J, 2020)
"Pioglitazone treatment started at the first signs of fibrosis in both models."1.51Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. ( Arora, G; Baumert, TF; Erstad, DJ; Fuchs, BC; Ghoshal, S; Hoshida, Y; Lanuti, M; Li, S; Masia, R; Sojoodi, M; Tanabe, KK, 2019)
"In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis."1.48From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. ( Gao, J; Gao, N; Jin, H; Li, J; Qiao, HL; Wang, GJ; Wang, Z; Wen, Q; Zhang, HX; Zhang, YF; Zhou, J, 2018)
"Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1."1.46RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017)
"The adenosine derivative treatment reduced diethylnitrosamine-induced collagen expression and decreased the proportion of nodules positive for the tumor marker γ-glutamyl transferase."1.46Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats. ( Chagoya de Sánchez, V; Pérez-Carreón, JI; Pérez-Martínez, L; Velasco-Loyden, G; Vidrio-Gómez, S, 2017)
"The development of hepatocellular carcinoma (HCC) is a common consequence of advanced liver fibrosis but the interactions between fibrogenesis and carcinogenesis are still poorly understood."1.43TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver. ( Bohner, A; Dapito, DH; Lammert, F; Schwabe, RF; Weber, SN, 2016)
"Diethylnitrosamine (DEN) is a potent toxic material that can cause necrosis and subsequent fibrosis in the liver."1.43Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats. ( Heo, JD; Jeong, EJ; Kim, NH; Kim, TB; Rho, JR; Yang, MH, 2016)
"Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process."1.42Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015)
"Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)."1.42Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis. ( Chung, YA; Ham, HJ; Jang, KS; Jung, YJ; Lee, J; Lee, JH; Maeng, LS; Park, MS; Park, SI, 2015)
"Sorafenib treatment restored mitochondrial function and reduced collagen deposition by nearly 63% compared to the NASH group."1.42Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model. ( Barbeiro, DF; Bida, PM; Carrilho, FJ; Coelho, AM; Cogliati, B; D'Albuquerque, LA; Kubrusly, MS; Mazo, DF; Oliveira, CP; Pereira, IV; Souza, HP; Stefano, JT; Torres, MM; Xerfan, MP, 2015)
"Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis."1.40The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014)
"A stable zebrafish liver fibrosis model was successfully established by inducing liver damage to facilitate studies of the pathogenesis of liver fibrosis and screening therapeutic drugs."1.40[Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish]. ( Chen, X; Dai, W; Hou, J; Liu, L; Wang, K; Zheng, X, 2014)
"The model of liver cirrhosis was established by induction of diethylnitrosamine (DEN) in rats."1.40Infusion of human umbilical cord‑derived mesenchymal stem cells effectively relieves liver cirrhosis in DEN‑induced rats. ( Han, J; Hong, J; Hu, H; Huang, Y; Jin, H; Li, L; Liu, J; Qian, Q; Qiu, L; Wang, D; Wu, M, 2014)
"A mouse model of fibrosis-associated liver cancer that was designed to emulate cirrhotic liver, a prevailing disease state observed in most humans with HCC, was used."1.40Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. ( Beland, FA; Chappell, G; Hoenerhoff, M; Hong, HH; Kutanzi, K; Pogribny, IP; Rusyn, I; Tryndyak, V; Uehara, T, 2014)
"The percentage of liver fibrosis was assessed via quantitative analysis of Masson trichrome staining using an average of 30 fields per section."1.39Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis. ( Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; White, SB; Yang, GY; Zhang, Y, 2013)
"Liver fibrosis was induced in rats with diethylnitrosamine and in mice with carbon tetrachloride."1.38Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models. ( Alford, JK; Caravan, P; Fuchs, BC; Guimaraes, AR; Lauwers, GY; Loving, GS; Polasek, M; Schühle, DT; Tanabe, KK; Uppal, R; Wei, L; Yamada, S, 2012)
"Patients with liver cirrhosis and HCC had significantly increased serum endotoxin levels."1.38Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. ( Chen, HY; Dai, RY; He, YQ; Li, YQ; Li, Z; Lin, Y; Liu, Q; Qiu, BJ; Shan, L; Tan, YX; Tang, L; Wang, C; Wang, HY; Wu, FQ; Wu, H; Yan, HX; Yang, W; Yu, LX; Zhai, B; Zhang, HL; Zheng, LY, 2012)
"Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC)."1.38Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. ( Chen, C; Ding, J; Feng, GS; Han, T; Huang, L; Li, Z; Ning, BF; Sun, W; Wang, C; Wang, HY; Wen, W; Wu, K; Wu, MC; Xie, WF; Yang, W, 2012)
" These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment."1.37Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011)
"Recent studies have demonstrated that frequent, low-dose metronomic (MET) dosing of cytotoxic agents may not only be as efficient as conventional maximum tolerated dose (MTD) chemotherapy but also less toxic."1.36Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. ( Bae, SH; Choi, JY; Hur, W; Jang, JW; Kim, GD; Kim, JD; Kwon, JH; Park, JA; Park, ST; Woo, HY; Yoo, CR; Yoon, SK, 2010)
"Liver fibrosis was induced in 27 male Wistar rats by means of weekly oral gavage with 5 mL of 1."1.36Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis. ( Chadashvili, T; Deng, J; Guo, Y; Jin, N; Larson, AC; Omary, RA; Yang, GY; Zhang, Y; Zhang, Z, 2010)
"In the liver cirrhosis and liver cancer group, Mphi had more prominences, meanwhile much more mitochondria, ribosome, rough endoplasmic reticulum, lysosome can be found in the cytoplasm, especially in the liver cancer group."1.35Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats. ( Huang, C; Li, ZF; Liu, ZW; Pan, D; Zhang, S; Zhou, R, 2009)
"In CDAA-induced liver fibrosis model, PE revealed a marked inhibitory effect of liver fibrosis development."1.31Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats. ( Fukui, H; Ikenaka, Y; Imazu, H; Kuriyama, S; Nakatani, T; Noguchi, R; Tsujinoue, H; Yanase, K; Yoshii, J; Yoshiji, H, 2002)
"The average score of liver cirrhosis associated with HCV was 1."1.30Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. ( Hino, S; Kamahora, T; Kawasaki, H; Miyata, H; Shimada, A; Shiota, G; Shiraki, K; Terada, T, 1998)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.57)18.7374
1990's1 (1.19)18.2507
2000's11 (13.10)29.6817
2010's54 (64.29)24.3611
2020's15 (17.86)2.80

Authors

AuthorsStudies
Ghufran, H1
Azam, M1
Mehmood, A1
Butt, H1
Riazuddin, S1
Chao, X1
Wang, S3
Hlobik, M1
Ballabio, A1
Ni, HM1
Ding, WX1
Mohamad, MI1
Desoky, IA1
Ahmed Zaki, K1
Sadek, DR1
Kamal Kassim, S1
Abdel-Wahab Mohamed, D1
Rodríguez, MJ2
Sabaj, M1
Tolosa, G1
Herrera Vielma, F1
Zúñiga, MJ1
González, DR2
Zúñiga-Hernández, J2
Wu, B1
Feng, J1
Guo, J1
Wang, J4
Xiu, G1
Xu, J3
Ning, K1
Ling, B1
Fu, Q1
Chen, Q2
You, X1
Yang, W4
Jiang, S2
Lai, J2
Zhang, H3
Bai, L2
Lin, YH1
Zhang, S4
Zhu, M1
Lu, T1
Chen, K1
Wen, Z1
Xiao, G1
Luo, D1
Jia, Y1
Li, L2
MacConmara, M1
Hoshida, Y4
Singal, AG1
Yopp, A1
Wang, T2
Zhu, H1
Lee, DY1
Yun, SM1
Song, MY1
Ji, SD1
Son, JG1
Kim, EH1
Sojoodi, M2
Wei, L4
Erstad, DJ2
Yamada, S3
Fujii, T2
Hirschfield, H1
Kim, RS1
Lauwers, GY4
Lanuti, M3
Tanabe, KK5
Fuchs, BC5
Esparza-Baquer, A1
Labiano, I1
Sharif, O1
Agirre-Lizaso, A1
Oakley, F1
Rodrigues, PM1
Zhuravleva, E1
O'Rourke, CJ1
Hijona, E1
Jimenez-Agüero, R1
Riaño, I1
Landa, A1
La Casta, A1
Zaki, MYW1
Munoz-Garrido, P1
Azkargorta, M1
Elortza, F1
Vogel, A1
Schabbauer, G1
Aspichueta, P1
Andersen, JB1
Knapp, S1
Mann, DA1
Bujanda, L1
Banales, JM1
Perugorria, MJ1
Dolicka, D1
Sobolewski, C1
Gjorgjieva, M1
Correia de Sousa, M1
Berthou, F1
De Vito, C1
Colin, DJ1
Bejuy, O1
Fournier, M1
Maeder, C1
Blackshear, PJ1
Rubbia-Brandt, L1
Foti, M1
Herrera, F1
Donoso, W1
Castillo, I1
Orrego, R1
Haberl, EM1
Pohl, R1
Rein-Fischboeck, L1
Höring, M1
Krautbauer, S1
Liebisch, G1
Buechler, C1
Sharma, R1
Ali, T1
Negi, I1
Das, A1
Duseja, A1
Kaur, J1
Zhang, B1
Meng, F1
Liu, Y2
Yuan, Y1
Wu, D2
Cui, Y1
Guo, H1
Liang, S1
Wang, W1
Klos, M1
Morgenstern, S1
Sun, L1
Ma, K1
Liu, X2
Wang, Y2
Han, J2
Yang, G1
Zheng, C1
Li, X3
Zhou, S1
Ji, C1
Bai, Q1
Liu, L4
Molina-Aguilar, C1
Guerrero-Carrillo, MJ1
Espinosa-Aguirre, JJ1
Olguin-Reyes, S1
Castro-Belio, T1
Vázquez-Martínez, O1
Rivera-Zavala, JB1
Díaz-Muñoz, M1
Perumal, N1
Perumal, M1
Halagowder, D1
Sivasithamparam, N1
Lewis, K1
Valanejad, L1
Cast, A1
Wright, M1
Wei, C2
Iakova, P1
Stock, L1
Karns, R1
Timchenko, L1
Timchenko, N1
Song, LY1
Ma, YT1
Wu, CF1
Wang, CJ1
Fang, WJ1
Liu, SK1
Romualdo, GR2
Grassi, TF1
Goto, RL1
Tablas, MB1
Bidinotto, LT1
Fernandes, AAH2
Cogliati, B3
Barbisan, LF2
Funaki, M1
Kitabayashi, J1
Shimakami, T1
Nagata, N1
Sakai, Y1
Takegoshi, K1
Okada, H1
Murai, K1
Shirasaki, T1
Oyama, T1
Yamashita, T1
Ota, T1
Takuwa, Y1
Honda, M1
Kaneko, S1
Chen, Y2
Meng, L1
Shang, H1
Dou, Q1
Lu, Z1
Wang, Z2
He, X1
Song, Y1
Wang, G1
Xiao, K1
Gao, J2
Weng, S1
Xu, C2
Qiao, HL3
Husain, H1
Latief, U1
Ahmad, R1
Wang, GJ1
Gao, N2
Li, J2
Zhang, YF1
Zhou, J1
Zhang, HX1
Wen, Q2
Jin, H3
Li, W1
Li, Y2
Siraj, S1
Fan, Y1
Yang, X2
Huang, X1
Wang, X1
Du, L1
Prata, GB1
da Silva, TC1
Moreno, FS1
Li, S2
Ghoshal, S1
Arora, G1
Masia, R1
Baumert, TF1
Guo, YY1
Fang, Y1
Wang, CE1
Das, BK1
Choukimath, SM1
Gadad, PC1
D'Souza, JC1
Sultan, LR1
Hunt, SJ1
Schultz, SM1
Brice, AK1
Wood, AKW1
Sehgal, CM1
Yang, C1
Lu, W1
Lin, T1
You, P1
Ye, M1
Huang, Y2
Jiang, X1
Wang, C4
Wang, F1
Lee, MH1
Yeung, SC1
Johnson, RL1
Tsai, RY1
Frazier, ML1
McKeehan, WL1
Luo, Y1
Zhang, Y3
Jin, N2
Deng, J2
Guo, Y2
White, SB1
Yang, GY2
Omary, RA2
Larson, AC2
Man, S1
Fan, W1
Gao, W1
Liu, Z1
Li, H1
Chappell, G1
Kutanzi, K2
Uehara, T3
Tryndyak, V1
Hong, HH1
Hoenerhoff, M1
Beland, FA1
Rusyn, I3
Pogribny, IP3
Rui, W1
Xie, L1
He, S1
Wu, C1
Zhang, X1
Zhang, L1
Yang, Y1
Hong, J1
Hu, H1
Liu, J1
Wang, D1
Wu, M2
Qiu, L1
Qian, Q1
Shen, T1
Khor, SC1
Zhou, F1
Duan, T1
Xu, YY1
Zheng, YF1
Hsu, S1
DE Stefano, J1
Yang, J1
Xu, LH1
Zhu, XQ1
McGinn, CM1
DePeralta, DK1
Chen, X2
Kuroda, T1
Schmitt, AD1
Gupta, S1
Crenshaw, A1
Onofrio, R1
Taylor, B1
Winckler, W1
Bardeesy, N1
Caravan, P3
Golub, TR1
Wang, K1
Dai, W1
Zheng, X1
Hou, J1
Su, B1
Luo, T1
Zhu, J2
Fu, J1
Zhao, X1
Chen, L1
Ren, Y1
Yu, L1
Feng, G1
Wang, H1
Bona, S1
Moreira, AJ1
Rodrigues, GR1
Cerski, CT1
da Silveira, TR1
Marroni, CA1
Marroni, NP1
Stefano, JT1
Pereira, IV1
Torres, MM1
Bida, PM1
Coelho, AM1
Xerfan, MP1
Barbeiro, DF1
Mazo, DF1
Kubrusly, MS1
D'Albuquerque, LA1
Souza, HP1
Carrilho, FJ1
Oliveira, CP1
Peng, B1
Liu, F1
Han, R1
Luo, G1
Cathopoulis, T1
Lu, K1
Yang, L1
Liu, GY1
Cai, JC1
Shi, SL1
Park, SI1
Lee, JH1
Ham, HJ1
Jung, YJ1
Park, MS1
Lee, J1
Maeng, LS1
Chung, YA1
Jang, KS1
Seifert, L1
Deutsch, M1
Alothman, S1
Alqunaibit, D1
Werba, G1
Pansari, M1
Pergamo, M1
Ochi, A1
Torres-Hernandez, A1
Levie, E1
Tippens, D1
Greco, SH1
Tiwari, S1
Ly, NNG1
Eisenthal, A1
van Heerden, E1
Avanzi, A1
Barilla, R1
Zambirinis, CP1
Rendon, M1
Daley, D1
Pachter, HL1
Hajdu, C1
Miller, G1
Bingül, İ1
Başaran-Küçükgergin, C1
Aydın, AF1
Soluk-Tekkeşin, M1
Olgaç, V1
Doğru-Abbasoğlu, S1
Uysal, M1
Kim, NH1
Heo, JD1
Kim, TB1
Rho, JR1
Yang, MH1
Jeong, EJ1
Weber, SN1
Bohner, A1
Dapito, DH2
Schwabe, RF2
Lammert, F1
Zhang, W1
Chen, HJ1
Wang, ZJ1
Huang, W1
Zhang, LJ1
Siegel, CT1
Shuai, L1
Lai, X1
Jiang, Y1
Bie, P1
Zhu, B1
Rotile, N1
Day, H1
Rietz, T1
Farrar, CT1
Rosen, B1
Tien, AJ1
Chien, CY1
Chen, YH1
Lin, LC1
Chien, CT1
Lai, KKY1
Kweon, SM1
Chi, F1
Hwang, E1
Kabe, Y1
Higashiyama, R1
Qin, L1
Yan, R1
Wu, RP1
Lai, K1
Fujii, N1
French, S1
Wang, JY1
Murali, R1
Mishra, L1
Lee, JS1
Ntambi, JM1
Tsukamoto, H1
Velasco-Loyden, G1
Pérez-Martínez, L1
Vidrio-Gómez, S1
Pérez-Carreón, JI1
Chagoya de Sánchez, V1
Ding, YF1
Wu, ZH1
Wei, YJ1
Shu, L1
Peng, YR1
Huang, KW1
Huang, YC1
Tai, KF1
Chen, BH1
Lee, PH1
Hwang, LH1
Kaji, K1
Yoshiji, H2
Kitade, M1
Ikenaka, Y2
Noguchi, R2
Yoshii, J2
Yanase, K2
Namisaki, T1
Yamazaki, M1
Moriya, K1
Tsujimoto, T1
Kawaratani, H1
Akahane, T1
Uemura, M1
Fukui, H2
Guo, DM1
Qiu, TS1
Bian, J1
Liu, SF1
Wang, CZ1
Liu, YF1
Zha, BS1
Zhang, HL3
Zhu, XJ1
Li, YH1
Guan, XH1
Feng, ZQ1
Zhang, JP1
Park, ST2
Jang, JW2
Kim, GD1
Park, JA1
Hur, W1
Woo, HY1
Kim, JD1
Kwon, JH2
Yoo, CR1
Bae, SH2
Choi, JY2
Yoon, SK2
Chadashvili, T1
Zhang, Z1
Li, ZF1
Pan, D1
Huang, C1
Zhou, R1
Liu, ZW1
Xu, XM1
Yuan, GJ1
Deng, JJ1
Wu, YG1
Ge, W1
Song, QB1
Yu, LX2
Yan, HX2
Liu, Q2
Wu, HP1
Dong, W1
Tang, L2
Lin, Y2
He, YQ2
Zou, SS1
Cao, GW1
Wu, MC2
Wang, HY3
Kluwe, J1
Wongsiriroj, N1
Troeger, JS1
Gwak, GY1
Pradere, JP1
Jiang, H1
Siddiqi, M1
Piantedosi, R1
O'Byrne, SM1
Blaner, WS1
Llorente Izquierdo, C1
Mayoral, R1
Flores, JM1
García-Palencia, P1
Cucarella, C1
Boscá, L1
Casado, M1
Martín-Sanz, P1
You, CR1
Jung, CK1
Polasek, M1
Uppal, R1
Schühle, DT1
Alford, JK1
Loving, GS1
Guimaraes, AR1
Wu, H1
Zhai, B1
Tan, YX1
Shan, L1
Chen, HY1
Dai, RY1
Qiu, BJ1
Zheng, LY1
Li, YQ1
Wu, FQ1
Li, Z2
Wu, K1
Ding, J1
Chen, C1
Sun, W1
Ning, BF1
Wen, W1
Huang, L1
Han, T1
Feng, GS1
Xie, WF1
Ainslie, GR1
Muskhelishvili, L1
Izawa, T1
Yamate, J1
Kosyk, O1
Shymonyak, S1
Bradford, BU1
Boorman, GA1
Bataller, R1
Zhou, JY1
Yin, ZY1
Wang, SY1
Yan, JH1
Zhao, YL1
Liu, ZJ1
Wang, XM1
Lim, IK2
SCHMAEHL, D1
THOMAS, C1
SATTLER, W1
Schiffer, E1
Housset, C1
Cacheux, W1
Wendum, D1
Desbois-Mouthon, C1
Rey, C1
Clergue, F1
Poupon, R1
Barbu, V1
Rosmorduc, O1
Xu, H1
Yang, ZH1
Xie, JX1
Zheng, JF1
Liang, LJ1
Wu, CX1
Chen, JS1
Zhang, ZS1
Shimada, A1
Shiota, G1
Miyata, H1
Kamahora, T1
Kawasaki, H1
Shiraki, K1
Hino, S1
Terada, T1
Park, TJ1
Kim, HS1
Byun, KH1
Jang, JJ1
Lee, YS1
Tsujinoue, H1
Nakatani, T1
Imazu, H1
Kuriyama, S1
Takayama, S1
Ishikawa, T1
Wehner, AP1
Busch, RH1
Olson, RJ1

Other Studies

84 other studies available for diethylnitrosamine and Cirrhosis, Liver

ArticleYear
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
    Experimental and molecular pathology, 2021, Volume: 123

    Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin

2021
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
    The American journal of pathology, 2022, Volume: 192, Issue:1

    Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes

2022
Pterostilbene ameliorates the disrupted Adars expression and improves liver fibrosis in DEN-induced liver injury in Wistar rats: A novel potential effect.
    Gene, 2022, Mar-01, Volume: 813

    Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Diethylnitrosamine; Gene Expression; L

2022
Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation.
    Cells, 2021, 12-03, Volume: 10, Issue:12

    Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Cytokines; Diethylnitrosamine; Doco

2021
ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis.
    Stem cell research & therapy, 2022, 10-04, Volume: 13, Issue:1

    Topics: Ammonia; Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Exosomes; Fib

2022
Survival of endogenous hepatic stem/progenitor cells in liver tissues during liver cirrhosis.
    Life sciences, 2020, Jan-15, Volume: 241

    Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Inflammation; Liver;

2020
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
    Gastroenterology, 2020, Volume: 158, Issue:6

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced

2020
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
    Cells, 2020, 02-28, Volume: 9, Issue:3

    Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine;

2020
Epigallocatechin Gallate Induces Hepatic Stellate Cell Senescence and Attenuates Development of Hepatocellular Carcinoma.
    Cancer prevention research (Philadelphia, Pa.), 2020, Volume: 13, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; Catechin; Cellular Senescen

2020
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
    Gut, 2021, Volume: 70, Issue:7

    Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio

2021
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
    Cellular and molecular gastroenterology and hepatology, 2021, Volume: 11, Issue:2

    Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr

2021
Pro-Resolving Lipid Mediator Resolvin E1 Mitigates the Progress of Diethylnitrosamine-Induced Liver Fibrosis in Sprague-Dawley Rats by Attenuating Fibrogenesis and Restricting Proliferation.
    International journal of molecular sciences, 2020, Nov-22, Volume: 21, Issue:22

    Topics: Alanine Transaminase; Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Eicosapentaenoic A

2020
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
    Lipids in health and disease, 2020, Dec-09, Volume: 19, Issue:1

    Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def

2020
Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model.
    Journal of molecular histology, 2021, Volume: 52, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Folic Acid; Liver; Liver Cirrhosis; Liver Ne

2021
Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy.
    Theranostics, 2021, Volume: 11, Issue:10

    Topics: Animals; Carbon Tetrachloride; Diethylnitrosamine; Hepatectomy; Hepatic Stellate Cells; Hepatocytes;

2021
Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine.
    Carcinogenesis, 2017, 08-01, Volume: 38, Issue:8

    Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neopla

2017
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling.
    Biochimie, 2017, Volume: 140

    Topics: Animals; Apoptosis Regulatory Proteins; Diethylnitrosamine; Flavonoids; Hepatic Stellate Cells; Huma

2017
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
    Molecular and cellular biology, 2017, Aug-15, Volume: 37, Issue:16

    Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2

2017
MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7.
    BioMed research international, 2017, Volume: 2017

    Topics: 3' Untranslated Regions; Animals; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regula

2017
An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: Histological, biochemical and molecular features.
    Toxicology letters, 2017, Nov-05, Volume: 281

    Topics: Alanine Transaminase; Animals; Annexin A2; Aspartate Aminotransferases; Carcinogenesis; Collagen; Co

2017
Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.
    Scientific reports, 2017, 12-05, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Gen

2017
β2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin.
    Cell death & disease, 2018, 04-01, Volume: 9, Issue:4

    Topics: AC133 Antigen; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tu

2018
Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats.
    Drug and chemical toxicology, 2019, Volume: 42, Issue:6

    Topics: Animals; Area Under Curve; Chlormethiazole; Chromatography, High Pressure Liquid; Diethylnitrosamine

2019
Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation.
    Scientific reports, 2018, 06-05, Volume: 8, Issue:1

    Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver

2018
From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor.
    Molecular carcinogenesis, 2018, Volume: 57, Issue:10

    Topics: Adult; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Diethylnitrosami

2018
FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Caspase 1; Diethylnitrosamine; Hepatocytes; Humans; Inflammasome

2019
Fibrosis-associated hepatocarcinogenesis revisited: Establishing standard medium-term chemically-induced male and female models.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Susceptibility

2018
Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019, Volume: 23, Issue:1

    Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Choline; Diet, High-

2019
High CYP2E1 activity aggravates hepatofibrosis by limiting macrophage polarization towards the M2 phenotype.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:8

    Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cytochrome P-450 CYP2E1; D

2019
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
    Life sciences, 2019, Aug-01, Volume: 230

    Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen

2019
B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach.
    Scientific reports, 2019, 06-18, Volume: 9, Issue:1

    Topics: Animals; Biopsy; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatic Veins; Humans;

2019
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
    BMC gastroenterology, 2013, Apr-17, Volume: 13

    Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic;

2013
Intra-voxel incoherent motion MRI in rodent model of diethylnitrosamine-induced liver fibrosis.
    Magnetic resonance imaging, 2013, Volume: 31, Issue:6

    Topics: Animals; Artifacts; Diethylnitrosamine; Disease Models, Animal; Humans; Image Enhancement; Image Int

2013
Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats.
    Journal of ethnopharmacology, 2014, Volume: 151, Issue:1

    Topics: Animals; Diethylnitrosamine; DNA Fragmentation; Gene Expression Regulation; Liver Cirrhosis; Liver C

2014
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
    International journal of cancer, 2014, Jun-15, Volume: 134, Issue:12

    Topics: Animals; beta Catenin; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Transformation, Neoplas

2014
Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription.
    Journal of ethnopharmacology, 2014, Volume: 151, Issue:1

    Topics: Animals; Astragalus Plant; Carcinoma, Hepatocellular; Diethylnitrosamine; Gene Expression Regulation

2014
Infusion of human umbilical cord‑derived mesenchymal stem cells effectively relieves liver cirrhosis in DEN‑induced rats.
    Molecular medicine reports, 2014, Volume: 9, Issue:4

    Topics: Animals; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Separation; Diethylnitrosamine

2014
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
    Anticancer research, 2014, Volume: 34, Issue:2

    Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver;

2014
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:4

    Topics: Animals; Bile Ducts; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cul

2014
[Establishment of a hepatic fibrosis model induced by diethylnitrosamine in zebrafish].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014, Volume: 34, Issue:6

    Topics: Animals; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Zebrafish

2014
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
    Current protocols in pharmacology, 2014, Sep-02, Volume: 66

    Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv

2014
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.
    Hepatology (Baltimore, Md.), 2015, Volume: 61, Issue:2

    Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Case-Control Studies; Cattle; CCAAT-Binding Factor;

2015
Diethylnitrosamine-induced cirrhosis in Wistar rats: an experimental feasibility study.
    Protoplasma, 2015, Volume: 252, Issue:3

    Topics: Animals; Blotting, Western; Body Weight; Diethylnitrosamine; Feasibility Studies; Lipid Peroxidation

2015
Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2015, Volume: 48, Issue:5

    Topics: Animals; Chaperonin 60; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrillar Collag

2015
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
    The international journal of biochemistry & cell biology, 2015, Volume: 66

    Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and

2015
Evaluation of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in rat models with hepatocellular carcinoma with liver cirrhosis.
    Bio-medical materials and engineering, 2015, Volume: 26 Suppl 1

    Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Feasibility Studies; Fluorodeoxyglucose F18;

2015
Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways.
    Cell reports, 2015, Dec-01, Volume: 13, Issue:9

    Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chemokine CCL2; Cytokines; Diethylnitrosa

2015
Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats.
    International journal of immunopathology and pharmacology, 2016, Volume: 29, Issue:3

    Topics: Animals; Antioxidants; Blueberry Plants; Catalase; Diethylnitrosamine; Glutathione; Lipid Peroxidati

2016
Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:6

    Topics: Acetates; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Diethyln

2016
TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4;

2016
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
    European radiology, 2017, Volume: 27, Issue:5

    Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models,

2017
Functional liver tissue engineering by an adult mouse liver-derived neuro-glia antigen 2-expressing stem/progenitor population.
    Journal of tissue engineering and regenerative medicine, 2018, Volume: 12, Issue:1

    Topics: Aging; Animals; Antigens; Cell Differentiation; Cell Lineage; Cell Proliferation; Diethylnitrosamine

2018
Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model.
    Hepatology (Baltimore, Md.), 2017, Volume: 65, Issue:3

    Topics: Analysis of Variance; Animals; Biopsy, Needle; Diethylnitrosamine; Disease Models, Animal; Elasticit

2017
Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
    The American journal of Chinese medicine, 2017, Volume: 45, Issue:1

    Topics: Alkylating Agents; Animals; Antrodia; Apoptosis; Autophagy; Carcinogenesis; Carcinoma, Hepatocellula

2017
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
    Gastroenterology, 2017, Volume: 152, Issue:6

    Topics: Animals; beta Catenin; beta Karyopherins; Carcinoma, Hepatocellular; Case-Control Studies; Cell Line

2017
Cancer chemoprevention by an adenosine derivative in a model of cirrhosis-hepatocellular carcinoma induced by diethylnitrosamine in rats.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:2

    Topics: Adenosine; Animals; Anticarcinogenic Agents; Diethylnitrosamine; Disease Models, Animal; Liver Cirrh

2017
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
    Journal of cancer research and clinical oncology, 2017, Volume: 143, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Progression; Hepatitis;

2017
Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2008, Volume: 16, Issue:10

    Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Diethylnitrosamine; Genetic Therapy; Interferon

2008
Impact of insulin resistance on the progression of chronic liver diseases.
    International journal of molecular medicine, 2008, Volume: 22, Issue:6

    Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu

2008
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2009, Volume: 8, Issue:1

    Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease M

2009
Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model.
    Journal of experimental & clinical cancer research : CR, 2009, Jul-29, Volume: 28

    Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Progression; Gene Ex

2009
Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Body Weight; Cell Proliferation; Cyclophospha

2010
Carbogen gas-challenge BOLD MR imaging in a rat model of diethylnitrosamine-induced liver fibrosis.
    Radiology, 2010, Volume: 254, Issue:1

    Topics: Analysis of Variance; Animals; Carbon Dioxide; Diethylnitrosamine; Disease Progression; Image Proces

2010
Changes of splenic macrophage during the process of liver cancer induced by diethylnitrosamine in rats.
    Chinese medical journal, 2009, Dec-20, Volume: 122, Issue:24

    Topics: Animals; Cells, Cultured; Diethylnitrosamine; Disease Models, Animal; Liver Cirrhosis; Liver Neoplas

2009
Hepatic oval cells activated by hepatocyte apoptosis in diethylnitrosamine-induced rat liver cirrhosis.
    Saudi medical journal, 2010, Volume: 31, Issue:5

    Topics: Animals; Apoptosis; Cell Proliferation; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; In Si

2010
Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:4

    Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine;

2010
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
    Gut, 2011, Volume: 60, Issue:9

    Topics: Acyltransferases; Animals; Carbon Tetrachloride; Cell Transformation, Neoplastic; Cells, Cultured; D

2011
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
    The American journal of pathology, 2011, Volume: 178, Issue:3

    Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy

2011
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
    Experimental & molecular medicine, 2011, May-31, Volume: 43, Issue:5

    Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die

2011
Molecular MR imaging of liver fibrosis: a feasibility study using rat and mouse models.
    Journal of hepatology, 2012, Volume: 57, Issue:3

    Topics: Animals; Carbon Tetrachloride; Collagen Type I; Contrast Media; Diethylnitrosamine; Disease Models,

2012
Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats.
    Journal of hepatology, 2012, Volume: 57, Issue:4

    Topics: Alkylating Agents; Animals; Anti-Bacterial Agents; Bifidobacterium; Carcinoma, Hepatocellular; Cytok

2012
Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:6

    Topics: AC133 Antigen; Animals; Antigens, CD; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers, Tum

2012
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 132, Issue:1

    Topics: Animals; Animals, Newborn; Carbon Tetrachloride; Cell Transformation, Neoplastic; Diethylnitrosamine

2013
[Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:11

    Topics: Actins; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile; Bil

2012
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
    Mechanisms of ageing and development, 2003, Volume: 124, Issue:5

    Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In

2003
[HEPATOTOXIC AND CIRRHOGENIC EFFECT OF DIETHYLNITROSAMINE IN DOGS].
    Arzneimittel-Forschung, 1964, Volume: 14

    Topics: Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dogs; Gastrointestinal Diseases; Hepatit

1964
Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis.
    Hepatology (Baltimore, Md.), 2005, Volume: 41, Issue:2

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamine; Er

2005
In vivo 1H MR spectroscopy in the evaluation of the serial development of hepatocarcinogenesis in an experimental rat model.
    Academic radiology, 2006, Volume: 13, Issue:12

    Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Choline; Diethylnitrosamine; Disease Models,

2006
Transplantation of fetal liver epithelial progenitor cells ameliorates experimental liver fibrosis in mice.
    World journal of gastroenterology, 2006, Dec-07, Volume: 12, Issue:45

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diethylnitrosamine; Epithelial Cells; Fe

2006
Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma.
    Cancer research, 1998, Oct-01, Volume: 58, Issue:19

    Topics: Animals; Antibodies, Monoclonal; Apoptosis; Biopsy, Needle; Carcinoma, Hepatocellular; Diethylnitros

1998
Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci
    Molecular carcinogenesis, 2001, Volume: 30, Issue:3

    Topics: Animals; Base Sequence; Cocarcinogenesis; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Ki

2001
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.
    Journal of hepatology, 2002, Volume: 37, Issue:1

    Topics: Alkylating Agents; Angiotensin-Converting Enzyme Inhibitors; Animals; Choline; Diethylnitrosamine; D

2002
Comparability of histological alterations during carcinogenesis in animals and man, with special reference to hepatocarcinogenesis in fish.
    IARC scientific publications, 1977, Issue:16

    Topics: Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Fish Diseases; Humans; H

1977
Effects of diethylnitrosamine and cigarette smoke on hamsters.
    Journal of the National Cancer Institute, 1976, Volume: 56, Issue:4

    Topics: Animals; Body Weight; Cricetinae; Diethylnitrosamine; Humans; Laryngeal Diseases; Liver Cirrhosis; L

1976