diethylnitrosamine has been researched along with Choline Deficiency in 32 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| " In an attempt to define the tumorigenic mechanism of DEA, N-nitrosodiethanolamine (NDELA) formation in vivo and development of choline deficiency were examined in mice." | 3.70 | Potential mechanisms of tumorigenic action of diethanolamine in mice. ( Bartels, MJ; Brzak, KA; Mar, M; Markham, DA; Stott, WT; Thornton, CM; Zeisel, SH, 2000) |
| " However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci." | 3.68 | Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990) |
| "Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes." | 1.62 | Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. ( Fujishiro, M; Honda, T; Ishigami, M; Ishizu, Y; Ito, T; Kato, A; Kawashima, H; Kuzuya, T; Ma, L; Nakamura, M; Tsuji, NM; Yamamoto, K; Yokoyama, S, 2021) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (31.25) | 18.7374 |
| 1990's | 10 (31.25) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Haberl, EM | 2 |
| Pohl, R | 2 |
| Rein-Fischboeck, L | 2 |
| Höring, M | 1 |
| Krautbauer, S | 1 |
| Liebisch, G | 1 |
| Buechler, C | 2 |
| Yamamoto, K | 1 |
| Honda, T | 1 |
| Yokoyama, S | 2 |
| Ma, L | 1 |
| Kato, A | 1 |
| Ito, T | 1 |
| Ishizu, Y | 1 |
| Kuzuya, T | 1 |
| Nakamura, M | 1 |
| Kawashima, H | 1 |
| Ishigami, M | 1 |
| Tsuji, NM | 1 |
| Fujishiro, M | 1 |
| Feder, S | 1 |
| Sinal, CJ | 1 |
| Kishida, N | 1 |
| Matsuda, S | 1 |
| Itano, O | 1 |
| Shinoda, M | 1 |
| Kitago, M | 1 |
| Yagi, H | 1 |
| Abe, Y | 1 |
| Hibi, T | 1 |
| Masugi, Y | 1 |
| Aiura, K | 1 |
| Sakamoto, M | 1 |
| Kitagawa, Y | 1 |
| Perra, A | 1 |
| Kowalik, MA | 1 |
| Pibiri, M | 1 |
| Ledda-Columbano, GM | 1 |
| Columbano, A | 1 |
| Wakabayashi, N | 1 |
| Okabe, K | 1 |
| Hayashi, M | 1 |
| Honoki, K | 1 |
| Tsujiuchi, T | 6 |
| Sanders, JA | 1 |
| Brilliant, KE | 1 |
| Clift, D | 1 |
| Patel, A | 1 |
| Cerretti, B | 1 |
| Claro, P | 1 |
| Mills, DR | 1 |
| Hixson, DC | 1 |
| Gruppuso, PA | 1 |
| Hemmings, SJ | 1 |
| Strickland, J | 1 |
| Sasaki, Y | 3 |
| Oka, Y | 1 |
| Kuniyasu, H | 1 |
| Konishi, Y | 7 |
| Tsutsumi, M | 4 |
| Takahashi, S | 1 |
| Lombardi, B | 5 |
| Shinozuka, H | 5 |
| Abanobi, SE | 1 |
| Perera, MI | 1 |
| Mikol, YB | 1 |
| Hoover, KL | 2 |
| Creasia, D | 1 |
| Poirier, LA | 3 |
| Wilson, MJ | 1 |
| Shivapurkar, N | 1 |
| Hälström, IP | 1 |
| Liao, D | 1 |
| Gustafsson, JA | 1 |
| Blanck, A | 2 |
| Tamura, K | 1 |
| Nakae, D | 4 |
| Horiguchi, K | 1 |
| Akai, H | 2 |
| Kobayashi, Y | 3 |
| Satoh, H | 1 |
| Denda, A | 4 |
| Kishida, H | 2 |
| Suzuki, T | 1 |
| Muramatsu, M | 1 |
| Takahama, M | 1 |
| Stott, WT | 1 |
| Bartels, MJ | 1 |
| Brzak, KA | 1 |
| Mar, M | 1 |
| Markham, DA | 1 |
| Thornton, CM | 1 |
| Zeisel, SH | 1 |
| Murata, N | 1 |
| Kubozoe, T | 1 |
| Kusuoka, O | 1 |
| Kitayama, W | 1 |
| Fukui, H | 1 |
| Sells, MA | 3 |
| Katyal, SL | 2 |
| Sell, S | 2 |
| Mirowski, M | 1 |
| Hanausek, M | 2 |
| Sherman, U | 2 |
| Adams, AK | 2 |
| Walaszek, Z | 1 |
| Slaga, TJ | 1 |
| Cameron, RG | 1 |
| Armstrong, D | 1 |
| Hinrichsen, LI | 1 |
| Floyd, RA | 1 |
| Sudilovsky, O | 1 |
| Sawada, N | 1 |
| Poirier, L | 1 |
| Moran, S | 1 |
| Xu, YH | 1 |
| Pitot, HC | 1 |
| Maruyama, H | 1 |
| Takashima, Y | 1 |
| Murata, Y | 1 |
| Eimoto, H | 1 |
| Reddy, TV | 1 |
| Laconi, E | 1 |
| Vasudevan, S | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
32 other studies available for diethylnitrosamine and Choline Deficiency
| Article | Year |
|---|---|
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Def | 2020 |
Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline Deficiency; Cyclin-De | 2021 |
Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis.
Topics: Adiponectin; Animals; Body Composition; Chemokines; Choline Deficiency; Diethylnitrosamine; Gene Exp | 2018 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
Thyroid hormone receptor ligands induce regression of rat preneoplastic liver lesions causing their reversion to a differentiated phenotype.
Topics: Animals; Apoptosis; Cell Differentiation; Choline Deficiency; Diethylnitrosamine; Glutathione Transf | 2009 |
Mutations and aberrant transcriptions of Stk11 (Lkb1) gene in rat liver tumors.
Topics: Amino Acids; AMP-Activated Protein Kinase Kinases; Animals; Carcinogens; Cell Transformation, Neopla | 2011 |
The inhibitory effect of rapamycin on the oval cell response and development of preneoplastic foci in the rat.
Topics: Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cel | 2012 |
Administration of diethylnitrosamine in the immediate postnatal period coupled with exposure to a choline deficient diet accelerates hepatocarcinogenesis in the rat.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Glucose; Choline Deficiency; Cocarcinogenesis | 2002 |
Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Choline Deficiency; Codon; Colchi | 2004 |
Progression of carcinogen-induced foci of gamma-glutamyltranspeptidase-positive hepatocytes to hepatomas in rats fed a choline-deficient diet.
Topics: 2-Acetylaminofluorene; Animal Feed; Animals; Cell Transformation, Neoplastic; Choline Deficiency; Di | 1982 |
Modulation of tumor promotion in liver carcinogenesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Di | 1983 |
Accelerated regression of carcinogen-induced preneoplastic hepatocyte foci by peroxisome proliferators, BR931, 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio (N-B-hydroxyethyl)acetamide, and di-(2-ethylhexyl)phthalate.
Topics: Animals; Cell Division; Choline Deficiency; Diethylhexyl Phthalate; Diethylnitrosamine; gamma-Glutam | 1984 |
Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets.
Topics: Adenoma, Bile Duct; Amino Acids; Animals; Bile Duct Neoplasms; Choline Deficiency; Diet; Diethylnitr | 1983 |
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
Topics: Animals; Cell Nucleus; Choline Deficiency; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Live | 1984 |
Ectopic pituitary grafts modify the response of male rats to sex differentiated promotion of diethylnitrosamine-initiated hepatic lesions with a choline-deficient diet.
Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; Disease Model | 1994 |
Inhibition by green tea extract of diethylnitrosamine-initiated but not choline-deficient, L-amino acid-defined diet-associated development of putative preneoplastic, glutathione S-transferase placental form-positive lesions in rat liver.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Diet; Diethylnitrosamine; DNA; Glutathione Transf | 1997 |
Inhibition of early-phase exogenous and endogenous liver carcinogenesis in transgenic rats harboring a rat glutathione S-transferase placental form gene.
Topics: Animals; Animals, Genetically Modified; Choline Deficiency; Diet; Diethylnitrosamine; Glutathione Tr | 1998 |
Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Topics: Amino Acids; Animals; beta Catenin; Carcinogens; Choline Deficiency; Cytoskeletal Proteins; Diet; Di | 1999 |
Potential mechanisms of tumorigenic action of diethanolamine in mice.
Topics: Administration, Cutaneous; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotrans | 2000 |
Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.
Topics: Animals; Carcinogens; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnit | 2000 |
Enhancement of hepatocarcinogenesis initiated with diethylnitrosamine or N-nitrosobis(2-hydroxypropyl)amine by a choline-deficient, L-amino acid-defined diet administered prior to the carcinogen exposure in rats.
Topics: Amino Acids; Animals; Choline Deficiency; Diet; Diethylnitrosamine; Glutathione Transferase; Liver N | 2000 |
Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Choline Deficiency; | 1979 |
Induction of foci of altered, gamma-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet.
Topics: alpha-Fetoproteins; Animals; Aspartate Aminotransferases; Cell Division; Choline Deficiency; Diethyl | 1979 |
An enzyme-linked immunosorbent assay for p65 oncofetal protein and its potential as a new marker for cancer risk assessment in rodents and humans.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biomarkers, Tumor; Choline; Choline Deficiency; Diethylni | 1992 |
Expression of a 65-kDa tumor-associated protein and persistence of altered hepatic foci.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Cell Division; Choline Deficiency; Diethylnitrosamin | 1991 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam | 1990 |
Is 8-hydroxydeoxyguanosine a mediator of carcinogenesis by a choline-devoid diet in the rat liver?
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Deoxyguanosine; Diethylnitrosamine; DNA; D | 1990 |
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver.
Topics: Animals; Body Weight; Choline Deficiency; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, Ex | 1990 |
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Choline Deficiency; Diethylnitrosamine; Female; Gl | 1990 |
Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransf | 1985 |
Complementarity between two rat liver tumor promoters.
Topics: Animals; Choline Deficiency; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neopl | 1987 |
Hepatocyte-like cells within the pancreas of rats fed methyl-deficient diets.
Topics: Animals; Cell Differentiation; Choline Deficiency; Diet; Diethylnitrosamine; Liver; Male; Methionine | 1986 |