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diethylnitrosamine and Carcinoma

diethylnitrosamine has been researched along with Carcinoma in 32 studies

Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
" To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma."7.75Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009)
"There is an increase in concentration of sanguinarine and diethylnitrosamine in CaGB blood and tissue in comparison to the cholelithiasis group suggesting an association with carcinoma of the gallbladder."3.79Association of mustard oil as cooking media with carcinoma of the gallbladder. ( Basu, S; Dixit, R; Mishra, PK; Shukla, VK; Srivastava, P, 2013)
" To explore the key genes involved in the development of liver cancer, we established a rat model induced by diethylnitrosamine to investigate the gene expression profiles of liver tissues during the transition to cirrhosis and carcinoma."3.75Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. ( Feng, ZQ; Guan, XH; Li, YH; Liu, YF; Zha, BS; Zhang, HL; Zhang, JP; Zhu, J; Zhu, XJ, 2009)
"Carcinomas developed in the mucosa of the esophagus in BUF strain rats ingesting diethylnitrosamine in the diet."3.65Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine. ( Reuber, MD, 1977)
") injections of diethylnitrosamine (DEN) to gerbils (Meriones unguiculatus) led to the induction of carcinomas of the nasal cavities in a high incidence."3.65Histogenesis of tumors from the nasal cavities induced by diethylnitrosamine. ( Althoff, J; Cardesa, A; Haas, H; Mohr, U; Pour, P, 1976)
" These rats had been treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) under different dosing regimens, but we used the same administered biweekly dose of 1."1.31Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. ( Lucier, GW; Portier, CJ; Sills, RC; Tritscher, AM; Walker, NJ, 2000)
" The data indicate that at least in hepatocellular tumours of the C57Bl/10J strain and using chronic dosing regimes the ras genes do not represent markers for in vivo genotoxic activity."1.28Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours. ( Hardaker, KJ; Lord, PG; Loughlin, JM; Marsden, AM; Orton, TC, 1992)
"4 mg/kg body weight with a total dosage of 420 mg/kg over an experimental period of five years."1.26Hepatocarcinogenetic effect of DENA in pigs. ( Berg, H; Graw, JJ, 1977)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199017 (53.13)18.7374
1990's5 (15.63)18.2507
2000's3 (9.38)29.6817
2010's7 (21.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, CL1
Zeng, T1
Zhao, XL1
Xie, KQ1
Lehman, CE1
Dillon, LW1
Nikiforov, YE1
Wang, YH1
Liu, YF1
Zha, BS1
Zhang, HL1
Zhu, XJ1
Li, YH1
Zhu, J1
Guan, XH1
Feng, ZQ1
Zhang, JP1
Kawai, M1
Saegusa, Y1
Kemmochi, S1
Harada, T1
Shimamoto, K1
Shibutani, M1
Mitsumori, K1
Kruel, CR1
Pinto, LF1
Blanco, TC1
Barja-Fidalgo, TC1
Melo, LL1
Kruel, CD1
Liu, WB1
Liu, JY1
Ao, L1
Zhou, ZY1
Zhou, YH1
Cui, ZH1
Cao, J1
Li, ZF1
Wang, J1
Huang, C1
Zhang, S1
Yang, J1
Jiang, A1
Zhou, R1
Pan, D1
Dixit, R1
Srivastava, P2
Basu, S1
Mishra, PK1
Shukla, VK1
Yamagishi, M1
Natsume, M1
Osakabe, N1
Okazaki, K1
Furukawa, F1
Imazawa, T1
Nishikawa, A1
Hirose, M1
DONTENWILL, W1
MOHR, U2
Koen, H1
Pugh, TD1
Nychka, D1
Goldfarb, S1
Mandard, AM1
Marnay, J1
Herlin, P1
Elie, H1
Tuyns, AJ1
Le Talaer, JY1
Feron, VJ2
Kruysse, A2
Woutersen, RA1
Ledwith, BJ1
Joslyn, DJ1
Troilo, P1
Leander, KR1
Clair, JH1
Soper, KA1
Manam, S1
Prahalada, S1
van Zwieten, MJ1
Nichols, WW1
Steinmetz, KL1
Klaunig, JE3
Yamada, Y1
Yoshimi, N1
Sugie, S1
Suzui, M1
Matsunaga, K1
Kawabata, K1
Hara, A1
Mori, H1
Walker, NJ1
Tritscher, AM1
Sills, RC1
Lucier, GW1
Portier, CJ1
Graw, JJ1
Berg, H1
Huang, DP1
Ho, JH1
Saw, D1
Teoh, TB1
Reuber, MD2
Cardesa, A1
Pour, P1
Haas, H1
Althoff, J1
Lord, PG1
Hardaker, KJ1
Loughlin, JM1
Marsden, AM1
Orton, TC1
Lijinsky, W1
Kovatch, RM2
Thomas, BJ1
Diwan, BA2
Lubet, RA1
Nims, RW1
Weghorst, CM1
Henneman, JR1
Ward, JM4
Rice, JM2
Hand, D1
Elliott, BM1
Griffin, M1
Pereira, MA1
Herren-Freund, SL1
Ruch, RJ1
Dragani, TA1
Manenti, G1
Della Porta, G1
Ohshima, M1
Hu, H1
Schuller, HM1
Singh, G1
Katyal, SL1
Anderson, LM1

Other Studies

32 other studies available for diethylnitrosamine and Carcinoma

ArticleYear
Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway.
    International journal of biological sciences, 2015, Volume: 11, Issue:6

    Topics: Allyl Compounds; alpha-Fetoproteins; Animals; Carcinoma; Cyclooxygenase 2; Diethylnitrosamine; I-kap

2015
DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.
    Carcinogenesis, 2017, 03-01, Volume: 38, Issue:3

    Topics: Benzene; Carcinoma; Carcinoma, Papillary; Chromosome Aberrations; Chromosome Fragile Sites; Diethyln

2017
Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model.
    Journal of experimental & clinical cancer research : CR, 2009, Jul-29, Volume: 28

    Topics: Alkylating Agents; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Progression; Gene Ex

2009
Cytokeratin 8/18 is a useful immunohistochemical marker for hepatocellular proliferative lesions in mice.
    The Journal of veterinary medical science, 2010, Volume: 72, Issue:3

    Topics: Adenoma; Animals; Biomarkers; Carcinoma; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatectomy;

2010
Evaluation of the heme oxygenase-1 expression in esophagitis and esophageal cancer induced by different reflux experimental models and diethylnitrosamine.
    Acta cirurgica brasileira, 2010, Volume: 25, Issue:3

    Topics: Animals; Biomarkers; Carcinogens; Carcinoma; Diethylnitrosamine; Disease Models, Animal; Esophageal

2010
Epigenetic silencing of cell cycle regulatory genes during 3-methylcholanthrene and diethylnitrosamine-induced multistep rat lung cancer.
    Molecular carcinogenesis, 2010, Volume: 49, Issue:6

    Topics: Animals; Carcinoma; Cell Cycle; CpG Islands; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent

2010
Gas chromatography/time-of-flight mass spectrometry-based metabonomics of hepatocarcinoma in rats with lung metastasis: elucidation of the metabolic characteristics of hepatocarcinoma at formation and metastasis.
    Rapid communications in mass spectrometry : RCM, 2010, Volume: 24, Issue:18

    Topics: Animals; Biomarkers, Tumor; Carcinoma; Computational Biology; Diethylnitrosamine; Gas Chromatography

2010
Association of mustard oil as cooking media with carcinoma of the gallbladder.
    Journal of gastrointestinal cancer, 2013, Volume: 44, Issue:2

    Topics: Benzophenanthridines; Carcinoma; Chromatography, Gas; Cooking; Diethylnitrosamine; Female; Gallbladd

2013
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine;

2003
[Carcinoma of the respiratory tract following treatment of the golden hamster with diethylnitrosamine].
    Zeitschrift fur Krebsforschung, 1961, Volume: 64

    Topics: Amines; Animals; Carcinogens; Carcinoma; Cricetinae; Diethylnitrosamine; Humans; Mesocricetus; Neopl

1961
Presence of alpha-fetoprotein-positive cells in hepatocellular foci and microcarcinomas induced by single injections of diethylnitrosamine in infant mice.
    Cancer research, 1983, Volume: 43, Issue:2

    Topics: alpha-Fetoproteins; Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experi

1983
[Cancer of the esophagus induced in the Wistar rat by ethyl-N-butyl-nitrosamine].
    Bulletin du cancer, 1984, Volume: 71, Issue:5

    Topics: Animals; Carcinoma; Cheek; Diethylnitrosamine; Esophageal Neoplasms; Female; Liver Neoplasms; Male;

1984
Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine.
    European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:1

    Topics: Acetaldehyde; Aerosols; Animals; Benzopyrenes; Body Weight; Carcinoma; Cricetinae; Diethylnitrosamin

1982
Induction of minisatellite DNA rearrangements by genotoxic carcinogens in mouse liver tumors.
    Carcinogenesis, 1995, Volume: 16, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; DNA

1995
Transforming growth factor-alpha in carcinogen-induced F344 rat hepatic foci.
    Toxicology and applied pharmacology, 1996, Volume: 140, Issue:1

    Topics: Adenoma; Animals; Carcinoma; Coloring Agents; Diethylnitrosamine; DNA; Glutathione Transferase; Immu

1996
Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:8

    Topics: Adenoma; Amino Acid Substitution; Animals; beta Catenin; Binding Sites; Carcinogenicity Tests; Carci

1999
Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 54, Issue:2

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Administration Schedule; Female;

2000
Hepatocarcinogenetic effect of DENA in pigs.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1977, Jun-27, Volume: 89, Issue:2

    Topics: Animals; Carcinoma; Diethylnitrosamine; Liver Neoplasms; Neoplasm Metastasis; Neoplasms, Experimenta

1977
Effects of exposure to furfural vapour in hamsters simultaneously treated with benzo[alpha] pyrene or diethylnitrosamine.
    Toxicology, 1978, Volume: 11, Issue:2

    Topics: Adenoma; Animals; Benzopyrenes; Body Weight; Carcinoma; Cocarcinogenesis; Cricetinae; Diethylnitrosa

1978
Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish.
    IARC scientific publications, 1978, Issue:20

    Topics: Adenocarcinoma; Animals; Carcinoma; China; Cricetinae; Diet; Diethylnitrosamine; Female; Fishes; Foo

1978
Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:2

    Topics: Animals; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diethylnitrosamine; Esophageal

1977
Carcinomas of the esophagus in rats ingesting diethylnitrosamine.
    European journal of cancer, 1975, Volume: 11, Issue:2

    Topics: Administration, Oral; Animals; Bronchopneumonia; Carcinoma; Carcinoma, Squamous Cell; Diethylnitrosa

1975
Histogenesis of tumors from the nasal cavities induced by diethylnitrosamine.
    Cancer, 1976, Volume: 37, Issue:1

    Topics: Adenocarcinoma; Animals; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Diethylnitrosami

1976
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
    Carcinogenesis, 1992, Volume: 13, Issue:8

    Topics: 2-Acetylaminofluorene; Adenoma; Aminobiphenyl Compounds; Animals; Base Sequence; Carcinoma; Diethyln

1992
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
    Carcinogenesis, 1992, Volume: 13, Issue:7

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy

1992
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam;

1989
Expression of the cytosolic and particulate forms of transglutaminase during chemically induced rat liver carcinogenesis.
    Biochimica et biophysica acta, 1988, Jun-30, Volume: 970, Issue:2

    Topics: Animals; Carcinoma; Cell Transformation, Neoplastic; Cell-Free System; Cytosol; Diethylnitrosamine;

1988
Leu 7 immunoreactivity in fetal olfactory epithelium and dysplastic or neoplastic olfactory lesions induced in Syrian golden hamsters by N-nitrosodiethylamine.
    The American journal of pathology, 1986, Volume: 123, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Carcino

1986
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:2

    Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma

1986
Genetic susceptibility to murine hepatocarcinogenesis is associated with high growth rate of NDEA-initiated hepatocytes.
    Journal of cancer research and clinical oncology, 1987, Volume: 113, Issue:3

    Topics: Adenoma; Animals; Carcinoma; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Male; Mice;

1987
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
    Environmental health perspectives, 1986, Volume: 65

    Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh

1986
Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occurring pulmonary neoplasms of mice.
    The American journal of pathology, 1985, Volume: 118, Issue:3

    Topics: Adenoma; Animals; Antigens; Apoproteins; Carcinoma; Diethylnitrosamine; Female; Hyperplasia; Immunoe

1985