diethylnitrosamine has been researched along with Carcinogenesis in 136 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 8.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 8.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 7.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| "Two-stage rat hepatocarcinogenesis model was used to induce early carcinogenesis in which thioacetamide (TAA) promotes diethylnitrosamine (DEN) initiated carcinogenesis." | 7.96 | Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. ( Dwivedi, DK; Jena, GB, 2020) |
| "Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis." | 7.91 | Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. ( Chariyakornkul, A; Chewonarin, T; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2019) |
| " The aim of this study was to evaluate the anti-cancer effect of neferine against diethylnitrosamine (DEN)-induced lung carcinogenesis in Wistar rats and to explore the underlying molecular mechanism." | 7.91 | Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats. ( Amirthalingam, V; Ganasan, K; Huang, CY; Sivalingam, K; Viswanadha, VP, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 7.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 7.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 7.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 7.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 7.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 7.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 7.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 7.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 7.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 7.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 7.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " The aim of this study was to investigate the possible therapeutic efficiency of myrtenal against diethylnitrosamine-induced experimental hepatocarcinogenesis by analyzing the key enzymes of carbohydrate metabolism, lysosomal and mitochondrial TCA cycle enzymes, and also the possible role of tumor suppressor protein p53, and scanning electron microscopic studies." | 7.79 | Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes. ( Lingaiah, HB; Natarajan, N; Periyasamy, BM; Srinivasan, P; Thamaraiselvan, R, 2013) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 5.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 5.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "These results suggest that once hepatocarcinogenesis is initiated, SFN may stimulate tumor progression." | 5.72 | Tumor Promoting Effects of Sulforaphane on Diethylnitrosamine-Induced Murine Hepatocarcinogenesis. ( Fang, X; Kim, DH; Kim, SH; Kim, SJ; Saeidi, S; Surh, YJ; Zheng, J, 2022) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 5.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| "ET in the prevention of liver cancer is poorly understood." | 5.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 5.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 5.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 5.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 5.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| "We show that hepatocellular cancers from Fgl1 null mice are molecularly distinct from those of the wild type mice." | 5.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| " To this end, chemical carcinogenesis protocols based on the injection of genotoxic compounds such as diethylnitrosamine (DEN) are widely used to model liver tumorigenesis in rodents." | 5.12 | Diethylnitrosamine-induced liver tumorigenesis in mice. ( Hasselblatt, P; Schulien, I, 2021) |
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 4.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| " In pre-clinical models, including diethylnitrosamine- (DEN-) induced hepatocellular carcinoma (HCC), anti-androgen therapies delay hepatocarcinogenesis." | 4.02 | Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks. ( Campbell, MJ; Clinton, SK; Coss, CC; Getaneh, S; Helms, TH; Kulp, SK; LeMoine, DM; Lucas, F; Mullins, RD; Phelps, MA; Schmidt, N; Thomas-Ahner, JM; Xie, Z, 2021) |
| "This study aimed to evaluate the cancer chemopreventive activity of vanillic acid (VA) in diethylnitrosamine- and 1,2-dimethylhydrazine-induced liver and colon carcinogenesis in rats." | 4.02 | Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. ( Chariyakornkul, A; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2021) |
| "Two-stage rat hepatocarcinogenesis model was used to induce early carcinogenesis in which thioacetamide (TAA) promotes diethylnitrosamine (DEN) initiated carcinogenesis." | 3.96 | Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. ( Dwivedi, DK; Jena, GB, 2020) |
| " Here, we investigated the effects of maternal diets differing in protein source on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in adult rat offspring." | 3.96 | Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring. ( Choi, J; Kwon, YH; Won, SB, 2020) |
| " Nimbolide is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties; however, its anticancer effects and molecular mechanism in hepatocellular carcinoma (HCC) remains obscure." | 3.96 | Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis. ( Ram, AK; Srinivas, BH; Vairappan, B, 2020) |
| " In the current study, we continued to assess the therapeutic efficaciousness of the newly synthesized gallium nanoparticles (GaNPs) combined with low level of gamma radiation (IR), on the incidence of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats." | 3.91 | Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats. ( El-Sonbaty, SM; Mansour, SZ; Moawed, FS, 2019) |
| "Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis." | 3.91 | Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. ( Chariyakornkul, A; Chewonarin, T; Jarukamjorn, K; Punvittayagul, C; Wongpoomchai, R, 2019) |
| "Mito-TEMPO was effective in combating hepatocarcinogenesis." | 3.91 | Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. ( Bharati, S; Kumar, R; Shetty, S, 2019) |
| " The aim of this study was to evaluate the anti-cancer effect of neferine against diethylnitrosamine (DEN)-induced lung carcinogenesis in Wistar rats and to explore the underlying molecular mechanism." | 3.91 | Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats. ( Amirthalingam, V; Ganasan, K; Huang, CY; Sivalingam, K; Viswanadha, VP, 2019) |
| "In hepatocarcinogenesis induced by diethylnitrosamine (DEN) in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a pivotal role." | 3.91 | Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis. ( Asari, M; Horioka, K; Ogawa, K; Okuda, K; Shimizu, K; Tanaka, H; Yamamoto, M; Yamazaki, K, 2019) |
| " Diethylnitrosamine (DEN) is one of the recognized risk factors for hepatocarcinogenesis likely due to CYP2E1-mediated metabolic activation." | 3.88 | Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. ( Chang, Z; Fang, Y; Gao, J; Gao, N; Jin, H; Qiao, HL; Wang, CE; Wang, GJ; Wang, J; Wang, Z; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "The present study was designed to evaluate the protective effects of hesperidin, a flavonoid on DEN initiated and Fe-NTA promoted renal carcinogenesis in Wistar rats." | 3.88 | Anti-carcinogenic effect of hesperidin against renal cell carcinoma by targeting COX-2/PGE2 pathway in Wistar rats. ( Saidullah, B; Siddiqi, A; Sultana, S, 2018) |
| " Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice." | 3.85 | Role of insulin receptor substrates in the progression of hepatocellular carcinoma. ( Aihara, M; Hayashi, T; Iwamoto, M; Kadowaki, T; Kubota, N; Kubota, T; Nishihara, H; Obata, A; Sakurai, Y; Takamoto, I, 2017) |
| " Using the Solt and Farber protocol in a rat model of hepatocarcinogenesis, the chemopreventive effect of EPM on diethylnitrosamine (DEN)-initiated, 2-acetylaminofluorene (2-AAF) and partial hepatectomy (PH)-promoted liver carcinogenesis in rats was evaluated." | 3.85 | Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats. ( Chang, HY; Chen, YC; Huang, GJ; Huang, SS; Lai, HC; Lu, CC; Yang, CH, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 3.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " Using the diethylnitrosamine-induced hepatocarcinogenesis model, 2-Formyl-8-hydroxy-quinolinium chloride showed strong antiangiogenic activity." | 3.83 | Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride. ( Bian, ZX; Chan, KW; Chan, RY; Cheng, CH; Cheng, GY; Chui, CH; Gambari, R; Hau, DK; Kok, SH; Lam, KH; Lau, FY; Lee, KK; Tang, JC; Tong, SW; Wong, RS; Wong, WY, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 3.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| " The aim of this study was to evaluate the anti-tumor effect of Celastrol against diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats and furthermore, to explore the underlying mechanism." | 3.83 | Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. ( Chang, W; He, W; Li, PP; Lu, JT; Song, SS; Wei, W; Yuan, PF, 2016) |
| "The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any." | 3.83 | Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. ( Barua, A; Pal, D; Panda, CK; Roy, A; Roy, R; Saha, P; Sur, S, 2016) |
| "In this study, we explored whether treatment with FGF-21 could prevent diethylnitrosamine (DEN) induced hepatocarcinogenesis in mice." | 3.81 | Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice. ( Li, D; Liu, M; Liu, Z; Rasoul, LM; Ren, G; Wang, W; Wu, Q; Xu, P; Ye, X; Yuan, Q; Zhang, Y, 2015) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " In this study, we characterized cell signaling events evoked by decorin deficiency in two experimental models of hepatocarcinogenesis using thioacetamide or diethyl nitrosamine as carcinogens." | 3.80 | Decorin deficiency promotes hepatic carcinogenesis. ( Baghy, K; Fullár, A; Horváth, Z; Iozzo, RV; Kiss, K; Kovalszky, I; Schaff, Z, 2014) |
| "The purpose of the present study was to evaluate the preventive effects of hydrazinocurcumin (HZC) on diethylnitrosamine (DEN)-induced hepatocarcinogenesis in a male Sprague Dawley (SD) rat model." | 3.80 | Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats. ( Geng, CZ; Liu, YP; Peng, L; Wang, SJ; Wang, X; Yang, HC; Zhao, JA, 2014) |
| " The chemically-induced mouse model of diethylnitrosamine (DEN) provides useful insight into liver carcinogenesis, namely HCC." | 3.80 | The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. ( Colaço, A; Da Costa, RM; Lopes, C; Oliveira, PA; Paula-Santos, N; Rocha, AF, 2014) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 3.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| " The aim of this study was to investigate the possible therapeutic efficiency of myrtenal against diethylnitrosamine-induced experimental hepatocarcinogenesis by analyzing the key enzymes of carbohydrate metabolism, lysosomal and mitochondrial TCA cycle enzymes, and also the possible role of tumor suppressor protein p53, and scanning electron microscopic studies." | 3.79 | Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes. ( Lingaiah, HB; Natarajan, N; Periyasamy, BM; Srinivasan, P; Thamaraiselvan, R, 2013) |
| " We recently find that the loss of toll-like receptor 2 (TLR2) activities promotes the diethylnitrosamine (DEN) induced hepatocellular carcinogenesis and tumor progression, which associates with an abundant accumulation of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress." | 3.79 | Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. ( Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ, 2013) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 3.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " In this study, we found that diethylnitrosamine initiation with CCl4 and ethanol promotion could induce a short-term, two-stage liver carcinogenesis model in male BALB/c mice, the process of hepatocarcinogenesis including liver damage, liver necrosis/cell death, liver inflammation, liver proliferation, liver hyperplasia, liver steatosis, and liver cirrhosis and hepatocellular nodules, which mimicked the usual sequence of events observed in human HCC." | 3.79 | Two-stage model of chemically induced hepatocellular carcinoma in mouse. ( Huang, SX; Kuang, ZP; Li, YD; Luo, M; Luo, XL; Wu, JN; Xie, YA; Yang, F, 2013) |
| " To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethylnitrosamine (DEN)." | 3.79 | CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. ( Chung, RT; Mueller, T; Nahmias, A; Scaiewicz, V; Shibolet, O; Tirosh, B, 2013) |
| "gigantea stem bark extracts in liver cancer HepG2 cells and diethylnitrosamine (DEN)-induced primary liver cancer in rats." | 1.72 | Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine. ( Intapa, C; Kaewkong, W; Parhira, S; Pekthong, D; Sawong, S; Somran, J; Srisawang, P; Suknoppakit, P; Winitchaikul, T, 2022) |
| "BALB/c mice model of hepatocarcinogenesis was established using N-nitrosodiethylamine as a carcinogen (200 mg/kg b." | 1.72 | MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model. ( Bharati, S; De, S; Qsee, HS; Tambe, PK, 2022) |
| "Diethylnitrosamine-induced hepatocellular carcinomas were then investigated in lean and diet-induced obese miR-22-deficient mice." | 1.72 | MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver. ( Ay, AS; Correia de Sousa, M; Delangre, E; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Sempoux, C; Sobolewski, C, 2022) |
| "Prunetin (PRU) is an O-methylated flavonoid that is present in various natural plants and a primary significant compound found in isoflavone." | 1.72 | Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. ( Chen, H; Li, G; Qi, L; Tian, G, 2022) |
| "Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC)." | 1.72 | Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet. ( Chun, HJ; Kwon, YH; Shim, YJ, 2022) |
| "Autophagy plays a dual role in liver cancer, as it suppresses tumor initiation and promotes tumor progression." | 1.72 | Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis. ( Ballabio, A; Chao, X; Ding, WX; Hlobik, M; Ni, HM; Wang, S, 2022) |
| " Here, we describe steps to establish liver cancer in a rat model, via chronic administration of diethylnitrosamine." | 1.62 | Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis. ( Chen, Z; Han, L; He, X; Li, S, 2021) |
| "The role of TTP in nonalcoholic steatohepatitis and HCC development was further examined through in vivo/vitro approaches using liver-specific TTP knockout mice and a panel of hepatic cancer cells." | 1.62 | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. ( Bejuy, O; Berthou, F; Blackshear, PJ; Colin, DJ; Correia de Sousa, M; De Vito, C; Dolicka, D; Foti, M; Fournier, M; Gjorgjieva, M; Maeder, C; Rubbia-Brandt, L; Sobolewski, C, 2021) |
| "TREM-2 plays a protective role in hepatocarcinogenesis via different pleiotropic effects, suggesting that TREM-2 agonism should be investigated as it might beneficially impact HCC pathogenesis in a multifactorial manner." | 1.62 | TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. ( Agirre-Lizaso, A; Andersen, JB; Aspichueta, P; Azkargorta, M; Banales, JM; Bujanda, L; Elortza, F; Esparza-Baquer, A; Hijona, E; Jimenez-Agüero, R; Knapp, S; La Casta, A; Labiano, I; Landa, A; Mann, DA; Munoz-Garrido, P; O'Rourke, CJ; Oakley, F; Perugorria, MJ; Riaño, I; Rodrigues, PM; Schabbauer, G; Sharif, O; Vogel, A; Zaki, MYW; Zhuravleva, E, 2021) |
| "Liver cancer was induced in mice with hepatocyte-specific disruption of Myc and control mice by administration of diethylnitrosamine." | 1.62 | Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma. ( Cai, J; Chen, L; Gao, Y; Gonzalez, FJ; Guo, X; Jiang, J; Krausz, KW; Liu, W; Luo, Y; Qu, A; Sun, L; Takahashi, S; Tang, W; Wang, Y; Xie, C; Yang, S; Yang, Y, 2021) |
| "Hepatocellular carcinoma in nonalcoholic steatohepatitis is caused by the complex factors of inflammation, fibrosis and microbiomes." | 1.62 | Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine. ( Fujishiro, M; Honda, T; Ishigami, M; Ishizu, Y; Ito, T; Kato, A; Kawashima, H; Kuzuya, T; Ma, L; Nakamura, M; Tsuji, NM; Yamamoto, K; Yokoyama, S, 2021) |
| "We compared gene expression profiles of Morris Hepatoma (MH3924a) and DEN (diethylnitrosamine)-induced HCC models to those of liver tissues from normal and rapidly regenerating liver models, and performed gain- and loss-of-function studies of the identified gene targets for their roles in cancer cell proliferation in vitro and in vivo." | 1.56 | Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. ( Chow, P; Denil, S; Ding, Z; Ericksen, RE; Escande-Beillard, N; Gruenewald, S; Haegebarth, A; Han, W; Lee, QY; Loh, A; Reversade, B; Steckel, M; Toh, HC; Wai Ho, TS, 2020) |
| "ET in the prevention of liver cancer is poorly understood." | 1.56 | Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine. ( Cao, L; Ding, S; Ji, B; Li, L; Qi, Z; Zhang, X, 2020) |
| "Animal carcinogenesis models induced by environmental chemicals have been widely used for basic and applied cancer research." | 1.56 | An organoid-based carcinogenesis model induced by in vitro chemical treatment. ( Hippo, Y; Imai, T; Maru, Y; Masui, R; Naruse, M; Ochiai, M, 2020) |
| " Thus, we hypothesized that chronic administration of different DEN treatments identifies the best-fit dose to induce the HCC and/or to determine whether small DEN doses act synergistically with other known hepatotoxins to induce HCC in mice." | 1.51 | Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice. ( Alarcón-Sánchez, BR; Aparicio-Bautista, DI; Arellanes-Robledo, J; Baltiérrez-Hoyos, R; Castro-Gil, MP; Fuentes-Hernández, S; Guerrero-Escalera, D; Idelfonso-García, OG; Lakshman, MR; López-González, ML; Montes-Aparicio, AV; Pérez-Carreón, JI; Pérez-Hernández, JL; Reyes-Gordillo, K; Rosas-Madrigal, S; Sierra-Santoyo, A; Vásquez-Garzón, VR; Villa-Treviño, S, 2019) |
| "In a nutritional model of hepatocarcinogenesis, the protein Nrf2 is frequently mutated/activated at early steps of the tumorigenic process." | 1.48 | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. ( Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P, 2018) |
| "In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis." | 1.48 | From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. ( Gao, J; Gao, N; Jin, H; Li, J; Qiao, HL; Wang, GJ; Wang, Z; Wen, Q; Zhang, HX; Zhang, YF; Zhou, J, 2018) |
| "In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation." | 1.48 | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). ( Gao, J; Jiang, G; Xiong, D; Xiong, R; Yin, T; Yin, Z; Zhang, S; Zhang, X; Zhao, W, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity, is an emerging risk factor for hepatocellular carcinoma (HCC)." | 1.48 | Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis. ( Inoue-Yamauchi, A; Itagaki, H; Oda, H, 2018) |
| "Non-alcoholic fatty liver disease (NAFLD) encompasses a broad spectrum of conditions, ranging from non-progressive bland steatosis to hepatocarcinoma." | 1.46 | Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. ( Bischetti, S; Casagrande, V; Federici, M; Mauriello, A; Mavilio, M; Menghini, R, 2017) |
| "Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1." | 1.46 | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017) |
| "Blocking lipogenesis in cultured liver cancer cells is sufficient to decrease cell viability; however, it is not known whether blocking lipogenesis in vivo can prevent liver tumorigenesis." | 1.46 | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Cooney, GJ; Hargett, SR; Hoehn, KL; James, DE; Lackner, C; Lahiri, S; Nelson, ME; Olzomer, EM; Slack-Davis, JK; Turner, N; Wu, LE, 2017) |
| "Bid participates in hepatic carcinogenesis but the mechanism is not fully understood." | 1.43 | Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers. ( Chen, X; Dong, Z; Khambu, B; Luo, J; Michalopoulos, GK; Wu, S; Yan, S; Yin, XM; Yu, C, 2016) |
| "Our findings showed that in hepatocarcinogenesis by diethylnitrosamine, cellular senescence is associated with p16 pathway activation and is mainly localized in myofibroblast-like cells." | 1.43 | Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. ( Alemán-Lazarini, L; Arellanes-Robledo, J; Fattel-Fazenda, S; Pacheco-Rivera, R; Pérez-Carreón, J; Rodríguez-Segura, M; Serrano-Luna, J; Shibayama, M; Silva-Olivares, A; Villa-Treviño, S, 2016) |
| "Indeed, primary liver cancers were nearly fourfold as frequent in Per2m/m mice as compared to wild-type (WT), 4 months after DEN exposure." | 1.43 | Clock gene Per2 as a controller of liver carcinogenesis. ( Filipski, E; Guettier, C; Lévi, F; Mteyrek, A; Okyar, A, 2016) |
| "The roles of gp96 on human hepatocellular carcinoma cells (HCC) were also examined pharmacologically with a targeted gp96 inhibitor." | 1.42 | Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. ( Chiosis, G; Clarke, CJ; Cowart, LA; Drake, RR; Hannun, YA; Jones, E; Li, Z; Liu, B; Ogretmen, B; Rachidi, S; Sun, S; Wu, BX, 2015) |
| "After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-β1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively." | 1.42 | MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells. ( Boye, A; He, S; Jiang, Y; Kan, H; Wu, C; Yang, X; Yang, Y, 2015) |
| "We show that hepatocellular cancers from Fgl1 null mice are molecularly distinct from those of the wild type mice." | 1.42 | Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. ( Bronson, RT; Cohen, DE; Demchev, V; Desai, A; Hornick, JL; Nayeb-Hashemi, H; Ukomadu, C, 2015) |
| "The results revealed that NDEA-induced hepatic cancer tumor tissue had altered molecular composition compared with normal liver tissue." | 1.42 | Fourier Transform Infrared Spectroscopic Studies on Modulation of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis by Azadirachta indica. ( Bharati, S; Koul, A; Rishi, P, 2015) |
| "Melatonin was given in drinking water at 1 mg/kg/d, beginning 5 or 12 weeks after the start of DEN administration." | 1.42 | Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis. ( Cerski, CT; García-Palomo, A; González-Gallego, J; Marroni, NP; Mauriz, JL; Moreira, AJ; Ordoñez, R; Picada, JN, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.47) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 92 (67.65) | 24.3611 |
| 2020's | 42 (30.88) | 2.80 |
| Authors | Studies |
|---|---|
| Chun, HJ | 1 |
| Shim, YJ | 1 |
| Kwon, YH | 2 |
| Sakai, H | 1 |
| Yamada, Y | 1 |
| Kubota, M | 2 |
| Imai, K | 1 |
| Shirakami, Y | 3 |
| Tomita, H | 1 |
| Hara, A | 1 |
| Shimizu, M | 3 |
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Chao, X | 1 |
| Wang, S | 2 |
| Hlobik, M | 1 |
| Ballabio, A | 1 |
| Ni, HM | 1 |
| Ding, WX | 1 |
| Li, G | 3 |
| Qi, L | 1 |
| Chen, H | 1 |
| Tian, G | 1 |
| Zheng, J | 1 |
| Kim, DH | 1 |
| Fang, X | 1 |
| Kim, SH | 1 |
| Saeidi, S | 1 |
| Kim, SJ | 1 |
| Surh, YJ | 1 |
| Punvittayagul, C | 4 |
| Luangsuphabool, T | 1 |
| Wongpoomchai, R | 6 |
| Sawong, S | 1 |
| Pekthong, D | 1 |
| Suknoppakit, P | 1 |
| Winitchaikul, T | 1 |
| Kaewkong, W | 1 |
| Somran, J | 1 |
| Intapa, C | 1 |
| Parhira, S | 1 |
| Srisawang, P | 1 |
| Qsee, HS | 1 |
| Tambe, PK | 1 |
| De, S | 1 |
| Bharati, S | 3 |
| Gjorgjieva, M | 2 |
| Ay, AS | 1 |
| Correia de Sousa, M | 2 |
| Delangre, E | 1 |
| Dolicka, D | 2 |
| Sobolewski, C | 2 |
| Maeder, C | 2 |
| Fournier, M | 2 |
| Sempoux, C | 1 |
| Foti, M | 2 |
| Seo, EB | 1 |
| Jang, HJ | 1 |
| Kwon, SH | 1 |
| Kwon, YJ | 1 |
| Kim, SK | 1 |
| Lee, SH | 1 |
| Jeong, AJ | 1 |
| Shin, HM | 1 |
| Kim, YN | 1 |
| Ma, S | 1 |
| Kim, H | 1 |
| Lee, YH | 2 |
| Suh, PG | 1 |
| Ye, SK | 1 |
| Farag, FSA | 1 |
| Anwar, HM | 1 |
| Aboushousha, T | 1 |
| Mohammed, HS | 1 |
| Ismail, LDM | 1 |
| Jamal, F | 1 |
| Ahmed, G | 1 |
| Farazuddin, M | 1 |
| Altaf, I | 1 |
| Farheen, S | 1 |
| Zia, Q | 1 |
| Azhar, A | 1 |
| Ahmad, H | 1 |
| Khan, AA | 1 |
| Somavarapu, S | 1 |
| Agrawal, A | 1 |
| Owais, M | 1 |
| Wang, H | 2 |
| Lin, F | 1 |
| Xu, Z | 1 |
| Yu, S | 1 |
| Liao, S | 1 |
| Zhao, W | 3 |
| Zhang, F | 1 |
| Wang, J | 2 |
| Ouyang, C | 1 |
| Zhang, C | 1 |
| Xia, H | 1 |
| Wu, Y | 1 |
| Jiang, B | 1 |
| Li, Q | 2 |
| Vachiraarunwong, A | 1 |
| Tuntiwechapikul, W | 1 |
| Wongnoppavich, A | 1 |
| Meepowpan, P | 1 |
| Bose, P | 2 |
| Siddique, MUM | 2 |
| Acharya, R | 1 |
| Jayaprakash, V | 1 |
| Sinha, BN | 1 |
| Lapenna, A | 2 |
| Pattanayak, SP | 2 |
| Ali, S | 1 |
| Ejaz, M | 1 |
| Dar, KK | 1 |
| Nasreen, S | 1 |
| Ashraf, N | 1 |
| Gillani, SF | 1 |
| Shafi, N | 1 |
| Safeer, S | 1 |
| Khan, MA | 1 |
| Andleeb, S | 1 |
| Akhtar, N | 1 |
| Mughal, TA | 1 |
| Mello, T | 1 |
| Materozzi, M | 1 |
| Zanieri, F | 1 |
| Simeone, I | 1 |
| Ceni, E | 1 |
| Bereshchenko, O | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Marroncini, G | 1 |
| Nerlov, C | 1 |
| Guasti, D | 1 |
| Bani, D | 1 |
| Pinzani, M | 1 |
| Galli, A | 1 |
| Ding, Z | 1 |
| Ericksen, RE | 1 |
| Escande-Beillard, N | 1 |
| Lee, QY | 1 |
| Loh, A | 1 |
| Denil, S | 1 |
| Steckel, M | 1 |
| Haegebarth, A | 1 |
| Wai Ho, TS | 1 |
| Chow, P | 1 |
| Toh, HC | 1 |
| Reversade, B | 1 |
| Gruenewald, S | 1 |
| Han, W | 2 |
| Dwivedi, DK | 1 |
| Jena, GB | 1 |
| Schulien, I | 2 |
| Hockenjos, B | 1 |
| van Marck, V | 1 |
| Ayata, CK | 1 |
| Follo, M | 1 |
| Thimme, R | 1 |
| Hasselblatt, P | 2 |
| Zhang, X | 2 |
| Cao, L | 1 |
| Ji, B | 1 |
| Li, L | 1 |
| Qi, Z | 1 |
| Ding, S | 1 |
| Saber, S | 1 |
| Ghanim, AMH | 1 |
| El-Ahwany, E | 1 |
| El-Kader, EMA | 1 |
| Naruse, M | 1 |
| Masui, R | 1 |
| Ochiai, M | 1 |
| Maru, Y | 1 |
| Hippo, Y | 1 |
| Imai, T | 1 |
| Choi, J | 1 |
| Won, SB | 1 |
| Lee, DY | 1 |
| Yun, SM | 1 |
| Song, MY | 1 |
| Ji, SD | 1 |
| Son, JG | 1 |
| Kim, EH | 1 |
| Badr El-Din, NK | 1 |
| Ali, DA | 1 |
| Othman, R | 1 |
| French, SW | 1 |
| Ghoneum, M | 1 |
| Ma, M | 1 |
| Zhou, Y | 1 |
| Sun, R | 2 |
| Shi, J | 1 |
| Tan, Y | 1 |
| Yang, H | 2 |
| Zhang, M | 1 |
| Shen, R | 1 |
| Xu, L | 1 |
| Wang, Z | 3 |
| Fei, J | 1 |
| Hanna, D | 1 |
| Sugamori, KS | 1 |
| Bott, D | 1 |
| Grant, DM | 1 |
| Ishii, N | 1 |
| Homma, T | 1 |
| Guo, X | 2 |
| Yamada, KI | 1 |
| Yamada, S | 1 |
| Fujii, J | 1 |
| Landerer, S | 1 |
| Kalthoff, S | 1 |
| Paulusch, S | 1 |
| Strassburg, CP | 1 |
| Esparza-Baquer, A | 1 |
| Labiano, I | 1 |
| Sharif, O | 1 |
| Agirre-Lizaso, A | 1 |
| Oakley, F | 1 |
| Rodrigues, PM | 1 |
| Zhuravleva, E | 1 |
| O'Rourke, CJ | 1 |
| Hijona, E | 1 |
| Jimenez-Agüero, R | 1 |
| Riaño, I | 1 |
| Landa, A | 1 |
| La Casta, A | 1 |
| Zaki, MYW | 1 |
| Munoz-Garrido, P | 1 |
| Azkargorta, M | 1 |
| Elortza, F | 1 |
| Vogel, A | 1 |
| Schabbauer, G | 1 |
| Aspichueta, P | 1 |
| Andersen, JB | 1 |
| Knapp, S | 1 |
| Mann, DA | 1 |
| Bujanda, L | 1 |
| Banales, JM | 1 |
| Perugorria, MJ | 1 |
| Berthou, F | 1 |
| De Vito, C | 1 |
| Colin, DJ | 1 |
| Bejuy, O | 1 |
| Blackshear, PJ | 1 |
| Rubbia-Brandt, L | 1 |
| Ram, AK | 1 |
| Vairappan, B | 1 |
| Srinivas, BH | 1 |
| Chariyakornkul, A | 3 |
| Sankam, P | 1 |
| Helms, TH | 1 |
| Mullins, RD | 1 |
| Thomas-Ahner, JM | 1 |
| Kulp, SK | 1 |
| Campbell, MJ | 1 |
| Lucas, F | 1 |
| Schmidt, N | 1 |
| LeMoine, DM | 1 |
| Getaneh, S | 1 |
| Xie, Z | 1 |
| Phelps, MA | 1 |
| Clinton, SK | 1 |
| Coss, CC | 1 |
| Chen, Z | 1 |
| Li, S | 1 |
| Han, L | 1 |
| He, X | 1 |
| Yamamoto, K | 1 |
| Honda, T | 2 |
| Yokoyama, S | 1 |
| Ma, L | 1 |
| Kato, A | 1 |
| Ito, T | 1 |
| Ishizu, Y | 1 |
| Kuzuya, T | 1 |
| Nakamura, M | 1 |
| Kawashima, H | 1 |
| Ishigami, M | 1 |
| Tsuji, NM | 1 |
| Fujishiro, M | 1 |
| Luo, Y | 1 |
| Gao, Y | 1 |
| Liu, W | 1 |
| Yang, Y | 3 |
| Jiang, J | 3 |
| Wang, Y | 1 |
| Tang, W | 1 |
| Yang, S | 1 |
| Sun, L | 1 |
| Cai, J | 1 |
| Takahashi, S | 1 |
| Krausz, KW | 1 |
| Qu, A | 1 |
| Chen, L | 1 |
| Xie, C | 1 |
| Gonzalez, FJ | 1 |
| Jarukamjorn, K | 2 |
| Pocasap, P | 1 |
| Weerapreeyakul, N | 1 |
| Molina-Aguilar, C | 1 |
| Guerrero-Carrillo, MJ | 1 |
| Espinosa-Aguirre, JJ | 1 |
| Olguin-Reyes, S | 1 |
| Castro-Belio, T | 1 |
| Vázquez-Martínez, O | 1 |
| Rivera-Zavala, JB | 1 |
| Díaz-Muñoz, M | 1 |
| Lewis, K | 1 |
| Valanejad, L | 1 |
| Cast, A | 1 |
| Wright, M | 1 |
| Wei, C | 1 |
| Iakova, P | 1 |
| Stock, L | 1 |
| Karns, R | 1 |
| Timchenko, L | 1 |
| Timchenko, N | 1 |
| Yan, G | 1 |
| Wang, X | 4 |
| Sun, C | 1 |
| Zheng, X | 1 |
| Wei, H | 2 |
| Tian, Z | 1 |
| Sakurai, Y | 1 |
| Kubota, N | 1 |
| Takamoto, I | 1 |
| Obata, A | 1 |
| Iwamoto, M | 1 |
| Hayashi, T | 1 |
| Aihara, M | 1 |
| Kubota, T | 1 |
| Nishihara, H | 1 |
| Kadowaki, T | 1 |
| Fu, Y | 1 |
| Silverstein, S | 1 |
| McCutcheon, JN | 1 |
| Dyba, M | 1 |
| Nath, RG | 1 |
| Aggarwal, M | 1 |
| Coia, H | 1 |
| Bai, A | 1 |
| Pan, J | 1 |
| Kallakury, B | 1 |
| Zhang, YW | 1 |
| Giaccone, G | 1 |
| He, AR | 1 |
| Chung, FL | 1 |
| Casagrande, V | 1 |
| Mauriello, A | 1 |
| Bischetti, S | 1 |
| Mavilio, M | 1 |
| Federici, M | 1 |
| Menghini, R | 1 |
| Ploeger, JM | 1 |
| Manivel, JC | 1 |
| Boatner, LN | 1 |
| Mashek, DG | 1 |
| Romualdo, GR | 1 |
| Grassi, TF | 1 |
| Goto, RL | 1 |
| Tablas, MB | 1 |
| Bidinotto, LT | 1 |
| Fernandes, AAH | 1 |
| Cogliati, B | 1 |
| Barbisan, LF | 1 |
| Inoue-Yamauchi, A | 1 |
| Itagaki, H | 1 |
| Oda, H | 1 |
| He, Q | 1 |
| Wang, F | 1 |
| Lindquist, DM | 1 |
| Dillman, JR | 1 |
| Timchenko, NA | 1 |
| Redington, AN | 1 |
| Ali, MM | 1 |
| H Borai, I | 1 |
| Ghanem, HM | 1 |
| H Abdel-Halim, A | 1 |
| Mousa, FM | 1 |
| Wu, Q | 2 |
| Chen, JX | 1 |
| Chen, Y | 1 |
| Cai, LL | 1 |
| Wang, XZ | 1 |
| Guo, WH | 1 |
| Zheng, JF | 1 |
| Gao, J | 3 |
| Wang, GJ | 2 |
| Zhang, HX | 2 |
| Gao, N | 2 |
| Wang, CE | 1 |
| Chang, Z | 1 |
| Fang, Y | 1 |
| Zhang, YF | 2 |
| Zhou, J | 2 |
| Jin, H | 2 |
| Qiao, HL | 2 |
| Chewonarin, T | 1 |
| Orrù, C | 1 |
| Szydlowska, M | 1 |
| Taguchi, K | 1 |
| Zavattari, P | 1 |
| Perra, A | 3 |
| Yamamoto, M | 3 |
| Columbano, A | 3 |
| Li, J | 1 |
| Wen, Q | 1 |
| Siddiqi, A | 1 |
| Saidullah, B | 1 |
| Sultana, S | 1 |
| Sunita, P | 1 |
| Chan, CH | 1 |
| Chen, CM | 1 |
| Lee, YW | 1 |
| You, LR | 1 |
| Kaltenecker, D | 1 |
| Themanns, M | 1 |
| Mueller, KM | 1 |
| Spirk, K | 1 |
| Golob-Schwarzl, N | 1 |
| Friedbichler, K | 1 |
| Kenner, L | 1 |
| Haybaeck, J | 1 |
| Moriggl, R | 1 |
| Sivalingam, K | 1 |
| Amirthalingam, V | 1 |
| Ganasan, K | 1 |
| Huang, CY | 1 |
| Viswanadha, VP | 1 |
| Xiong, R | 1 |
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| Zhang, S | 2 |
| Yin, T | 1 |
| Jiang, G | 1 |
| Yin, Z | 1 |
| Tripathy, A | 1 |
| Thakurela, S | 1 |
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| Jeong, WJ | 1 |
| Park, JC | 1 |
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1 review available for diethylnitrosamine and Carcinogenesis
| Article | Year |
|---|---|
Diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Liver; Liver Neoplas | 2021 |
135 other studies available for diethylnitrosamine and Carcinogenesis
| Article | Year |
|---|---|
Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet.
Topics: Amino Acids; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cholesterol; Cholesterol, Dietary; | 2022 |
The phosphorylated retinoid X receptor-α promotes diethylnitrosamine-induced hepatocarcinogenesis in mice through the activation of β-catenin signaling pathway.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Doxycycline; L | 2022 |
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Topics: Alcohol Drinking; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinogenes | 2022 |
Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.
Topics: Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Humans; Isofla | 2022 |
Tumor Promoting Effects of Sulforaphane on Diethylnitrosamine-Induced Murine Hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; NF-E2- | 2022 |
Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogenesis; Diethylnitrosamine; Female; Glutathio | 2022 |
Calotropis gigantea stem bark extracts inhibit liver cancer induced by diethylnitrosamine.
Topics: Adenosine Triphosphate; Animals; Calotropis; Carcinogenesis; Caspase 3; Diethylnitrosamine; Doxorubi | 2022 |
MitoQ demonstrates connexin- and p53-mediated cancer chemoprevention in N-nitrosodiethylamine-induced hepatocarcinogenesis rodent model.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Chemoprevention; Connexins; Diethylnitrosamine; | 2022 |
MiR-22 Deficiency Fosters Hepatocellular Carcinoma Development in Fatty Liver.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Fatt | 2022 |
Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3-mediated cancer development.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Humans; | 2022 |
Ameliorative Effects of Thunbergia erecta L. Leaves Against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in the Rat Model.
Topics: Animals; Butanols; Carcinogenesis; Diethylnitrosamine; Liver; Plant Leaves; Rats; Rats, Wistar | 2023 |
Potential of siRNA-Bearing Subtilosomes in the Treatment of Diethylnitrosamine-Induced Hepatocellular Carcinoma.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cyclooxygenase 2; Diethylnitrosamine; | 2023 |
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitrosamine; Humans; Li | 2023 |
2,4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Cleistocalyx nervosum var. paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Colorectal Neoplasms; Diethylnitrosamine; Humans; Ra | 2023 |
Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.
Topics: 2-Acetylaminofluorene; Animals; Antineoplastic Agents; Antioxidants; Carcinogenesis; Carcinogens; Cy | 2020 |
Evaluation of chemopreventive and chemotherapeutic effect of Artemisia vulgaris extract against diethylnitrosamine induced hepatocellular carcinogenesis in Balb C mice.
Topics: Animals; Artemisia; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver Neoplasms; | 2020 |
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
Topics: Aldehyde Dehydrogenase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; delt | 2020 |
Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Topics: Animals; Body Weight; Carcinogenesis; Diethylnitrosamine; Dimethyl Fumarate; DNA Damage; Glyburide; | 2020 |
Extracellular ATP and Purinergic P2Y
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; C | 2020 |
Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Diethyln | 2020 |
Novel complementary antitumour effects of celastrol and metformin by targeting IκBκB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosa | 2020 |
An organoid-based carcinogenesis model induced by in vitro chemical treatment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamide; Animals; Carcinogenesis; Carcinogens; Diethylnitrosami | 2020 |
Maternal Consumption of a Low-Isoflavone Soy Protein Isolate Diet Accelerates Chemically Induced Hepatic Carcinogenesis in Male Rat Offspring.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caseins; Diet, Vegetarian; Diethylnitrosamine; F | 2020 |
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats.
Topics: Animals; Bombyx; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; | 2020 |
Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinogenesis; Cell Cycle | 2020 |
STAT3 and AKT signaling pathways mediate oncogenic role of NRSF in hepatocellular carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Diethylnitros | 2020 |
The impact of sex on hepatotoxic, inflammatory and proliferative responses in mouse models of liver carcinogenesis.
Topics: Aging; Aminobiphenyl Compounds; Animals; Carcinogenesis; Cell Proliferation; Chemical and Drug Induc | 2020 |
Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice.
Topics: Aldehyde Reductase; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Carcinogenesis; Chemical and D | 2020 |
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice.
Topics: Animals; Biopsy; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Enzyme Activation; Fema | 2020 |
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.
Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferatio | 2021 |
Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Diethylnitr | 2021 |
Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Inflammation; Limonins; Live | 2020 |
Inhibitory Effect of Thai Purple Rice Husk Extract on Chemically Induced Carcinogenesis in Rats.
Topics: 3,3'-Diaminobenzidine; Animals; Apoptosis; Carcinogenesis; Diethylnitrosamine; Liver; Male; Oryza; P | 2021 |
Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; | 2021 |
Optimized protocol for an inducible rat model of liver tumor with chronic hepatocellular injury, inflammation, fibrosis, and cirrhosis.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Humans; Inflammation; Liver Cirrhosis, Experimental; Li | 2021 |
Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline Deficiency; Cyclin-De | 2021 |
Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Animals; Arginine; Carcinogenesis; Carcinoma, Hep | 2021 |
Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats.
Topics: 1,2-Dimethylhydrazine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Carcin | 2021 |
Chemopreventive Effect of
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Clusiaceae | 2021 |
Time-caloric restriction inhibits the neoplastic transformation of cirrhotic liver in rats treated with diethylnitrosamine.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinoma, Hepatocellular; Cell Transformation, Neopla | 2017 |
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2 | 2017 |
Chronic Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis via Immune Disturbances.
Topics: Alcohol Drinking; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Pr | 2017 |
Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Progre | 2017 |
An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice.
Topics: Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease M | 2018 |
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Topics: ADAM17 Protein; Albumins; Animals; ATP Binding Cassette Transporter, Subfamily B; Carcinogenesis; Ca | 2017 |
Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinogens; Chemical and Drug Induced Liver Injury; D | 2017 |
An integrative analysis of chemically-induced cirrhosis-associated hepatocarcinogenesis: Histological, biochemical and molecular features.
Topics: Alanine Transaminase; Animals; Annexin A2; Aspartate Aminotransferases; Carcinogenesis; Collagen; Co | 2017 |
Eicosapentaenoic acid attenuates obesity-related hepatocellular carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diet, High-Fat; Diethylnitrosamine; | 2018 |
Intravenous miR-144 inhibits tumor growth in diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Administration, Intravenous; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Pro | 2017 |
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; | 2018 |
The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepato | 2018 |
Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 | 2018 |
Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogenesis; Carcinogens; Cell Proliferation; Colon; Diethylnitro | 2019 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosa | 2018 |
From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor.
Topics: Adult; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Diethylnitrosami | 2018 |
Anti-carcinogenic effect of hesperidin against renal cell carcinoma by targeting COX-2/PGE2 pathway in Wistar rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Carcinoma, Renal Cell; Cell Prolifer | 2018 |
Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.
Topics: 5-Methoxypsoralen; Animals; Body Weight; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulat | 2018 |
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
Topics: Animals; Carcinogenesis; DEAD-box RNA Helicases; Diethylnitrosamine; DNA Damage; Female; Liver Neopl | 2019 |
STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytokines; Diethylni | 2019 |
Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzylisoquinolines; Carcinogenesis; Diethyln | 2019 |
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcino | 2018 |
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.
Topics: Adult; Aged; Aged, 80 and over; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Di | 2018 |
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Chromosom | 2019 |
Identification of the Potential Metabolic Pathways Involved in the Hepatic Tumorigenesis of Rat Diethylnitrosamine-Induced Hepatocellular Carcinoma via
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine; Glucose; Glutamic Acid; Glut | 2019 |
Diethylnitrosamine enhances hepatic tumorigenic pathways in mice fed with high fat diet (Hfd).
Topics: Alkylating Agents; Animals; Carcinogenesis; Diet, High-Fat; Diethylnitrosamine; Liver; Liver Neoplas | 2019 |
Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.
Topics: Adenocarcinoma of Lung; Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Diethylnitrosamine; | 2019 |
Gallium nanoparticles along with low-dose gamma radiation modulate TGF-β/MMP-9 expression in hepatocellular carcinogenesis in rats.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; Disease Models, A | 2019 |
Mito-TEMPO, a mitochondria-targeted antioxidant, prevents N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.
Topics: Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cyclic N-Oxides | 2019 |
Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause.
Topics: Acetyl-CoA Carboxylase; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Diet, High-Fat; Diethyln | 2019 |
Chronic administration of diethylnitrosamine to induce hepatocarcinogenesis and to evaluate its synergistic effect with other hepatotoxins in mice.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Drug Syn | 2019 |
Overproduction of thrombopoietin by BRAFV600E-mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis.
Topics: Animals; Biopsy; Blood Platelets; Bone Marrow; Capillaries; Carcinogenesis; Carcinogens; Cell Prolif | 2019 |
Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.
Topics: Animals; Apoptosis; Arsenicals; Aryl Hydrocarbon Hydroxylases; bcl-2-Associated X Protein; Body Weig | 2013 |
Two-stage model of chemically induced hepatocellular carcinoma in mouse.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferat | 2013 |
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethyl | 2013 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
Loss of estrogen-related receptor α promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances.
Topics: Animals; Blotting, Western; Carcinogenesis; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromat | 2013 |
Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Administration, Oral; Amino Acids, Branched-Chain; Animals; Anticarcinogenic Agents; Carcinogenesis; | 2013 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, | 2014 |
CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model.
Topics: Active Transport, Cell Nucleus; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Nucleus; Di | 2013 |
Decorin deficiency promotes hepatic carcinogenesis.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cyclin-Dependent Kinase Inhib | 2014 |
Preventive effect of hydrazinocurcumin on carcinogenesis of diethylnitrosamine-induced hepatocarcinoma in male SD rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carcinogenesis; Ca | 2014 |
Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogenesis; Diethylnitrosamine | 2013 |
Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt/β-catenin signaling pathway.
Topics: Alcohol Drinking; Alkylating Agents; Animals; Blotting, Western; Carcinogenesis; Cell Proliferation; | 2014 |
Suppression of sulfoconjugation reduces the protective effect of ortho-aminoazotoluene on hepatocarcinogenesis induced by diethylnitrosamine in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogenesis; Diethylnitrosamine; Female; Liver; Liver Neoplasms | 2014 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.
Topics: Animals; Carcinogenesis; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Disease Models, Ani | 2015 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellul | 2015 |
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Diethylnitr | 2015 |
The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamine | 2014 |
MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Flavonoi | 2015 |
Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model.
Topics: Animals; Carcinogenesis; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, | 2015 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Long-Term Administration of Fibroblast Growth Factor 21 Prevents Chemically-Induced Hepatocarcinogenesis in Mice.
Topics: Animals; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Prolif | 2015 |
The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cysteine-R | 2016 |
β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling.
Topics: Alkylating Agents; Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Blotting, W | 2015 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.
Topics: Animals; Apoptosis Regulatory Proteins; Carcinogenesis; Carcinoma, Hepatocellular; Diethylnitrosamin | 2015 |
MiR-17-92 cluster promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease | 2015 |
Fourier Transform Infrared Spectroscopic Studies on Modulation of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis by Azadirachta indica.
Topics: Alkylating Agents; Animals; Azadirachta; Carcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; | 2015 |
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular | 2016 |
Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cytokines; Diethylnitrosamine; DNA-Binding Prote | 2015 |
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.
Topics: Animals; beta-Galactosidase; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell Proliferation; Cel | 2016 |
Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Hepatocellular; Comet Assay; Cyclo | 2015 |
Induction of autophagy promotes the growth of early preneoplastic rat liver nodules.
Topics: Alkylating Agents; Animals; Autophagy; Carcinogenesis; Diethylnitrosamine; Disease Progression; Gene | 2016 |
Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blotting, Western; Carcinogenesis; Carcinoma, Hep | 2016 |
Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Cholic Acid; Cyclin D1; Diethylnitrosamine; | 2016 |
Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice.
Topics: Animals; Apoptosis; beta Catenin; Biflavonoids; Body Weight; Carcinogenesis; Catechin; Cell Prolifer | 2016 |
Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carcinogenesis; Carcinoma, Hepatocellular; | 2016 |
Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.
Topics: Animals; Antineoplastic Agents; bcl-2-Associated X Protein; bcl-X Protein; Carcinogenesis; Carcinoma | 2016 |
Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carcinogenesis; Carcinoma, Hepatocellular; Ce | 2016 |
Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice.
Topics: Animals; Carcinogenesis; Cell Cycle; Cytokines; Diethylnitrosamine; Female; Gene Expression Regulati | 2017 |
LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Glutaminase; Gl | 2016 |
Ethanol extract of Phellinus merrillii protects against diethylnitrosamine- and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Basidiomycota; Carcinogenesis; Cytoprotection; Diethylnitrosamine; E | 2017 |
Clock gene Per2 as a controller of liver carcinogenesis.
Topics: Animals; Carcinogenesis; Circadian Rhythm; Diethylnitrosamine; Interleukin-6; Liver; Liver Neoplasms | 2016 |
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Topics: Animals; Autophagy; Carcinogenesis; Carcinoma, Hepatocellular; Death-Associated Protein Kinases; Die | 2016 |
Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinogenesis; Diethylnitrosamine; Lipid Per | 2016 |
The dark side of "the force" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice.
Topics: Animals; Carcinogenesis; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Humans; Lip | 2017 |
Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma.
Topics: Animals; beta-Arrestin 2; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement | 2016 |
Enhancement of DEN-induced liver tumorigenesis in heme oxygenase-1 G143H mutant transgenic mice.
Topics: Animals; Carcinogenesis; Carcinogens; Diethylnitrosamine; Heme Oxygenase-1; Liver Neoplasms; Membran | 2016 |
CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Carcinogenesis; Cell Death; Cell Line, | 2017 |
Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects.
Topics: Animals; Animals, Suckling; Body Weight; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytochrome P-450 E | 2016 |
Effect of Chokeberry Juice on N-Nitrosodiethylamine-Induced Rat Liver Carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinogens; Diethylnitrosamine; Fruit and Vegetable Juices; Liver; Liver N | 2016 |
A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cells, Cultured; Diethylnitros | 2016 |
Fruiting Bodies of Antrodia cinnamomea and Its Active Triterpenoid, Antcin K, Ameliorates N-Nitrosodiethylamine-Induced Hepatic Inflammation, Fibrosis and Carcinogenesis in Rats.
Topics: Alkylating Agents; Animals; Antrodia; Apoptosis; Autophagy; Carcinogenesis; Carcinoma, Hepatocellula | 2017 |
The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents, Immunological; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proli | 2017 |
Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice.
Topics: Animals; Carcinogenesis; Carcinogens; Crystallography, X-Ray; Diethylnitrosamine; Liver; Liver Neopl | 2017 |
A long term, non-tumorigenic rat hepatocyte cell line and its malignant counterpart, as tools to study hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Cell Line; Cell Line, Transformed; Cell Transformation, | 2017 |
Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Topics: Acetyl-CoA Carboxylase; Alkylating Agents; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatoc | 2017 |
Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Disease Models, Animal; | 2017 |
Myrtenal ameliorates diethylnitrosamine-induced hepatocarcinogenesis through the activation of tumor suppressor protein p53 and regulation of lysosomal and mitochondrial enzymes.
Topics: Animals; Antineoplastic Agents; Bicyclic Monoterpenes; Carbohydrate Metabolism; Carcinogenesis; Citr | 2013 |
DEN+2-AAF-induced multistep hepatotumorigenesis in Wistar rats: supportive evidence and insights.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenesis; Diethylnitrosamine; Disease Models, Animal; Lipid Pe | 2013 |
[Quantitative DNA and RNA changes in the rat liver cell during diethylnitrosamine carcinogenesis].
Topics: Animals; Carcinogenesis; Diethylnitrosamine; DNA; DNA, Neoplasm; Hepatocytes; Liver; Neoplasms; Nitr | 1962 |
[AUTORADIOGRAPHIC STUDIES DURING EXPERIMENTAL CARCINOGENESIS IN THE RESPIRATORY TRACT OF THE HAMSTER AFTER TREATMENT WITH DIETHYLNITROSAMINE].
Topics: Animals; Autoradiography; Carcinogenesis; Cricetinae; Diethylnitrosamine; Neoplasms; Neoplasms, Expe | 1964 |