diethylnitrosamine has been researched along with Body Weight in 267 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 8.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| "Two-stage rat hepatocarcinogenesis model was used to induce early carcinogenesis in which thioacetamide (TAA) promotes diethylnitrosamine (DEN) initiated carcinogenesis." | 7.96 | Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. ( Dwivedi, DK; Jena, GB, 2020) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 7.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 7.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 7.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 7.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 7.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| "In rats, hexachlorobenzene (HCB) causes uroporphyria and liver tumours predominantly in females." | 7.67 | Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria. ( Cabral, JR; Manson, MM; Smith, AG; Stewart, FP, 1989) |
| "to induce liver cancer." | 5.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Our previous study demonstrated that purple rice bran extract (PRBE) could inhibit diethylnitrosamine (DEN)-induced hepatocarcinogenesis." | 4.12 | Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Luangsuphabool, T; Punvittayagul, C; Wongpoomchai, R, 2022) |
| "Swiss Albino (BALB/c) mice of around 10-12 weeks old were exposed to a known hepatocarcinogen-diethylnitrosamine at a dose of 20 mg/kg body weight at weekly intervals for a period of 4, 8, 12, & 16 weeks." | 4.12 | Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma. ( Kma, L; Priya, S, 2022) |
| "Two-stage rat hepatocarcinogenesis model was used to induce early carcinogenesis in which thioacetamide (TAA) promotes diethylnitrosamine (DEN) initiated carcinogenesis." | 3.96 | Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. ( Dwivedi, DK; Jena, GB, 2020) |
| "To test the hypotheses that (i) heavier rats demonstrate improved survival with diminished fibrosis in a diethylnitrosamine (DEN)-induced model of hepatocellular carcinoma (HCC) and (ii) transarterial embolization via femoral artery access decreases procedure times versus carotid access." | 3.85 | Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. ( Furth, EE; Gade, TP; Hunt, SJ; Kiefer, RM; Nadolski, GJ; Pickup, S; Pulido, S; Soulen, MC, 2017) |
| " Hepatocellular Carcinoma (HCC) was induced in the liver of male Sprague Dawley (SD) rats by treating with diethylnitrosamine (DEN)." | 3.85 | In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model. ( Antony Joseph, SR; Krishnan, GS; Rajagopal, V; Savarimuthu, I; Sebastian, D; Selvaraj, KRN; Thobias, AF, 2017) |
| " In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced rat model of HCC." | 3.83 | Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats. ( Chang, M; Choi, HJ; Jang, JJ; Jang, S; Jo, W; Lee, HJ; Park, HK; Ryu, JE; Son, WC; Yu, ES, 2016) |
| "The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any." | 3.83 | Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice. ( Barua, A; Pal, D; Panda, CK; Roy, A; Roy, R; Saha, P; Sur, S, 2016) |
| " The present investigation was carried out to evaluate antioxidant status and lipid peroxidation level of anticancer activity of Solanum xanthocarpum (SXC) on Diethylnitrosamine (DEN) induced hepato carcinogenesis in male Wistar albino rats." | 3.83 | Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis. ( Indumathi, D; Iyappan, P; Velu, P; Vijayalakshmi, A, 2016) |
| " In the present study we found that DPAA significantly enhanced the development of diethylnitrosamine-induced preneoplastic lesions in the liver in a medium-term rat liver carcinogenesis assay." | 3.79 | Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats. ( Fujioka, M; Kakehashi, A; Kato, M; Kitano, M; Tago, Y; Wanibuchi, H; Wei, M; Yamada, T; Yamano, S, 2013) |
| " Rats received an intraperitoneal (ip) injection of 200 mg/kg body weight of N-diethylnitrosamine (DEN) and fed a diet containing 0, 0." | 3.78 | Mechanistic study on liver tumor promoting effects of flutamide in rats. ( Hayashi, H; Inokuma, H; Mitsumori, K; Shibutani, M; Shimamoto, K; Suzuki, K; Tawfeeq, MM, 2012) |
| ") injection of 200 mg/kg body weight diethylnitrosamine (DEN)." | 3.73 | Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Dhachinamoorthi, D; Panayappan, L; Srivastawa, S, 2006) |
| " Since this receptor is also expressed on the cells of well differentiated human hepatocellular carcinomas (HCCs), we studied whether conjugation of doxorubicin (DOXO) with lactosaminated human albumin (L-HSA) increases the drug efficacy on HCCs induced in rats by diethylnitrosamine (DENA)." | 3.73 | Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine. ( Bolondi, L; Busi, C; Chieco, P; Di Stefano, G; Fiume, L; Kratz, F; Lanza, M; Mattioli, A, 2005) |
| ") injection of diethylnitrosamine (DEN) (125 mg kg(-1) body weight) at week 4 followed by promotion with streptozotocin (STZ) (65 mg kg(-1) body weight with a single i." | 3.71 | 1alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes and the development of gamma-glutamyltranspeptidase-positive foci in diethylnitrosamine-initiated and streptozotocin-induced diabetes-promoted hepatocarcinogenesis. ( Bhattacharya, R; Chatterjee, M; Saha, BK, 2002) |
| "We investigated whether changes in apoptosis and cell proliferation induced by starvation and refeeding in rat liver may contribute to the initiation mechanism of liver cancer by 20 mg/kg of diethylnitrosamine (DENA)." | 3.70 | Apoptosis and cell proliferation are involved in the initiation of liver carcinogenesis by a subnecrogenic dose of diethylnitrosamine in refed rats. ( Tessitore, L, 2000) |
| " A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0." | 3.69 | Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995) |
| " Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
| "The present study examines the dose-response relationship for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) promotion of histologic and biochemical parameters by using a two-stage model for hepatocarcinogenesis in female Sprague-Dawley rats initiated with a single intraperitoneal dose of 175 mg of diethylnitrosamine (DEN)/kg body weight at 70 days of age." | 3.68 | Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints. ( Clark, G; Foley, JF; Goldsworthy, T; Lucier, G; Maronpot, RR; Portier, C; Takahashi, K; Tritscher, A, 1993) |
| " Animals were given a single dose of diethylnitrosamine (100 mg/kg body weight)." | 3.68 | Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci. ( Chelo, A; Columbano, A; Curto, M; Ennas, MG; Ledda-Columbano, GM; Pani, P, 1990) |
| "The effects of the chronic administration of methyl-deficient, amino acid-defined diets on liver tumor formation were examined in male weanling C3H/HeN mice previously treated with a single ip injection of 0 or 150 mg diethylnitrosamine/kg body weight [(DENA) CAS: 55-18-5]." | 3.67 | Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets. ( Creasia, D; Hoover, KL; Mikol, YB; Poirier, LA; Shivapurkar, N; Wilson, MJ, 1986) |
| "The aim of this study was to determine whether a dietary restriction, which significantly decreases body weight gain, also influences the development of diethylnitrosamine (DEN)-induced liver tumours in Swiss mice." | 3.67 | The influence of food intake on the development of diethylnitrosamine-induced liver tumours in mice. ( Lagopoulos, L; Stalder, R, 1987) |
| " Each of 50 rats per group received one injection 20 mg diethylnitrosamine [(DENA) CAS: 55-18-5; N-nitrosodiethylamine]/kg body weight at 4 weeks of age, and then each was maintained on a methyl group-adequate (MA) diet for 52 weeks (groups 2 and 5) or on an MD diet for 15 weeks followed by the MA diet for 37 weeks (group 4)." | 3.67 | Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection. ( Hoover, KL; Lynch, PH; Poirier, LA, 1984) |
| "In rats, hexachlorobenzene (HCB) causes uroporphyria and liver tumours predominantly in females." | 3.67 | Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria. ( Cabral, JR; Manson, MM; Smith, AG; Stewart, FP, 1989) |
| " Rats were initially given a single ip injection of diethylnitrosamine (200 mg/kg body weight) and fed basal diet containing 0." | 3.67 | Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis. ( Inoue, K; Ito, N; Masui, T; Ogiso, T; Tsuda, H, 1986) |
| " injection of diethylnitrosamine (DEN) (25-mg/kg body weight)." | 3.67 | Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine. ( Jirtle, RL; Michalopoulos, G; Novicki, DL; Novotny, A; Rosenberg, MR, 1985) |
| "0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice." | 3.66 | Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. ( Goldfarb, S; He, YZ; Koen, H; Pugh, TD, 1983) |
| "to induce liver cancer." | 1.91 | Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. ( Amudha, P; Jayalakshmi, M; Poojitha, BN; Vidya, R, 2023) |
| "The DEN-challenged liver cancer in experimental rats caused increased liver weight, 8-OHD, hepatic tissue injury marker, lipid peroxidation, and tumor markers levels." | 1.62 | Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells. ( Alahmadi, TA; Chinnathambi, A; Li, Z; Lu, B; Xie, Y; You, Y; Zhang, L; Zhu, F, 2021) |
| "Liver fibrosis is a complex process characterized by the excessive accumulation of extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of chronic liver diseases such as cirrhosis, hepatocellular carcinoma (HCC) and liver failure." | 1.62 | Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation. ( González, DR; Herrera Vielma, F; Rodríguez, MJ; Sabaj, M; Tolosa, G; Zúñiga, MJ; Zúñiga-Hernández, J, 2021) |
| "Diethylnitrosamine was widely employed as a carcinogenic agent to stimulate the cancer in animal models." | 1.56 | Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats. ( Bolla, SR; Chen, Y; Gong, G; Li, Y; Veeraraghavan, VP; Xu, C; Zhang, C; Zhang, M, 2020) |
| "Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens." | 1.43 | Dietary sugar intake increases liver tumor incidence in female mice. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Hargett, SR; Healy, ME; Hoehn, KL; Kenwood, BM; Lackner, C; Lahiri, S; Taddeo, EP, 2016) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Pretreatment with bicyclol showed a marked reduction in the above condition." | 1.38 | A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. ( Liu, G; Sun, H; Wei, H; Yu, L, 2012) |
| "Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine (NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl(4)(3 mL/kg/week) for 6 weeks, as the promoter of carcinogenic effect." | 1.38 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats. ( Fareed, S; Hussain, T; Rao, CV; Siddiqui, HH; Vijayakumar, M, 2012) |
| "Recent studies have demonstrated that frequent, low-dose metronomic (MET) dosing of cytotoxic agents may not only be as efficient as conventional maximum tolerated dose (MTD) chemotherapy but also less toxic." | 1.36 | Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis. ( Bae, SH; Choi, JY; Hur, W; Jang, JW; Kim, GD; Kim, JD; Kwon, JH; Park, JA; Park, ST; Woo, HY; Yoo, CR; Yoon, SK, 2010) |
| "Fenofibrate (FF) has previously been shown to induce hepatocellular neoplasia in a conventional mouse bioassay (NDA 1993), but there has been no report to examine the carcinogenic susceptibility of rasH2 mice to this chemical." | 1.35 | Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice. ( Dewa, Y; Jin, M; Kawai, M; Matsumoto, S; Mitsumori, K; Nishimura, J; Saegusa, Y; Shibutani, M; Taniai, E, 2008) |
| "Diethylnitrosamine (DEN) is a representative chemical carcinogen with the potential to cause tumors in various organs, including the liver, skin, gastrointestinal tract, and respiratory system." | 1.35 | Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat. ( Jang, JJ; Lee, MJ; Li, L; Park, DH; Park, SK; Seo, JN; Shin, JW, 2009) |
| "Potassium bromate (KBrO(3)) is a genotoxic carcinogen inducing kidney cancers at high doses in male F344 rats, but little is known about its carcinogenic effects in other strains of rats." | 1.35 | Potassium bromate enhances N-ethyl-N-hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold. ( Doi, K; Fukushima, S; Hamoud, AS; Kakehashi, A; Kitano, M; Kushida, M; Morimura, K; Wanibuchi, H; Wei, M; Yamaguchi, T, 2009) |
| "Cotreatment with morin prevented the elevation of marker enzymes induced by N-nitrosodiethylamine." | 1.35 | Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. ( Niranjali Devaraj, S; Praveen Kumar, VR; Shilpa, PN; Sivaramakrishnan, V, 2008) |
| " From 5 weeks after the completion of 2-AAF administration, the rats were orally dosed with 0." | 1.32 | Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation. ( Akahane, M; Hayashi, M; Kuroda, J; Machida, N; Mitsumori, K; Moriwaki, H; Ohnota, H; Shibata, N; Tamura, T, 2004) |
| "Kojic acid (KA) has been used as a food additive for preventing enzymatic browning of crustaceans and as a cosmetic agent for skin whitening." | 1.32 | Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine. ( Hirose, M; Imai, T; Izumi, K; Mitsumori, K; Onose, J; Takizawa, T; Tamura, T; Ueda, M, 2004) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| "Melatonin treatment were performed only during the night (between 18:00 to 09:00) in order to maintain their circadian rhythm, since serum melatonin levels are high at midnight." | 1.31 | Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure. ( Asamoto, M; Futakuchi, M; Hagiwara, A; Imaida, K; Ogawa, K; Sano, M; Shirai, T; Tamano, S; Yoshino, H, 2000) |
| "Diethylnitrosamine (DEN) was administered to rats as a single dose, which is known not to give rise to liver tumours without subsequent promotion." | 1.30 | Iron promotes DEN initiated GST-P foci in rat liver. ( Carthew, P; Edwards, RE; Nolan, BM; Smith, AG, 1997) |
| "Co-treatment of rotenone and WY-14,643 (group IV) decreased focal DNA synthesis and mitosis and increased the incidence of apoptotic hepatocytes." | 1.30 | Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone. ( Ayoubi, SA; Isenberg, JS; Klaunig, JE; Kolaja, KL; Watkins, JB, 1997) |
| " In the present study we examined the dose-response effect of dieldrin (at several doses) on focal lesion growth (tumor promotion), hepatocyte apoptosis and DNA synthesis in rat and mouse liver." | 1.29 | Selective dieldrin promotion of hepatic focal lesions in mice. ( Klaunig, JE; Kolaja, KL; Stevenson, DE; Walborg, EF, 1996) |
| " We report here that the bioassay can rapidly detect carcinogenic doses of HCB and that there is a clear dose-response relationship." | 1.29 | Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene. ( Cabral, R; Hakoi, K; Hasegawa, R; Hoshiya, T; Ito, N, 1996) |
| " In Experiment 2, a total of 45 female SD rats were dosed with DEN (100 mg/kg, i." | 1.29 | Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats. ( Ahn, B; Bae, JH; Han, BS; Jang, JJ; Kim, DJ; Lee, KK, 1994) |
| "Propranolol is a lipophilic non-selective beta-blocker mainly eliminated via the liver; atenolol is a hydrophilic beta 1-selective blocking agent, mainly eliminated via the kidney." | 1.29 | Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats. ( Ameri, L; Arias, E; Girotti, P; Mazzoleni, G; Presta, M; Radaelli, G; Ragnotti, G; Zavanella, T, 1994) |
| " At dosage levels equimolar to 500 ppm PB, none of the three compounds promoted development of hepatocellular adenomas or carcinomas, in contrast to PB." | 1.28 | Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat. ( Diwan, BA; Henneman, JR; Lubet, RA; Nims, RW; Rice, JM; Ward, JM, 1992) |
| "Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old." | 1.28 | Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state. ( Ahotupa, M; Bartsch, H; Béréziat, JC; Bussacchini-Griot, V; Cabral, JR; Camus, AM; Hietanen, E; Laitinen, M; Wild, H, 1991) |
| "d-Limonene treatment alone caused a significant increase in the number of atypical tubules and atypical hyperplasias in F344 rats when compared with the F344 vehicle control." | 1.28 | The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors. ( Dietrich, DR; Swenberg, JA, 1991) |
| " Four-day-old female F344/N rats were dosed with diethylnitrosamine (10 mg/kg)." | 1.28 | Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Duitsman, P; Hendrich, S; Jackson, A; Krueger, SK; Myers, RK, 1991) |
| " Although no toxicity-related hepatocyte lesions were found, severe renal toxic tubular lesions and regeneration were evident." | 1.28 | Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman. ( Hagiwara, A; Ito, N; Kato, T; Kurata, Y; Tanaka, H; Tsuda, H, 1990) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| "Methionine was contained in both the amino acid and the lipotrope supplement and probably was responsible for reducing hepatocarcinoma incidence." | 1.26 | Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet. ( Rogers, AE, 1977) |
| " Cyclopentenone was dosed at a level of 18 ppm (seven hr/day, five days/week) during the first 52 weeks, and at a level of 27 ppm during the last 26 weeks of the study." | 1.26 | Repeated exposure to cyclopentenone vapour: long-term study in Syrian golden hamsters. ( Feron, VJ; Kruysse, A, 1976) |
| "Fe2O3 caused pulmonary fibrosis and synthetic smog caused alveolar bronchiolization in many of the exposed animals." | 1.25 | Carcinogenic and cocarcinogenic effects of inhaled synthetic smog and ferric oxide particles. ( Creasia, DA; Mitchell, TJ; Nettesheim, P, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (22.85) | 18.7374 |
| 1990's | 96 (35.96) | 18.2507 |
| 2000's | 63 (23.60) | 29.6817 |
| 2010's | 36 (13.48) | 24.3611 |
| 2020's | 11 (4.12) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez, MJ | 1 |
| Sabaj, M | 1 |
| Tolosa, G | 1 |
| Herrera Vielma, F | 1 |
| Zúñiga, MJ | 1 |
| González, DR | 1 |
| Zúñiga-Hernández, J | 1 |
| Amudha, P | 1 |
| Jayalakshmi, M | 1 |
| Vidya, R | 1 |
| Poojitha, BN | 1 |
| Punvittayagul, C | 1 |
| Luangsuphabool, T | 1 |
| Wongpoomchai, R | 1 |
| Shen, H | 1 |
| Li, Q | 1 |
| Yu, Y | 1 |
| Priya, S | 1 |
| Kma, L | 1 |
| Yang, F | 1 |
| Shi, X | 1 |
| Yang, W | 2 |
| Gao, C | 1 |
| Cui, Z | 1 |
| Wang, W | 1 |
| Dwivedi, DK | 1 |
| Jena, GB | 1 |
| Alarcón-Sánchez, BR | 1 |
| Guerrero-Escalera, D | 1 |
| Rosas-Madrigal, S | 1 |
| Ivette Aparicio-Bautista, D | 1 |
| Reyes-Gordillo, K | 1 |
| Lakshman, MR | 1 |
| Ortiz-Fernández, A | 1 |
| Quezada, H | 1 |
| Medina-Contreras, Ó | 1 |
| Villa-Treviño, S | 1 |
| Isael Pérez-Carreón, J | 1 |
| Arellanes-Robledo, J | 1 |
| Zhang, C | 1 |
| Chen, Y | 1 |
| Zhang, M | 2 |
| Xu, C | 1 |
| Gong, G | 1 |
| Veeraraghavan, VP | 1 |
| Bolla, SR | 1 |
| Li, Y | 1 |
| You, Y | 1 |
| Zhu, F | 1 |
| Li, Z | 1 |
| Zhang, L | 1 |
| Xie, Y | 1 |
| Chinnathambi, A | 1 |
| Alahmadi, TA | 1 |
| Lu, B | 1 |
| Cahyani, DM | 1 |
| Miatmoko, A | 1 |
| Hariawan, BS | 1 |
| Purwantari, KE | 1 |
| Sari, R | 1 |
| Kiefer, RM | 1 |
| Hunt, SJ | 2 |
| Pulido, S | 1 |
| Pickup, S | 1 |
| Furth, EE | 1 |
| Soulen, MC | 1 |
| Nadolski, GJ | 1 |
| Gade, TP | 1 |
| Fathy, AH | 1 |
| Bashandy, MA | 1 |
| Bashandy, SAE | 1 |
| Mansour, AM | 1 |
| Elsadek, B | 1 |
| Krishnan, GS | 1 |
| Rajagopal, V | 1 |
| Antony Joseph, SR | 1 |
| Sebastian, D | 1 |
| Savarimuthu, I | 1 |
| Selvaraj, KRN | 1 |
| Thobias, AF | 1 |
| Kot, M | 1 |
| Daujat-Chavanieu, M | 1 |
| Pattanayak, SP | 1 |
| Bose, P | 1 |
| Sunita, P | 1 |
| Siddique, MUM | 1 |
| Lapenna, A | 1 |
| Fernández-Bedmar, Z | 1 |
| Anter, J | 1 |
| Alonso-Moraga, A | 1 |
| Delgado de la Torre, P | 1 |
| Luque de Castro, MD | 1 |
| Millán-Ruiz, Y | 1 |
| Sánchez-Frías, M | 1 |
| Guil-Luna, S | 1 |
| D'Souza, JC | 1 |
| Sultan, LR | 1 |
| Schultz, SM | 1 |
| Brice, AK | 1 |
| Wood, AKW | 1 |
| Sehgal, CM | 1 |
| Arul, D | 1 |
| Subramanian, P | 1 |
| Dai, ZJ | 1 |
| Wu, WY | 1 |
| Kang, HF | 1 |
| Ma, XB | 2 |
| Zhang, SQ | 2 |
| Min, WL | 2 |
| Kang, WF | 1 |
| Lu, WF | 1 |
| Lin, S | 1 |
| Wang, XJ | 1 |
| Hu, WT | 1 |
| Li, HC | 1 |
| Lee, SK | 1 |
| Ma, HC | 1 |
| Yang, CH | 1 |
| Chen, HL | 1 |
| Lo, SY | 1 |
| Wei, M | 4 |
| Yamada, T | 2 |
| Yamano, S | 2 |
| Kato, M | 1 |
| Kakehashi, A | 3 |
| Fujioka, M | 1 |
| Tago, Y | 1 |
| Kitano, M | 2 |
| Wanibuchi, H | 4 |
| Kumamoto, R | 1 |
| Uto, H | 1 |
| Oda, K | 1 |
| Ibusuki, R | 1 |
| Tanoue, S | 1 |
| Arima, S | 1 |
| Mawatari, S | 1 |
| Kumagai, K | 1 |
| Numata, M | 1 |
| Tamai, T | 1 |
| Moriuchi, A | 1 |
| Fujita, H | 1 |
| Oketani, M | 1 |
| Ido, A | 1 |
| Tsubouchi, H | 1 |
| Sharma, V | 1 |
| Bona, S | 1 |
| Moreira, AJ | 1 |
| Rodrigues, GR | 1 |
| Cerski, CT | 1 |
| da Silveira, TR | 1 |
| Marroni, CA | 1 |
| Marroni, NP | 1 |
| Jo, W | 1 |
| Yu, ES | 1 |
| Chang, M | 1 |
| Park, HK | 1 |
| Choi, HJ | 1 |
| Ryu, JE | 1 |
| Jang, S | 1 |
| Lee, HJ | 1 |
| Jang, JJ | 10 |
| Son, WC | 1 |
| Healy, ME | 1 |
| Lahiri, S | 1 |
| Hargett, SR | 1 |
| Chow, JD | 1 |
| Byrne, FL | 1 |
| Breen, DS | 1 |
| Kenwood, BM | 1 |
| Taddeo, EP | 1 |
| Lackner, C | 1 |
| Caldwell, SH | 1 |
| Hoehn, KL | 1 |
| Sur, S | 1 |
| Pal, D | 1 |
| Roy, R | 1 |
| Barua, A | 1 |
| Roy, A | 1 |
| Saha, P | 1 |
| Panda, CK | 1 |
| Kishida, N | 1 |
| Matsuda, S | 1 |
| Itano, O | 1 |
| Shinoda, M | 1 |
| Kitago, M | 1 |
| Yagi, H | 1 |
| Abe, Y | 1 |
| Hibi, T | 1 |
| Masugi, Y | 1 |
| Aiura, K | 1 |
| Sakamoto, M | 1 |
| Kitagawa, Y | 1 |
| Velu, P | 1 |
| Vijayalakshmi, A | 1 |
| Iyappan, P | 1 |
| Indumathi, D | 1 |
| Il'nitskaya, SI | 1 |
| Kaledin, VI | 1 |
| Bogdanova, LA | 1 |
| Morozkova, TS | 1 |
| Kapustina, VI | 1 |
| Perepechaeva, ML | 1 |
| Grishanova, AY | 1 |
| Wada, K | 1 |
| Nishino, R | 1 |
| Fukuyama, T | 1 |
| Matsumoto, K | 3 |
| Xu, M | 1 |
| Zhao, Q | 1 |
| Shao, D | 1 |
| Liu, H | 1 |
| Qi, J | 1 |
| Qin, C | 1 |
| Duan, T | 1 |
| Sun, W | 1 |
| Ge, J | 1 |
| He, Y | 1 |
| Zhang, J | 1 |
| Zheng, Y | 1 |
| Shen, HM | 1 |
| Yang, J | 1 |
| Zhu, X | 1 |
| Yu, P | 1 |
| Kawabe, M | 2 |
| Futakuchi, M | 4 |
| Tamano, S | 10 |
| Shirai, T | 15 |
| Hirose, M | 7 |
| Muguruma, M | 4 |
| Kawai, M | 3 |
| Dewa, Y | 7 |
| Nishimura, J | 5 |
| Saegusa, Y | 4 |
| Yasuno, H | 1 |
| Jin, M | 7 |
| Matsumoto, S | 3 |
| Takabatake, M | 1 |
| Arai, K | 1 |
| Mitsumori, K | 15 |
| Taniai, E | 3 |
| Shibutani, M | 7 |
| Mittal, G | 1 |
| Vadhera, S | 1 |
| Brar, AP | 1 |
| Soni, G | 1 |
| Furtado, KS | 2 |
| Pires, PW | 1 |
| Justulin, LA | 1 |
| Rodrigues, MA | 2 |
| Felisbino, SL | 1 |
| Barbisan, LF | 6 |
| Bishayee, A | 2 |
| Dhir, N | 1 |
| Moto, M | 3 |
| Murata, Y | 2 |
| Silva, JF | 1 |
| Bidinotto, LT | 1 |
| Salvadori, DM | 2 |
| Rivelli, DP | 1 |
| Barros, SB | 1 |
| Singh, BN | 1 |
| Singh, BR | 1 |
| Sarma, BK | 1 |
| Singh, HB | 1 |
| Granado-Serrano, AB | 1 |
| Martín, MA | 1 |
| Bravo, L | 1 |
| Goya, L | 1 |
| Ramos, S | 1 |
| Said, RA | 1 |
| Grassi, TF | 1 |
| Scolastici, C | 2 |
| Alves de Lima, RO | 1 |
| Darros, BR | 1 |
| de Camargo, JL | 2 |
| Harada, T | 1 |
| Park, ST | 1 |
| Jang, JW | 1 |
| Kim, GD | 1 |
| Park, JA | 1 |
| Hur, W | 1 |
| Woo, HY | 1 |
| Kim, JD | 1 |
| Kwon, JH | 1 |
| Yoo, CR | 1 |
| Bae, SH | 1 |
| Choi, JY | 1 |
| Yoon, SK | 1 |
| Park, DH | 1 |
| Shin, JW | 1 |
| Park, SK | 1 |
| Seo, JN | 1 |
| Li, L | 1 |
| Lee, MJ | 3 |
| Hamoud, AS | 1 |
| Yamaguchi, T | 2 |
| Morimura, K | 2 |
| Doi, K | 1 |
| Kushida, M | 1 |
| Fukushima, S | 7 |
| Khan, MS | 1 |
| Devaraj, H | 1 |
| Devaraj, N | 1 |
| Shimamoto, K | 4 |
| Kemmochi, S | 2 |
| Hayashi, H | 3 |
| Imaoka, M | 2 |
| Llorente Izquierdo, C | 1 |
| Mayoral, R | 1 |
| Flores, JM | 1 |
| García-Palencia, P | 1 |
| Cucarella, C | 1 |
| Boscá, L | 1 |
| Casado, M | 1 |
| Martín-Sanz, P | 1 |
| Ishii, Y | 2 |
| Morita, R | 2 |
| Kuwata, K | 1 |
| Suzuki, K | 3 |
| Tawfeeq, MM | 1 |
| Inokuma, H | 1 |
| Xie, XL | 1 |
| Tajiri, M | 1 |
| Zhang, CL | 1 |
| Zeng, T | 1 |
| Zhao, XL | 1 |
| Yu, LH | 1 |
| Zhu, ZP | 1 |
| Xie, KQ | 1 |
| Sun, H | 1 |
| Yu, L | 1 |
| Wei, H | 1 |
| Liu, G | 1 |
| Hussain, T | 1 |
| Siddiqui, HH | 1 |
| Fareed, S | 1 |
| Vijayakumar, M | 1 |
| Rao, CV | 1 |
| Yamamoto, R | 1 |
| Kimura, M | 1 |
| Fujii, Y | 1 |
| Zhou, JY | 1 |
| Yin, ZY | 1 |
| Wang, SY | 1 |
| Yan, JH | 1 |
| Zhao, YL | 1 |
| Wu, D | 1 |
| Liu, ZJ | 1 |
| Zhang, S | 1 |
| Wang, XM | 1 |
| Saha, BK | 1 |
| Bhattacharya, R | 1 |
| Chatterjee, M | 6 |
| Kapadia, GJ | 1 |
| Azuine, MA | 1 |
| Sridhar, R | 1 |
| Okuda, Y | 1 |
| Tsuruta, A | 1 |
| Ichiishi, E | 1 |
| Mukainake, T | 1 |
| Takasaki, M | 1 |
| Konoshima, T | 1 |
| Nishino, H | 2 |
| Tokuda, H | 1 |
| Thapliyal, R | 1 |
| Naresh, KN | 1 |
| Rao, KV | 1 |
| Maru, GB | 1 |
| Lu, S | 1 |
| Archer, MC | 1 |
| Cui, R | 1 |
| Wang, B | 1 |
| Zhang, F | 1 |
| Chen, G | 1 |
| Yin, S | 1 |
| Pinheiro, F | 1 |
| Faria, RR | 1 |
| Spinardi-Barbisan, AL | 2 |
| da Eira, AF | 1 |
| Mauriz, JL | 1 |
| Linares, P | 1 |
| Macias, RI | 1 |
| Jorquera, F | 1 |
| Honrado, E | 1 |
| Olcoz, JL | 1 |
| González, P | 1 |
| González-Gallego, J | 1 |
| Espandiari, P | 1 |
| Glauert, HP | 5 |
| Lehmler, HJ | 2 |
| Lee, EY | 1 |
| Srinivasan, C | 2 |
| Robertson, LW | 4 |
| Hayashi, M | 2 |
| Ohnota, H | 2 |
| Tamura, T | 3 |
| Kuroda, J | 2 |
| Shibata, N | 2 |
| Akahane, M | 2 |
| Moriwaki, H | 1 |
| Machida, N | 1 |
| Chattopadhyay, MB | 1 |
| C B, MK | 1 |
| Kanna, PS | 1 |
| Ray, RS | 1 |
| Roy, S | 1 |
| Kuklin, AI | 1 |
| Mynatt, RL | 1 |
| Klebig, ML | 1 |
| Kiefer, LL | 1 |
| Wilkison, WO | 1 |
| Woychik, RP | 1 |
| Michaud, EJ | 1 |
| Takizawa, T | 1 |
| Imai, T | 1 |
| Onose, J | 1 |
| Ueda, M | 1 |
| Izumi, K | 3 |
| Sakata, K | 1 |
| Hara, A | 1 |
| Hirose, Y | 1 |
| Yamada, Y | 2 |
| Kuno, T | 1 |
| Katayama, M | 1 |
| Yoshida, K | 1 |
| Zheng, Q | 1 |
| Murakami, A | 1 |
| Ohigashi, H | 1 |
| Ikemoto, K | 1 |
| Koshimizu, K | 1 |
| Tanaka, T | 4 |
| Mori, H | 4 |
| Agner, AR | 1 |
| Kashida, Y | 2 |
| Yang, FC | 1 |
| Zheng, SS | 1 |
| Jiang, TA | 1 |
| Jeyabal, PV | 1 |
| Syed, MB | 1 |
| Venkataraman, M | 1 |
| Sambandham, JK | 1 |
| Sakthisekaran, D | 3 |
| Kang, JS | 2 |
| Ahn, B | 3 |
| Kim, CK | 1 |
| Han, BS | 3 |
| Che, JH | 1 |
| Kim, S | 1 |
| Jang, DD | 1 |
| Yang, KH | 1 |
| Takekoshi, H | 1 |
| Mizoguchi, T | 1 |
| Komasa, Y | 1 |
| Chubachi, H | 1 |
| Inoue, Y | 1 |
| Imanishi, H | 1 |
| Nakano, M | 1 |
| Fiume, L | 1 |
| Bolondi, L | 1 |
| Busi, C | 1 |
| Chieco, P | 1 |
| Kratz, F | 1 |
| Lanza, M | 1 |
| Mattioli, A | 1 |
| Di Stefano, G | 1 |
| Liu, JG | 1 |
| Zhao, HJ | 1 |
| Liu, YJ | 1 |
| Wang, XL | 1 |
| Thirunavukkarasu, C | 2 |
| Premkumar, K | 2 |
| Jagadeeswaran, R | 1 |
| Ramakrishnan, G | 2 |
| Raghavendran, HR | 1 |
| Vinodhkumar, R | 2 |
| Devaki, T | 2 |
| Chakraborty, T | 1 |
| Chatterjee, A | 1 |
| Dhachinamoorthi, D | 1 |
| Srivastawa, S | 1 |
| Panayappan, L | 1 |
| Okamura, M | 1 |
| Ito, T | 2 |
| Augustine, TA | 1 |
| Jagan, S | 1 |
| Moreno, FS | 1 |
| Toledo, LP | 1 |
| de Conti, A | 1 |
| Heidor, R | 1 |
| Jordão, A | 1 |
| Vannucchi, H | 1 |
| Cardozo, MT | 1 |
| Ong, TP | 1 |
| Yadav, AS | 1 |
| Bhatnagar, D | 1 |
| Bunaciu, RP | 1 |
| Tharappel, JC | 1 |
| Kania-Korwel, I | 1 |
| Spear, BT | 1 |
| Kono, T | 1 |
| Takahashi, M | 1 |
| Kenmochi, Y | 1 |
| Yokouchi, Y | 1 |
| Sivaramakrishnan, V | 1 |
| Shilpa, PN | 1 |
| Praveen Kumar, VR | 1 |
| Niranjali Devaraj, S | 1 |
| Sheriff, AK | 1 |
| Okamura, T | 1 |
| Umemura, T | 1 |
| Yager, JD | 2 |
| Yager, R | 1 |
| Shinozuka, H | 1 |
| Lombardi, B | 2 |
| Schwartz, SJ | 1 |
| von Elbe, JH | 1 |
| Pariza, MW | 1 |
| Goldsworthy, T | 2 |
| Pitot, HC | 8 |
| Tsuda, H | 11 |
| Imaida, K | 7 |
| Sakata, T | 4 |
| Ito, N | 22 |
| Deml, E | 1 |
| Oesterle, D | 1 |
| Hiasa, Y | 5 |
| Enoki, N | 2 |
| Kitahori, Y | 4 |
| Konishi, N | 5 |
| Shimoyama, T | 2 |
| Ohshima, M | 6 |
| Masuda, A | 1 |
| Miyashiro, A | 1 |
| Hoover, KL | 2 |
| Lynch, PH | 2 |
| Poirier, LA | 2 |
| Hasegawa, R | 12 |
| Deangelo, AB | 1 |
| Garrett, CT | 1 |
| Shirachi, DY | 1 |
| Johansen, MG | 1 |
| McGowan, JP | 1 |
| Tu, SH | 1 |
| Diwan, BA | 9 |
| Rice, JM | 9 |
| Ward, JM | 12 |
| Campbell, HA | 1 |
| Longnecker, DS | 1 |
| Roebuck, BD | 1 |
| Benoit, MC | 1 |
| Preston, BD | 1 |
| Van Miller, JP | 1 |
| Moore, RW | 1 |
| Allen, JR | 1 |
| Goldfarb, S | 1 |
| Pugh, TD | 1 |
| Koen, H | 1 |
| He, YZ | 1 |
| Fujita, T | 1 |
| Yuasa, T | 1 |
| Mochizuki, Y | 1 |
| Furukawa, K | 1 |
| Sawada, N | 2 |
| Feron, VJ | 5 |
| Kruysse, A | 4 |
| Woutersen, RA | 1 |
| Ruebner, BH | 1 |
| Gershwin, ME | 1 |
| Hsieh, L | 1 |
| Dunn, P | 1 |
| Siglin, JC | 1 |
| Weghorst, CM | 3 |
| Rodwell, DE | 1 |
| Klaunig, JE | 4 |
| Yaono, M | 1 |
| Mizoguchi, Y | 1 |
| Nakamura, T | 2 |
| Ramesh, G | 1 |
| Das, UN | 1 |
| Nishii, K | 2 |
| Hayashi, I | 1 |
| Nakaoka, S | 2 |
| Yabuno, T | 1 |
| Okazaki, S | 1 |
| Hoshiya, T | 6 |
| Takahashi, S | 3 |
| Saito, K | 1 |
| Lok, E | 1 |
| Mehta, R | 1 |
| Jee, P | 1 |
| Laver, G | 1 |
| Nera, EA | 1 |
| McMullen, E | 1 |
| Clayson, DB | 1 |
| La Porta, CA | 1 |
| Comolli, R | 1 |
| Hemming, H | 1 |
| Bager, Y | 2 |
| Flodström, S | 4 |
| Nordgren, I | 1 |
| Kronevi, T | 1 |
| Ahlborg, UG | 1 |
| Wärngård, L | 5 |
| Takashi, M | 1 |
| Nakano, Y | 1 |
| Takagi, Y | 1 |
| Hibi, H | 1 |
| Miyake, K | 1 |
| Ogiso, T | 4 |
| Kim, SH | 1 |
| Lee, YS | 5 |
| Lee, MS | 2 |
| Kim, TH | 2 |
| Storer, RD | 1 |
| Cartwright, ME | 1 |
| Cook, WO | 1 |
| Soper, KA | 1 |
| Nichols, WW | 1 |
| Berberian, I | 1 |
| Chen, LC | 1 |
| Robinson, FR | 1 |
| Chow, CK | 1 |
| Kurata, Y | 5 |
| Hagiwara, A | 6 |
| Maisin, JR | 1 |
| Vankerkom, J | 1 |
| De Saint-Georges, L | 1 |
| Janowski, M | 1 |
| Lambiet-Collier, M | 1 |
| Mattelin, G | 1 |
| Wambersie, A | 1 |
| Merlino, GT | 1 |
| Zavanella, T | 2 |
| Radaelli, G | 2 |
| Girotti, P | 1 |
| Arias, E | 1 |
| Ameri, L | 1 |
| Presta, M | 1 |
| Mazzoleni, G | 1 |
| Ragnotti, G | 2 |
| Tanaka, H | 3 |
| Nagao, M | 2 |
| Sugimura, T | 2 |
| Blanck, A | 2 |
| Assefaw-Redda, Y | 2 |
| Eriksson, LC | 3 |
| Gustafsson, JA | 2 |
| Ekvärn, S | 1 |
| Hällström, IP | 2 |
| Kim, DJ | 4 |
| Lee, KK | 3 |
| Bae, JH | 2 |
| Godin, CS | 1 |
| Flemming, CD | 1 |
| Drerup, JM | 1 |
| Wall, HG | 1 |
| Standeven, AM | 1 |
| Wolf, DC | 2 |
| Goldsworthy, TL | 2 |
| Maronpot, RR | 1 |
| Foley, JF | 1 |
| Takahashi, K | 1 |
| Clark, G | 1 |
| Tritscher, A | 1 |
| Portier, C | 1 |
| Lucier, G | 1 |
| Takada, N | 1 |
| Matsuda, T | 1 |
| Otoshi, T | 1 |
| Yano, Y | 1 |
| Otani, S | 1 |
| Hasegawa, T | 1 |
| Nakae, D | 3 |
| Konishi, Y | 6 |
| Henneman, JR | 4 |
| Nims, RW | 4 |
| Cho, KJ | 2 |
| Uno, H | 1 |
| Waalkes, MP | 1 |
| Cherian, MG | 1 |
| Goyer, RA | 1 |
| Witschi, H | 1 |
| Wilson, DW | 1 |
| Plopper, CG | 1 |
| Melhem, MF | 1 |
| Kunz, HW | 1 |
| Gill, TJ | 1 |
| Asakawa, E | 1 |
| Sano, M | 2 |
| Shioya, S | 1 |
| Kojima, T | 1 |
| Kawamori, T | 1 |
| Yoshimi, N | 1 |
| Cabral, R | 2 |
| Hakoi, K | 5 |
| Boonyaphiphat, P | 1 |
| Lee, KW | 1 |
| Wang, HJ | 1 |
| Murphy, PA | 1 |
| Hendrich, S | 4 |
| Dragan, YP | 1 |
| Fahey, S | 1 |
| Nuwaysir, E | 1 |
| Sattler, C | 1 |
| Babcock, K | 1 |
| Vaughan, J | 1 |
| McCague, R | 1 |
| Jordan, VC | 1 |
| Kolaja, KL | 3 |
| Stevenson, DE | 2 |
| Walborg, EF | 2 |
| Liao, DZ | 1 |
| Ohlson, LC | 1 |
| Sahlin, L | 1 |
| Eneroth, P | 1 |
| Carthew, P | 1 |
| Nolan, BM | 1 |
| Smith, AG | 2 |
| Edwards, RE | 1 |
| Kim, HC | 1 |
| Nishikawa, A | 2 |
| Moser, GJ | 1 |
| Wong, BA | 1 |
| Okada, N | 1 |
| Honda, A | 1 |
| Kawabata, M | 1 |
| Yajima, N | 1 |
| Isenberg, JS | 1 |
| Ayoubi, SA | 1 |
| Watkins, JB | 1 |
| Taki, M | 1 |
| Watanabe, S | 1 |
| Wake, K | 1 |
| Aimoto, A | 1 |
| Kamimura, Y | 1 |
| Shimizu, I | 1 |
| Yasuda, M | 1 |
| Mizobuchi, Y | 1 |
| Ma, YR | 1 |
| Liu, F | 1 |
| Shiba, M | 1 |
| Horie, T | 1 |
| Ito, S | 1 |
| Takasuka, N | 1 |
| Kim, JM | 1 |
| Sekine, K | 1 |
| Ota, T | 1 |
| Asamoto, M | 2 |
| Murakoshi, M | 1 |
| Nir, Z | 1 |
| Kato, Y | 1 |
| Haag-Grönlund, M | 1 |
| Johansson, N | 1 |
| Fransson-Steen, R | 2 |
| Hâkansson, H | 1 |
| Scheu, G | 2 |
| Hong, JT | 1 |
| Singh, S | 1 |
| Khanduja, KL | 1 |
| Mittal, PK | 1 |
| Shiota, G | 1 |
| Harada, K | 1 |
| Ishida, M | 1 |
| Tomie, Y | 1 |
| Okubo, M | 1 |
| Katayama, S | 1 |
| Ito, H | 1 |
| Kawasaki, H | 1 |
| Rahman, KM | 2 |
| Sugie, S | 2 |
| Okamoto, K | 2 |
| Watanabe, T | 2 |
| Wang, GS | 1 |
| Xia, L | 1 |
| Olsson, J | 1 |
| Stål, P | 1 |
| Choe, GY | 1 |
| Kim, YI | 1 |
| Park, SH | 1 |
| Park, IA | 1 |
| Cardani, R | 1 |
| Lee, JH | 1 |
| van den Heiligenberg, S | 1 |
| Deprés-Brummer, P | 1 |
| Barbason, H | 1 |
| Claustrat, B | 1 |
| Reynes, M | 1 |
| Lévi, F | 1 |
| Denda, A | 5 |
| Kitayama, W | 1 |
| Yan, Y | 1 |
| Fukamachi, Y | 1 |
| Miura, M | 1 |
| Gotoh, S | 1 |
| Ikemura, K | 1 |
| Abe, T | 1 |
| Higashi, T | 1 |
| Higashi, K | 1 |
| Bhattacharya, S | 1 |
| Shoda, T | 1 |
| Onodera, H | 1 |
| Toyoda, K | 1 |
| Uneyama, C | 1 |
| Imazawa, T | 1 |
| Tessitore, L | 1 |
| Balansky, R | 1 |
| Gyosheva, B | 1 |
| Ganchev, G | 1 |
| Mircheva, Z | 1 |
| Minkova, S | 1 |
| Georgiev, G | 1 |
| Finnberg, N | 1 |
| Stenius, U | 1 |
| Högberg, J | 1 |
| Wyde, ME | 1 |
| Seely, J | 1 |
| Lucier, GW | 2 |
| Walker, NJ | 1 |
| Furukawa, F | 1 |
| Miyauchi, M | 1 |
| Nakamura, H | 1 |
| Son, HY | 1 |
| Yamagishi, M | 1 |
| Kaneno, R | 1 |
| Marchesan Rodrigues, MA | 1 |
| Fávero Salvadori, DM | 1 |
| Trindade Moreira, EL | 1 |
| Viana de Camargo, JL | 1 |
| Yoshino, H | 1 |
| Ogawa, K | 2 |
| Laconi, E | 1 |
| Tomasi, C | 1 |
| Curreli, F | 1 |
| Diana, S | 1 |
| Laconi, S | 1 |
| Serra, G | 1 |
| Collu, M | 1 |
| Pani, P | 2 |
| Viluksela, M | 1 |
| Tuomisto, JT | 1 |
| Unkila, M | 1 |
| Pohjanvirta, R | 1 |
| Kosma, VM | 1 |
| Mäki-Paakkanen, J | 1 |
| Vartiainen, T | 1 |
| Klimm, C | 1 |
| Schramm, KW | 1 |
| Tuomisto, J | 1 |
| Basak, R | 1 |
| Nakatani, T | 1 |
| Roy, G | 1 |
| Fujimoto, N | 1 |
| Asahara, T | 1 |
| Ito, A | 1 |
| Ou, YC | 1 |
| Conolly, RB | 1 |
| Thomas, RS | 1 |
| Xu, Y | 1 |
| Andersen, ME | 1 |
| Chubb, LS | 2 |
| Yang, RS | 1 |
| Iwai, S | 1 |
| Tanaka, R | 1 |
| Matsunaga, S | 1 |
| Yoshitake, A | 1 |
| Seki, S | 1 |
| Iatropoulos, MJ | 2 |
| Jeffrey, AM | 1 |
| Schlüter, G | 1 |
| Enzmann, HG | 1 |
| Williams, GM | 3 |
| Ushida, J | 1 |
| Minami, T | 1 |
| Kaneda, S | 1 |
| Otsuka, T | 1 |
| Jiao, Z | 1 |
| Suzuki, Y | 1 |
| Steinberg, P | 1 |
| Zschaler, I | 1 |
| Thom, E | 1 |
| Kuna, M | 1 |
| Wüst, G | 1 |
| Schäfer-Schwebel, A | 1 |
| Müller, R | 1 |
| Kramer, PJ | 1 |
| Weisse, G | 1 |
| Dean, CE | 1 |
| Benjamin, SA | 1 |
| Tessari, JD | 1 |
| Keefe, TJ | 1 |
| Rogers, AE | 1 |
| Kyono, Y | 1 |
| Wehner, AP | 1 |
| Busch, RH | 1 |
| Olson, RJ | 1 |
| Nettesheim, P | 1 |
| Creasia, DA | 1 |
| Mitchell, TJ | 1 |
| Reddy, TV | 2 |
| Daniel, FB | 1 |
| Lin, EL | 1 |
| Stober, JA | 1 |
| Olson, GR | 1 |
| Leveston, AO | 1 |
| Yada, H | 1 |
| Devor, DE | 1 |
| Lubet, RA | 3 |
| Amanuma, T | 1 |
| Maruyama, H | 3 |
| Tsujiuchi, T | 2 |
| Tsutsumi, M | 3 |
| Tiwawech, D | 1 |
| Takaba, K | 2 |
| Vickers, AE | 1 |
| Hietanen, E | 1 |
| Bartsch, H | 1 |
| Ahotupa, M | 1 |
| Béréziat, JC | 1 |
| Bussacchini-Griot, V | 1 |
| Cabral, JR | 2 |
| Camus, AM | 1 |
| Laitinen, M | 1 |
| Wild, H | 1 |
| Yoshiji, H | 1 |
| Kinugasa, T | 2 |
| Matsuzaki, M | 1 |
| Tsujii, T | 1 |
| Joong, KD | 1 |
| Thamavit, W | 2 |
| Pairojkul, C | 1 |
| Buchmann, A | 2 |
| Ziegler, S | 1 |
| Wolf, A | 1 |
| Durham, SK | 1 |
| Schwarz, M | 2 |
| Wada, S | 1 |
| Yamaguchi, S | 2 |
| Dietrich, DR | 1 |
| Swenberg, JA | 1 |
| Iwasaki, S | 1 |
| Appel, KE | 1 |
| Menden, M | 1 |
| Lagopoulos, L | 3 |
| Sunahara, GI | 2 |
| Würzner, H | 2 |
| Dombrowsky, I | 1 |
| Stalder, R | 3 |
| Tokumo, K | 1 |
| Xu, YH | 2 |
| Maronpot, R | 1 |
| Columbano, A | 1 |
| Ledda-Columbano, GM | 1 |
| Ennas, MG | 1 |
| Curto, M | 1 |
| Chelo, A | 1 |
| Shibata, MA | 1 |
| Arai, M | 2 |
| Fliesen, T | 1 |
| Duitsman, P | 1 |
| Krueger, SK | 1 |
| Jackson, A | 1 |
| Myers, RK | 1 |
| Sano, N | 1 |
| Otsuka, H | 1 |
| Kinouchi, T | 1 |
| Ohnishi, Y | 1 |
| Kato, T | 1 |
| Poirier, L | 1 |
| Moran, S | 1 |
| Nylen, ES | 1 |
| Becker, KL | 1 |
| Joshi, PA | 1 |
| Snider, RH | 1 |
| Schuller, HM | 1 |
| Takashima, Y | 2 |
| Eimoto, H | 2 |
| Shibata, M | 1 |
| Ura, H | 1 |
| Kitazawa, S | 1 |
| Hosokawa, S | 1 |
| Tatematsu, M | 2 |
| Aoki, T | 1 |
| Nakanowatari, J | 1 |
| Igarashi, T | 1 |
| Stewart, FP | 1 |
| Manson, MM | 1 |
| Yokoyama, S | 1 |
| Sells, MA | 1 |
| Mera, Y | 1 |
| LeBoeuf, RA | 1 |
| Laishes, BA | 1 |
| Hoekstra, WG | 1 |
| Greaves, P | 1 |
| Irisarri, E | 1 |
| Monro, AM | 1 |
| Sidransky, H | 2 |
| Verney, E | 2 |
| Wang, D | 2 |
| Gelderblom, WC | 2 |
| Marasas, WF | 2 |
| Jaskiewicz, K | 2 |
| Combrinck, S | 1 |
| van Schalkwyk, DJ | 1 |
| Thiel, PG | 1 |
| Horak, RM | 1 |
| Vleggaar, R | 1 |
| Kriek, NP | 1 |
| Hu, H | 2 |
| Masui, T | 1 |
| Inoue, K | 1 |
| Gans, JH | 1 |
| Pintauro, SJ | 1 |
| Takanashi, H | 1 |
| Homma, H | 1 |
| Matsui, M | 1 |
| Rosenberg, MR | 1 |
| Novicki, DL | 1 |
| Jirtle, RL | 1 |
| Novotny, A | 1 |
| Michalopoulos, G | 1 |
| Inoue, T | 1 |
| Suzuki, E | 1 |
| Okada, M | 1 |
| Shivapurkar, N | 1 |
| Wilson, MJ | 1 |
| Mikol, YB | 1 |
| Creasia, D | 1 |
| Yamashita, T | 1 |
| Lesna, M | 1 |
| Taylor, W | 1 |
| Drinkwater, NR | 1 |
| Ginsler, JJ | 1 |
| Nishizumi, M | 1 |
| Masuda, Y | 1 |
| Dove, LF | 1 |
267 other studies available for diethylnitrosamine and Body Weight
| Article | Year |
|---|---|
Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Proliferation; Cytokines; Diethylnitrosamine; Doco | 2021 |
Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats.
Topics: Animals; Antioxidants; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Lipids; Liver; Li | 2023 |
Protocatechuic acid as a potent anticarcinogenic compound in purple rice bran against diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogenesis; Diethylnitrosamine; Female; Glutathio | 2022 |
Chemoprotective Effect of Decalactone on Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Bilirubin; Body Weight; Carcinoma, Hepatocellular; Diethy | 2022 |
Modulation of EphA7 and pEphA7 Protein Expression: Potential Biomarkers for Early Detection of Hepatocellular Carcinoma.
Topics: alpha-Fetoproteins; Animals; Body Weight; Carcinoma, Hepatocellular; Caspase 3; Diethylnitrosamine; | 2022 |
Pueraria montana (Kudzu vine) Ameliorate the Inflammation and Oxidative Stress against Fe-NTA Induced Renal Cancer.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Creatinine; Cyclooxygenase 2; Diethylnitrosam | 2022 |
Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Topics: Animals; Body Weight; Carcinogenesis; Diethylnitrosamine; Dimethyl Fumarate; DNA Damage; Glyburide; | 2020 |
Nucleoredoxin interaction with flightless-I/actin complex is differentially altered in alcoholic liver disease.
Topics: Animals; Body Weight; Cell Proliferation; Cytochrome P-450 CYP2E1; Diethylnitrosamine; Ethanol; Fatt | 2020 |
Vicenin-2 Treatment Attenuated the Diethylnitrosamine-Induced Liver Carcinoma and Oxidative Stress through Increased Apoptotic Protein Expression in Experimental Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Apo | 2020 |
Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Bi | 2021 |
N-nitrosodiethylamine induces inflammation of liver in mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Inflammation; Liver; Liver Neoplasms, Experimental; Mice; | 2021 |
Relative Initial Weight Is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Emboliz | 2017 |
Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Lipids; | 2017 |
In vitro, In silico and In vivo Antitumor Activity of Crude Methanolic Extract of Tetilla dactyloidea (Carter, 1869) on DEN Induced HCC in a Rat Model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinoma, Hepatocellu | 2017 |
Altered cytokine profile under control of the serotonergic system determines the regulation of CYP2C11 and CYP3A isoforms.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Body Weight; Cytochrome P-450 CYP3A; Cytochrome | 2018 |
Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.
Topics: 5-Methoxypsoralen; Animals; Body Weight; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulat | 2018 |
Red and White Wine Lees Show Inhibitory Effects on Liver Carcinogenesis.
Topics: Alu Elements; Animals; Anticarcinogenic Agents; Body Weight; Catechols; Diethylnitrosamine; DNA Meth | 2019 |
B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach.
Topics: Animals; Biopsy; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Hepatic Veins; Humans; | 2019 |
Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Biomarkers, Tumor; Body Weight; Cell Proli | 2013 |
Protective effects of Scutellaria barbata against rat liver tumorigenesis.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-L-Fucosidase; Animals; Aspartate Aminotransferases | 2013 |
Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Body Weight; Cell Line, Tumor; Cell Pro | 2013 |
Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.
Topics: Animals; Apoptosis; Arsenicals; Aryl Hydrocarbon Hydroxylases; bcl-2-Associated X Protein; Body Weig | 2013 |
Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Biomarkers; Body Weight; Deoxyguanosine; | 2013 |
Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogenesis; Diethylnitrosamine | 2013 |
Diethylnitrosamine-induced cirrhosis in Wistar rats: an experimental feasibility study.
Topics: Animals; Blotting, Western; Body Weight; Diethylnitrosamine; Feasibility Studies; Lipid Peroxidation | 2015 |
Metformin inhibits early stage diethylnitrosamine‑induced hepatocarcinogenesis in rats.
Topics: Adenylate Kinase; Animals; Blotting, Western; Body Weight; Carcinogenesis; Carcinoma, Hepatocellular | 2016 |
Dietary sugar intake increases liver tumor incidence in female mice.
Topics: Adiposity; Animal Feed; Animals; Body Weight; Carcinogens; Dietary Fats; Dietary Sucrose; Diethylnit | 2016 |
Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice.
Topics: Animals; Apoptosis; beta Catenin; Biflavonoids; Body Weight; Carcinogenesis; Catechin; Cell Prolifer | 2016 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
Evaluation of antioxidant and stabilizing lipid peroxidation nature of Solanum xanthocarpum leaves in experimentally diethylnitrosamine induced hepatocellular carcinogenesis.
Topics: Animals; Antioxidants; Biomarkers, Tumor; Body Weight; Carcinogenesis; Diethylnitrosamine; Lipid Per | 2016 |
Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects.
Topics: Animals; Animals, Suckling; Body Weight; Carcinogenesis; Cytochrome P-450 CYP2E1; Cytochrome P-450 E | 2016 |
Evaluation of the PIGRET assay as a short-term test using a single dose of diethylnitrosamine.
Topics: Animals; Body Weight; Diethylnitrosamine; Erythrocytes; Female; Male; Membrane Proteins; Mutagenicit | 2016 |
Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.
Topics: Administration, Oral; Animals; Body Weight; Cell Proliferation; Chenodeoxycholic Acid; Diethylnitros | 2017 |
Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile.
Topics: Animals; Apoptosis; Body Weight; Caloric Restriction; Cell Proliferation; Cell Transformation, Neopl | 2017 |
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Dieth | 2008 |
Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Gene Expres | 2009 |
Hepatocarcinogenic susceptibility of fenofibrate and its possible mechanism of carcinogenicity in a two-stage hepatocarcinogenesis model of rasH2 mice.
Topics: Animals; Body Weight; Carcinogenicity Tests; Diethylnitrosamine; Disease Models, Animal; Fenofibrate | 2008 |
Protective role of chickpea seed coat fibre on N-nitrosodiethylamine-induced toxicity in hypercholesterolemic rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cicer; Dietary Fiber; Diethylnitrosami | 2009 |
Metalloproteinases 2 and 9 activity during promotion and progression stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diethylnitrosamine; Disease Progression; Glutathione S- | 2009 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice.
Topics: Alkylating Agents; Animals; Antioxidants; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell | 2009 |
Maté attenuates DNA damage and carcinogenesis induced by diethylnitrosamine and thermal injury in rat esophagus.
Topics: Animals; Anticarcinogenic Agents; Aquifoliaceae; Aspartate Aminotransferases; Beverages; Body Weight | 2009 |
Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark.
Topics: Acacia; Animals; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Carcinogens; Diethylnitrosami | 2009 |
A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Body | 2009 |
Absence of chemopreventive influence of propolis on the rat liver altered foci development.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Brazil; Cocarcinogenesis; Diethylnitrosamine; Glutath | 2010 |
Mechanistic study on hepatocarcinogenesis of piperonyl butoxide in mice.
Topics: Activating Transcription Factor 3; Animals; Body Weight; Carcinogenicity Tests; Cyclin D; Diethylnit | 2009 |
Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Body Weight; Cell Proliferation; Cyclophospha | 2010 |
Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat.
Topics: Actins; Alkylating Agents; Animals; Blotting, Western; Body Weight; Cell Cycle; Cell Cycle Proteins; | 2009 |
Potassium bromate enhances N-ethyl-N-hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Bromates; Carcinogens; Deoxyguanosine; Diethylnit | 2009 |
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arrestins; beta-Arrestin | 2011 |
Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Enzyme Induc | 2011 |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy | 2011 |
Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Carcinogens; Deoxyguanosine; Diethylnitrosamine; | 2011 |
Mechanistic study on liver tumor promoting effects of flutamide in rats.
Topics: Androgen Antagonists; Animals; Body Weight; Diethylnitrosamine; Flutamide; Immunohistochemistry; Lip | 2012 |
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways.
Topics: Animals; beta Catenin; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cell Adhesion; Cel | 2012 |
Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Allyl Compounds; Animals; Anticarcinogenic Agents; Antioxidants; Apopto | 2012 |
A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biphenyl Compounds; Body Weight; Cell Line; Di | 2012 |
Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl4-induced hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Body Weight; Carbon Tetrachloride; Ca | 2012 |
Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Indole | 2013 |
[Influence of bear bile on rat hepatocarcinoma induced by diethylnitrosamine].
Topics: Actins; Alanine Transaminase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Bile; Bil | 2012 |
1alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes and the development of gamma-glutamyltranspeptidase-positive foci in diethylnitrosamine-initiated and streptozotocin-induced diabetes-promoted hepatocarcinogenesis.
Topics: Animals; Body Weight; Calcitriol; Cytoplasm; Diabetes Mellitus, Experimental; Diethylnitrosamine; En | 2002 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body | 2003 |
Inhibition of nitrosodiethylamine-induced hepatocarcinogenesis by dietary turmeric in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Curcuma; Diet; Diethylnitrosamine; Dose-Response Rela | 2003 |
Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia.
Topics: Animals; Animals, Newborn; Body Weight; Carcinogens; Diethylnitrosamine; Gene Expression Regulation; | 2003 |
Suppressive effect of herbal compound 861 on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Blotting, Northern; Blotting, Western; Body Weight; Diethylnitrosami | 2003 |
Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Eati | 2003 |
TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Blotting, Western; Body Weight; Carcinoma, Hepatocellular; Cyc | 2003 |
Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model.
Topics: 2-Acetylaminofluorene; Adenoma, Liver Cell; Administration, Oral; Animals; Biphenyl Compounds; Body | 2004 |
Inhibitory effects of KAT-681, a liver-selective thyromimetic, on development of hepatocellular proliferative lesions in rats induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Body Weight; Carcinogens; Cell Proliferation; Diethylnitr | 2004 |
Combined supplementation of vanadium and beta-carotene suppresses placental glutathione S-transferase-positive foci and enhances antioxidant functions during the inhibition of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: Animals; Antioxidants; beta Carotene; Body Weight; Cytosol; Diethylnitrosamine; Drug Synergism; Fema | 2004 |
Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes.
Topics: Agouti Signaling Protein; Albumins; Animals; Blood Glucose; Body Weight; Carcinogens; Diabetes Melli | 2004 |
Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.
Topics: Animals; Antioxidants; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Dru | 2004 |
Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Body Weight; Carcinogens; Citrus; Coumari | 2004 |
Absence of carcinogenic and anticarcinogenic effects of annatto in the rat liver medium-term assay.
Topics: Animals; Anticarcinogenic Agents; Bixaceae; Body Weight; Carcinogens; Carotenoids; Comet Assay; Diet | 2004 |
Different inhibitory effects in the early and late phase of treatment with KAT-681, a liver-selective thyromimetic, on rat hepatocarcinogenesis induced by 2-acetylaminofluorene and partial hepatectomy after diethylnitrosamine initiation.
Topics: 2-Acetylaminofluorene; Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell P | 2005 |
A modified rat model for hepatocellular carcinoma.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Laparot | 2004 |
Apigenin inhibits oxidative stress-induced macromolecular damage in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinogenesis in Wistar albino rats.
Topics: Albinism; Animals; Antioxidants; Apigenin; Body Weight; Carcinogenicity Tests; Diethylnitrosamine; D | 2005 |
Suppression of chemically-induced liver tumors by castration or estradiol-3-benzoate treatment in F344 rats.
Topics: Animals; Blotting, Western; Body Weight; Diethylnitrosamine; Estradiol; Estrogen Receptor alpha; Imm | 2005 |
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa.
Topics: Animals; Body Weight; Chlorella; Diet; Diethylnitrosamine; Eating; Glutathione Transferase; Immunohi | 2005 |
Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Doxorub | 2005 |
Effect of selenium-enriched malt on hepatocarcinogenesis, paraneoplastic syndrome and the hormones regulating blood glucose in rats treated by diethylnitrosamine.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Calcium; Carcinogens; Diethylnitrosamine; Edible | 2006 |
The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels.
Topics: alpha-Fetoproteins; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 2005 |
Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Lipid Perox | 2006 |
Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; DNA Damage; gamma-Glutamyltransfe | 2006 |
Gene expression analysis on the dicyclanil-induced hepatocellular tumors in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinoma, Hepatocellular; Cocarcinogenesis; Diethylnitrosamine; DN | 2006 |
Effect of silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; alpha-Fetoproteins; Animals; Antioxidants; Aspartate Ami | 2007 |
Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage.
Topics: Animals; Antineoplastic Agents; Body Weight; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, | 2007 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocyte | 2007 |
The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats.
Topics: Administration, Oral; Alkylating Agents; Animals; Body Weight; Carcinogens, Environmental; Cell Prol | 2007 |
Enhancement of hepatocellular proliferative activity of kojic acid in mice by a simultaneous administration of ascorbic acid.
Topics: Animals; Antioxidants; Ascorbic Acid; Body Weight; Diethylnitrosamine; Drug Interactions; Immunohist | 2007 |
Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Body Weight; Carcinoembryonic Antigen; Carcinoma, Hepatoc | 2008 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Possible involvement of oxidative stress in fenofibrate-induced hepatocarcinogenesis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Body Weight; Carcinogens; Deoxyguanosine; D | 2008 |
Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats.
Topics: Adenoma; Animals; Body Weight; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Diet; Diethyln | 1980 |
Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
Topics: Animals; Body Weight; Choline; Cocarcinogenesis; Diet; Diethylnitrosamine; gamma-Glutamyltransferase | 1980 |
Inability of red beet betalain pigments to initiate or promote hepatocarcinogenesis.
Topics: Animals; Betalains; Body Weight; Carcinogens; Diethylnitrosamine; Female; Food Coloring Agents; gamm | 1983 |
Modification of carcinogenesis by antioxidants and other compounds.
Topics: Acetaminophen; Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnit | 1984 |
Sex-dependent promoting effect of polychlorinated biphenyls on enzyme-altered islands induced by diethylnitrosamine in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Live | 1982 |
DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Mal | 1984 |
Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Folic Acid; Kidney Neoplasms; Lead; Male; Nit | 1984 |
Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetates; Animals; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Kidney Neopla | 1984 |
Profound postinitiation enhancement by short-term severe methionine, choline, vitamin B12, and folate deficiency of hepatocarcinogenesis in F344 rats given a single low-dose diethylnitrosamine injection.
Topics: Animals; Body Weight; Choline; Diet; Diethylnitrosamine; Drug Synergism; Folic Acid Deficiency; Live | 1984 |
Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Anisoles; Body Weight; Butylated Hydroxyanisole; Carcinogens; Diethylnitrosamine; Drug Inte | 1983 |
Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.
Topics: Animals; Body Weight; Diet; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Interactions; Enzyme In | 1983 |
Tumorigenic effect of sodium arsenite in rat kidney.
Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neopl | 1983 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol but not estradiol.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Estradiol; Ethinyl Estradiol; Female; Liver N | 1984 |
Promoting effects of polychlorinated biphenyls (Aroclor 1254) and polychlorinated dibenzofuran-free Aroclor 1254 on diethylnitrosamine-induced tumorigenesis in the rat.
Topics: Animals; Aroclors; Benzofurans; Body Weight; Carcinogens; Chlorodiphenyl (54% Chlorine); Cocarcinoge | 1981 |
Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Cell Division; Diethylnitrosamine; Liver Neopla | 1983 |
beta-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; beta-Cyclodextrins; Body Weight; Carcinogens; Cocarcinogenesis; Cyclodextrins; Dextrins; Di | 1982 |
Effects of various concentrations of ethyl-alpha-p-chlorophenoxyisobutyrate (clofibrate) on diethylnitrosamine-induced hepatic tumorigenesis in the rat.
Topics: Animals; Body Weight; Clofibrate; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1982 |
Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine.
Topics: Acetaldehyde; Aerosols; Animals; Benzopyrenes; Body Weight; Carcinoma; Cricetinae; Diethylnitrosamin | 1982 |
Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse.
Topics: Aging; Animals; Body Weight; Dieldrin; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbred | 1980 |
Gender-dependent differences in hepatic tumor promotion in diethylnitrosamine initiated infant B6C3F1 mice by alpha-hexachlorocyclohexane.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; DNA, Neoplasm; Drug Interactions; Female; Hex | 1995 |
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Glutathione | 1995 |
Effect of dietary fat on diethylnitrosamine induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Body Weight; Dietary Fats; Diethylnitrosamine; Fatty Acids; Lipid Peroxides; Liver Neoplasm | 1995 |
Inhibitory effect of potassium citrate on rat renal tumors induced by N-ethyl-N-hydroxyethylnitrosamine followed by potassium dibasic phosphate.
Topics: Alpha-Globulins; Animals; Body Weight; Calcium; Citrates; Citric Acid; Diethylnitrosamine; Kidney; K | 1993 |
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenoma; Administration, Oral; Alpha-Globulins; Animals; Body Weight; Carcinoma, Renal Cell; Catecho | 1993 |
The effect of butylated hydroxytoluene on the growth of enzyme-altered foci in male Fischer 344 rat liver tissue.
Topics: 2-Acetylaminofluorene; Analysis of Variance; Animals; Antioxidants; Body Weight; Butylated Hydroxyto | 1995 |
Over-expression of protein kinase C delta is associated with a delay in preneoplastic lesion development in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Caseins; Diet; Diethylnitrosamine; gamma-G | 1995 |
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; F | 1995 |
Liver tumour promoting activity of 3,4,5,3',4'-pentachlorobiphenyl and its interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy; Liver; Liver Neopl | 1995 |
Initiation-stage enhancement by uracil of N-ethyl-N-hydroxyethylnitrosamine-induction of kidney carcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Diethylnitrosamine; Drug Synergism; Female; Kidne | 1994 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; | 1995 |
Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Female; Gamma Rays; Glutathione Transferase; Liver; Liver | 1994 |
Short-term carcinogenesis bioassay of genotoxic procarcinogens in PIM transgenic mice.
Topics: 2-Acetylaminofluorene; Animals; Benzene; Biotransformation; Body Weight; Carcinogenicity Tests; Carc | 1995 |
Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl and 2,2',4,4',5,5'-hexachlorobiphenyl in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Diterpenes; Drug Interact | 1995 |
Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Topics: Administration, Oral; Agricultural Workers' Diseases; Animals; Body Weight; Diethylnitrosamine; Dise | 1995 |
Effect of neutrons alone or combined with diethylnitrosamine on tumor induction in the livers of infant C57BL mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Ma | 1995 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Evaluation of the tumor-promoting activity of two beta-adrenoreceptor blocking agents, propranolol and atenolol, in liver of Fischer 344 rats.
Topics: Animals; Atenolol; Body Weight; Carcinogens; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1994 |
Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogens; Diethylnitro | 1994 |
Growth hormone administration after treatment in the resistant hepatocyte model does not affect progression of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Body Weight; Cell Division; Diethylnitrosamine; Fem | 1994 |
Biphasic modifying effect of indole-3-carbinol on diethylnitrosamine-induced preneoplastic glutathione S-transferase placental form-positive liver cell foci in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Enzyme Inducti | 1994 |
Evaluation of the promotion potential of chlorotrifluoroethylene trimer acid in male Sprague-Dawley rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Drug Synergism; Fatty Acids; gamma-Gluta | 1993 |
Interactive effects of unleaded gasoline and estrogen on liver tumor promotion in female B6C3F1 mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Estradiol; Estrogen Antagonists; Estrog | 1994 |
Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.
Topics: Animals; Body Weight; Cell Division; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; G | 1993 |
Enhancement by organosulfur compounds from garlic and onions of diethylnitrosamine-induced glutathione S-transferase positive foci in the rat liver.
Topics: Allium; Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Drug Synergism; Garlic; Glutathio | 1994 |
Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
Topics: Adenoma; Animals; Body Weight; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; | 1993 |
Effects of carbon tetrachloride, ethanol and acetaldehyde on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Acetaldehyde; Animals; Animals, Newborn; Body Weight; Carbon Tetrachloride; Diethylnitrosamine; Etha | 1993 |
Alterations in populations of GST-p-immunoreactive single hepatocytes and hepatocellular foci after a single injection of N-nitrosodiethylamine with or without phenobarbital promotion in male F344/NCr rats.
Topics: Animals; Body Weight; Cells, Cultured; Diethylnitrosamine; Glutathione Transferase; Liver; Male; Org | 1993 |
Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cadmium; Diethylnitrosamine; Liver; Liver Neoplasms, | 1993 |
Modulation of N-nitrosodiethylamine-induced hamster lung tumors by ozone.
Topics: Administration, Inhalation; Animals; Body Weight; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; | 1993 |
A major histocompatibility complex-linked locus in the rat critically influences resistance to diethylnitrosamine carcinogenesis.
Topics: Animals; Body Weight; Diethylnitrosamine; Genetic Linkage; Liver Neoplasms; Liver Neoplasms, Experim | 1993 |
No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.
Topics: Animals; Ascorbic Acid; Body Weight; Carcinogens; Diethylnitrosamine; Glutamates; Male; Methylnitros | 1993 |
Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by a simple phenolic acid protocatechuic acid in rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Sche | 1993 |
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
Topics: Animals; Body Weight; Captan; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Diethylnitrosami | 1993 |
Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diethylnitrosamine; Female; gamma-Glutam | 1995 |
Medium-term bioassay for the hepatocarcinogenicity of hexachlorobenzene.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dose-Response Relation | 1996 |
The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Dose-Response Relationship, Drug; | 1996 |
Promotion potential of tamoxifen on hepatocarcinogenesis in female SD or F344 rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, | 1996 |
Selective dieldrin promotion of hepatic focal lesions in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diethylnitrosamine; DNA, Neop | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Role of the pituitary in tumor promotion with ethinyl estradiol in rat liver.
Topics: Animals; Body Weight; Bromocriptine; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Estradiol Co | 1996 |
Iron promotes DEN initiated GST-P foci in rat liver.
Topics: Animals; Biomarkers; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitros | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosami | 1997 |
Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Estrus; Female; Gasoline; Liver Neoplasms; Ma | 1997 |
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; DNA; Drug Synergism; Lac Op | 1997 |
Inhibition of WY-14,643 induced hepatic lesion growth in mice by rotenone.
Topics: Adenoma; Animals; Apoptosis; Body Weight; Bromodeoxyuridine; Carcinogens; Diethylnitrosamine; DNA; L | 1997 |
Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay.
Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Corticosterone; Diethylnitrosamine; Electromagnet | 1998 |
Suppressive effect of oestradiol on chemical hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers, Tumor; Body Weight; Diethylnitrosamine; Estradiol; Femal | 1998 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethy | 1997 |
Initiation and promotion of altered hepatic foci in female rats and inhibition of cell-cell communication by the imidazole fungicide prochloraz.
Topics: Animals; Body Weight; Carcinogens; Cell Communication; Cell Line; Diethylnitrosamine; Epithelial Cel | 1998 |
Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Dose-Res | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Effect of 50 Hz sinusoidal electromagnetic field on the kinetics of 14CO2 exhalation after [14C]-N-nitrosodiethylamine administration in mice.
Topics: Animals; Body Burden; Body Weight; Carbon Dioxide; Carbon Radioisotopes; Carcinogens; Diethylnitrosa | 1999 |
Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Diethylnitrosamine; Disease Models, Animal; | 1999 |
Modulating effects of diets high in omega-3 and omega-6 fatty acids in initiation and postinitiation stages of diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Corn Oil; Diet, Fat-Restricted; Dietary Fats, | 1999 |
Dietary iron overload inhibits carbon tetrachloride-induced promotion in chemical hepatocarcinogenesis: effects on cell proliferation, apoptosis, and antioxidation.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Carbon Tetrachloride; Carcinogens; Cell Division; Die | 1999 |
Correlation of changes in natural killer cell activity and glutathione S-transferase placental form positive hepatocytes in diethylnitrosamine-induced rat hepatocarcinogenesis.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Female; Glutathione Transferase; Killer Cells | 1999 |
Influence of beta-adrenergic antagonists on cell proliferation rates in the kidney of untreated and diethylnitrosamine-treated male F344 rats.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Body Weight; Carcinogens; Cell Division; Diethylnitr | 1999 |
Maternal or paternal exposure to radiation increases susceptibility to the induction of glutathione S-transferase-positive hepatic foci in offspring rats.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Diethylnitrosamine; Disease Susceptibility; Enzyme | 1998 |
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Temperature; Body Weight; Carcinogens; Circadian Rhythm; Diethylnitrosamine; Laparotom | 1999 |
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
Topics: Animals; Blotting, Northern; Body Weight; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA; | 1999 |
Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diethylnitrosamine; Drinking Behavior; E | 1999 |
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Clofibrate; Connexins; Cytochrome P-450 En | 1999 |
Apoptosis and cell proliferation are involved in the initiation of liver carcinogenesis by a subnecrogenic dose of diethylnitrosamine in refed rats.
Topics: Analysis of Variance; Animals; Apoptosis; Autoradiography; Body Weight; Cell Division; Diethylnitros | 2000 |
Inhibitory effects of freeze-dried milk fermented by selected Lactobacillus bulgaricus strains on carcinogenesis induced by 1,2-dimethylhydrazine in rats and by diethylnitrosamine in hamsters.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Biological Therapy; Body Weight; Carcinogen | 1999 |
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Fe | 2000 |
Toxicity of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in diethylnitrosamine-initiated ovariectomized rats implanted with subcutaneous 17 beta-estradiol pellets.
Topics: Animals; Body Weight; Clinical Chemistry Tests; Cocarcinogenesis; Diethylnitrosamine; Drug Implants; | 2000 |
Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenocarcinoma; Adenoma; Adrenal Glands; Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitros | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxyb | 2000 |
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Topics: Adrenocorticotropic Hormone; Alkylating Agents; Animals; Biological Assay; Body Weight; Bromodeoxyur | 2000 |
Early exposure to restraint stress enhances chemical carcinogenesis in rat liver.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Glutathione Transf | 2000 |
Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Cytochrome P-4 | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Sex hormone dependency of diethylnitrosamine-induced liver tumors in mice and chemoprevention by leuprorelin.
Topics: Animals; Antineoplastic Agents, Hormonal; Body Weight; Crosses, Genetic; Diethylnitrosamine; Estradi | 2001 |
A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.
Topics: Animals; Biological Assay; Body Weight; Calibration; Carcinogens; Cell Count; Cell Division; Chlorob | 2001 |
Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Body Weight; Chemoprevention; Diethylnitrosamin | 2001 |
Bioassay of mannitol and caprolactam and assessment of response to diethylnitrosamine in heterozygous p53-deficient (+/-) and wild type (+/+) mice.
Topics: Administration, Oral; Alkylating Agents; Animals; Apoptosis; Biological Assay; Body Weight; Caprolac | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogenicity Tests; Carcinoma, Hepatocellular; C | 2001 |
The polycyclic musk 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthaline lacks liver tumor initiating and promoting activity in rats exposed to human-relevant doses.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; | 2001 |
Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers.
Topics: Adipose Tissue; Animals; Body Weight; Carcinogens; Constitutive Androstane Receptor; Diethylnitrosam | 2002 |
Reduction of N-nitrosodiethylamine carcinogenesis in rats by lipotrope or amino acid supplementation of a marginally deficient diet.
Topics: Amino Acids; Animals; Body Weight; Carcinoma, Hepatocellular; Choline; Diet; Dietary Fats; Diethylni | 1977 |
Effects of exposure to acetaldehyde in syrian hamsters simultaneously treated with benzo(a)pyrene or diethylnitrosamine.
Topics: Acetaldehyde; Animals; Benzopyrenes; Body Weight; Cocarcinogenesis; Cricetinae; Diethylnitrosamine; | 1979 |
Temperature effects during and after the diethylnitrosamine treatment on liver tumorigenesis in the fish, Oryzias latipes.
Topics: Animals; Body Weight; Diethylnitrosamine; Fishes; Japan; Liver Neoplasms; Neoplasms, Experimental; N | 1978 |
Effects of exposure to furfural vapour in hamsters simultaneously treated with benzo[alpha] pyrene or diethylnitrosamine.
Topics: Adenoma; Animals; Benzopyrenes; Body Weight; Carcinoma; Cocarcinogenesis; Cricetinae; Diethylnitrosa | 1978 |
Effects of exposure to acrolein vapor in hamsters simultaneously treated with benzo[a]pyrene or diethylnitrosamine.
Topics: Acrolein; Aerosols; Aldehydes; Animals; Benzopyrenes; Body Weight; Carcinogens; Cricetinae; Diethyln | 1977 |
Effects of diethylnitrosamine and cigarette smoke on hamsters.
Topics: Animals; Body Weight; Cricetinae; Diethylnitrosamine; Humans; Laryngeal Diseases; Liver Cirrhosis; L | 1976 |
Repeated exposure to cyclopentenone vapour: long-term study in Syrian golden hamsters.
Topics: Amyloidosis; Animals; Benzopyrenes; Body Weight; Cricetinae; Cyclopentanes; Diethylnitrosamine; Fema | 1976 |
Carcinogenic and cocarcinogenic effects of inhaled synthetic smog and ferric oxide particles.
Topics: Air Pollutants; Animals; Body Weight; Carcinogens; Cricetinae; Diethylnitrosamine; Drug Synergism; F | 1975 |
Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.
Topics: Analysis of Variance; Animals; Body Weight; Chloroform; Cytochrome P-450 CYP1A1; Cytochrome P-450 CY | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats.
Topics: Allyl Compounds; Animals; Body Weight; Carcinogens; Colonic Neoplasms; Diethylnitrosamine; Disulfide | 1992 |
Progressive atypia in spontaneous and N-nitrosodiethylamine-induced hepatocellular adenomas of C3H/HeNCr mice.
Topics: Aging; Animals; Body Weight; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male; | 1992 |
Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.
Topics: Animals; Barbiturates; Body Weight; Cocarcinogenesis; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzy | 1992 |
The insecticide endosulfan and its two stereoisomers promote the growth of altered hepatic foci in rats.
Topics: Animals; Body Weight; Carcinogens; Diethylnitrosamine; Endosulfan; Hepatectomy; Liver Neoplasms; Mal | 1992 |
Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Animals; Body Weight; Bromodeoxyuridine; Carcinogens; Carcinoma, Renal Cell; Copper; Copper Sulfate; | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Topics: Animals; Antioxidants; Benzodioxoles; Body Weight; Bromodeoxyuridine; Butylated Hydroxyanisole; Cate | 1992 |
Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats.
Topics: Animals; Body Weight; Cell Count; Cell Division; Cell Fractionation; Cell Separation; Diethylnitrosa | 1991 |
Mechanisms of fat-related modulation of N-nitrosodiethylamine-induced tumors in rats: organ distribution, blood lipids, enzymes and pro-oxidant state.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Body Weight; Cell Mem | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
Promotion of rat hepatocarcinogenesis by praziquantel.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Diethylnitrosa | 1991 |
Effects of polychlorinated biphenyls in rat liver: correlation between primary subcellular effects and promoting activity.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethy | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
The presence of alpha 2u-globulin is necessary for d-limonene promotion of male rat kidney tumors.
Topics: Adenoma; Alpha-Globulins; Animals; Body Weight; Carcinogens; Cell Division; Cyclohexenes; Diethylnit | 1991 |
Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses.
Topics: Amines; Animals; Body Weight; Carcinogenicity Tests; Carcinogens, Environmental; Diethylnitrosamine; | 1991 |
Effect of varying the concentration of phenobarbital and its duration of treatment on the evolution of carcinogen induced enzyme-altered foci in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Rela | 1991 |
The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumours and its correlation to insulinaemia.
Topics: Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Eating; Female; | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carbon Tetrachloride; Cell Division; Diethylnitrosa | 1990 |
Lack of modifying effects of p-phenylenediamine on induction of gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Drug Interactions; Enzyme Induction; gamma-Glutamyltransfe | 1990 |
The correlation of body growth with diethylnitrosamine-induced hepatocarcinogenesis in relation to serum insulin and somatomedin-C.
Topics: Animals; Body Weight; Caffeine; Diethylnitrosamine; Eating; Fasting; Injections, Intraperitoneal; In | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indole | 1991 |
Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Analysis of Variance; Animals; Body Weight; Butylated Hydroxyanisole; Diethylnitrosamine; Eating; Li | 1991 |
Tumor promoting potential in male F344 rats and mutagenicity in Salmonella typhimurium of dipyrone.
Topics: Animals; Body Weight; Diethylnitrosamine; Dipyrone; Dose-Response Relationship, Drug; Drinking; Kidn | 1991 |
Lack of hepatotoxicity or promotion of enzyme-altered liver foci development in rats treated with harman or norharman.
Topics: Alkaloids; Animals; Body Weight; Carbolines; Cocarcinogenesis; Diethylnitrosamine; Glutathione Trans | 1990 |
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver.
Topics: Animals; Body Weight; Choline Deficiency; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, Ex | 1990 |
Pulmonary bombesin and calcitonin in hamsters during exposure to hyperoxia and diethylnitrosamine.
Topics: Animals; Body Weight; Bombesin; Calcitonin; Chromatography, High Pressure Liquid; Cricetinae; Cytopl | 1990 |
Lack of hepatocarcinogenic potential of acetaminophen in rats with liver damage associated with a choline-devoid diet.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Choline Deficiency; Diethylnitrosamine; Female; Gl | 1990 |
Lack of modifying effects of 2,2'-[(4-aminophenyl) imino] bisethanol sulfate on induction of preneoplastic gamma-glutamyl transpeptidase-positive foci in a medium-term bioassay system using F344 rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Eating; gamma-Glutamyltransferase; Hair | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethyl | 1989 |
Modulation of diethylnitrosamine-initiated placental glutathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; Female; Glutathione Transferase; Immunoenzyme | 1989 |
Hexachlorobenzene as a promoter of diethylnitrosamine-initiated hepatocarcinogenesis in rats and comparison with induction of porphyria.
Topics: Animals; Body Weight; Carcinogens; Chlorobenzenes; Diethylnitrosamine; Female; Hexachlorobenzene; Li | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransf | 1985 |
Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase.
Topics: Animals; Anisoles; Body Weight; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Diethylnitrosami | 1985 |
Inhibitory potential of acetaminophen and o-, m-, p- aminophenols for development of gamma-glutamyltranspeptidase-positive liver cell foci in rats pretreated with diethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; gamma-Glutamyltransferase; Li | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, D | 1985 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Effects of varying fat content of a high tryptophan diet on the induction of gamma-glutamyltranspeptidase positive foci in the livers of rats treated with hepatocarcinogen.
Topics: Animals; Body Weight; Diet; Dietary Fats; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy | 1986 |
Influence of level of dietary protein on tryptophan-induced promotional activity in induction of gamma-glutamyl transpeptidase-positive foci of rat liver.
Topics: Animals; Body Weight; Dietary Proteins; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; | 1987 |
Cancer promoting potential of different strains of Fusarium moniliforme in a short-term cancer initiation/promotion assay.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Ducks; Fusarium; gamma-Glutamyltransfera | 1988 |
Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme.
Topics: Animals; Body Weight; Carcinogens, Environmental; Chromatography; Diethylnitrosamine; Fumonisins; Fu | 1988 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aniline Compounds; Animals; Body Weight; Butylated Hydroxyanis | 1986 |
Liver scarring induced by polychlorinated biphenyl administration to mice previously treated with diethylnitrosamine.
Topics: Animals; Aroclors; Body Weight; Chlorodiphenyl (54% Chlorine); Cicatrix; Diethylnitrosamine; Fibrosi | 1986 |
Effects of administration of N-nitrosodialkylamines and N-nitrodiethylamine on hepatic UDP-glucuronosyltransferase activity in Wistar rats.
Topics: Aminophenols; Animals; Body Weight; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Glucuron | 1988 |
Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Kidney Neoplasms; Kidney Tubules; Male; | 1985 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; En | 1988 |
Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder.
Topics: Animals; Ascorbic Acid; Body Weight; Butylhydroxybutylnitrosamine; Citrates; Citric Acid; Diethylnit | 1988 |
Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets.
Topics: Animals; Body Weight; Choline; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; | 1986 |
Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl)phthalate in rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylhexyl Phthalate | 1987 |
Reciprocal modifying effects of isomeric forms of aminophenol on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.
Topics: Acetaminophen; Aminophenols; Animals; Body Weight; Diethylnitrosamine; Glutathione Transferase; Kidn | 1987 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Liver lesions in BALB/C mice induced by an anabolic androgen (Decadurabolin), with and without pretreatment with diethylnitrosamine.
Topics: Anabolic Agents; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Mal | 1986 |
Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice.
Topics: Alleles; Animals; Body Weight; Crosses, Genetic; Diethylnitrosamine; DNA; Female; Liver Neoplasms, E | 1986 |
The chronic hepatotoxic, tumor-promoting, and carcinogenic effects of acetaminophen in male B6C3F1 mice.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnit | 1986 |
Enhancing effect of 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran on diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Benzofurans; Body Weight; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Polymers | 1986 |
The influence of food intake on the development of diethylnitrosamine-induced liver tumours in mice.
Topics: Animals; Body Weight; Diethylnitrosamine; Energy Intake; Food Deprivation; Liver; Liver Neoplasms; M | 1987 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe | 1985 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |