diethylnitrosamine has been researched along with Angiogenesis, Pathologic in 35 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 7.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 5.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 5.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| " The aim of this study was to investigate molecular mechanisms for the chemopreventive effects of folic acid and tributyrin alone or in combination on rat hepatocarcinogenesis." | 3.80 | Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. ( Beland, FA; Campos, A; Carrilho, J; de Conti, A; Furtado, KS; Fuscoe, JC; Guariento, AH; Han, T; Moreno, FS; Pogribny, IP; Purgatto, E; Ross, SA; Shinohara, EM; Tryndyak, V, 2014) |
| "Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide." | 1.62 | Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis. ( Fares, NH; Mahmoud, AA; Mahmoud, YI; Shehata, AMM, 2021) |
| "Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis." | 1.48 | In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa ( Fathy, M; Nikaido, T, 2018) |
| "Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy." | 1.46 | Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis. ( Duraikannu, A; Fredrick, WS; Gobalakrishnan, R; Kodisundaram, P; Ravichandran, S; Sadeeshkumar, V, 2017) |
| "Wister rat model of liver cancer was set up using diethylnitrosamine (DEN)." | 1.43 | Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia. ( Adel, S; Nasr, MI; Salem, TA; Talaat, RM, 2016) |
| "At present, the treatment of hepatocellular carcinoma (HCC) is an international problem." | 1.42 | Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Chen, Q; Li, Y; Liu, W; Tang, H; Yang, X; Zhao, X, 2015) |
| "Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1α hepatic expression." | 1.40 | Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice. ( Hamed, O; Kazem, A; Nasr, M; Selima, E, 2014) |
| "This experiment was designed to compare the effect of two selenium sources at the dosage of therapeutic level on hepatocarcinogenesis and angiogenic cytokines in DEN-induced hepatocarcinoma rats to further approach their possible anticancer's mechanism." | 1.38 | Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. ( Liu, JG; Liu, YJ; Liu, YW; Wang, XL; Zhao, HJ, 2012) |
| " These results provide a rationale for long-term MET dosing in future clinical trials of HCC treatment." | 1.37 | Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma. ( Bae, SH; Choi, JY; Jang, JW; Jung, CK; Kwon, JH; Park, ST; Yoon, SK; You, CR, 2011) |
| " To induce hepatocarcinoma, groups II-V rats received diethylnitrosamine solution (100mg/L) at the dosage of 10mg/kg body weight in drinking water daily for 16 weeks, followed by sterilized water for a further 2 weeks." | 1.36 | Effect of selenium-enriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. ( Liu, JG; Liu, YJ; Wang, XL; Zhao, HJ, 2010) |
| "Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN)." | 1.35 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis. ( Bozova, S; Elpek, GO; Gokhan, GA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 10 (28.57) | 29.6817 |
| 2010's | 22 (62.86) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Ghufran, H | 1 |
| Azam, M | 1 |
| Mehmood, A | 1 |
| Butt, H | 1 |
| Riazuddin, S | 1 |
| Mahmoud, YI | 1 |
| Shehata, AMM | 1 |
| Fares, NH | 1 |
| Mahmoud, AA | 1 |
| Sadeeshkumar, V | 1 |
| Duraikannu, A | 1 |
| Ravichandran, S | 1 |
| Kodisundaram, P | 1 |
| Fredrick, WS | 1 |
| Gobalakrishnan, R | 1 |
| Mahmoud, AM | 1 |
| Zaki, AR | 1 |
| Hassan, ME | 1 |
| Mostafa-Hedeab, G | 1 |
| Ali, MM | 1 |
| H Borai, I | 1 |
| Ghanem, HM | 1 |
| H Abdel-Halim, A | 1 |
| Mousa, FM | 1 |
| Fathy, M | 1 |
| Nikaido, T | 1 |
| Cha, JH | 1 |
| Bae, SH | 2 |
| Kim, HL | 1 |
| Park, NR | 1 |
| Choi, ES | 1 |
| Jung, ES | 1 |
| Choi, JY | 2 |
| Yoon, SK | 2 |
| Nasr, M | 1 |
| Selima, E | 1 |
| Hamed, O | 1 |
| Kazem, A | 1 |
| Guariento, AH | 1 |
| Furtado, KS | 1 |
| de Conti, A | 1 |
| Campos, A | 1 |
| Purgatto, E | 1 |
| Carrilho, J | 1 |
| Shinohara, EM | 1 |
| Tryndyak, V | 1 |
| Han, T | 1 |
| Fuscoe, JC | 1 |
| Ross, SA | 1 |
| Beland, FA | 1 |
| Pogribny, IP | 1 |
| Moreno, FS | 1 |
| Lu, M | 1 |
| Wu, J | 1 |
| He, F | 1 |
| Wang, XL | 3 |
| Li, C | 1 |
| Chen, ZN | 1 |
| Bian, H | 1 |
| Gao, JZ | 1 |
| Wang, YL | 1 |
| Li, J | 1 |
| Wei, LX | 1 |
| Zhao, X | 1 |
| Chen, Q | 1 |
| Li, Y | 1 |
| Tang, H | 1 |
| Liu, W | 1 |
| Yang, X | 2 |
| Rajasekaran, D | 1 |
| Siddiq, A | 2 |
| Willoughby, JL | 1 |
| Biagi, JM | 1 |
| Christadore, LM | 1 |
| Yunes, SA | 1 |
| Gredler, R | 2 |
| Jariwala, N | 1 |
| Robertson, CL | 2 |
| Akiel, MA | 1 |
| Shen, XN | 2 |
| Subler, MA | 2 |
| Windle, JJ | 2 |
| Schaus, SE | 1 |
| Fisher, PB | 2 |
| Hansen, U | 1 |
| Sarkar, D | 2 |
| Bhatia, N | 1 |
| Gupta, P | 1 |
| Singh, B | 1 |
| Koul, A | 1 |
| Vandewynckel, YP | 1 |
| Laukens, D | 1 |
| Devisscher, L | 1 |
| Bogaerts, E | 1 |
| Paridaens, A | 1 |
| Van den Bussche, A | 1 |
| Raevens, S | 1 |
| Verhelst, X | 1 |
| Van Steenkiste, C | 2 |
| Jonckx, B | 1 |
| Libbrecht, L | 3 |
| Geerts, A | 3 |
| Carmeliet, P | 2 |
| Van Vlierberghe, H | 3 |
| Talaat, RM | 1 |
| Adel, S | 1 |
| Salem, TA | 1 |
| Nasr, MI | 1 |
| Zhang, W | 1 |
| Chen, HJ | 1 |
| Wang, ZJ | 1 |
| Huang, W | 1 |
| Zhang, LJ | 1 |
| Kaji, K | 1 |
| Yoshiji, H | 2 |
| Kitade, M | 2 |
| Ikenaka, Y | 2 |
| Noguchi, R | 2 |
| Yoshii, J | 2 |
| Yanase, K | 2 |
| Namisaki, T | 2 |
| Yamazaki, M | 2 |
| Moriya, K | 1 |
| Tsujimoto, T | 2 |
| Kawaratani, H | 1 |
| Akahane, T | 2 |
| Uemura, M | 2 |
| Fukui, H | 2 |
| Liu, JG | 2 |
| Zhao, HJ | 2 |
| Liu, YJ | 2 |
| Heindryckx, F | 2 |
| Mertens, K | 1 |
| Charette, N | 2 |
| Vandeghinste, B | 1 |
| Casteleyn, C | 2 |
| Slaets, D | 1 |
| Staelens, S | 1 |
| Starkel, P | 2 |
| Colle, I | 2 |
| Jang, JW | 1 |
| Park, ST | 1 |
| Kwon, JH | 1 |
| You, CR | 1 |
| Jung, CK | 1 |
| Borbath, I | 1 |
| Schneider-Merck, T | 1 |
| De Saeger, C | 1 |
| Abarca, J | 1 |
| Leclercq, I | 1 |
| Horsmans, Y | 1 |
| Liu, YW | 1 |
| Srivastava, J | 1 |
| Emdad, L | 1 |
| Santhekadur, PK | 1 |
| Chen, D | 1 |
| Dumur, CI | 1 |
| Hylemon, PB | 1 |
| Mukhopadhyay, ND | 1 |
| Bhere, D | 1 |
| Shah, K | 1 |
| Ahmad, R | 1 |
| Giashuddin, S | 1 |
| Stafflinger, J | 1 |
| Coulon, S | 1 |
| Terrie, E | 1 |
| Stassen, JM | 1 |
| Allemeersch, J | 1 |
| Turlin, B | 1 |
| Le Quilleuc, D | 1 |
| Leroyer, P | 1 |
| Brissot, P | 1 |
| Deugnier, Y | 1 |
| Loréal, O | 1 |
| Lu, P | 1 |
| Fujii, C | 1 |
| Nakamoto, Y | 1 |
| Gao, JL | 1 |
| Kaneko, S | 1 |
| Murphy, PM | 1 |
| Mukaida, N | 1 |
| Kuriyama, S | 1 |
| Asada, K | 1 |
| Huang, X | 1 |
| Yu, C | 1 |
| Jin, C | 1 |
| Kobayashi, M | 1 |
| Bowles, CA | 1 |
| Wang, F | 1 |
| McKeehan, WL | 1 |
| Meng, F | 1 |
| Henson, R | 1 |
| Patel, T | 1 |
| Bozova, S | 2 |
| Elpek, GO | 2 |
| Gokhan, GA | 1 |
| Yamamoto, T | 1 |
| Kaneda, K | 1 |
| Hirohashi, K | 1 |
| Kinoshita, H | 1 |
| Sakurai, M | 1 |
| Barajas, M | 1 |
| Mazzolini, G | 1 |
| Genové, G | 1 |
| Bilbao, R | 1 |
| Narvaiza, I | 1 |
| Schmitz, V | 1 |
| Sangro, B | 1 |
| Melero, I | 1 |
| Qian, C | 1 |
| Prieto, J | 1 |
| Corpechot, C | 1 |
| Barbu, V | 1 |
| Wendum, D | 1 |
| Kinnman, N | 1 |
| Rey, C | 1 |
| Poupon, R | 1 |
| Housset, C | 1 |
| Rosmorduc, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors[NCT03792724] | Phase 1/Phase 2 | 32 participants (Anticipated) | Interventional | 2019-01-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
35 other studies available for diethylnitrosamine and Angiogenesis, Pathologic
| Article | Year |
|---|---|
Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment.
Topics: Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamin | 2021 |
Spirulina inhibits hepatocellular carcinoma through activating p53 and apoptosis and suppressing oxidative stress and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosa | 2021 |
Modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during NDEA-induced rat hepatocarcinogenesis.
Topics: Animals; Apoptosis; Benzofurans; Cell Proliferation; Cell Transformation, Neoplastic; Diethylnitrosa | 2017 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbon Tetrachloride; Carcinogenesis; Cell Proliferation; | 2018 |
In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Liver; Li | 2018 |
Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis.
Topics: Administration, Oral; Amino Acids, Branched-Chain; Animals; Anticarcinogenic Agents; Carcinogenesis; | 2013 |
Targeting different angiogenic pathways with combination of curcumin, leflunomide and perindopril inhibits diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antineoplastic Agents; Antirheumatic Agents; Carc | 2014 |
Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis.
Topics: Animals; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinoma, | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Effects of VEGF/VEGFR/K-ras signaling pathways on miRNA21 levels in hepatocellular carcinoma tissues in rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; Gene Expression Regu | 2015 |
Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumo | 2015 |
Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Carcinoma, Hepatocellular; Cell Cycle Chec | 2015 |
Lycopene Enriched Tomato Extract Inhibits Hypoxia, Angiogenesis, and Metastatic Markers in early Stage N-Nitrosodiethylamine Induced Hepatocellular Carcinoma.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carotenoids; Cell Hypoxia; Dietary Supplements; | 2015 |
Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Diethylnitrosamine; Disease Models, Animal; eIF-2 | 2016 |
Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia.
Topics: Animals; Cyclooxygenase 2; Diethylnitrosamine; Disease Models, Animal; Enzyme-Linked Immunosorbent A | 2016 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model.
Topics: Angiography; Animals; Carcinoma, Hepatocellular; Contrast Media; Diethylnitrosamine; Disease Models, | 2017 |
Impact of insulin resistance on the progression of chronic liver diseases.
Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu | 2008 |
Effect of selenium-enriched malt on VEGF and several relevant angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Topics: Animals; Cytokines; Diethylnitrosamine; Edible Grain; Liver Neoplasms, Experimental; Neovascularizat | 2010 |
Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms, Experimental; Mic | 2010 |
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Proliferation; Cyclophosphamide; Die | 2011 |
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Cycle; Cell Proliferation; Cyclin D; Diethylnitr | 2012 |
Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Topics: alpha-Fetoproteins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; gamma-Glutamyltransferas | 2012 |
Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Transformat | 2012 |
The placental growth factor as a target against hepatocellular carcinoma in a diethylnitrosamine-induced mouse model.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Hepatocellular; Diethylnitrosamin | 2013 |
High vascular endothelial growth factor (VEGF) expression in chemically-induced hepatic microcancers in mice.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Disease Models, Animal; Endothelial Growth Factors; | 2002 |
Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemokine CCL3; Chemokine CCL4; Diethylnitros | 2006 |
Amelioration of carcinogenesis and tumor growth in the rat liver by combination of vitamin K2 and angiotensin-converting enzyme inhibitor via anti-angiogenic activities.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Transformation, Neoplastic; Diethylnitrosami | 2006 |
Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis.
Topics: Animals; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 2006 |
Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells.
Topics: Animals; Antigens, CD; Antimetabolites, Antineoplastic; Apoptosis; Cadherins; Cell Movement; Cells, | 2007 |
Hypoxia-inducible factor-1alpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis.
Topics: Alkylating Agents; Animals; Diethylnitrosamine; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Li | 2007 |
Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis.
Topics: Animals; Antigens, CD34; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Gene Expression Regul | 2008 |
Sinusoidal capillarization and arterial blood supply continuously proceed with the advance of the stages of hepatocarcinogenesis in the rat.
Topics: Animals; Capillaries; Carcinoma, Hepatocellular; Diethylnitrosamine; Factor VIII; Hyperplasia; Liver | 1996 |
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12.
Topics: Adenoviridae; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Geneti | 2001 |
Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis.
Topics: Alkylating Agents; Animals; Cells, Cultured; Collagen Type I; Collagen Type IV; Diethylnitrosamine; | 2002 |