diethylnitrosamine has been researched along with Aging in 32 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 8.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| "Here, we utilized an established model of age- and obesity-associated HCC, the low dose diethylnitrosamine (DEN)/high fat diet (HFD), a regimen promoting liver inflammation and tumorigenesis over a long period of 9 months." | 4.02 | Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin. ( Cabibi, D; Faldyna, M; Frohlich, J; Giallongo, S; Giannone, AG; Kovacovicova, K; Leva, L; Lo Re, O; Oben, JA; Raffaele, M; Vinciguerra, M, 2021) |
| " Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals." | 3.81 | Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging. ( Fujisawa, K; Furutani-Seiki, M; Matsumoto, T; Nishina, H; Sakaida, I; Takami, T; Terai, S; Yamamoto, N, 2015) |
| " Diethylnitrosamine (DEN) when given in drinking water at the dose of 4 mg/kg body weight/day, induced esophageal papillomas consistently in 100% of the animals, in a short period of 12 weeks." | 3.67 | ICRC mouse with congenital mega-esophagus as a model to study esophageal tumorigenesis. ( Deo, MG; Ghaisas, S; Saranath, D, 1989) |
| "Examination of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop much more severe liver cancer that is associated with elimination of the mutant CUGBP1." | 1.46 | RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner. ( Cast, A; Iakova, P; Karns, R; Lewis, K; Stock, L; Timchenko, L; Timchenko, N; Valanejad, L; Wei, C; Wright, M, 2017) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| " Our observations indicate that long term administration of I3C in the diet inhibits DEN-initiated hepatocarcinogenesis in the infant mouse model." | 1.30 | Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model. ( Hendricks, JD; Oganesian, A; Williams, DE, 1997) |
| "5." | 1.28 | Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine. ( Pulga, VB; Sulakhe, SJ; Tran, ST, 1992) |
| "Tfm (testicular feminization) mutant mice lack functional androgen receptors." | 1.28 | Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous. ( Drinkwater, NR; Kemp, CJ; Leary, CN, 1989) |
| " The dose-response relationship was also determined in juvenile rats for a single and for up to 64 daily doses of 3 mg/kg DENA started on day 32 of age." | 1.27 | The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats. ( Herren-Freund, SL; Khoury, MM; Long, RE; Pereira, MA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (46.88) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 6 (18.75) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Guedj, A | 1 |
| Volman, Y | 1 |
| Geiger-Maor, A | 1 |
| Bolik, J | 1 |
| Schumacher, N | 1 |
| Künzel, S | 1 |
| Baines, JF | 1 |
| Nevo, Y | 1 |
| Elgavish, S | 1 |
| Galun, E | 1 |
| Amsalem, H | 1 |
| Schmidt-Arras, D | 1 |
| Rachmilewitz, J | 1 |
| Hanna, D | 2 |
| Sugamori, KS | 2 |
| Bott, D | 1 |
| Grant, DM | 2 |
| Raffaele, M | 1 |
| Kovacovicova, K | 1 |
| Frohlich, J | 1 |
| Lo Re, O | 1 |
| Giallongo, S | 1 |
| Oben, JA | 1 |
| Faldyna, M | 1 |
| Leva, L | 1 |
| Giannone, AG | 1 |
| Cabibi, D | 1 |
| Vinciguerra, M | 1 |
| Lewis, K | 1 |
| Valanejad, L | 1 |
| Cast, A | 1 |
| Wright, M | 1 |
| Wei, C | 1 |
| Iakova, P | 1 |
| Stock, L | 1 |
| Karns, R | 1 |
| Timchenko, L | 1 |
| Timchenko, N | 1 |
| Fujisawa, K | 1 |
| Terai, S | 1 |
| Matsumoto, T | 1 |
| Takami, T | 1 |
| Yamamoto, N | 1 |
| Nishina, H | 1 |
| Furutani-Seiki, M | 1 |
| Sakaida, I | 1 |
| Zhang, H | 1 |
| Siegel, CT | 1 |
| Li, J | 1 |
| Lai, J | 1 |
| Shuai, L | 1 |
| Lai, X | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Bie, P | 1 |
| Bai, L | 1 |
| Riedmaier, AE | 1 |
| Herranz, D | 1 |
| Muñoz-Martin, M | 1 |
| Cañamero, M | 1 |
| Mulero, F | 1 |
| Martinez-Pastor, B | 1 |
| Fernandez-Capetillo, O | 1 |
| Serrano, M | 1 |
| Llorente Izquierdo, C | 1 |
| Mayoral, R | 1 |
| Flores, JM | 1 |
| García-Palencia, P | 1 |
| Cucarella, C | 1 |
| Boscá, L | 1 |
| Casado, M | 1 |
| Martín-Sanz, P | 1 |
| Lim, IK | 1 |
| Hashimoto, K | 1 |
| Takasaki, W | 1 |
| Sato, I | 1 |
| Tsuda, S | 1 |
| Peraino, C | 2 |
| Staffeldt, EF | 2 |
| Carnes, BA | 2 |
| Ludeman, VA | 2 |
| Blomquist, JA | 2 |
| Vesselinovitch, SD | 3 |
| Park, EH | 1 |
| Kim, DS | 1 |
| Löfberg, B | 1 |
| Tjälve, H | 1 |
| Dalbey, WE | 1 |
| Clapp, NK | 2 |
| Perkins, EH | 2 |
| Klima, WC | 2 |
| Cacheiro, LH | 2 |
| Ruebner, BH | 1 |
| Gershwin, ME | 1 |
| Hsieh, L | 1 |
| Dunn, P | 1 |
| Lijinsky, W | 1 |
| Oganesian, A | 1 |
| Hendricks, JD | 1 |
| Williams, DE | 1 |
| Glover, PL | 1 |
| Sulakhe, SJ | 1 |
| Pulga, VB | 1 |
| Tran, ST | 1 |
| Jang, JJ | 1 |
| Weghorst, CM | 2 |
| Henneman, JR | 1 |
| Devor, DE | 1 |
| Ward, JM | 1 |
| Jenke, HS | 1 |
| Michel, G | 1 |
| Hornhardt, S | 1 |
| Berndt, J | 1 |
| Hasegawa, R | 1 |
| Takahashi, S | 1 |
| Imaida, K | 1 |
| Yamaguchi, S | 1 |
| Shirai, T | 1 |
| Ito, N | 1 |
| Ghaisas, S | 1 |
| Saranath, D | 1 |
| Deo, MG | 1 |
| Kemp, CJ | 1 |
| Leary, CN | 1 |
| Drinkwater, NR | 1 |
| Ogawa, K | 1 |
| Mukai, H | 1 |
| Mori, M | 1 |
| Herren-Freund, SL | 1 |
| Pereira, MA | 2 |
| Long, RE | 1 |
| Khoury, MM | 1 |
| Klaunig, JE | 1 |
| Sugioka, Y | 1 |
| Fujii-Kuriyama, Y | 1 |
| Kitagawa, T | 1 |
| Muramatsu, M | 1 |
32 other studies available for diethylnitrosamine and Aging
| Article | Year |
|---|---|
Gut microbiota shape 'inflamm-ageing' cytokines and account for age-dependent decline in DNA damage repair.
Topics: Aging; Animals; Anti-Bacterial Agents; Cytokines; Diethylnitrosamine; Disease Models, Animal; DNA Da | 2020 |
The impact of sex on hepatotoxic, inflammatory and proliferative responses in mouse models of liver carcinogenesis.
Topics: Aging; Aminobiphenyl Compounds; Animals; Carcinogenesis; Cell Proliferation; Chemical and Drug Induc | 2020 |
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin.
Topics: Aging; Animals; Dasatinib; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Disease Progr | 2021 |
RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.
Topics: Aging; Animals; Carcinogenesis; CELF1 Protein; Child; Diethylnitrosamine; Disease Models, Animal; E2 | 2017 |
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Genetically Modified; Carcinogenesis; Carcinoma, Hepat | 2015 |
Functional liver tissue engineering by an adult mouse liver-derived neuro-glia antigen 2-expressing stem/progenitor population.
Topics: Aging; Animals; Antigens; Cell Differentiation; Cell Lineage; Cell Proliferation; Diethylnitrosamine | 2018 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.
Topics: Aging; Animals; Dietary Fats; Diethylnitrosamine; DNA Damage; Female; Glucose Tolerance Test; Liver | 2010 |
Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis.
Topics: Aging; Animals; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin E; Cyclooxy | 2011 |
Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680].
Topics: Aging; Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Cycle; Cyclin-Dependent Kinase In | 2003 |
DNA damage measured by comet assay and 8-OH-dG formation related to blood chemical analyses in aged rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Blood Chemical Analysis; Comet Assay; Deoxyguanosine; D | 2007 |
Characterization of histochemically detectable altered hepatocyte foci and their relationship to hepatic tumorigenesis in rats treated once with diethylnitrosamine or benzo(a)pyrene within one day after birth.
Topics: Aging; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Diethylnitrosamine; Fem | 1984 |
Relationship of histochemically detectable altered hepatocyte foci to hepatic tumorigenesis.
Topics: Aging; Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Liver; Liver Neoplasms; Male; Nitrosamin | 1984 |
Hepatocarcinogenicity of diethylnitrosamine to the self-fertilizing hermaphroditic fish Rivulus marmoratus (Teleostomi: Cyprinodontidae).
Topics: Aging; Animals; Cyprinidae; Diethylnitrosamine; Female; Hermaphroditic Organisms; Larva; Liver; Live | 1984 |
The disposition and metabolism of N-nitrosodiethylamine in adult, infant and foetal tissues of the Syrian golden hamster.
Topics: Aging; Animals; Autoradiography; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Fem | 1984 |
Formaldehyde and tumors in hamster respiratory tract.
Topics: Adenoma; Aging; Animals; Carcinogens; Cricetinae; Diethylnitrosamine; Formaldehyde; Male; Mesocricet | 1982 |
Temporal advancement of diethylnitrosamine carcinogenesis in aging mice.
Topics: Aging; Animals; Diethylnitrosamine; Female; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms, Experi | 1981 |
Ultrastructure of spontaneous neoplasms induced by diethylnitrosamine and dieldrin in the C3H mouse.
Topics: Aging; Animals; Body Weight; Dieldrin; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, Inbred | 1980 |
Infant mouse as a sensitive bioassay system for carcinogenicity of N-nitroso compounds.
Topics: Adenoma; Aging; Animals; Animals, Newborn; Biological Assay; Diethylnitrosamine; Dose-Response Relat | 1980 |
Life-span and cancer: the induction time of tumors in diverse animal species treated with nitrosodiethylamine.
Topics: Aging; Animals; Diethylnitrosamine; Life Expectancy; Liver Neoplasms; Neoplasms, Experimental; Speci | 1993 |
Long term dietary indole-3-carbinol inhibits diethylnitrosamine-initiated hepatocarcinogenesis in the infant mouse model.
Topics: Administration, Oral; Aging; Animals; Anticarcinogenic Agents; Breast Neoplasms; Carcinogens; Diethy | 1997 |
A positive correlation between declining immune competence and early mortality associated with diethylnitrosamine carcinogenesis in aging mice.
Topics: Aging; Animals; Antibody Formation; Antibody-Producing Cells; Diethylnitrosamine; Dose-Response Rela | 1979 |
Diethylnitrosamine-induced increase in gamma-glutamyltranspeptidase in rat liver: its association with thyroid hormone deficiency and its reversal by tri-iodothyronine.
Topics: Aging; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Precanc | 1992 |
Progressive atypia in spontaneous and N-nitrosodiethylamine-induced hepatocellular adenomas of C3H/HeNCr mice.
Topics: Aging; Animals; Body Weight; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Male; | 1992 |
Protooncogene expression in rat liver by polychlorinated biphenyls (PCB).
Topics: Aging; Animals; Autoradiography; Blotting, Northern; Carcinogens; Cell Nucleus; Diet; Diethylnitrosa | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
ICRC mouse with congenital mega-esophagus as a model to study esophageal tumorigenesis.
Topics: Aging; Animals; Diethylnitrosamine; Esophageal Neoplasms; Esophagus; Female; Male; Mice; Mice, Inbre | 1989 |
Promotion of murine hepatocarcinogenesis by testosterone is androgen receptor-dependent but not cell autonomous.
Topics: Aging; Androgen-Insensitivity Syndrome; Animals; Diethylnitrosamine; Disease Susceptibility; Female; | 1989 |
Effect of aging on proliferative activity of normal and carcinogen-altered hepatocytes in rat liver after a two-thirds partial hepatectomy.
Topics: Aging; Animals; Cell Division; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver; Liver Rege | 1985 |
The effect of single versus split doses of diethylnitrosamine on the induction of gamma-glutamyltranspeptidase-foci in the livers of adult and juvenile rats.
Topics: Aging; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; gamma-Glutam | 1986 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aging; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver; L | 1985 |