diethylnitrosamine has been researched along with Acute Liver Injury, Drug-Induced in 83 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 7.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| " Treatment with 2500 ppm ACI for 26 weeks after initiation with diethylnitrosamine increased the incidence and multiplicities of altered foci and adenomas in hepatocytes from WT mice; these effects were significantly reduced in CARKO mice." | 3.83 | Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2016) |
| "Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver." | 3.79 | Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. ( Başaran-Küçükgergin, C; Bingül, İ; Doğru-Abbasoğlu, S; Olgaç, V; Tekkeşin, MS; Uysal, M, 2013) |
| " In this study we report that gavage administration of 200 mg/kg or 600 mg/kg CCM effectively suppressed diethylnitrosamine (DEN)-induced liver inflammation and hyperplasia in rats, as evidenced by histopathological examination." | 3.70 | Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. ( Cheng, AL; Chuang, SE; Kuo, ML; Lin, JK, 2000) |
| "The urgent unmet need for hepatocellular carcinoma (HCC) therapies is addressed here by characterising a novel mouse model of HCC in the context of ongoing liver damage and overnutrition." | 1.48 | Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. ( Chen, J; Gorrell, MD; Henderson, JM; Kench, JG; McCaughan, GW; Polak, N; Roediger, B; Weninger, W; Zhang, HE, 2018) |
| "The incidence of liver cancer is higher in men than in women." | 1.43 | Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse. ( Grant, DM; Hanna, D; Riedmaier, AE; Sugamori, KS, 2016) |
| "Diethylnitrosamine (DEN) was used to induce pre-carcinoma and early HCC nodules in the experimental group." | 1.43 | Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model. ( Feng, GL; Jiang, HJ; Li, DQ; Li, JP; Wan, Y; Wang, HB; Zhao, DL, 2016) |
| "Liver cancer is a major health-care concern and its oncogenic mechanisms are still largely unclear." | 1.42 | Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. ( Eguchi, A; Feldstein, AE; Font-Burgada, J; Johnson, CD; Karin, M; Povero, D; Wree, A, 2015) |
| "Experimentally induced hepatocellular carcinoma is considered one of the representative laboratory models for studying this process." | 1.42 | Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells. ( Cai, JC; Cathopoulis, T; Han, R; Li, X; Liu, F; Liu, GY; Lu, K; Luo, G; Peng, B; Shi, SL; Yang, L, 2015) |
| "Human hepatocellular carcinoma (HCC) develops most often as a complication of fibrosis or cirrhosis." | 1.40 | The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. ( Pogribny, IP; Rusyn, I; Uehara, T, 2014) |
| "Uric acid level was lower in DEN group than in control." | 1.39 | Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats. ( Atakisi, E; Atakisi, O; Karapehlivan, M; Kart, A; Ozcan, A, 2013) |
| "Embelin treatment significantly prevented NDEA or CCl4 induced increase in biochemical marker enzymes: glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, glutathione-S-transferase, lipid peroxidase as well as hypoproteinemia, hypoalbuminuria and glutathione depletion." | 1.36 | Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver. ( Bhagwat, S; Gupta, S; Khade, B; Maru, G; Poojari, R, 2010) |
| "Diethylnitrosamine (DEN) is a representative chemical carcinogen with the potential to cause tumors in various organs, including the liver, skin, gastrointestinal tract, and respiratory system." | 1.35 | Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat. ( Jang, JJ; Lee, MJ; Li, L; Park, DH; Park, SK; Seo, JN; Shin, JW, 2009) |
| "Diethylnitrosamine (DEN) was used to induce liver lesions in rats." | 1.33 | [Evaluation of early stage diffused liver lesions with MR functional diffusion-weighted imaging--an experimental study]. ( Cao, G; Guan, S; Mao, J; Peng, WJ; Sun, F; Tang, F; Zhao, WD; Zhou, KR, 2005) |
| " blazei exerts a hepatoprotective effect on both liver toxicity and hepatocarcinogenesis process induced by a moderately toxic dose of DEN." | 1.31 | Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. ( Barbisan, LF; de Camargo, JL; Eira, AF; Miyamoto, M; Ribeiro, LR; Salvadori, DM; Scolastici, C, 2002) |
| "Curcumin has been widely used as a spice and coloring agent in foods." | 1.31 | Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. ( Chen, CR; Cheng, AL; Chuang, SE; Hsieh, CY; Hsu, CH; Kuo, ML; Lai, GM; Lin, JK, 2000) |
| "Diethylnitrosamine (DEN) was administered to rats as a single dose, which is known not to give rise to liver tumours without subsequent promotion." | 1.30 | Iron promotes DEN initiated GST-P foci in rat liver. ( Carthew, P; Edwards, RE; Nolan, BM; Smith, AG, 1997) |
| " Trend tests and a probit dose-response model showed a significantly positive correlation (p = 0." | 1.30 | N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure. ( Brown-Peterson, NJ; Hawkins, WE; Krol, RM; Zhu, Y, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (12.05) | 18.7374 |
| 1990's | 11 (13.25) | 18.2507 |
| 2000's | 14 (16.87) | 29.6817 |
| 2010's | 42 (50.60) | 24.3611 |
| 2020's | 6 (7.23) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, A | 1 |
| Dar, MY | 1 |
| Nagar, DP | 1 |
| Tomar, RS | 1 |
| Shrivastava, S | 1 |
| Shukla, S | 1 |
| Kim, JY | 1 |
| Han, YH | 1 |
| Nam, MW | 1 |
| Kim, HJ | 1 |
| Lee, MO | 1 |
| Lin, YH | 1 |
| Zhang, S | 2 |
| Zhu, M | 1 |
| Lu, T | 1 |
| Chen, K | 1 |
| Wen, Z | 1 |
| Wang, S | 1 |
| Xiao, G | 1 |
| Luo, D | 1 |
| Jia, Y | 1 |
| Li, L | 2 |
| MacConmara, M | 1 |
| Hoshida, Y | 1 |
| Singal, AG | 1 |
| Yopp, A | 1 |
| Wang, T | 1 |
| Zhu, H | 1 |
| Hanna, D | 2 |
| Sugamori, KS | 2 |
| Bott, D | 1 |
| Grant, DM | 2 |
| Ishii, N | 1 |
| Homma, T | 1 |
| Guo, X | 1 |
| Yamada, KI | 1 |
| Yamada, S | 1 |
| Fujii, J | 1 |
| Julian, L | 1 |
| Naylor, G | 1 |
| Wickman, GR | 1 |
| Rath, N | 1 |
| Castino, G | 1 |
| Stevenson, D | 1 |
| Bryson, S | 1 |
| Munro, J | 1 |
| McGarry, L | 1 |
| Mullin, M | 1 |
| Rice, A | 1 |
| Del Río Hernández, A | 1 |
| Olson, MF | 1 |
| Ploeger, JM | 1 |
| Manivel, JC | 1 |
| Boatner, LN | 1 |
| Mashek, DG | 1 |
| Moreno-Marín, N | 1 |
| Barrasa, E | 1 |
| Morales-Hernández, A | 1 |
| Paniagua, B | 1 |
| Blanco-Fernández, G | 1 |
| Merino, JM | 1 |
| Fernández-Salguero, PM | 1 |
| Husain, H | 1 |
| Latief, U | 1 |
| Ahmad, R | 1 |
| Henderson, JM | 1 |
| Polak, N | 1 |
| Chen, J | 1 |
| Roediger, B | 1 |
| Weninger, W | 1 |
| Kench, JG | 1 |
| McCaughan, GW | 1 |
| Zhang, HE | 1 |
| Gorrell, MD | 1 |
| Lee, C | 1 |
| Kim, M | 1 |
| Lee, JH | 1 |
| Oh, J | 1 |
| Shin, HH | 1 |
| Lee, SM | 1 |
| Scherer, PE | 1 |
| Kwon, HM | 1 |
| Choi, JH | 1 |
| Park, J | 1 |
| Khan, H | 1 |
| Ullah, H | 1 |
| Nabavi, SM | 1 |
| Adebayo, OA | 1 |
| Akinloye, O | 1 |
| Adaramoye, OA | 1 |
| Atakisi, O | 1 |
| Atakisi, E | 1 |
| Ozcan, A | 1 |
| Karapehlivan, M | 1 |
| Kart, A | 1 |
| Yang, C | 1 |
| Lu, W | 1 |
| Lin, T | 1 |
| You, P | 1 |
| Ye, M | 1 |
| Huang, Y | 1 |
| Jiang, X | 1 |
| Wang, C | 1 |
| Wang, F | 1 |
| Lee, MH | 1 |
| Yeung, SC | 1 |
| Johnson, RL | 1 |
| Wei, C | 1 |
| Tsai, RY | 1 |
| Frazier, ML | 1 |
| McKeehan, WL | 1 |
| Luo, Y | 1 |
| Bingül, İ | 2 |
| Başaran-Küçükgergin, C | 2 |
| Tekkeşin, MS | 2 |
| Olgaç, V | 2 |
| Doğru-Abbasoğlu, S | 2 |
| Uysal, M | 2 |
| Shaban, NZ | 2 |
| El-Kersh, MA | 2 |
| El-Rashidy, FH | 1 |
| Habashy, NH | 1 |
| Ajiboye, TO | 1 |
| Abdussalam, FA | 1 |
| Adeleye, AO | 1 |
| Iliasu, GA | 1 |
| Ariyo, FA | 1 |
| Adediran, ZA | 1 |
| Raji, KO | 1 |
| Raji, HO | 1 |
| Papp, V | 1 |
| Rókusz, A | 1 |
| Dezső, K | 1 |
| Bugyik, E | 1 |
| Szabó, V | 1 |
| Pávai, Z | 1 |
| Paku, S | 1 |
| Nagy, P | 1 |
| Xu, B | 1 |
| Li, SH | 1 |
| Zheng, R | 1 |
| Gao, SB | 1 |
| Ding, LH | 1 |
| Yin, ZY | 1 |
| Lin, X | 1 |
| Feng, ZJ | 1 |
| Wang, XM | 1 |
| Jin, GH | 1 |
| Ikeda, Y | 1 |
| Morioka, S | 1 |
| Matsumoto, K | 1 |
| Ninomiya-Tsuji, J | 1 |
| Bader-Eldin, MM | 1 |
| Kato, SA | 1 |
| Hamoda, AF | 1 |
| Ali, F | 1 |
| Naz, F | 1 |
| Jyoti, S | 1 |
| Siddique, YH | 1 |
| Poornima, K | 1 |
| Chella Perumal, P | 1 |
| Gopalakrishnan, VK | 1 |
| Uehara, T | 1 |
| Pogribny, IP | 1 |
| Rusyn, I | 1 |
| Kumar, AK | 1 |
| Vijayalakshmi, K | 1 |
| Kadasa, NM | 1 |
| Abdallah, H | 1 |
| Afifi, M | 1 |
| Gowayed, S | 1 |
| Chen, N | 1 |
| Nishio, N | 1 |
| Ito, S | 1 |
| Tanaka, Y | 1 |
| Sun, Y | 1 |
| Isobe, K | 1 |
| Li, X | 3 |
| Wang, Z | 1 |
| Zou, Y | 1 |
| Lu, E | 1 |
| Duan, J | 1 |
| Yang, H | 2 |
| Wu, Q | 1 |
| Zhao, X | 1 |
| Wang, Y | 1 |
| You, L | 1 |
| He, L | 1 |
| Xi, T | 1 |
| Yang, Y | 1 |
| Wree, A | 1 |
| Johnson, CD | 1 |
| Font-Burgada, J | 1 |
| Eguchi, A | 1 |
| Povero, D | 1 |
| Karin, M | 1 |
| Feldstein, AE | 1 |
| Sun, Q | 1 |
| Long, Z | 1 |
| Wu, H | 1 |
| Liu, Y | 1 |
| Wang, L | 1 |
| Zhang, X | 1 |
| Wang, X | 1 |
| Hai, C | 1 |
| Peng, B | 1 |
| Liu, F | 1 |
| Han, R | 1 |
| Luo, G | 1 |
| Cathopoulis, T | 1 |
| Lu, K | 1 |
| Yang, L | 1 |
| Liu, GY | 1 |
| Cai, JC | 1 |
| Shi, SL | 1 |
| Mu, X | 1 |
| Pradere, JP | 1 |
| Affò, S | 1 |
| Dapito, DH | 1 |
| Friedman, R | 1 |
| Lefkovitch, JH | 1 |
| Schwabe, RF | 1 |
| Kuwata, K | 1 |
| Inoue, K | 1 |
| Ichimura, R | 1 |
| Takahashi, M | 1 |
| Kodama, Y | 1 |
| Shibutani, M | 1 |
| Yoshida, M | 1 |
| Subramaniam, SR | 1 |
| Ellis, EM | 1 |
| Shaker, ME | 1 |
| Ashamallah, SA | 1 |
| El-Mesery, M | 1 |
| Wei, T | 1 |
| Chen, W | 1 |
| Wen, L | 1 |
| Zhang, J | 1 |
| Zhang, Q | 1 |
| Yang, J | 1 |
| Liu, H | 1 |
| Chen, BW | 1 |
| Zhou, Y | 1 |
| Feng, X | 1 |
| Yang, Q | 1 |
| Bai, X | 1 |
| Liang, T | 1 |
| Riedmaier, AE | 1 |
| Liang, L | 1 |
| Yang, X | 1 |
| Yu, Y | 1 |
| Wu, Y | 1 |
| Shi, R | 1 |
| Jiang, J | 1 |
| Gao, L | 1 |
| Ye, F | 1 |
| Zhao, Q | 1 |
| Li, R | 1 |
| Wei, L | 1 |
| Han, Z | 1 |
| Li, JP | 1 |
| Feng, GL | 1 |
| Li, DQ | 1 |
| Wang, HB | 1 |
| Zhao, DL | 1 |
| Wan, Y | 1 |
| Jiang, HJ | 1 |
| Qiu, P | 1 |
| Sun, J | 1 |
| Man, S | 1 |
| Ma, L | 1 |
| Yu, P | 1 |
| Gao, W | 1 |
| Ding, YF | 1 |
| Wu, ZH | 1 |
| Wei, YJ | 1 |
| Shu, L | 1 |
| Peng, YR | 1 |
| Mittal, G | 1 |
| Vadhera, S | 1 |
| Brar, AP | 1 |
| Soni, G | 1 |
| Granado-Serrano, AB | 1 |
| Martín, MA | 1 |
| Bravo, L | 1 |
| Goya, L | 1 |
| Ramos, S | 1 |
| Park, DH | 1 |
| Shin, JW | 1 |
| Park, SK | 1 |
| Seo, JN | 1 |
| Jang, JJ | 1 |
| Lee, MJ | 1 |
| Poojari, R | 2 |
| Gupta, S | 2 |
| Maru, G | 2 |
| Khade, B | 2 |
| Bhagwat, S | 2 |
| Bishayee, A | 1 |
| Barnes, KF | 1 |
| Bhatia, D | 1 |
| Darvesh, AS | 1 |
| Carroll, RT | 1 |
| Pradeep, K | 2 |
| Raj Mohan, CV | 1 |
| Gobianand, K | 2 |
| Karthikeyan, S | 2 |
| Krajka-Kuźniak, V | 1 |
| Szaefer, H | 1 |
| Ignatowicz, E | 1 |
| Adamska, T | 1 |
| Baer-Dubowska, W | 1 |
| Cardinale, V | 1 |
| Carpino, G | 1 |
| Reid, LM | 1 |
| Gaudio, E | 1 |
| Alvaro, D | 1 |
| Karim, R | 1 |
| Iwai, S | 1 |
| Morimura, K | 1 |
| Wanibuchi, H | 1 |
| Tanaka, R | 1 |
| Matsunaga, S | 1 |
| Yoshitake, A | 1 |
| Fukushima, S | 1 |
| Barbisan, LF | 2 |
| Miyamoto, M | 1 |
| Scolastici, C | 1 |
| Salvadori, DM | 2 |
| Ribeiro, LR | 2 |
| Eira, AF | 1 |
| de Camargo, JL | 2 |
| Spinardi-Barbisan, AL | 1 |
| Moreira, EL | 1 |
| da Eira, AF | 1 |
| SYDOW, G | 1 |
| SCHMAEHL, D | 1 |
| THOMAS, C | 1 |
| SATTLER, W | 1 |
| STANTON, MF | 1 |
| Guan, S | 1 |
| Zhao, WD | 1 |
| Zhou, KR | 1 |
| Peng, WJ | 1 |
| Tang, F | 1 |
| Mao, J | 1 |
| Cao, G | 1 |
| Sun, F | 1 |
| Ferencz, V | 1 |
| Horváth, C | 1 |
| Kári, B | 1 |
| Gaál, J | 1 |
| Mészáros, S | 1 |
| Wolf, Z | 1 |
| Hegedus, D | 1 |
| Horváth, A | 1 |
| Folhoffer, A | 1 |
| Szalay, F | 1 |
| Mohan, CV | 1 |
| Koul, A | 1 |
| Binepal, G | 1 |
| Gangar, SC | 1 |
| Mazzantini, RP | 1 |
| de Conti, A | 1 |
| Moreno, FS | 1 |
| Schmerold, I | 1 |
| Tempel, K | 1 |
| Ungemach, FR | 1 |
| Hegner, D | 1 |
| Okazaki, S | 1 |
| Hoshiya, T | 1 |
| Takahashi, S | 1 |
| Futakuchi, M | 1 |
| Saito, K | 1 |
| Hirose, M | 1 |
| Puapairoj, P | 1 |
| Cui, L | 1 |
| Ogawa, K | 2 |
| Akagi, K | 1 |
| Hasegawa, R | 2 |
| Ito, N | 3 |
| Imai, T | 1 |
| Masui, T | 1 |
| Ichinose, M | 1 |
| Nakanishi, H | 1 |
| Yanai, T | 1 |
| Masegi, T | 1 |
| Muramatsu, M | 1 |
| Tatematsu, M | 2 |
| Carthew, P | 1 |
| Nolan, BM | 1 |
| Smith, AG | 1 |
| Edwards, RE | 1 |
| Sekijima, M | 1 |
| Tsutsumi, T | 1 |
| Yoshida, T | 1 |
| Harada, T | 1 |
| Tashiro, F | 1 |
| Chen, G | 1 |
| Yu, SZ | 1 |
| Ueno, Y | 1 |
| Brown-Peterson, NJ | 1 |
| Krol, RM | 1 |
| Zhu, Y | 1 |
| Hawkins, WE | 1 |
| Chuang, SE | 2 |
| Kuo, ML | 2 |
| Hsu, CH | 1 |
| Chen, CR | 1 |
| Lin, JK | 2 |
| Lai, GM | 1 |
| Hsieh, CY | 1 |
| Cheng, AL | 2 |
| Murasaki, G | 1 |
| Nakanishi, K | 1 |
| Miyata, Y | 1 |
| Shinohara, Y | 1 |
| Letnansky, K | 1 |
| Wenzel, J | 1 |
| Braunbeck, TA | 1 |
| Teh, SJ | 1 |
| Lester, SM | 1 |
| Hinton, DE | 1 |
| Wada, S | 1 |
| Yamaguchi, S | 1 |
| Couch, JA | 1 |
| Hwang, DL | 1 |
| Lev-Ran, A | 1 |
| Tay, YC | 1 |
| De Meyts, P | 1 |
| Bunton, TE | 1 |
| Nii, A | 1 |
| Nakayama, H | 1 |
| Inoue, S | 1 |
| Fujiwara, K | 1 |
| Hagiwara, A | 1 |
| Ward, JM | 1 |
| Stout, DL | 1 |
| Becker, FF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Omega-5 Fatty Acid Supplement on Markers of Inflammation and Oxidative Stress in Patients With Severe Alcoholic Hepatitis Treated With Prednisone[NCT03732586] | 40 participants (Actual) | Interventional | 2018-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diethylnitrosamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Carbon Tetrachloride; Chemical and D | 2019 |
82 other studies available for diethylnitrosamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Biomimetic synthesis of silver nanoparticles for treatment of N-Nitrosodiethylamine-induced hepatotoxicity.
Topics: Animals; Biomimetic Materials; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Male; Met | 2022 |
RORα suppresses interleukin-6-mediated hepatic acute phase response.
Topics: Acute-Phase Reaction; Adenoviridae; Animals; Chemical and Drug Induced Liver Injury; Chemokine CXCL1 | 2019 |
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Topics: Animals; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cells, Cultured; Chemical and Drug Induced | 2020 |
The impact of sex on hepatotoxic, inflammatory and proliferative responses in mouse models of liver carcinogenesis.
Topics: Aging; Aminobiphenyl Compounds; Animals; Carcinogenesis; Cell Proliferation; Chemical and Drug Induc | 2020 |
Ascorbic acid prevents N-nitrosodiethylamine-induced hepatic injury and hepatocarcinogenesis in Akr1a-knockout mice.
Topics: Aldehyde Reductase; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Carcinogenesis; Chemical and D | 2020 |
Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Shape; Chemical and Drug Induced Liver | 2021 |
Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice.
Topics: Animals; Caloric Restriction; Carcinogenesis; Carcinogens; Chemical and Drug Induced Liver Injury; D | 2017 |
Dioxin Receptor Adjusts Liver Regeneration After Acute Toxic Injury and Protects Against Liver Carcinogenesis.
Topics: Animals; Biomarkers; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethy | 2017 |
Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver | 2018 |
Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diet, | 2018 |
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Communication; Chemical an | 2019 |
Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Inflammation; Liver; Ma | 2020 |
Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Fatty Acids, Omega-3; Free Radi | 2013 |
Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.
Topics: AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; | 2013 |
Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Blueberry Plants; Cell Proliferation; Chemical and Dru | 2013 |
Protective role of Punica granatum (pomegranate) peel and seed oil extracts on diethylnitrosamine and phenobarbital-induced hepatic injury in male rats.
Topics: Animals; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; DNA Fragmentation; G | 2013 |
Bridelia ferruginea promotes reactive oxygen species detoxification in N-nitrosodiethylamine-treated rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; DNA Fragmentation | 2013 |
Expansion of hepatic stem cell compartment boosts liver regeneration.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cell Different | 2014 |
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Tetrachloride; Carcinogenesis; Carcinoma, Hepa | 2013 |
TAK1 binding protein 2 is essential for liver protection from stressors.
Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Animals; Apoptosis; Blotting, Western; Chem | 2014 |
Effect of Punica granatum (pomegranate) juice extract on healthy liver and hepatotoxicity induced by diethylnitrosamine and phenobarbital in male rats.
Topics: Animals; Beverages; Caspase 3; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Glutathio | 2014 |
Protective effect of apigenin against N-nitrosodiethylamine (NDEA)-induced hepatotoxicity in albino rats.
Topics: Alanine Transaminase; Alkylating Agents; Animals; Apigenin; Aspartate Aminotransferases; Bone Marrow | 2014 |
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi | 2014 |
The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma.
Topics: Animals; Carbon Tetrachloride; Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liv | 2014 |
Protective effect of Punica granatum peel and Vitis vinifera seeds on DEN-induced oxidative stress and hepatocellular damage in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Lipid Peroxidatio | 2015 |
Effects of carnosine, taurine, and betaine pretreatments on diethylnitrosamine-induced oxidative stress and tissue injury in rat liver.
Topics: Animals; Antioxidants; Betaine; Biomarkers; Carcinogens, Environmental; Carnosine; Chemical and Drug | 2016 |
Hepatoprotective effects of curcumin against diethyl nitrosamine induced hepatotoxicity in albino rats.
Topics: alpha-Fetoproteins; Animals; Antioxidants; Carcinoma, Hepatocellular; Catalase; Chemical and Drug In | 2015 |
Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model.
Topics: Animals; Carcinogenesis; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, | 2015 |
Pretreatment with lipopolysaccharide attenuates diethylnitrosamine-caused liver injury in mice via TLR4-dependent induction of Kupffer cell M2 polarization.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Models, Animal; Kupffer | 2015 |
Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.
Topics: Animals; BH3 Interacting Domain Death Agonist Protein; Carbon Tetrachloride; Cell Proliferation; Cel | 2015 |
Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction.
Topics: Alcohol Drinking; Animals; Blotting, Western; Carcinogens; Chemical and Drug Induced Liver Injury; D | 2015 |
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Chemical and | 2015 |
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2016 |
Involvement of Mouse Constitutive Androstane Receptor in Acifluorfen-Induced Liver Injury and Subsequent Tumor Development.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Cell Transformation, Neoplastic | 2016 |
Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diethylnitrosam | 2016 |
The novel c-Met inhibitor capmatinib mitigates diethylnitrosamine acute liver injury in mice.
Topics: Animals; Benzamides; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Response Relat | 2016 |
G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis.
Topics: Animals; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Diethylnitrosamine | 2016 |
Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse.
Topics: Aging; Alanine Transaminase; Aminobiphenyl Compounds; Animals; Animals, Newborn; Carbon Tetrachlorid | 2016 |
Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway.
Topics: Animals; Cell Proliferation; Chemical and Drug Induced Liver Injury; Cyclin D1; Cytokines; Cytoprote | 2016 |
Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model.
Topics: Animals; Area Under Curve; Blood Flow Velocity; Capillary Permeability; Carcinoma, Hepatocellular; C | 2016 |
Curcumin Attenuates N-Nitrosodiethylamine-Induced Liver Injury in Mice by Utilizing the Method of Metabonomics.
Topics: Animals; Chemical and Drug Induced Liver Injury; Curcumin; Diethylnitrosamine; Humans; Liver; Male; | 2017 |
Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Disease Progression; Hepatitis; | 2017 |
Protective role of chickpea seed coat fibre on N-nitrosodiethylamine-induced toxicity in hypercholesterolemic rats.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cicer; Dietary Fiber; Diethylnitrosami | 2009 |
A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Body | 2009 |
Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1/S-phase regulatory proteins in rat.
Topics: Actins; Alkylating Agents; Animals; Blotting, Western; Body Weight; Cell Cycle; Cell Cycle Proteins; | 2009 |
Sida rhombifolia ssp. retusa seed extract inhibits DEN induced murine hepatic preneoplasia and carbon tetrachloride hepatotoxicity.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferase, Mitochondrial; Carbon Tetrachloride; Chem | 2009 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzoquinones; Carbon Tetrachloride; Chemical and Dr | 2010 |
Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats.
Topics: Animals; Antioxidants; Cassia; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Ethanol; | 2010 |
Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats.
Topics: Alkylating Agents; Animals; Beta vulgaris; Beverages; Blotting, Western; Chemical and Drug Induced L | 2012 |
Notch2 signaling and undifferentiated liver cancers: evidence of hepatic stem/progenitor cell origin.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylni | 2013 |
Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Diethylnitrosa | 2002 |
Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine.
Topics: Agaricus; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Re | 2002 |
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.
Topics: Agaricus; Animals; Anticarcinogenic Agents; Apoptosis; Biomarkers, Tumor; Brazil; Bromodeoxyuridine; | 2003 |
[THE HEXOKINASE ACTIVITY IN THE MITOCHONDRIA OF THE PRECANCEROUS RAT LIVER AND TRANSPLANTED DIETHYLNITROSAMINE HEPATOMA].
Topics: Carcinogens; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; | 1964 |
[HEPATOTOXIC AND CIRRHOGENIC EFFECT OF DIETHYLNITROSAMINE IN DOGS].
Topics: Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dogs; Gastrointestinal Diseases; Hepatit | 1964 |
DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.
Topics: Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Fishes; Hepatitis; | 1965 |
[Evaluation of early stage diffused liver lesions with MR functional diffusion-weighted imaging--an experimental study].
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Diffusion Magnetic Resonance Im | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tet | 2005 |
Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Alkylating Agents; Animals; Antioxidants; Aspartate Amin | 2007 |
Impediment of diethylnitrosamine induced hepatotoxicity in male Balb/c mice by pretreatment with aqueous Azadirachta indica leaf extract.
Topics: Alkylating Agents; Animals; Azadirachta; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 2007 |
Persistent and remodeling hepatic preneoplastic lesions present differences in cell proliferation and apoptosis, as well as in p53, Bcl-2 and NF-kappaB pathways.
Topics: 2-Acetylaminofluorene; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; | 2008 |
[DNase II activation in rat liver in the course of acute diethylnitrosamine-induced damage (author's transl)].
Topics: Animals; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cycloheximide; Cytosol; Deoxyribonucl | 1981 |
Thymidine transport in hepatocytes. An assay for hepatotoxicity.
Topics: Animals; Biological Transport; Cell Division; Chemical and Drug Induced Liver Injury; Diethylnitrosa | 1980 |
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Topics: Adenoma; Administration, Oral; Alpha-Globulins; Animals; Body Weight; Carcinoma, Renal Cell; Catecho | 1993 |
Effect of ethanol on paraquat toxicity in F344 rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Ethanol; Glutathione Transferas | 1994 |
Reduction of glutathione S-transferase P-form mRNA expression in remodeling nodules in rat liver revealed by in situ hybridization.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Carcinogens; Chemical and Drug Induced Liver Injury; Coc | 1997 |
Iron promotes DEN initiated GST-P foci in rat liver.
Topics: Animals; Biomarkers; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitros | 1997 |
Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats.
Topics: Aflatoxin B1; Animals; Bacterial Toxins; Biomarkers; Chemical and Drug Induced Liver Injury; Diethyl | 1999 |
N-nitrosodiethylamine initiation of carcinogenesis in Japanese medaka (Oryzias latipes): hepatocellular proliferation, toxicity, and neoplastic lesions resulting from short term, low level exposure.
Topics: Age Factors; Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Chemical and Drug Induced L | 1999 |
Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Biomarkers; Carcinogens; | 2000 |
Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; CDC2 Protein Kinase; Cell Cycle Proteins; Che | 2000 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
The phosphorylation of histones in rat liver undergoing malignant transformation.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Histones; | 1977 |
Ultrastructural alterations in liver of medaka (Oryzias latipes) exposed to diethylnitrosamine.
Topics: Acid Phosphatase; Animals; Carcinogenicity Tests; Catalase; Chemical and Drug Induced Liver Injury; | 1992 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Spongiosis hepatis: chemical induction, pathogenesis, and possible neoplastic fate in a teleost fish model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyprinidae; Diethylnitrosamine; Disease Models, Ani | 1991 |
Hepatotoxicity induced by diethylnitrosamine causes no significant disturbances of systemic glucose homeostasis in rats.
Topics: Animals; Aspartate Aminotransferases; Blood Glucose; Chemical and Drug Induced Liver Injury; Diethyl | 1990 |
Hepatopathology of diethylnitrosamine in the medaka (Oryzias latipes) following short-term exposure.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose-Response Relationship, Dru | 1990 |
Liver lesions in mice treated with diethylnitrosamine and inoculated with the Tyzzer's organism.
Topics: Animals; Bacillus; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Female; Liver Disease | 1987 |
The chronic hepatotoxic, tumor-promoting, and carcinogenic effects of acetaminophen in male B6C3F1 mice.
Topics: Acetaminophen; Animals; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnit | 1986 |
Heme enzyme patterns in rat liver nodules and tumors.
Topics: 2-Acetylaminofluorene; 5-Aminolevulinate Synthetase; Animals; Catalase; Chemical and Drug Induced Li | 1987 |