diethylnitrosamine has been researched along with Abnormalities, Autosome in 40 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of diethylnitrosamine (DEN) and vinylethylnitrosamine (VEN) in the F1 generation of Syrian golden hamsters are described after the compounds were administered to the P generation during the second half of pregnancy." | 3.66 | Assessment of nitrosamine transplacental carcinogenesis in the Syrian golden hamster. ( Althoff, J; Emura, M; Michiels, F; Mohr, U; Richter-Reichhelm, HB; Schmidt-Riese, L; Tsuda, H, 1983) |
| "Buprenorphine was injected subcutaneously twice a day with at least a 6-hr interval for 2 days from just after partial hepatectomy." | 1.42 | Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy. ( Hattori, C; Itoh, S; Nagata, M; Takasaki, W, 2015) |
| " In the present study, we assessed a twice dosing regimen, in which the genotoxicant is dosed both before and after partial hepatectomy, using the four chromosome aberration inducers used in the previous study." | 1.42 | Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test. ( Hattori, C; Igarashi, M; Itoh, S; Nagata, M, 2015) |
| "Lycopene, is a well known antioxidant and have promising preventive potentials, however the mechanism of action remain hypothetical and unclear." | 1.39 | Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system. ( Bansal, MP; Gupta, P; Koul, A, 2013) |
| " We have already reported that dosing of the test compound after partial hepatectomy (PH) is essential to detect genotoxicity of numerical chromosome aberration inducers in mice [Mutat." | 1.38 | Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy. ( Hattori, C; Itoh, S; Nagata, M; Sanbuissho, A, 2012) |
| "An increased number of chromosomal aberrations were observed after pre-treatment with PB." | 1.37 | N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF, 2011) |
| "p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse." | 1.36 | Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. ( Dan, YY; Farrell, G; Fausto, N; Gu, Y; Hou, J; Mitchell, C; Pyakurel, P; Swisshelm, K; Teoh, N, 2010) |
| " Chromosome stickiness suggests a NDEA toxic effect." | 1.36 | Ability of Allium cepa L. root tips and Tradescantia pallida var. purpurea in N-nitrosodiethylamine genotoxicity and mutagenicity evaluation. ( Aiub, CA; de Rainho, CR; Felzenszwalb, I; Kaezer, A, 2010) |
| "Vanadium treatment also inhibited DPCs (P<0." | 1.33 | Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats. ( Chakraborty, T; Chatterjee, A; Chatterjee, M; Ghosh, B; Pandey, N; Rana, B, 2006) |
| "Vanadium (V) has recently been found to possess potent anti-neoplastic activity in rat hepatocarcinogenesis." | 1.31 | Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3). ( Basak, R; Chatterjee, M; Saha, BK, 2000) |
| "All chemicals tested without S9 induced chromosomal aberrations (CA) in MCL-5 cells but not in human lymphocytes." | 1.30 | Comparative studies of MCL-5 cells and human lymphocytes for detecting indirect-acting clastogens. ( Kusakabe, H; Tanaka, N; Yamakage, K, 1998) |
| "The determination of chromosome aberrations (CA) in Chinese hamster lung fibroblast (CHL) cells was compared with that in normal human bronchial epithelial (BEAS-2B) cells, which upon adenovirus infection were reported to possess carcinogen metabolizing capacities similar to polycyclic aromatic hydrocarbons." | 1.30 | In vitro chromosome aberration assay using human bronchial epithelial cells. ( Lee, BH; Lee, SJ, 1998) |
| "The in vivo induction of chromosome aberrations has been studied in the liver cells of rats exposed to N-nitrosodiethylamine (DEN)." | 1.27 | Sensitive induction of chromosome aberrations in the in vivo liver cells of rats by N-nitrosodiethylamine. ( Horiuchi, T; Ito, K; Suzuki, M; Umeda, M, 1984) |
| "However, significant induction of chromosomal aberrations was not observed in the mesenchymal cells from DEN-treated groups." | 1.27 | Transplacental effect of N-diethylnitrosamine on chromosomal aberrations in fetal tracheal cells of the Syrian hamster: comparison between epithelial and mesenchymal cells. ( Böning, W; Emura, M; Mohr, U; Richter-Reichhelm, HB; Tsuda, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (37.50) | 18.7374 |
| 1990's | 11 (27.50) | 18.2507 |
| 2000's | 3 (7.50) | 29.6817 |
| 2010's | 10 (25.00) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Negishi, T | 1 |
| Yamada, K | 2 |
| Miyamoto, K | 1 |
| Mori, E | 1 |
| Taira, K | 1 |
| Fujii, A | 1 |
| Goto, Y | 1 |
| Arimoto-Kobayashi, S | 1 |
| Okamoto, K | 1 |
| Gupta, P | 1 |
| Bansal, MP | 1 |
| Koul, A | 1 |
| Itoh, S | 3 |
| Nagata, M | 3 |
| Hattori, C | 3 |
| Takasaki, W | 1 |
| Igarashi, M | 1 |
| Lehman, CE | 1 |
| Dillon, LW | 1 |
| Nikiforov, YE | 1 |
| Wang, YH | 1 |
| Teoh, N | 1 |
| Pyakurel, P | 1 |
| Dan, YY | 1 |
| Swisshelm, K | 1 |
| Hou, J | 1 |
| Mitchell, C | 1 |
| Fausto, N | 1 |
| Gu, Y | 1 |
| Farrell, G | 1 |
| Srivastava, S | 1 |
| Singh, M | 1 |
| George, J | 1 |
| Bhui, K | 1 |
| Murari Saxena, A | 1 |
| Shukla, Y | 1 |
| de Rainho, CR | 1 |
| Kaezer, A | 1 |
| Aiub, CA | 2 |
| Felzenszwalb, I | 2 |
| McClendon, AK | 1 |
| Dean, JL | 1 |
| Ertel, A | 1 |
| Fu, Z | 1 |
| Rivadeneira, DB | 1 |
| Reed, CA | 1 |
| Bourgo, RJ | 1 |
| Witkiewicz, A | 1 |
| Addya, S | 1 |
| Mayhew, CN | 1 |
| Grimes, HL | 1 |
| Fortina, P | 1 |
| Knudsen, ES | 1 |
| Gadermaier, G | 1 |
| Oliveira, I | 1 |
| Ferreira, F | 1 |
| Ribeiro Pinto, LF | 1 |
| Eckl, P | 1 |
| Sanbuissho, A | 1 |
| Chakraborty, T | 1 |
| Pandey, N | 1 |
| Chatterjee, A | 1 |
| Ghosh, B | 1 |
| Rana, B | 1 |
| Chatterjee, M | 3 |
| Scolastici, C | 1 |
| Alves de Lima, RO | 1 |
| Barbisan, LF | 1 |
| Ferreira, AL | 1 |
| Ribeiro, DA | 1 |
| Salvadori, DM | 1 |
| Mohr, U | 3 |
| Richter-Reichhelm, HB | 3 |
| Emura, M | 3 |
| Schmidt-Riese, L | 1 |
| Tsuda, H | 3 |
| Michiels, F | 1 |
| Althoff, J | 1 |
| Horiuchi, T | 1 |
| Ito, K | 1 |
| Suzuki, M | 1 |
| Umeda, M | 1 |
| Böning, W | 2 |
| Zimmering, S | 1 |
| den Engelse, L | 1 |
| Floot, BG | 1 |
| de Brij, RJ | 1 |
| Tates, AD | 2 |
| Herens, C | 2 |
| Massart, S | 1 |
| Bouzahzah, B | 1 |
| Koulischer, L | 1 |
| Barbason, H | 2 |
| Van Goethem, F | 1 |
| de Stoppelaar, J | 1 |
| Hoebee, B | 1 |
| Kirsch-Volders, M | 1 |
| Armstrong, MJ | 1 |
| Galloway, SM | 1 |
| Yamashita, Y | 1 |
| Sumi, N | 1 |
| Arimoto, S | 1 |
| Hayatsu, H | 1 |
| Sarkar, A | 1 |
| Basak, R | 2 |
| Bishayee, A | 1 |
| Basak, J | 1 |
| Yamakage, K | 1 |
| Kusakabe, H | 1 |
| Tanaka, N | 1 |
| Lee, BH | 2 |
| Lee, SJ | 2 |
| Saha, BK | 1 |
| Hitachi, PM | 1 |
| Takayama, S | 1 |
| Bauknecht, T | 1 |
| Vogel, W | 1 |
| Bayer, U | 1 |
| Wild, D | 1 |
| Natarajan, AT | 1 |
| Van Buul, PP | 1 |
| Meijers, M | 1 |
| De Vogel, N | 1 |
| Sobels, FH | 1 |
| Vogel, E | 1 |
| Popescu, NC | 1 |
| Evans, CH | 1 |
| DiPaolo, JA | 1 |
| Alvarez Gonzalez, ML | 1 |
| Sargent, LM | 1 |
| Sattler, GL | 1 |
| Roloff, B | 1 |
| Xu, YH | 1 |
| Sattler, CA | 1 |
| Meisner, L | 1 |
| Pitot, HC | 1 |
| Danielsen, HE | 1 |
| Brøgger, A | 1 |
| Reith, A | 1 |
| Holecek, BU | 1 |
| Kerler, R | 1 |
| Rabes, HM | 1 |
| Dittberner, U | 1 |
| Eisenbrand, G | 1 |
| Zankl, H | 1 |
| Mehta, R | 1 |
| Silinskas, KC | 1 |
| Zucker, PF | 1 |
| Ronen, A | 1 |
| Heddle, JA | 1 |
| Archer, MC | 1 |
| Garry, VF | 1 |
| Jacobs, DR | 1 |
| Kreiger, RA | 1 |
| Nelson, RL | 1 |
| Loeppky, R | 1 |
| Harkins, ME | 1 |
40 other studies available for diethylnitrosamine and Abnormalities, Autosome
| Article | Year |
|---|---|
Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila.
Topics: Animals; Chromosome Aberrations; Chromosomes; Diethylnitrosamine; Dimethylnitrosamine; DNA Breaks, D | 2020 |
Lycopene modulates initiation of N-nitrosodiethylamine induced hepatocarcinogenesis: studies on chromosomal abnormalities, membrane fluidity and antioxidant defense system.
Topics: Animals; Carotenoids; Catalase; Chromosome Aberrations; Diethylnitrosamine; Female; Glutathione Pero | 2013 |
Effect of buprenorphine on genotoxicity evaluation of chemicals by the rat liver micronucleus test with partial hepatectomy.
Topics: 1,2-Dimethylhydrazine; Analgesics; Animals; Benzimidazoles; Buprenorphine; Carbamates; Cells, Cultur | 2015 |
Assessment of a twice dosing regimen both before and after partial hepatectomy in the rat liver micronucleus test.
Topics: 1,2-Dimethylhydrazine; Animals; Benzimidazoles; Carbamates; Chromosome Aberrations; Colchicine; Diet | 2015 |
DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.
Topics: Benzene; Carcinoma; Carcinoma, Papillary; Chromosome Aberrations; Chromosome Fragile Sites; Diethyln | 2017 |
Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Caspase 3; Ce | 2010 |
Genotoxic and carcinogenic risks associated with the dietary consumption of repeatedly heated coconut oil.
Topics: Animals; Antioxidants; Biomarkers; Carcinogens; Chromosome Aberrations; Coconut Oil; Cocos; Cooking; | 2010 |
Ability of Allium cepa L. root tips and Tradescantia pallida var. purpurea in N-nitrosodiethylamine genotoxicity and mutagenicity evaluation.
Topics: Chromosome Aberrations; Chromosomes, Plant; Diethylnitrosamine; Mutagenicity Tests; Onions; Plant Ro | 2010 |
RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chromosome Aberrations; Comparat | 2011 |
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrat | 2011 |
Structural and numerical chromosome aberration inducers in liver micronucleus test in rats with partial hepatectomy.
Topics: Aneugens; Animals; Benzimidazoles; Carbamates; Chromosome Aberrations; Colchicine; Diethylnitrosamin | 2012 |
Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antimutagenic Agents; Chromosome Aberrations; Deoxyguanosine; | 2006 |
Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test.
Topics: Antimutagenic Agents; Carotenoids; Cell Line; Chromosome Aberrations; Comet Assay; Cytokinesis; Diet | 2008 |
Assessment of nitrosamine transplacental carcinogenesis in the Syrian golden hamster.
Topics: Animals; Arvicolinae; Chromosome Aberrations; Diethylnitrosamine; Female; Fetus; Gestational Age; Ne | 1983 |
Sensitive induction of chromosome aberrations in the in vivo liver cells of rats by N-nitrosodiethylamine.
Topics: Animals; Chromosome Aberrations; Diethylnitrosamine; Hepatectomy; Liver; Liver Regeneration; Male; N | 1984 |
Transplacental effect of N-diethylnitrosamine on chromosomal aberrations in fetal tracheal cells of the Syrian hamster: comparison between epithelial and mesenchymal cells.
Topics: Animals; Chromosome Aberrations; Cricetinae; Diethylnitrosamine; Epithelium; Female; Kinetics; Mater | 1983 |
Review of the current status of the mei-9a test for chromosome loss in Drosophila melanogaster: an assay with radically improved detection capacity for chromosome lesions induced by methyl methanesulfonate (MMS), dimethylnitrosamine (DMN), and especially
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Diethylnitrosamine; Dimethylnitrosamine; Droso | 1981 |
The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects.
Topics: Alkylation; Animals; Carcinogens; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; D | 1983 |
Chromosomal aberrations in tracheal epithelial cells of the fetal Syrian golden hamster after transplacental N-diethylnitrosamine administration.
Topics: Animals; Cell Division; Cells, Cultured; Chromosome Aberrations; Cricetinae; Diethylnitrosamine; Epi | 1982 |
Nuclear lesions during rat hepatocarcinogenesis. II. Measuring the micronuclei during initiation, promotion and progression of rat hepatocarcinogenesis induced with diethylnitrosamine.
Topics: Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; Diethylnitrosamine; Hepatectomy; L | 1995 |
Identification of clastogenic and/or aneugenic events during the preneoplastic stages of experimental rat hepatocarcinogenesis by fluorescence in situ hybridization.
Topics: Aneuploidy; Animals; Carbon Tetrachloride; Chromosome Aberrations; Diethylnitrosamine; In Situ Hybri | 1995 |
Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Benzene; Chromosome Aberrations; Diethylnitros | 1993 |
Synergistic action of N-nitrosodialkylamines and near-UV in the induction of chromosome aberrations in Chinese hamster lung fibroblasts in vitro.
Topics: Animals; Antioxidants; Biotransformation; Cells, Cultured; Chromosome Aberrations; Cricetinae; Dealk | 1995 |
Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Anticarcinogenic Agents; Antioxidants; beta Car | 1997 |
Comparative studies of MCL-5 cells and human lymphocytes for detecting indirect-acting clastogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Biotransformation; Cell Line; Cell Survival | 1998 |
In vitro chromosome aberration assay using human bronchial epithelial cells.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Bronchi; Carcinogens; Cell Line; Chromosome Aberrations; | 1998 |
Preventive effects of a mixed disulphide from dithiocarbamate and N-acetylcysteine on the genotoxicity of N-nitrosodiethylamine.
Topics: Acetylcysteine; Animals; Antimutagenic Agents; Chromosome Aberrations; Cricetinae; Cricetulus; Dieth | 1999 |
Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3).
Topics: Animals; Antineoplastic Agents; Calcitriol; Chromosome Aberrations; Diethylnitrosamine; DNA Damage; | 2000 |
Cytologic changes induced in rat livers cells by short-term exposure to chemical substances.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Butanes; Carcinogens; Chromosome Aberrations; DDT; Dieth | 1975 |
Comparative in vivo mutagenicity testing by SCE and micronucleus induction in mouse bone marrow.
Topics: Animals; Bromodeoxyuridine; Chromatids; Chromosome Aberrations; Crossing Over, Genetic; Cyclophospha | 1977 |
Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of ra
Topics: Carcinogens; Cell Line; Chromatids; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; | 1976 |
Assaying potential carcinogens with Drosophila.
Topics: Animals; Aziridines; Biological Assay; Carcinogens; Chromosome Aberrations; Diethylnitrosamine; Dros | 1976 |
Chromosome patterns (G and C bands) of in vitro chemical carcinogen-transformed guinea pig cells.
Topics: Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; | 1976 |
Cytogenetic changes in hepatocarcinomas from rats treated with chronic exposure to diethylnitrosamine.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Diethylnitrosamine; Karyotyping; Liver Neoplas | 1992 |
Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.
Topics: Animals; Carcinogens; Cell Division; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorde | 1992 |
Specific gain of chromosome 19 in preneoplastic mouse liver cells after diethylnitrosamine treatment.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Diethylnitrosamine; Karyotyping; | 1991 |
Chromosomal analysis of a diethylnitrosamine-induced tumorigenic and a nontumorigenic rat liver cell line.
Topics: Animals; Cell Line; Chromosome Aberrations; Diethylnitrosamine; Karyotyping; Liver Neoplasms, Experi | 1989 |
Cytogenetic effects of N-nitrosodiethanolamine (NDELA) and NDELA-monoacetate in human lymphocytes.
Topics: Carcinogens; Chromosome Aberrations; Diethylnitrosamine; Female; Humans; Lymphocytes; Micronucleus T | 1988 |
Micronucleus formation induced in rat liver and esophagus by nitrosamines.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Diethylnitrosamine; Dimethylnitrosamine; Esophagus; L | 1987 |
Integration of laboratory and epidemiologic studies to evaluate genotoxic exposure in tool and die workers.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Chromosome Aberrations; Diethylnitrosamine; | 1986 |