diethylcarbamazine and Parasitic Skin Diseases studies

Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Research Excerpts

Excerpt	Relevance	Reference
"We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial."	9.05	Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. ( Aziz, MA; Cupp, EW; D'Anna, SA; Goldschmidt, LP; Greene, BM; Murphy, RP; Newland, HS; Schulz-Key, H; Taylor, HR; White, AT, 1985)
"We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial."	5.05	Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. ( Aziz, MA; Cupp, EW; D'Anna, SA; Goldschmidt, LP; Greene, BM; Murphy, RP; Newland, HS; Schulz-Key, H; Taylor, HR; White, AT, 1985)
"In persons with onchocerciasis, topical application of the anthelminthic diethylcarbamazine (DEC) induces clinical and histologic responses similar to acute papular onchodermatitis, including recruitment of eosinophils to the skin."	3.70	Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. ( Boatin, BA; Gilles, AA; Higgins, AW; Pearlman, E; Toé, L; Unnasch, TR, 1999)
"Retreatment with diethylcarbamazine again caused pruritus, but this was tolerated as were subsequent treatments."	1.26	Subcutaneous nodules as a manifestation of onchocerciasis. A rare condition in the United States. ( Beaver, PC; Bray, DM; Grannis, FW; Palomar, JM, 1976)

Research

Studies (17)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Effectiveness of Killing Adult Female Worms

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (58.82)	18.7374
1990's	3 (17.65)	18.2507
2000's	2 (11.76)	29.6817
2010's	2 (11.76)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Senanayake, MP	1
Infaq, ML	1
Adikaram, SG	1
Udagama, PV	1
Gaur, MK	1
Goel, A	1
Gupta, S	1
Sbeity, ZH	1
Jaksche, A	1
Martin, S	1
Loeffler, KU	1
Cahill, KM	1
Vermeer, BJ	1
van der Kaay, HJ	1
Rozenman, D	1
Kremer, M	1
Zuckerman, F	1
Krautheim, H	1
Edungbola, LD	1
Takeuchi, T	1
Pearlman, E	1
Toé, L	1
Boatin, BA	1
Gilles, AA	1
Higgins, AW	1
Unnasch, TR	1
Goljan, J	1
Nahorski, W	1
Tomaszewski, R	1
Felczak-Korzybska, I	1
Górski, J	1
Connor, DH	1
Palomar, JM	1
Bray, DM	1
Grannis, FW	1
Beaver, PC	1
Bergner, T	1
Löscher, T	1
Barutzki, D	1
Przybilla, B	1
Albiez, EJ	1
Newland, HS	2
White, AT	2
Kaiser, A	1
Greene, BM	2
Taylor, HR	2
Büttner, DW	1
Cupp, EW	1
Murphy, RP	1
Aziz, MA	1
Schulz-Key, H	1
D'Anna, SA	1
Goldschmidt, LP	1
Duke, BO	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis[NCT04188301]	Phase 2	154 participants (Actual)	Interventional	2019-12-06	Completed
Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis[NCT06070116]	Phase 2	300 participants (Anticipated)	Interventional	2024-01-15	Not yet recruiting
Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462]		231 participants (Actual)	Interventional	2018-08-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The effectiveness of three treatment regimens for killing adult female O. volvulus worms based on the percentage of all adult female worms in nodules that are alive 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment

Percentage of Worms Killed Across Study Arms

Intervention	Female worms in nodule (Count of Units)
IVM + ALB	127
IDA x 1 Dose	142
IDA x 3 Doses	159

The effect of three treatment regimens for killing adult female O. volvulus worms will be compared based on the percentage of all adult female worms in nodules that are alive with embryos in the uterus 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.

Percentage of Worms Sterilized Across Study Arms

Intervention	Female worms in nodules (Count of Units)
IVM + ALB	127
IDA x 1 Dose	142
IDA x 3 Doses	159

The effect of three treatment regimens for sterilizing adult female O. volvulus worms will be compared based on the percentage of all adult female worms that are fertile in the nodules 18 months after treatment. (NCT04188301)
Timeframe: 18 months following treatment.

Rates of Ocular Adverse Events (Any Grade) by Treatment Group

Intervention	Female worms with intact uterus (Count of Units)
IVM + ALB	41
IDA x 1 Dose	40
IDA x 3 Doses	34

Rates of ocular adverse events of any grade within 3 months will be compared by treatment group. (NCT04188301)
Timeframe: within 3 months of treatment with IDA

Rates of SAEs by Treatment Group in Those With Intraocular Microfilariae Just Prior to Treatment With IDA

Intervention	Participants (Count of Participants)
IVM + ALB	4
IDA x 1 Dose	4
IDA x 3 Doses	3

Rates of adverse events grade 3 or higher that occur within 7 days of treatment in the subset of participants who have intraocular microfilariae just prior to treatment with IDA will be compared by treatment group. (NCT04188301)
Timeframe: within 7 days following end of treatment

Rates of Severe Adverse Events (SAEs) Across Study Arms

Intervention	Participants (Count of Participants)
IVM + ALB	0
IDA x 1 Dose	0
IDA x 3 Doses	0

Rates of severe adverse events (grade 3 or higher) following 1-day or 3-day triple drug treatment will be compared against those of the comparator regimen of 1 day of IVM/ALB. (NCT04188301)
Timeframe: Within 7 days following end of treatment

Effectiveness for Preventing Reappearance of Microfilariae in the Skin by Skin Snips

Intervention	Participants (Count of Participants)
IVM + ALB	0
IDA x 1 Dose	0
IDA x 3 Doses	0

The effectiveness of three treatment regimens for preventing reappearance of microfilariae in the skin as determined by skin snips at 12 and 18 months after treatment will be compared by treatment arm. Measured by the presence of microfilariae in skin snips. (NCT04188301)
Timeframe: Baseline, 12 months, and 18 months following treatment

Effectiveness of Clearing Microfilariae From Skin by Skin Snips

Intervention	Count of microfilarae+ participants (Number)
	Baseline	Month 12	Month 18
IDA x 1 Dose	6	21	15
IDA x 3 Doses	0	21	17
IVM + ALB	7	23	20

The effectiveness of three treatment regimens for complete clearance of microfilariae from the skin as determined by skin snips at 3, 12, and 18 months after treatment with IDA will be compared by treatment arm. (NCT04188301)
Timeframe: Baseline, 3 months, 12 months, & 18 months following treatment.

Intervention	Count of Skin Microfilaria (Geometric Mean)
	Baseline	Month 3	Month 12	Month 18
IDA x 1 Dose	1.7	3	2.5	9.0
IDA x 3 Doses	NA	2.1	4.7	8.6
IVM + ALB	3.1	1.9	4.9	7.0

Article	Year
Chemotherapy of onchocerciasis with high doses of diethylcarbamazine or a single dose of ivermectin: microfilaria levels and side effects. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1988, Volume: 39, Issue:1 Topics: Adult; Animals; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Diethylcarbamazine; Double-B	1988
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985
Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. The New England journal of medicine, 1985, Jul-18, Volume: 313, Issue:3 Topics: Adult; Anthelmintics; Antiparasitic Agents; Clinical Trials as Topic; Cornea; Corneal Opacity; Dieth	1985

Article	Year
Ocular and subcutaneous dirofilariasis in a Sri Lankan infant: an environmental hazard caused by dogs and mosquitoes. Paediatrics and international child health, 2013, Volume: 33, Issue:2 Topics: Animals; Diethylcarbamazine; Dirofilaria repens; Dirofilariasis; Eye Diseases; Filaricides; Humans;	2013
An elephantine problem. European journal of internal medicine, 2017, Volume: 44 Topics: Adult; Animals; Diethylcarbamazine; Elephantiasis, Filarial; Filaricides; Humans; Male; Skin Disease	2017
Loa loa macrofilariasis in the eyelid: case report of the first periocular subcutaneous manifestation in Germany. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2006, Volume: 244, Issue:7 Topics: Adult; Africa; Animals; Diethylcarbamazine; Eye Infections, Parasitic; Eyelid Diseases; Female; Fila	2006
Bancroftian filarial nodule. Report of a case. The American journal of tropical medicine and hygiene, 1967, Volume: 16, Issue:5 Topics: Adult; Complement Fixation Tests; Diethylcarbamazine; Filariasis; Granuloma; Humans; Male; Skin Dise	1967
Loiasis: a case report. Acta dermato-venereologica, 1982, Volume: 62, Issue:1 Topics: Adult; Diethylcarbamazine; Eyelid Diseases; Female; Filariasis; Humans; Loiasis; Netherlands; Nigeri	1982
Onchocerciasis in Israel. Archives of dermatology, 1984, Volume: 120, Issue:4 Topics: Adolescent; Diagnosis, Differential; Diethylcarbamazine; Ethiopia; Eye Diseases; Humans; Israel; Mal	1984
[Loaiasis. Clinical aspects and therapy in the field of dermatology]. Die Medizinische Welt, 1982, Jun-11, Volume: 33, Issue:23 Topics: Adult; Antiparasitic Agents; Diagnosis, Differential; Diethylcarbamazine; Female; Filariasis; Humans	1982
Prevalence of onchocerciasis in Ile-Ire District, (Ifelodun), Kwara State, Nigeria. Tropical and geographical medicine, 1982, Volume: 34, Issue:3 Topics: Adolescent; Adult; Aged; Blindness; Child; Child, Preschool; Diethylcarbamazine; Female; Humans; Inf	1982
Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. The Journal of infectious diseases, 1999, Volume: 180, Issue:4 Topics: Administration, Topical; Adolescent; Animals; Antiparasitic Agents; Chemokine CCL11; Chemokines, CC;	1999
Diagnosing and treatment of skin filariases based on own observations. International maritime health, 2000, Volume: 51, Issue:1-4 Topics: Adolescent; Adult; Antiparasitic Agents; Diethylcarbamazine; Female; Filariasis; Filaricides; Humans	2000
Onchocercal dermatitis-current concepts of pathogenesis. The Southeast Asian journal of tropical medicine and public health, 1978, Volume: 9, Issue:2 Topics: Dermatitis; Diethylcarbamazine; Humans; Onchocerciasis; Skin; Skin Diseases, Parasitic	1978
Subcutaneous nodules as a manifestation of onchocerciasis. A rare condition in the United States. Archives of surgery (Chicago, Ill. : 1960), 1976, Volume: 111, Issue:8 Topics: Adult; Antiparasitic Agents; Diethylcarbamazine; Female; Humans; Onchocerciasis; Skin; Skin Diseases	1976
[Subcutaneous dirofilariasis: infection with Dirofilaria repens]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1990, Volume: 41, Issue:5 Topics: Animals; Antiparasitic Agents; Diethylcarbamazine; Dirofilaria; Dirofilariasis; Facial Dermatoses; F	1990
Onchocerciasis. British medical journal, 1968, Nov-02, Volume: 4, Issue:5626 Topics: Africa; Central America; Diagnosis, Differential; Diethylcarbamazine; Eye Manifestations; Humans; On	1968

diethylcarbamazine and Parasitic Skin Diseases