diethylcarbamazine has been researched along with Innate Inflammatory Response in 18 studies
Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diethylcarbamazine citrate (DEC) had been known as anti-inflammatory drug but its effect on obesity-induced insulin resistance as a result of released inflammatory mediators from adipose tissue (AT) was not known." | 7.81 | Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. ( Abdel-Latif, M, 2015) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Tropical pulmonary eosinophilia (TPE) presents as an acute syndrome with dyspnea, fluffy infiltrates, and rounded opacities on the chest radiograph, reduced lung function, marked eosinophilia in the blood and lower respiratory tract, and high titers of specific IgE and IgG antifilarial antibodies." | 5.28 | Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine. ( Cornelius, MJ; Crystal, RG; Kumaraswami, V; Ottesen, EA; Prabhakar, R; Rom, WN; Vijayan, VK, 1990) |
| " The Wolbachia activation of innate inflammation also drives inflammatory adverse events in response to chemotherapy with either diethylcarbamazine (DEC) or ivermectin." | 4.87 | Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment. ( Gentil, K; Halliday, A; Hoerauf, A; Pearlman, E; Tamarozzi, F; Taylor, MJ, 2011) |
| " DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further." | 3.96 | Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? ( Abeygunasekera, A; Jayasinghe, S, 2020) |
| " Here we investigated whether a cyclooxygenase-2 (COX-2) inhibitor or diethylcarbamazine (DEC), that is known for its 5-lipoxygenase inhibiting and antioxidant actions, modify the development of PAH in the Sugen 5416/hypoxia (SuHx) rat model." | 3.81 | Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension. ( Abbate, A; Al-Husseini, A; Chalfant, CE; Drake, JI; Farkas, L; Kraskauskas, D; Van Tassel, B; Voelkel, NF; Wijesinghe, DS, 2015) |
| "Diethylcarbamazine citrate (DEC) had been known as anti-inflammatory drug but its effect on obesity-induced insulin resistance as a result of released inflammatory mediators from adipose tissue (AT) was not known." | 3.81 | Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. ( Abdel-Latif, M, 2015) |
| " To explore a possible therapeutic application of substances that inhibit 15-LO of soybean in vitro, we have tested several active compounds, namely nordihydroguaiaretic acid (NDGA), phenidone, diethylcarbamazine and mefenamic acid, on the following in vivo inflammation models in the rat: plantar oedema induced by carrageenin; cutaneous vascular hyperpermeability induced by pafacether; pleurisy induced by carrageenin." | 3.67 | In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro. ( Braquet, P; Clostre, F; Etienne, A; Soulard, C; Touvay, C, 1985) |
| "Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid." | 1.40 | Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. ( Barbosa, KP; da Silva Junior, VA; da Silva, BS; Donato, MA; Fragoso, IT; Gomes, FO; Peixoto, CA; Ribeiro, EL; Rocha, SW; Soares e Silva, AK, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Tropical pulmonary eosinophilia (TPE) presents as an acute syndrome with dyspnea, fluffy infiltrates, and rounded opacities on the chest radiograph, reduced lung function, marked eosinophilia in the blood and lower respiratory tract, and high titers of specific IgE and IgG antifilarial antibodies." | 1.28 | Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine. ( Cornelius, MJ; Crystal, RG; Kumaraswami, V; Ottesen, EA; Prabhakar, R; Rom, WN; Vijayan, VK, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Abeygunasekera, A | 1 |
| Jayasinghe, S | 1 |
| Eddy, BA | 1 |
| Blackstock, AJ | 1 |
| Williamson, JM | 1 |
| Addiss, DG | 1 |
| Streit, TG | 1 |
| Beau de Rochars, VM | 1 |
| Fox, LM | 1 |
| Ribeiro, EL | 2 |
| Barbosa, KP | 3 |
| Fragoso, IT | 2 |
| Donato, MA | 2 |
| Gomes, FO | 2 |
| da Silva, BS | 1 |
| Soares e Silva, AK | 1 |
| Rocha, SW | 2 |
| da Silva Junior, VA | 1 |
| Peixoto, CA | 3 |
| de França, ME | 1 |
| Rodrigues, GB | 1 |
| Nunes, AK | 1 |
| Pastor, AF | 1 |
| Oliveira, AG | 1 |
| Oliveira, WH | 1 |
| Luna, RL | 1 |
| Al-Husseini, A | 1 |
| Wijesinghe, DS | 1 |
| Farkas, L | 1 |
| Kraskauskas, D | 1 |
| Drake, JI | 1 |
| Van Tassel, B | 1 |
| Abbate, A | 1 |
| Chalfant, CE | 1 |
| Voelkel, NF | 1 |
| Abdel-Latif, M | 1 |
| Silva, AK | 1 |
| Oliveira, AC | 1 |
| Araújo, SM | 1 |
| Santos, LA | 1 |
| Tamarozzi, F | 1 |
| Halliday, A | 1 |
| Gentil, K | 1 |
| Hoerauf, A | 1 |
| Pearlman, E | 1 |
| Taylor, MJ | 1 |
| Shakya, S | 1 |
| Bajpai, P | 1 |
| Sharma, S | 1 |
| Misra-Bhattacharya, S | 1 |
| Lewis, RA | 1 |
| Austen, KF | 1 |
| Matuschak, GM | 1 |
| Mattingly, ME | 1 |
| Tredway, TL | 1 |
| Lechner, AJ | 1 |
| Pinsky, MR | 1 |
| Roman, A | 1 |
| Buurman, W | 1 |
| Content, J | 1 |
| Vincent, JL | 1 |
| Chand, N | 1 |
| Eyre, P | 1 |
| Henson, PM | 1 |
| Mackenzie, CD | 1 |
| Spector, WG | 1 |
| Rom, WN | 1 |
| Vijayan, VK | 1 |
| Cornelius, MJ | 1 |
| Kumaraswami, V | 1 |
| Prabhakar, R | 1 |
| Ottesen, EA | 1 |
| Crystal, RG | 1 |
| Etienne, A | 1 |
| Soulard, C | 1 |
| Touvay, C | 1 |
| Clostre, F | 1 |
| Braquet, P | 1 |
| Feldbush, TL | 1 |
| Hichens, M | 1 |
| Cello, RM | 1 |
4 reviews available for diethylcarbamazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.
Topics: Animals; Diethylcarbamazine; Filaricides; Humans; Inflammation; Ivermectin; Onchocerca volvulus; Onc | 2011 |
The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchial Spasm; Chemical Phenomena; Chemistry; Diethy | 1984 |
Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Ascariasis; Aspirin; Cattle; Cattle Disea | 1977 |
Ocular onchocerciasis in the horse.
Topics: Animals; Anterior Chamber; Austria; California; Cataract; Ciliary Body; Conjunctivitis; Diethylcarba | 1971 |
1 trial available for diethylcarbamazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Inflammatory reactions in onchocerciasis: a report on current knowledge and recommendations for further study.
Topics: Anti-Inflammatory Agents; Antinematodal Agents; Clinical Trials as Topic; Complement C5; Diethylcarb | 1979 |
13 other studies available for diethylcarbamazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?
Topics: Anti-Inflammatory Agents; Antiviral Agents; Arachidonic Acid; Betacoronavirus; Coronavirus Infection | 2020 |
A longitudinal analysis of the effect of mass drug administration on acute inflammatory episodes and disease progression in lymphedema patients in Leogane, Haiti.
Topics: Adolescent; Adult; Aged; Albendazole; Anthelmintics; Child; Diethylcarbamazine; Elephantiasis, Filar | 2014 |
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Diethylcarba | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
Increased eicosanoid levels in the Sugen/chronic hypoxia model of severe pulmonary hypertension.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arterioles; Cyclooxyg | 2015 |
Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation.
Topics: Adipose Tissue; Animals; Dietary Fats; Diethylcarbamazine; Gene Expression Regulation; Inflammation; | 2015 |
Diethylcarbamazine attenuates LPS-induced acute lung injury in mice by apoptosis of inflammatory cells.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Diethylcarbamazine; Inflammation; I | 2017 |
Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi.
Topics: Animals; Anti-Bacterial Agents; Brugia malayi; Diethylcarbamazine; Disease Models, Animal; Drug Admi | 2008 |
Liver-lung interactions during E. coli endotoxemia. TNF-alpha:leukotriene axis.
Topics: Animals; Bacteremia; Bronchoalveolar Lavage Fluid; Diethylcarbamazine; Endotoxins; Escherichia coli | 1994 |
Effect of ibuprofen and diethylcarbamazine on the hemodynamic and inflammatory response to endotoxin in the dog.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Diethylcarbamazine; Dogs; Endotox | 2000 |
Persistent lower respiratory tract inflammation associated with interstitial lung disease in patients with tropical pulmonary eosinophilia following conventional treatment with diethylcarbamazine.
Topics: Acute Disease; Adult; Bronchoalveolar Lavage Fluid; Diethylcarbamazine; Eosinophils; Female; Humans; | 1990 |
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenas | 1985 |
An acute allergic inflammation in the rat.
Topics: Animals; Antibodies; Antibody Formation; Diethylcarbamazine; Freund's Adjuvant; Hindlimb; Histamine | 1970 |