diethylcarbamazine has been researched along with Disease Models, Animal in 38 studies
Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diethylcarbamazine citrate (DEC) is known as an effective treatment for bronchial asthma because of its ability to reduce eosinophil trafficking to the lung tissue." | 7.96 | Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. ( Abdel-Latif, M; Abdul-Razek, N; Abuelsaad, ASA; M El-Mallah, AM, 2020) |
| "The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway." | 7.85 | Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. ( Jia, G; Liu, X; Zao, M, 2017) |
| "Diethylcarbamazine (DEC), which blocks leukotriene production, abolishes the challenge-induced increase in eosinopoiesis in bone-marrow from ovalbumin- (OVA-) sensitized mice, suggesting that 5-lipoxygenase (5-LO) products contribute to the hematological responses in experimental asthma models." | 7.80 | Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma. ( Gaspar-Elsas, MI; Masid-de-Brito, D; Queto, T; Xavier-Elsas, P, 2014) |
| "Chronic inflammation was induced by i." | 5.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| "Diethylcarbamazine citrate (DEC) is known as an effective treatment for bronchial asthma because of its ability to reduce eosinophil trafficking to the lung tissue." | 3.96 | Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. ( Abdel-Latif, M; Abdul-Razek, N; Abuelsaad, ASA; M El-Mallah, AM, 2020) |
| "The present study investigated the protective effect of diethylcarbamazine in inhibiting nuclear factor (NF)-κB activation in isoproterenol‑induced acute myocardial infarction (AMI) rats through the poly ADP ribose polymerase (PARP) pathway." | 3.85 | Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway. ( Jia, G; Liu, X; Zao, M, 2017) |
| "We tested whether diethylcarbamazine (DEC) or ivermectin (IVM), both antiparasitic drugs with reported immunomodulatory properties, were able to affect the immune system to potentiate host defense mechanisms and protect against actinomycetoma in a mouse model." | 3.80 | Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis. ( Brattig, NW; Castro-Corona, MA; García-Hernández, M; Medina-De la Garza, CE; Segoviano-Ramírez, JC, 2014) |
| "Diethylcarbamazine citrate (DEC) is widely used to treat lymphatic filariasis and Tropical Pulmonary Eosinophilia." | 3.80 | Diethylcarbamazine inhibits NF-κB activation in acute lung injury induced by carrageenan in mice. ( Barbosa, KP; Donato, MA; Fragoso, IT; França, ME; Gomes, FO; Peixoto, CA; Ribeiro, EL; Rocha, SW; Rodrigues, GB; Santos, LA; Silva, AK; Silva, BS; Silva, TG, 2014) |
| "Diethylcarbamazine (DEC), which blocks leukotriene production, abolishes the challenge-induced increase in eosinopoiesis in bone-marrow from ovalbumin- (OVA-) sensitized mice, suggesting that 5-lipoxygenase (5-LO) products contribute to the hematological responses in experimental asthma models." | 3.80 | Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma. ( Gaspar-Elsas, MI; Masid-de-Brito, D; Queto, T; Xavier-Elsas, P, 2014) |
| "Diethylcarbamazine (DEC) is a piperazine derivative drug with anti-inflammatory properties." | 1.40 | Inhibition of NF-κB activation by diethylcarbamazine prevents alcohol-induced liver injury in C57BL/6 mice. ( da Silva, BS; E Silva, AK; Gomes, FO; Peixoto, CA; Ribeiro, EL; Rocha, SW; Rodrigues, GB, 2014) |
| "Chronic inflammation was induced by i." | 1.40 | Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice. ( Barbosa, KP; de França, ME; Luna, RL; Nunes, AK; Oliveira, AG; Oliveira, WH; Pastor, AF; Peixoto, CA; Rocha, SW; Rodrigues, GB, 2014) |
| " viteae homogenate did not protect against adverse reactions to a subsequent microfilaricidal treatment." | 1.33 | Lethal LPS-independent side effects after microfilaricidal treatment in Acanthocheilonema viteae-infected rodents. ( Müller, HA; Zahner, H, 2005) |
| " At 20 days after infection when Brugia were in the 4th larval stage, and at 8 weeks when worms were young adults, cats were divided into groups to test the efficacy of diethylcarbamazine citrate (DEC) at various dosage levels." | 1.26 | Effect of diethylcarbamazine citrate on fourth stage and adult Brugia malayi in cats. ( Emerson, GA; Ewert, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (39.47) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 4 (10.53) | 29.6817 |
| 2010's | 9 (23.68) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Walsh, DA | 1 |
| Green, JB | 1 |
| Franzyshen, SK | 1 |
| Nolan, JC | 1 |
| Yanni, JM | 1 |
| Kausar, S | 1 |
| Khan, W | 1 |
| Dwivedi, S | 1 |
| Azam, A | 1 |
| Abdul-Razek, N | 1 |
| M El-Mallah, AM | 1 |
| Abuelsaad, ASA | 1 |
| Abdel-Latif, M | 1 |
| Jia, G | 1 |
| Zao, M | 1 |
| Liu, X | 1 |
| Rodrigues, GB | 4 |
| Oliveira, EE | 1 |
| Junior, FJBM | 1 |
| Santos, LAMD | 1 |
| Oliveira, WH | 2 |
| França, MER | 1 |
| Lós, DB | 1 |
| Gabínio, BM | 1 |
| de Lira, FCML | 1 |
| Peixoto, CA | 4 |
| da Silva, BS | 1 |
| Rocha, SW | 3 |
| Ribeiro, EL | 2 |
| Gomes, FO | 2 |
| E Silva, AK | 1 |
| García-Hernández, M | 1 |
| Castro-Corona, MA | 1 |
| Segoviano-Ramírez, JC | 1 |
| Brattig, NW | 1 |
| Medina-De la Garza, CE | 1 |
| Santos, LA | 1 |
| Barbosa, KP | 2 |
| Fragoso, IT | 1 |
| Donato, MA | 1 |
| Silva, BS | 1 |
| Silva, AK | 1 |
| França, ME | 1 |
| Silva, TG | 1 |
| de França, ME | 1 |
| Nunes, AK | 1 |
| Pastor, AF | 1 |
| Oliveira, AG | 1 |
| Luna, RL | 1 |
| Masid-de-Brito, D | 1 |
| Queto, T | 1 |
| Gaspar-Elsas, MI | 1 |
| Xavier-Elsas, P | 1 |
| Kushwaha, V | 1 |
| Saxena, K | 1 |
| Verma, R | 1 |
| Verma, SK | 1 |
| Katoch, D | 1 |
| Kumar, N | 1 |
| Lal, B | 1 |
| Murthy, PK | 1 |
| Singh, B | 1 |
| Dangi, A | 1 |
| Dwivedi, V | 1 |
| Vedi, S | 2 |
| Owais, M | 1 |
| Misra-Bhattacharya, S | 3 |
| Müller, HA | 1 |
| Zahner, H | 1 |
| Srivastava, K | 1 |
| Srivastava, S | 1 |
| Shigeno, S | 1 |
| Fujimaki, Y | 1 |
| Toriyama, K | 1 |
| Ichinose, A | 1 |
| Mitsui, Y | 1 |
| Aoki, Y | 2 |
| Kimura, E | 1 |
| Shakya, S | 1 |
| Bajpai, P | 1 |
| Sharma, S | 1 |
| Donnelly, JJ | 3 |
| Rockey, JH | 3 |
| Bianco, AE | 3 |
| Soulsby, EJ | 1 |
| Denham, DA | 1 |
| Schmidt, GM | 1 |
| Krehbiel, JD | 1 |
| Coley, SC | 1 |
| Leid, RW | 1 |
| Chen, SN | 1 |
| Eberhard, ML | 1 |
| Dickerson, JW | 1 |
| Tsang, VC | 1 |
| Walker, EM | 1 |
| Ottesen, EA | 1 |
| Chandrashekar, R | 1 |
| Weil, GJ | 1 |
| Trpis, M | 1 |
| Strobert, E | 1 |
| Constantinidis, I | 1 |
| Schützer, KM | 1 |
| Larsson, A | 1 |
| Risberg, B | 1 |
| Falk, A | 1 |
| Mukhopadhyay, S | 1 |
| Dash, AP | 1 |
| Ravindran, B | 1 |
| Horii, Y | 1 |
| Lämmler, G | 2 |
| Wolf, E | 1 |
| Ewert, A | 1 |
| Emerson, GA | 1 |
| Coperman, DB | 1 |
| Pfaff, MC | 1 |
| Gayral, P | 1 |
| Mahuzier, G | 1 |
| Lonigro, AJ | 1 |
| Stephenson, AH | 1 |
| Sprague, RS | 1 |
| Haldar, JP | 1 |
| Khatami, M | 2 |
| Lok, JB | 2 |
| Mak, JW | 1 |
| Lam, PL | 1 |
| Choong, MF | 1 |
| Suresh, K | 1 |
| Rubin, EH | 1 |
| Zorumski, CF | 1 |
| Hsueh, W | 1 |
| Gonzalez-Crussi, F | 1 |
| Arroyave, JL | 1 |
| Bain, O | 1 |
| Vuong, PN | 1 |
| Petit, G | 1 |
| Chabaud, A | 1 |
| Capron, A | 1 |
| Cesbron, JY | 1 |
| Nwachukwu, MA | 1 |
| Townson, S | 1 |
| Doenhoff, MJ | 1 |
| Muller, RL | 1 |
| Taylor, HR | 1 |
| Young, E | 1 |
| Herzog, H | 1 |
| Brocklehurst, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Microfilarial Clearance From the Eye and Ocular Changes Associated With Ivermectin Treatment in Individuals With Onchocerciasis[NCT03517462] | 231 participants (Actual) | Interventional | 2018-08-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for diethylcarbamazine and Disease Models, Animal
| Article | Year |
|---|---|
The role of slow-reacting substance in asthma.
Topics: Anaphylaxis; Animals; Asthma; Bronchi; Chromones; Diethylcarbamazine; Disease Models, Animal; Guinea | 1970 |
37 other studies available for diethylcarbamazine and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives.
Topics: Anaphylaxis; Animals; Dimethylamines; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; | 1990 |
Antifilarial effect of nanocomposite of silver nanoparticles with nitazoxanide against the microfilariae of Setaria cervi-infected albino rats.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Drug Compounding; Drug Synergism; Filaricides; | 2020 |
Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Antibodies, Monoclonal; Asthma; Biomarkers; Cy | 2020 |
Protective effect of diethylcarbamazine inhibits NF-κB activation in isoproterenol-induced acute myocardial infarction rat model through the PARP pathway.
Topics: Animals; Casein Kinases; Cyclooxygenase 2; Diethylcarbamazine; Disease Models, Animal; I-kappa B Pro | 2017 |
Characterization and evaluation of nanoencapsulated diethylcarbamazine in model of acute hepatic inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capsules; Cytokines; Diethylcarbamazine; Disease M | 2017 |
Inhibition of NF-κB activation by diethylcarbamazine prevents alcohol-induced liver injury in C57BL/6 mice.
Topics: Alcoholism; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury, Chronic; Diethylcarb | 2014 |
Immunomodulatory effect of diethylcarbamazine in mice infected with Nocardia brasiliensis.
Topics: Animals; Antibody Formation; Antiparasitic Agents; Cell Proliferation; Cells, Cultured; Diethylcarba | 2014 |
Diethylcarbamazine inhibits NF-κB activation in acute lung injury induced by carrageenan in mice.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Curcumin; Diethylcarbamazine; Disease Models, Animal | 2014 |
Diethylcarbamazine reduces chronic inflammation and fibrosis in carbon tetrachloride- (CCl₄-) induced liver injury in mice.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Col | 2014 |
Roles of 5-lipoxygenase and cysteinyl-leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma.
Topics: Allergens; Animals; Arachidonate 5-Lipoxygenase; Asthma; Diethylcarbamazine; Disease Models, Animal; | 2014 |
Antifilarial activity of diterpenoids from Taxodium distichum.
Topics: Animals; Brugia malayi; Diethylcarbamazine; Disease Models, Animal; Diterpenes; Elephantiasis, Filar | 2016 |
Improvement in the antifilarial efficacy of doxycycline and rifampicin by combination therapy and drug delivery approach.
Topics: Animals; Brugia malayi; Diethylcarbamazine; Disease Models, Animal; Doxycycline; Drug Therapy, Combi | 2010 |
Lethal LPS-independent side effects after microfilaricidal treatment in Acanthocheilonema viteae-infected rodents.
Topics: Animals; Diethylcarbamazine; Dipetalonema; Dipetalonema Infections; Disease Models, Animal; Drug The | 2005 |
Wuchereria bancrofti: effect of single and multiple larval inoculations on infection dynamics and development of clinical manifestations in non-human primate Presbytis entellus.
Topics: Animals; Cercopithecidae; Culex; Diethylcarbamazine; Disease Models, Animal; Elephantiasis, Filarial | 2007 |
Temporary shift of microfilariae of Brugia pahangi from the lungs to muscles in Mongolian jirds, Meriones unguiculatus, after a single injection of diethylcarbamazine.
Topics: Animals; Blood Vessels; Brugia pahangi; Diethylcarbamazine; Disease Models, Animal; Filaricides; Ger | 2006 |
Prior killing of intracellular bacteria Wolbachia reduces inflammatory reactions and improves antifilarial efficacy of diethylcarbamazine in rodent model of Brugia malayi.
Topics: Animals; Anti-Bacterial Agents; Brugia malayi; Diethylcarbamazine; Disease Models, Animal; Drug Admi | 2008 |
Aqueous humor and serum IgE antibody in experimental ocular Onchocerca infection of guinea pigs.
Topics: Animals; Aqueous Humor; Diethylcarbamazine; Disease Models, Animal; Eye Diseases; Guinea Pigs; Immun | 1983 |
The action of diethylcarbamazine on the skin-dwelling microfilariae of Monanema globulosa (Nematoda: Filarioidea) in rodents.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Female; Filariasis; Filarioidea; Gerbillinae; G | 1984 |
Equine ocular onchocerciasis: histopathologic study.
Topics: Age Factors; Animals; Diethylcarbamazine; Disease Models, Animal; Eye Diseases; Horse Diseases; Hors | 1982 |
Chemotherapy of filariasis.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Filariasis; Filarioidea; Humans; Levamisole; Su | 1981 |
Onchocerca volvulus: parasitologic and serologic responses in experimentally infected chimpanzees and mangabey monkeys.
Topics: Animals; Antibodies, Helminth; Cercocebus; Diethylcarbamazine; Disease Models, Animal; Magnetic Reso | 1995 |
Leukotriene receptor antagonism prevents lung protein leakage and hypoxaemia in a septic cat model.
Topics: Analysis of Variance; Animals; Capillary Permeability; Cats; Diethylcarbamazine; Disease Models, Ani | 1994 |
Setaria digitata microfilaraemia in Mastomys coucha: an animal model for chemotherapeutic and immunobiological studies.
Topics: Aedes; Animals; Antibody Formation; Diethylcarbamazine; Disease Models, Animal; Drug Therapy; Erythr | 1996 |
Plasma levels of diethylcarbamazine and their effects on implanted microfilariae of Brugia pahangi in rats.
Topics: Animals; Brugia pahangi; Chromatography, Gas; Diethylcarbamazine; Disease Models, Animal; Dose-Respo | 1997 |
[Chemoprophylactic activity of filaricidal compounds on litomosoides carinii infection of Mastomys natalensis (author's transl)].
Topics: Animals; Anthelmintics; Bisbenzimidazole; Diethylcarbamazine; Disease Models, Animal; Drug Evaluatio | 1977 |
Effect of diethylcarbamazine citrate on fourth stage and adult Brugia malayi in cats.
Topics: Animals; Brugia; Cats; Diethylcarbamazine; Disease Models, Animal; Dose-Response Relationship, Drug; | 1979 |
An evaluation of the bovine -- Onchocerca gibsoni, Onchocerca gutturosa model as a tertiary screen for drugs against Onchocerca volvulus in man.
Topics: Animals; Cattle; Diethylcarbamazine; Disease Models, Animal; Drug Therapy, Combination; Filaricides; | 1979 |
[Gas chromatographic determination of diethylcarbamazine (Hetrazan) in serum of laboratory rodents (author's transl)].
Topics: Animals; Chromatography, Gas; Cricetinae; Diethylcarbamazine; Disease Models, Animal; Filariasis; Ra | 1978 |
Role of arachidonic acid metabolites in the pathogenesis of acute lung injury.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate 5-Lipoxygenase; | 1991 |
Experimental ocular onchocerciasis: local and systemic antibody and cell-mediated immune responses.
Topics: Animals; Antibodies, Helminth; Cornea; Diethylcarbamazine; Disease Models, Animal; Enzyme-Linked Imm | 1990 |
Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata.
Topics: Administration, Oral; Animals; Brugia; Cercopithecidae; Diethylcarbamazine; Disease Models, Animal; | 1990 |
Limbic seizures, kindling, and psychosis: a link between neurobiology and clinical psychiatry.
Topics: Animals; Bipolar Disorder; Diethylcarbamazine; Disease Models, Animal; Epilepsies, Partial; Humans; | 1985 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Anim | 1986 |
[Cutaneous changes induced by a dose of DEC in rodents with skin microfilaria: relevance of these phenomena for understanding the Mazzotti reaction and the pathogenesis of human onchocerciasis].
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Filariasis; Humans; Microfilariae; Onchocercias | 1987 |
Evaluation of drugs against Onchocerca microfiliariae in an inbred mouse model.
Topics: Animals; Anthelmintics; Diethylcarbamazine; Disease Models, Animal; Drug Evaluation, Preclinical; El | 1986 |
Experimental ocular onchocerciasis in cynomolgus monkeys.
Topics: Animals; Anterior Chamber; Diethylcarbamazine; Disease Models, Animal; Eye; Eye Diseases; Macaca fas | 1986 |
Chemotherapeutic studies on Litomosoides carinii infection of Mastomys natalensis. 4. The prophylactic and suppressive activity of suramin.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Female; Humans; Injections, Intradermal; Male; | 1974 |