diethylcarbamazine and Congenital Familial Lymphedema
diethylcarbamazine has been researched along with Congenital Familial Lymphedema in 31 studies
Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term effect of three different strategies for mass diethylcarbamazine (DEC) administration in bancroftian filariasis was assessed 10 years after start of treatment in three endemic communities in Tanzania." | 7.72 | Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment. ( Magesa, SM; Meyrowitsch, DW; Simonsen, PE, 2004) |
| "Since diethylcarbamazine at the dosages used to treat filarial infections has little direct toxicity, most of the post-treatment reactions (termed Mazzotti reactions in onchocerciasis) result from the immunological inflammatory mechanisms activated in the process of clearing and killing the skin-swelling or blood-borne microfilariae." | 4.77 | Description, mechanisms and control of reactions to treatment in the human filariases. ( Ottesen, EA, 1987) |
| "The long-term effect of three different strategies for mass diethylcarbamazine (DEC) administration in bancroftian filariasis was assessed 10 years after start of treatment in three endemic communities in Tanzania." | 3.72 | Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment. ( Magesa, SM; Meyrowitsch, DW; Simonsen, PE, 2004) |
| " This was independent of age (p = 0·27), symptomatic status (p = 0·57) and semi-annual/bi-annual dosing (p = 0·46)." | 2.84 | Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment. ( Agrawala, BK; Das, BK; Dwibedi, B; Horton, J; Kar, SK; Ramachandran, CP, 2017) |
| "The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs." | 2.70 | Mass treatment to eliminate filariasis in Papua New Guinea. ( Alexander, ND; Alpers, MP; Bockarie, F; Bockarie, MJ; Dimber, Z; Ibam, E; Kastens, W; Kazura, JW; Tisch, DJ, 2002) |
| "Diethylcarbamazine (DEC) was studied with and without 56 BaP." | 2.67 | Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). ( Casley-Smith, J; Casley-Smith, JR; Jamal, S, 1993) |
| "Lymphatic filariasis is widely endemic in Myanmar." | 1.48 | The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar. ( Aye, NN; Bradbury, RS; Dickson, BFR; Douglass, J; Graves, PM; McBride, WJ; Nwe, TW; Shwe, M; Wai, T; Win, SS, 2018) |
| "Nearly 45% of people living at risk for lymphatic filariasis (LF) worldwide live in India." | 1.36 | Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs. ( Cantey, PT; Fox, LM; Rao, G; Rout, J; Williamson, J, 2010) |
| "Although acute tropical pulmonary eosinophilia (TPE) is well recognized as a manifestation of filarial infection, the processes that mediate the abnormalities of the lung in TPE are unknown." | 1.27 | Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy. ( Cornelius, MJ; Ferrans, VJ; Kumaraswami, V; Nutman, TB; O'Donnell, KM; Pinkston, P; Rom, WN; Takemura, T; Vijayan, VK; Yenokida, G, 1987) |
Research
Studies (31)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (64.52) | 18.7374 |
| 1990's | 3 (9.68) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kar, SK | 1 |
| Dwibedi, B | 1 |
| Das, BK | 1 |
| Agrawala, BK | 1 |
| Ramachandran, CP | 1 |
| Horton, J | 1 |
| Lammie, PJ | 1 |
| Eberhard, ML | 1 |
| Addiss, DG | 1 |
| Won, KY | 1 |
| Beau de Rochars, M | 1 |
| Direny, AN | 1 |
| Milord, MD | 1 |
| Lafontant, JG | 1 |
| Streit, TG | 1 |
| Dickson, BFR | 1 |
| Graves, PM | 1 |
| Aye, NN | 1 |
| Nwe, TW | 1 |
| Wai, T | 1 |
| Win, SS | 1 |
| Shwe, M | 1 |
| Douglass, J | 1 |
| Bradbury, RS | 1 |
| McBride, WJ | 1 |
| Wijesinghe, RS | 1 |
| Wickremasinghe, AR | 1 |
| Ekanayake, S | 1 |
| Perera, MS | 1 |
| Cantey, PT | 1 |
| Rout, J | 1 |
| Rao, G | 1 |
| Williamson, J | 1 |
| Fox, LM | 1 |
| Taylor, MJ | 1 |
| Hoerauf, A | 1 |
| Bockarie, M | 1 |
| Bockarie, MJ | 1 |
| Tisch, DJ | 1 |
| Kastens, W | 1 |
| Alexander, ND | 1 |
| Dimber, Z | 1 |
| Bockarie, F | 1 |
| Ibam, E | 1 |
| Alpers, MP | 1 |
| Kazura, JW | 2 |
| WILLIAMS, HW | 1 |
| Meyrowitsch, DW | 1 |
| Simonsen, PE | 1 |
| Magesa, SM | 1 |
| Lloyd-Davies, RW | 1 |
| Edwards, JM | 1 |
| Kinmonth, JB | 1 |
| Partono, F | 3 |
| Oemijati, S | 1 |
| Soewarta, A | 2 |
| Ge, ZH | 1 |
| Liu, WX | 1 |
| Mergerian, H | 1 |
| Bommer, W | 1 |
| Casley-Smith, JR | 3 |
| Jamal, S | 2 |
| Casley-Smith, J | 1 |
| Shenoy, RK | 2 |
| Sandhya, K | 1 |
| Suma, TK | 2 |
| Kumaraswami, V | 3 |
| Rajan, K | 1 |
| Radhakuttyamma, G | 1 |
| Guillozet, N | 1 |
| Ottesen, EA | 1 |
| Pinkston, P | 1 |
| Vijayan, VK | 1 |
| Nutman, TB | 1 |
| Rom, WN | 1 |
| O'Donnell, KM | 1 |
| Cornelius, MJ | 1 |
| Ferrans, VJ | 1 |
| Takemura, T | 1 |
| Yenokida, G | 1 |
| Kim, JS | 1 |
| No, BU | 1 |
| Lee, WY | 1 |
| Raccurt, CP | 1 |
| Helmcke, MS | 1 |
| Kernizan, MS | 1 |
| Desinor, G | 1 |
| Duverseau, YT | 1 |
| Lowrie, RC | 1 |
| Mak, JW | 1 |
| Vickery, AC | 1 |
| Nayar, JK | 1 |
| Tamplin, ML | 1 |
| Fanning, MM | 1 |
| Sutanto, I | 1 |
| Boreham, PF | 1 |
| Munawar, M | 1 |
| Charters, AD | 1 |
| Wolfe, MS | 1 |
| Petersen, JL | 1 |
| Neafie, RC | 1 |
| Connor, DH | 1 |
| Purtilo, DT | 1 |
| Comen, AP | 1 |
| Ciferri, F | 1 |
| Siliga, N | 1 |
| Long, G | 1 |
| Kessel, JF | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Albendazole Dose and Interval on Brugia Malayi Microfilarial Clearance in India: A Randomized, Open Label Study[NCT00511004] | Phase 2 | 40 participants (Actual) | Interventional | 2007-07-31 | Completed | ||
| A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02929134] | Phase 3 | 219 participants (Actual) | Interventional | 2018-02-16 | Completed | ||
| A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02927496] | Phase 3 | 220 participants (Actual) | Interventional | 2018-06-19 | Completed | ||
| A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02929121] | Phase 3 | 235 participants (Actual) | Interventional | 2019-01-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Adult Worm Burdens at 2 Years
Doppler detected worm nests at 2 years (NCT00511004)
Timeframe: 2 years from the time enrolled.
| Intervention | Number of nests (Median) |
|---|---|
| Standard Therapy Annual DEC/ALB | 0 |
| High Dose Annual DEC/ALB | 0 |
| High Dose Semiannual DEC/ALB | 0 |
Brugia Specific Immunoglobulin G4 (IgG4) Antibodies
IgG4 antibodies directed against Brugia malayi antigen (NCT00511004)
Timeframe: 2 years
| Intervention | ng/ml (Median) |
|---|---|
| Standard Therapy Annual DEC/ALB | 150 |
| High Dose Annual DEC/ALB | 224 |
| High Dose Semiannual DEC/ALB | 128 |
Microfilarial Counts at 1 Year
Night time microfilarial counts at 1 year (NCT00511004)
Timeframe: 1 year from time enrolled
| Intervention | MF/ML (Median) |
|---|---|
| Standard Therapy Annual DEC/ALB | 0 |
| High Dose Annual DEC/ALB | 0 |
| High Dose Semiannual DEC/ALB | 0 |
Microfilarial Levels at 2 Years
Night time microfilarial levels at 2 years (NCT00511004)
Timeframe: 2 years from time enrolled
| Intervention | MF/ML (Median) |
|---|---|
| Diethylcarbamazine/Albendazole -STD | 0 |
| Diethylcarbamazine/Albendazole- HD1 | 0 |
| Diethylcarbamazine/Albendazole-HD2 | 0 |
Reviews
2 reviews available for diethylcarbamazine and Congenital Familial Lymphedema
| Article | Year |
|---|---|
Lymphatic filariasis and onchocerciasis.
Topics: Africa South of the Sahara; Age Factors; Albendazole; Animals; Anti-Bacterial Agents; Antinematodal | 2010 |
Description, mechanisms and control of reactions to treatment in the human filariases.
Topics: Animals; Anthelmintics; Diethylcarbamazine; Elephantiasis, Filarial; Filariasis; Filaricides; Humans | 1987 |
Trials
6 trials available for diethylcarbamazine and Congenital Familial Lymphedema
Other Studies
23 other studies available for diethylcarbamazine and Congenital Familial Lymphedema
| Article | Year |
|---|---|
Translating Research into Reality: Elimination of Lymphatic Filariasis from Haiti.
Topics: Diethylcarbamazine; Disease Eradication; Elephantiasis, Filarial; Filaricides; Haiti; Humans; Lymphe | 2017 |
The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albendazole; Animals; Child; Child, Preschool; Cross-Sec | 2018 |
Treatment-seeking behavior and treatment practices of lymphatic filariasis patients with lymphoedema in the Colombo district, Sri Lanka.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Diethylca | 2008 |
Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albendazole; Analysis of Variance; Animals; Child; Child | 2010 |
FILARIAL LYMPHOEDEMA AND ITS SURGICAL TREATMENT.
Topics: Animals; Diethylcarbamazine; Filariasis; Fluorides; Humans; India; Lymphedema; Procaine; Surgical Pr | 1963 |
Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment.
Topics: Adolescent; Adult; Animals; Child; Diethylcarbamazine; Drug Administration Schedule; Endemic Disease | 2004 |
Chyluria: a report of five cases with particular reference to lymphography and direct surgery.
Topics: Adult; Aged; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; Kidney Diseases; Lymphatic Syste | 1967 |
The long term effects of repeated diethylcarbamazine administration with special reference to microfilaraemia and elephantiasis.
Topics: Adolescent; Adult; Aged; Animals; Blood; Brugia; Child; Child, Preschool; Diethylcarbamazine; Elepha | 1981 |
[A preliminary study on the changes in pathology and histochemistry of affected limbs in filarial elephantiasis after the treatment with the baking-bandage method and hetrazan].
Topics: Adult; Bandages; Diethylcarbamazine; Elephantiasis; Female; Filariasis; Hot Temperature; Humans; Lym | 1982 |
[Elephantiasis - a tropical nematode infection].
Topics: Adult; Diagnosis, Differential; Diethylcarbamazine; Elephantiasis; Female; Humans; Lymphedema; Male | 1982 |
Upper extremity lymphedema in filariasis.
Topics: Adult; Arm; Diethylcarbamazine; Filariasis; Humans; Lymphedema; Male | 1979 |
A simple method to control Brugia timori by diethylcarbamazine administration.
Topics: Brugia; Diethylcarbamazine; Drug Administration Schedule; Filariasis; Humans; Indonesia; Lymphangiti | 1979 |
Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy.
Topics: Adult; Bronchi; Brugia; Cell Count; Diethylcarbamazine; Elephantiasis, Filarial; Eosinophils; Female | 1987 |
Brugian filariasis: 10-year follow-up study on the effectiveness of selective chemotherapy with diethylcarbamazine on Che Ju island, Republic of Korea.
Topics: Adolescent; Adult; Aged; Brugia; Child; Child, Preschool; Diethylcarbamazine; Elephantiasis, Filaria | 1987 |
[Wuchereria bancrofti: value of the diethylcarbamazine provocation test for the diurnal detection of microfilaria carriers].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Circadian Rhythm; Diethylcarbamazine; Elephantiasi | 1986 |
Problems in filariasis control and the need for human behaviour and socio-economic research.
Topics: Attitude to Health; Brugia; Diethylcarbamazine; Emigration and Immigration; Filariasis; Humans; Lymp | 1986 |
Diethylcarbamazine-mediated clearance of Brugia pahangi microfilariae in immunodeficient nude mice.
Topics: Animals; Brugia; Diethylcarbamazine; Elephantiasis, Filarial; Female; Fluorescent Antibody Technique | 1985 |
Brugia malayi: clearance of microfilaremia induced by diethylcarbamazine independently of antibody.
Topics: Animals; Antibodies; Brugia; Diethylcarbamazine; Elephantiasis, Filarial; Liver; Lymphedema; Mice; N | 1985 |
Adverse reactions to a single dose of diethylcarbamazine in patients with Brugia malayi infection in Riau Province, West Indonesia.
Topics: Adolescent; Adult; Blood Pressure; Brugia; Child; Diethylcarbamazine; Elephantiasis, Filarial; Femal | 1985 |
Filariasis in immigrants in Western Australia, including a case of chyluria recurring in seven pregnancies.
Topics: Adult; Aged; Australia; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; India; Lymphedema; Ma | 1970 |
Onchocerciasis presenting with swelling of limb.
Topics: Adult; Ankle; Biopsy; Brazil; Collagen; Diethylcarbamazine; Eosinophils; Extremities; Fluorescent An | 1974 |
Onchocerciasis in the Kaffa Province of Ethiopia.
Topics: Adolescent; Adult; Child; Child, Preschool; Diethylcarbamazine; Eosinophilia; Ethiopia; Female; Huma | 1967 |
A filariasis-control program in American Samoa.
Topics: Adolescent; Adult; Age Factors; Aged; Carrier State; Child; Child, Preschool; Diethylcarbamazine; Fe | 1969 |