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diethylcarbamazine and Congenital Familial Lymphedema

diethylcarbamazine has been researched along with Congenital Familial Lymphedema in 31 studies

Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

Research Excerpts

ExcerptRelevanceReference
"The long-term effect of three different strategies for mass diethylcarbamazine (DEC) administration in bancroftian filariasis was assessed 10 years after start of treatment in three endemic communities in Tanzania."7.72Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment. ( Magesa, SM; Meyrowitsch, DW; Simonsen, PE, 2004)
"Since diethylcarbamazine at the dosages used to treat filarial infections has little direct toxicity, most of the post-treatment reactions (termed Mazzotti reactions in onchocerciasis) result from the immunological inflammatory mechanisms activated in the process of clearing and killing the skin-swelling or blood-borne microfilariae."4.77Description, mechanisms and control of reactions to treatment in the human filariases. ( Ottesen, EA, 1987)
"The long-term effect of three different strategies for mass diethylcarbamazine (DEC) administration in bancroftian filariasis was assessed 10 years after start of treatment in three endemic communities in Tanzania."3.72Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment. ( Magesa, SM; Meyrowitsch, DW; Simonsen, PE, 2004)
" This was independent of age (p = 0·27), symptomatic status (p = 0·57) and semi-annual/bi-annual dosing (p = 0·46)."2.84Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment. ( Agrawala, BK; Das, BK; Dwibedi, B; Horton, J; Kar, SK; Ramachandran, CP, 2017)
"The global initiative to eradicate bancroftian filariasis currently relies on mass treatment with four to six annual doses of antifilarial drugs."2.70Mass treatment to eliminate filariasis in Papua New Guinea. ( Alexander, ND; Alpers, MP; Bockarie, F; Bockarie, MJ; Dimber, Z; Ibam, E; Kastens, W; Kazura, JW; Tisch, DJ, 2002)
"Diethylcarbamazine (DEC) was studied with and without 56 BaP."2.67Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC). ( Casley-Smith, J; Casley-Smith, JR; Jamal, S, 1993)
"Lymphatic filariasis is widely endemic in Myanmar."1.48The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar. ( Aye, NN; Bradbury, RS; Dickson, BFR; Douglass, J; Graves, PM; McBride, WJ; Nwe, TW; Shwe, M; Wai, T; Win, SS, 2018)
"Nearly 45% of people living at risk for lymphatic filariasis (LF) worldwide live in India."1.36Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs. ( Cantey, PT; Fox, LM; Rao, G; Rout, J; Williamson, J, 2010)
"Although acute tropical pulmonary eosinophilia (TPE) is well recognized as a manifestation of filarial infection, the processes that mediate the abnormalities of the lung in TPE are unknown."1.27Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy. ( Cornelius, MJ; Ferrans, VJ; Kumaraswami, V; Nutman, TB; O'Donnell, KM; Pinkston, P; Rom, WN; Takemura, T; Vijayan, VK; Yenokida, G, 1987)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199020 (64.52)18.7374
1990's3 (9.68)18.2507
2000's3 (9.68)29.6817
2010's5 (16.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kar, SK1
Dwibedi, B1
Das, BK1
Agrawala, BK1
Ramachandran, CP1
Horton, J1
Lammie, PJ1
Eberhard, ML1
Addiss, DG1
Won, KY1
Beau de Rochars, M1
Direny, AN1
Milord, MD1
Lafontant, JG1
Streit, TG1
Dickson, BFR1
Graves, PM1
Aye, NN1
Nwe, TW1
Wai, T1
Win, SS1
Shwe, M1
Douglass, J1
Bradbury, RS1
McBride, WJ1
Wijesinghe, RS1
Wickremasinghe, AR1
Ekanayake, S1
Perera, MS1
Cantey, PT1
Rout, J1
Rao, G1
Williamson, J1
Fox, LM1
Taylor, MJ1
Hoerauf, A1
Bockarie, M1
Bockarie, MJ1
Tisch, DJ1
Kastens, W1
Alexander, ND1
Dimber, Z1
Bockarie, F1
Ibam, E1
Alpers, MP1
Kazura, JW2
WILLIAMS, HW1
Meyrowitsch, DW1
Simonsen, PE1
Magesa, SM1
Lloyd-Davies, RW1
Edwards, JM1
Kinmonth, JB1
Partono, F3
Oemijati, S1
Soewarta, A2
Ge, ZH1
Liu, WX1
Mergerian, H1
Bommer, W1
Casley-Smith, JR3
Jamal, S2
Casley-Smith, J1
Shenoy, RK2
Sandhya, K1
Suma, TK2
Kumaraswami, V3
Rajan, K1
Radhakuttyamma, G1
Guillozet, N1
Ottesen, EA1
Pinkston, P1
Vijayan, VK1
Nutman, TB1
Rom, WN1
O'Donnell, KM1
Cornelius, MJ1
Ferrans, VJ1
Takemura, T1
Yenokida, G1
Kim, JS1
No, BU1
Lee, WY1
Raccurt, CP1
Helmcke, MS1
Kernizan, MS1
Desinor, G1
Duverseau, YT1
Lowrie, RC1
Mak, JW1
Vickery, AC1
Nayar, JK1
Tamplin, ML1
Fanning, MM1
Sutanto, I1
Boreham, PF1
Munawar, M1
Charters, AD1
Wolfe, MS1
Petersen, JL1
Neafie, RC1
Connor, DH1
Purtilo, DT1
Comen, AP1
Ciferri, F1
Siliga, N1
Long, G1
Kessel, JF1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Albendazole Dose and Interval on Brugia Malayi Microfilarial Clearance in India: A Randomized, Open Label Study[NCT00511004]Phase 240 participants (Actual)Interventional2007-07-31Completed
A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02929134]Phase 3219 participants (Actual)Interventional2018-02-16Completed
A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02927496]Phase 3220 participants (Actual)Interventional2018-06-19Completed
A Multi-center, Double-blind, Randomized, 24-month Study, to Compare the Efficacy of Doxycycline Once Daily for 6 Weeks Versus Placebo in Improving Filarial Lymphedema Independent of Active Filarial Infection[NCT02929121]Phase 3235 participants (Actual)Interventional2019-01-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Adult Worm Burdens at 2 Years

Doppler detected worm nests at 2 years (NCT00511004)
Timeframe: 2 years from the time enrolled.

InterventionNumber of nests (Median)
Standard Therapy Annual DEC/ALB0
High Dose Annual DEC/ALB0
High Dose Semiannual DEC/ALB0

Brugia Specific Immunoglobulin G4 (IgG4) Antibodies

IgG4 antibodies directed against Brugia malayi antigen (NCT00511004)
Timeframe: 2 years

Interventionng/ml (Median)
Standard Therapy Annual DEC/ALB150
High Dose Annual DEC/ALB224
High Dose Semiannual DEC/ALB128

Microfilarial Counts at 1 Year

Night time microfilarial counts at 1 year (NCT00511004)
Timeframe: 1 year from time enrolled

InterventionMF/ML (Median)
Standard Therapy Annual DEC/ALB0
High Dose Annual DEC/ALB0
High Dose Semiannual DEC/ALB0

Microfilarial Levels at 2 Years

Night time microfilarial levels at 2 years (NCT00511004)
Timeframe: 2 years from time enrolled

InterventionMF/ML (Median)
Diethylcarbamazine/Albendazole -STD0
Diethylcarbamazine/Albendazole- HD10
Diethylcarbamazine/Albendazole-HD20

Reviews

2 reviews available for diethylcarbamazine and Congenital Familial Lymphedema

ArticleYear
Lymphatic filariasis and onchocerciasis.
    Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747

    Topics: Africa South of the Sahara; Age Factors; Albendazole; Animals; Anti-Bacterial Agents; Antinematodal

2010
Description, mechanisms and control of reactions to treatment in the human filariases.
    Ciba Foundation symposium, 1987, Volume: 127

    Topics: Animals; Anthelmintics; Diethylcarbamazine; Elephantiasis, Filarial; Filariasis; Filaricides; Humans

1987

Trials

6 trials available for diethylcarbamazine and Congenital Familial Lymphedema

ArticleYear
Lymphatic pathology in asymptomatic and symptomatic children with Wuchereria bancrofti infection in children from Odisha, India and its reversal with DEC and albendazole treatment.
    PLoS neglected tropical diseases, 2017, Volume: 11, Issue:10

    Topics: Administration, Oral; Adolescent; Albendazole; Animals; Asymptomatic Infections; Child; Child, Presc

2017
Mass treatment to eliminate filariasis in Papua New Guinea.
    The New England journal of medicine, 2002, Dec-05, Volume: 347, Issue:23

    Topics: Adolescent; Adult; Animals; Child; Child, Preschool; Culicidae; Diethylcarbamazine; Disease Reservoi

2002
Reduction of filaritic lymphoedema and elephantiasis by 5,6 benzo-alpha-pyrone (coumarin), and the effects of diethylcarbamazine (DEC).
    Annals of tropical medicine and parasitology, 1993, Volume: 87, Issue:3

    Topics: Adult; Aged; Coumarins; Diethylcarbamazine; Double-Blind Method; Drug Therapy, Combination; Elephant

1993
A preliminary study of filariasis related acute adenolymphangitis with special reference to precipitating factors and treatment modalities.
    The Southeast Asian journal of tropical medicine and public health, 1995, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Brugia; Causality; Diethylcarbamazine; Elep

1995
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
A double-blind, placebo-controlled study of the efficacy of oral penicillin, diethylcarbamazine or local treatment of the affected limb in preventing acute adenolymphangitis in lymphoedema caused by brugian filariasis.
    Annals of tropical medicine and parasitology, 1999, Volume: 93, Issue:4

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Animals; Brugia; Diethylcarbamazine; D

1999
The effects of 5,6 benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India. Preliminary results.
    Annals of tropical medicine and parasitology, 1989, Volume: 83, Issue:3

    Topics: Analysis of Variance; Coumarins; Diethylcarbamazine; Double-Blind Method; Elephantiasis, Filarial; F

1989

Other Studies

23 other studies available for diethylcarbamazine and Congenital Familial Lymphedema

ArticleYear
Translating Research into Reality: Elimination of Lymphatic Filariasis from Haiti.
    The American journal of tropical medicine and hygiene, 2017, Volume: 97, Issue:4_Suppl

    Topics: Diethylcarbamazine; Disease Eradication; Elephantiasis, Filarial; Filaricides; Haiti; Humans; Lymphe

2017
The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albendazole; Animals; Child; Child, Preschool; Cross-Sec

2018
Treatment-seeking behavior and treatment practices of lymphatic filariasis patients with lymphoedema in the Colombo district, Sri Lanka.
    Asia-Pacific journal of public health, 2008, Volume: 20, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Child; Cross-Sectional Studies; Diethylca

2008
Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs.
    PLoS neglected tropical diseases, 2010, Jun-29, Volume: 4, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albendazole; Analysis of Variance; Animals; Child; Child

2010
FILARIAL LYMPHOEDEMA AND ITS SURGICAL TREATMENT.
    The Journal of the Christian Medical Association of India, 1963, Volume: 38

    Topics: Animals; Diethylcarbamazine; Filariasis; Fluorides; Humans; India; Lymphedema; Procaine; Surgical Pr

1963
Long-term effect of three different strategies for mass diethylcarbamazine administration in bancroftian filariasis: follow-up at 10 years after treatment.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2004, Volume: 98, Issue:11

    Topics: Adolescent; Adult; Animals; Child; Diethylcarbamazine; Drug Administration Schedule; Endemic Disease

2004
Chyluria: a report of five cases with particular reference to lymphography and direct surgery.
    British journal of urology, 1967, Volume: 39, Issue:5

    Topics: Adult; Aged; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; Kidney Diseases; Lymphatic Syste

1967
The long term effects of repeated diethylcarbamazine administration with special reference to microfilaraemia and elephantiasis.
    Acta tropica, 1981, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Aged; Animals; Blood; Brugia; Child; Child, Preschool; Diethylcarbamazine; Elepha

1981
[A preliminary study on the changes in pathology and histochemistry of affected limbs in filarial elephantiasis after the treatment with the baking-bandage method and hetrazan].
    Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1982, Volume: 2, Issue:2

    Topics: Adult; Bandages; Diethylcarbamazine; Elephantiasis; Female; Filariasis; Hot Temperature; Humans; Lym

1982
[Elephantiasis - a tropical nematode infection].
    Zeitschrift fur Lymphologie. Journal of lymphology, 1982, Volume: 6, Issue:1

    Topics: Adult; Diagnosis, Differential; Diethylcarbamazine; Elephantiasis; Female; Humans; Lymphedema; Male

1982
Upper extremity lymphedema in filariasis.
    Archives of internal medicine, 1979, Volume: 139, Issue:9

    Topics: Adult; Arm; Diethylcarbamazine; Filariasis; Humans; Lymphedema; Male

1979
A simple method to control Brugia timori by diethylcarbamazine administration.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1979, Volume: 73, Issue:5

    Topics: Brugia; Diethylcarbamazine; Drug Administration Schedule; Filariasis; Humans; Indonesia; Lymphangiti

1979
Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:1

    Topics: Adult; Bronchi; Brugia; Cell Count; Diethylcarbamazine; Elephantiasis, Filarial; Eosinophils; Female

1987
Brugian filariasis: 10-year follow-up study on the effectiveness of selective chemotherapy with diethylcarbamazine on Che Ju island, Republic of Korea.
    Bulletin of the World Health Organization, 1987, Volume: 65, Issue:1

    Topics: Adolescent; Adult; Aged; Brugia; Child; Child, Preschool; Diethylcarbamazine; Elephantiasis, Filaria

1987
[Wuchereria bancrofti: value of the diethylcarbamazine provocation test for the diurnal detection of microfilaria carriers].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1986, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Circadian Rhythm; Diethylcarbamazine; Elephantiasi

1986
Problems in filariasis control and the need for human behaviour and socio-economic research.
    The Southeast Asian journal of tropical medicine and public health, 1986, Volume: 17, Issue:3

    Topics: Attitude to Health; Brugia; Diethylcarbamazine; Emigration and Immigration; Filariasis; Humans; Lymp

1986
Diethylcarbamazine-mediated clearance of Brugia pahangi microfilariae in immunodeficient nude mice.
    The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:3

    Topics: Animals; Brugia; Diethylcarbamazine; Elephantiasis, Filarial; Female; Fluorescent Antibody Technique

1985
Brugia malayi: clearance of microfilaremia induced by diethylcarbamazine independently of antibody.
    Experimental parasitology, 1985, Volume: 60, Issue:3

    Topics: Animals; Antibodies; Brugia; Diethylcarbamazine; Elephantiasis, Filarial; Liver; Lymphedema; Mice; N

1985
Adverse reactions to a single dose of diethylcarbamazine in patients with Brugia malayi infection in Riau Province, West Indonesia.
    The Southeast Asian journal of tropical medicine and public health, 1985, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Blood Pressure; Brugia; Child; Diethylcarbamazine; Elephantiasis, Filarial; Femal

1985
Filariasis in immigrants in Western Australia, including a case of chyluria recurring in seven pregnancies.
    The Medical journal of Australia, 1970, Nov-14, Volume: 2, Issue:20

    Topics: Adult; Aged; Australia; Chyle; Diethylcarbamazine; Female; Filariasis; Humans; India; Lymphedema; Ma

1970
Onchocerciasis presenting with swelling of limb.
    The American journal of tropical medicine and hygiene, 1974, Volume: 23, Issue:3

    Topics: Adult; Ankle; Biopsy; Brazil; Collagen; Diethylcarbamazine; Eosinophils; Extremities; Fluorescent An

1974
Onchocerciasis in the Kaffa Province of Ethiopia.
    Tropical and geographical medicine, 1967, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Diethylcarbamazine; Eosinophilia; Ethiopia; Female; Huma

1967
A filariasis-control program in American Samoa.
    The American journal of tropical medicine and hygiene, 1969, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Carrier State; Child; Child, Preschool; Diethylcarbamazine; Fe

1969