diethyl-maleate and Kidney-Diseases

diethyl-maleate has been researched along with Kidney-Diseases* in 2 studies

Other Studies

2 other study(ies) available for diethyl-maleate and Kidney-Diseases

Article	Year
Effects of cysteine and diethylmaleate pretreatments on renal function and response to a nephrotoxicant. Archives of toxicology, 1986, Volume: 59, Issue:1 The effects of treatment with either cysteine (2 X 150 mg/kg) or diethylmaleate (0.7 ml/kg) on renal function and response to the nephrotoxicant hexachloro-1,3-butadiene (HCBD) were examined. Cysteine caused oliguria, blocked the polyuric and glucosuric effects of HCBD and attenuated the reduction of urine osmolality. Diethylmaleate (DEM) decreased urine osmolality; further decreases of urine osmolality were not seen after HCBD. DEM pretreatment increased HCBD-induced proteinuria. HCBD-induced elevation of plasma creatinine concentration was not affected by either of the pretreatments whereas the plasma urea nitrogen concentration was greater in the DEM-pretreated group. The latter may represent an effect of DEM on non-filtration handling of urea. The results suggest that cysteine and diethylmaleate each have effects on kidney function which alter the response of the nephron tubule to a subsequently administered toxic agent. Topics: Animals; Blood Urea Nitrogen; Butadienes; Cysteine; Glycosuria; Kidney Diseases; Male; Maleates; Proteinuria; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Time Factors	1986
Potentiation of acute chloroform nephrotoxicity by the glutathione depletor diethyl maleate and protection by the microsomal enzyme inhibitor piperonyl butoxide. Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3 Topics: Animals; Chloroform; Drug Synergism; Glutathione; Kidney Cortex; Kidney Diseases; Male; Maleates; Mice; Mice, Inbred ICR; Microsomes, Liver; Piperonyl Butoxide; Proadifen	1981

Article

Year

Effects of cysteine and diethylmaleate pretreatments on renal function and response to a nephrotoxicant.

Archives of toxicology, 1986, Volume: 59, Issue:1

The effects of treatment with either cysteine (2 X 150 mg/kg) or diethylmaleate (0.7 ml/kg) on renal function and response to the nephrotoxicant hexachloro-1,3-butadiene (HCBD) were examined. Cysteine caused oliguria, blocked the polyuric and glucosuric effects of HCBD and attenuated the reduction of urine osmolality. Diethylmaleate (DEM) decreased urine osmolality; further decreases of urine osmolality were not seen after HCBD. DEM pretreatment increased HCBD-induced proteinuria. HCBD-induced elevation of plasma creatinine concentration was not affected by either of the pretreatments whereas the plasma urea nitrogen concentration was greater in the DEM-pretreated group. The latter may represent an effect of DEM on non-filtration handling of urea. The results suggest that cysteine and diethylmaleate each have effects on kidney function which alter the response of the nephron tubule to a subsequently administered toxic agent.

Topics: Animals; Blood Urea Nitrogen; Butadienes; Cysteine; Glycosuria; Kidney Diseases; Male; Maleates; Proteinuria; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Time Factors

1986

Potentiation of acute chloroform nephrotoxicity by the glutathione depletor diethyl maleate and protection by the microsomal enzyme inhibitor piperonyl butoxide.

Toxicology and applied pharmacology, 1981, Volume: 59, Issue:3

Topics: Animals; Chloroform; Drug Synergism; Glutathione; Kidney Cortex; Kidney Diseases; Male; Maleates; Mice; Mice, Inbred ICR; Microsomes, Liver; Piperonyl Butoxide; Proadifen

1981