diethyl-maleate and Dermatitis--Contact

Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was shown to be a more effective vehicle than petrolatum, when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk-benefit judgments is discussed briefly.

Topics: Coumarins; Dermatitis, Contact; Ethanol; Humans; Immunization; Irritants; Maleates; Oils; Petrolatum; Pharmaceutical Vehicles