Compounds > diepoxybutane
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diepoxybutane and Chromosomal Breakage

diepoxybutane has been researched along with Chromosomal Breakage in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.76)18.2507
2000's10 (58.82)29.6817
2010's5 (29.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cirković, S; Guć-Sćekić, M; Mićić, D; Skorić, D; Vujić, D1
Alter, BP; Fargo, JH; Giri, N; Olson, SB; Rochowski, A; Savage, SA1
Auerbach, AD1
Al-Haggar, M; Al-Morsy, Z; Chalaby, N; Mesbah, A; Ragab, A; Yahia, S1
Porto, B; Porto, G; Vieira, R1
Bitencourt, MA; Cavalli, IJ; Magdalena, NI; Pasquini, R; Pereira, NF; Pilonetto, DV; Ribeiro, RC; Veiga, LB; Vieira, ER1
Ghosh, K; Korgaonkar, S; Vundinti, BR1
Barbot, J; Gaspar, J; Gonçalves, C; Malheiro, I; Porto, B; Rueff, J; Sousa, R1
D'Andrea, AD; Haining, N; Montes de Oca, R; Moreau, LA; Nathan, DG; Shimamura, A; Svenson, JL1
Chiecchio, L; Faber, A; Gaspar, J; Malheiro, I; Pinho, L; Porto, B; Rueff, J1
Deviren, A; Hacihanefioglu, S; Yalman, N1
Carnevale, A; Esmer, C; Frias, S; Molina, B; Ramos, S; Sánchez, S1
Carvalho, F; Gaspar, J; Malheiro, I; Oliveira, RJ; Porto, B; Rueff, J; Sousa, C1
Hirsch-Kauffmann, M; Meisslitzer, C; Ruppitsch, W; Schweiger, M1
Eastmond, DA; Murg, Mn; Schuler, M1
Dokal, I1
Bruun, D; Cox, B; D'Andrea, AD; Grompe, M; Hejna, J; Lucas, L; Moses, R; Olson, S; Reifsteck, C; Taniguchi, T; Thayer, M; Timmers, C1

Reviews

1 review(s) available for diepoxybutane and Chromosomal Breakage

ArticleYear
The genetics of Fanconi's anaemia.
    Bailliere's best practice & research. Clinical haematology, 2000, Volume: 13, Issue:3

    Topics: Cells, Cultured; Chromosome Breakage; DNA Damage; Epoxy Compounds; Fanconi Anemia; Genetic Testing; Genetic Therapy; Humans; Mitomycin; Phenotype

2000

Trials

1 trial(s) available for diepoxybutane and Chromosomal Breakage

ArticleYear
Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients.
    Indian journal of pediatrics, 2008, Volume: 75, Issue:7

    Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosomal Instability; Chromosome Breakage; Dose-Response Relationship, Radiation; Egypt; Epoxy Compounds; Fanconi Anemia; Female; Growth Hormone; Humans; Insulin-Like Growth Factor I; Lymphocytes; Male; Mitomycin; Mutagens; Nucleic Acid Synthesis Inhibitors; Thyroid Hormones; Thyrotropin

2008

Other Studies

15 other study(ies) available for diepoxybutane and Chromosomal Breakage

ArticleYear
Chromosomal instability in patients with Fanconi anemia from Serbia.
    Vojnosanitetski pregled, 2014, Volume: 71, Issue:4

    Topics: Case-Control Studies; Child; Chromosomal Instability; Chromosome Breakage; Cytogenetic Analysis; Epoxy Compounds; Fanconi Anemia; Humans; Sensitivity and Specificity; Serbia

2014
Comparison of chromosome breakage in non-mosaic and mosaic patients with Fanconi anemia, relatives, and patients with other inherited bone marrow failure syndromes.
    Cytogenetic and genome research, 2014, Volume: 144, Issue:1

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Bone Marrow Diseases; Bone Marrow Failure Disorders; Child; Child, Preschool; Chromosome Breakage; Cohort Studies; Epoxy Compounds; Fanconi Anemia; Female; Genetic Carrier Screening; Genotype; Hemoglobinuria, Paroxysmal; Humans; Infant; Lymphocytes; Male; Middle Aged; Mitomycin; Mosaicism; Mutagens; Young Adult

2014
Diagnosis of Fanconi anemia by diepoxybutane analysis.
    Current protocols in human genetics, 2015, Apr-01, Volume: 85

    Topics: Chromosome Breakage; Epoxy Compounds; Fanconi Anemia; Fibroblasts; Genetic Techniques; Humans; Phenotype; Postnatal Care; Prenatal Diagnosis; Staining and Labeling

2015
Increased capacity of lymphocytes from hereditary hemochromatosis patients homozygous for the C282Y HFE mutation to respond to the genotoxic effect of diepoxybutane.
    Mutation research, 2009, Feb-19, Volume: 673, Issue:1

    Topics: Adult; Aged; Cells, Cultured; Chromosomal Instability; Chromosome Breakage; Epoxy Compounds; Female; Hemochromatosis; Hemochromatosis Protein; Histocompatibility Antigens Class I; Homozygote; Humans; Iron Overload; Lymphocytes; Male; Membrane Proteins; Middle Aged; Young Adult

2009
FANCD2 Western blot as a diagnostic tool for Brazilian patients with Fanconi anemia.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2009, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Blotting, Western; Case-Control Studies; Child; Child, Preschool; Chromosome Breakage; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Female; Genetic Markers; Humans; Male; Phenotype; Sensitivity and Specificity; Young Adult

2009
Clinical, genetic and cytogenetic study of Fanconi anemia in an Indian population.
    Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:1

    Topics: Adolescent; Carcinoma, Squamous Cell; Cells, Cultured; Child; Child, Preschool; Chromosome Breakage; Chromosome Fragility; Chromosomes, Human; Consanguinity; Epoxy Compounds; Fanconi Anemia; Female; Humans; India; Infant; Leukemia, Myeloid; Male; Mitomycin; Myelodysplastic Syndromes; Young Adult

2010
Normal red blood cells partially decrease diepoxybutane-induced chromosome breakage in cultured lymphocytes from Fanconi anaemia patients.
    Cell proliferation, 2010, Volume: 43, Issue:6

    Topics: Cell Proliferation; Cells, Cultured; Chromosome Breakage; Cytogenetic Analysis; Epoxy Compounds; Erythrocytes; Fanconi Anemia; Female; Gene Deletion; Genotype; Glutathione Transferase; Humans; Lymphocytes; Male

2010
A novel diagnostic screen for defects in the Fanconi anemia pathway.
    Blood, 2002, Dec-15, Volume: 100, Issue:13

    Topics: Blotting, Western; Bone Marrow Diseases; Cell Line, Transformed; Chromosome Breakage; Chromosomes, Human; DNA, Complementary; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Genetic Heterogeneity; Genetic Testing; Genetic Vectors; Humans; Lymphocytes; Microscopy, Fluorescence; Mitomycin; Nuclear Proteins; Protein Processing, Post-Translational; Retroviridae; Transfection; Ubiquitin

2002
Role of haemoglobin in the protection of cultured lymphocytes against diepoxybutane (DEB), assessed by in vitro induced chromosome breakage.
    Mutation research, 2003, Apr-20, Volume: 536, Issue:1-2

    Topics: Adult; Cells, Cultured; Chromosome Breakage; Chromosomes, Human; Cytoprotection; DNA Damage; Epoxy Compounds; Erythrocytes; Female; Glutathione Transferase; Hemoglobins; Humans; Lymphocytes; Male; Middle Aged; Mutagens

2003
Differential diagnosis of Fanconi anemia by nitrogen mustard and diepoxybutane.
    Annals of hematology, 2003, Volume: 82, Issue:4

    Topics: Alkylating Agents; Chromosome Breakage; Diagnosis, Differential; Epoxy Compounds; Fanconi Anemia; Humans; Lymphocytes; Mechlorethamine

2003
DEB test for Fanconi anemia detection in patients with atypical phenotypes.
    American journal of medical genetics. Part A, 2004, Jan-01, Volume: 124A, Issue:1

    Topics: Adult; Anemia, Aplastic; Case-Control Studies; Chromosome Breakage; Diagnosis, Differential; Epoxy Compounds; Esophageal Atresia; Fanconi Anemia; Female; Genetic Testing; Humans; Male; Mutagens; Phenotype; Prognosis; Tracheoesophageal Fistula

2004
The role of foetal red blood cells in protecting cultured lymphocytes against diepoxybutane-induced chromosome breaks.
    Mutation research, 2006, Jan-31, Volume: 603, Issue:1

    Topics: Adult; Carcinogens; Catalase; Cell Communication; Cells, Cultured; Chromosome Breakage; Epoxy Compounds; Erythrocytes; Female; Fetal Blood; Fetus; Glutathione Transferase; Humans; Lymphocytes; Male; Middle Aged; Superoxide Dismutase

2006
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
    FEBS letters, 1998, Jan-23, Volume: 422, Issue:1

    Topics: Antioxidants; Cell Line; Cell Survival; Chromosome Breakage; Cytokines; DNA Damage; Epoxy Compounds; Fanconi Anemia; Gene Expression Regulation; Humans; Male; Micronucleus Tests; Mitomycin; Neoplasm Proteins; NF-kappa B; Oxidative Stress; Thioredoxins; Transfection; Transformation, Genetic

1998
Evaluation of micronuclei and chromosomal breakage in the 1cen-q12 region by the butadiene metabolites epoxybutene and diepoxybutane in cultured human lymphocytes.
    Mutagenesis, 1999, Volume: 14, Issue:6

    Topics: Butadienes; Carcinogens; Cells, Cultured; Centromere; Chromosome Breakage; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 9; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; In Situ Hybridization, Fluorescence; Kinetochores; Lymphocytes; Male; Micronucleus Tests; Mutagens; Polymerase Chain Reaction

1999
Positional cloning of a novel Fanconi anemia gene, FANCD2.
    Molecular cell, 2001, Volume: 7, Issue:2

    Topics: Alleles; Amino Acid Sequence; Base Sequence; Blotting, Western; Cell Line; Chromosome Breakage; Cloning, Molecular; DNA Mutational Analysis; Drosophila Proteins; Epoxy Compounds; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Female; Gene Expression Profiling; Genetic Complementation Test; Humans; Male; Mitomycin; Molecular Sequence Data; Mutation; Nuclear Proteins; Pedigree; Phenotype; Protein Isoforms; RNA, Messenger; Sequence Alignment; Transduction, Genetic

2001