dieldrin and Starvation

Topics: Adipose Tissue; Adrenal Cortex Hormones; Aminopyrine; Animals; Autopsy; Body Weight; Bridged-Ring Compounds; Chlordan; DDT; Dieldrin; Dogs; Drug Synergism; Female; Fertility; Health; Humans; Hydrocarbons, Halogenated; Insecticides; Lactation; Male; Mammary Glands, Animal; Microsomes; Milk, Human; Naphthalenes; Nitrosamines; Organothiophosphorus Compounds; Pesticides; Pregnancy; Rats; Sex Factors; Starvation

Topics: Animals; Bile; Chickens; Dieldrin; Digestive System; Feces; Male; Starvation

A series of experiments were conducted to find ways of removing dieldrin2 residues from tissues of broiler-type turkeys (Meleagris gallopavo). The turkeys were contaminated with dieldrin and dieldrin-14C by oral dosing. Elimination was measured by assaying for 14C in the droppings. Carcass retention was measured by assaying the tissue for 14C, and in one experiment, dieldrin residues were measured by electron capture gas-liquid chromatography. Charcoal, Colestipol, and cholestyramine at dosages approximately equal to an intake of 5% of the diet were ineffective gastrointestinal adsorbants for removing dieldrin residues from the turkeys. Starvation accelerated the elimination of dieldrin from the turkeys, but only if the body lipids were reduced to approximately 10% or less of the carcass dry matter.

Topics: Aging; Animals; Charcoal; Cholestyramine Resin; Colestipol; Dieldrin; Feces; Lipid Metabolism; Male; Starvation; Turkeys

A series of experiments was conducted with chickens contaminated with dieldrin-14C to find ways of accelerating the elimination of dieldrin from their bodies. The results of these experiments indicated that charcoal, imbiber beads, and the anion exchanges resins, Dowex XFS-4022 and Dowex SBR-C1, would not be useful agents for increasing the amount of dieldrin eliminated via feces (droppings) of chickens. Further, imbiber beads coalesced in the gizzard of the chickens and reduced their appetites. The anion exchange resin, cholestyramine, might be useful as gastrointestinal absorbant for increasing dieldrin elimination in chickens because it increased carbon-14 elimination in droppings, but its effect on carbon-14 residues in carcasses was not clear. We elected not to investigate this compound further. Probucol, investigated because it might alter gastrointestinal absorption or blood physiology that would affect dieldrin elimination, did not increase dieldrin elimination. Severe starvation was the only method investigated that clearly was useful for increasing dieldrin elimination because it increased carbon-14 elimination in droppings and reduced carbon-14 residues in carcasses.

Topics: Animals; Anion Exchange Resins; Charcoal; Chickens; Cholestyramine Resin; Dieldrin; Gallbladder; Probucol; Starvation

Topics: Adipose Tissue; Animals; Brain Chemistry; Chromatography, Gas; Dieldrin; Diet; Feces; Kidney; Liver; Male; Myocardium; Obesity; Rats; Starvation

Topics: Age Factors; Animals; Body Weight; DDT; Dieldrin; Drug Interactions; Female; Liver; Male; Organ Size; Rats; Rats, Inbred Strains; Sex Factors; Starvation

Topics: Adipose Tissue; Anesthesia, General; Biopsy; Body Composition; Body Weight; Dieldrin; Female; Humans; Male; Naphthalenes; Starvation; Stress, Physiological

Topics: Dieldrin; Lipid Metabolism; Metabolism; Rats; Research; Starvation; Toxicology

Topics: Bile; Body Fluids; Central Nervous System; Dieldrin; Feces; Fluids and Secretions; Injections, Intravenous; Intestinal Absorption; Lipid Metabolism; Metabolism; Rats; Research; Seizures; Starvation; Toxicology; Urine