dieldrin and Liver-Diseases

The effect of vitamin E on dieldrin-induced hepatic focal lesion growth in male B6C3F1 mice previously treated with diethylnitrosamine (DEN) was investigated. After hepatic focal lesions were formed, mice were placed into one of the following treatment groups: Group 1, 50 mg vitamin E/kg diet (control NIH-07 diet); Group 2, 10 mg dieldrin/kg NIH-07 diet; Group 3, 10 mg dieldrin and 450 mg vitamin E/kg NIH-07 diet; and Group 4, 450 mg vitamin E/kg NIH-07 diet. Mice were killed and necropsied after 30 and 60 d of dietary treatment. The effect of treatment on lesion growth was examined by measuring the number of focal lesions per liver and the relative hepatic focal lesion volume. In addition, the possible cellular mechanism of focal hepatocyte growth was investigated by examining both focal DNA synthesis and apoptosis. Dieldrin treatment alone (Group 2) increased the focal lesion volume, focal lesion number, and focal lesion labeling index. Supplementation with vitamin E (Group 3) blocked this effect. Vitamin E supplementation to the diet alone (Group 4) also enhanced focal lesion growth and increased the number of lesions per liver, the relative focal volume, and the labeling index in hepatic focal lesions. Interestingly, vitamin E supplementation inhibited apoptosis in normal liver but did not produce an observable decrease in apoptosis in hepatic focal lesions. The present study showed that dieldrin (Group 2) or vitamin E supplementation alone (Group 4) promoted the growth of hepatic focal lesions in mice. However, when vitamin E is supplemented to dieldrin-fed mice (Group 3), there is an inhibition of hepatic focal lesion growth.

Topics: Animals; Apoptosis; Carcinogens; Chemical and Drug Induced Liver Injury; Dieldrin; Insecticides; Liver; Liver Diseases; Male; Mice; Precancerous Conditions; Vitamin E

The development of hyperplastic and neoplastic lesions of parenchymal cells of the liver adjacent to central veins was observed in C3H mice ingesting the chlorinated hydrocarbons, dieldrin or aldrin, in the diet. Lesions could be followed from pericentral hyperplasia to areas of hyperplasia, nodules of hyperplasia, small hepatocellular carcinomas, and large well-developed carcinomas, occasionally with metastases. Sometimes pericentral hyperplasia was diffuse throughout most or all of one lobe of the liver. These hyperplastic cells collided to become one large nodule and also one large carcinoma. The carcinomas were well-differentiated or moderately well-differentiated and grew on transplantation to isologous hosts. Histologically, the hyperplastic cells adjacent to central veins were increased in size, frequently with double nuclei. Carcinoma cells varied in size and shape and were huge with large nuclei, prominent nucleoli, and eosinophilic cytoplasm. Similar hepatocellular carcinomas were seen previously with carbon tetrachloride, another organochlorine chemical.

Topics: Aldrin; Animals; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Dieldrin; Female; Hepatic Veins; Hyperplasia; Liver Diseases; Liver Neoplasms; Male; Mice; Mice, Inbred C3H

Topics: Adipose Tissue; Brain; Brain Chemistry; Chlordan; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; DDT; Dieldrin; Gallbladder Diseases; Heptachlor; Heptachlor Epoxide; Histocytochemistry; Humans; Lipids; Liver; Liver Cirrhosis; Liver Diseases; Organ Specificity; Probability; Silicon Dioxide; Staining and Labeling

Topics: Adipose Tissue; Aldrin; Animals; Chlordan; DDT; Dieldrin; Dogs; Drug Synergism; Endrin; Environmental Exposure; Estrus; Female; Fertility; Food Deprivation; Humans; Hydrocarbons, Halogenated; Lactation; Liver Diseases; Male; Mice; Neoplasms; Pesticides; Pregnancy; Rats; Reproduction

Topics: Aflatoxins; Benzopyrenes; Carbon Tetrachloride Poisoning; DDT; Dieldrin; Ethionine; Foodborne Diseases; Humans; Liver Diseases; Poisons; Progesterone; Thalidomide

Topics: Adipose Tissue; Arteriosclerosis; Brain Chemistry; Brain Neoplasms; Cerebral Hemorrhage; Chromatography, Gas; DDT; Dichlorodiphenyldichloroethane; Dieldrin; Encephalomalacia; Humans; Hypertension; Kidney Diseases; Liver; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Pesticides; Statistics as Topic