dieldrin and Abnormalities--Drug-Induced

Dose of 1.5 and 4.0 mg/kg/day of HEOD in corn oil and 0.25, 0.5 and 1.0 mg/kg/day of HEOD in dimethyl sulphoxide (DMSO) were administered to pregnant CF1 mice on days 6 to 14 (inclusive) of gestation. Some maternal and foetal toxicity was seen in the HEOD in DMSO and DMSO control groups compared with the untreated controls, such as reduced body weight gains, some maternal deaths, lower foetal body weights and increased incidence of delayed ossification of the foetal bones. No maternal or foetal toxicity was seen in the HEOD in corn oil or the corn oil control groups. No compound-related teratogenic effects were observed.

Topics: Abnormalities, Drug-Induced; Animals; Dieldrin; Dimethyl Sulfoxide; Female; Fetus; Mice; Osteogenesis; Pregnancy

Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Dieldrin; Female; Fetus; Gestational Age; Liver; Mice; Organ Size; Photochemistry; Pregnancy; Rats

Topics: Abnormalities, Drug-Induced; Aldrin; Animals; Cleft Lip; Cleft Palate; Cricetinae; Dieldrin; Endrin; Eye Abnormalities; Fetus; Foot Deformities, Congenital; Mice

Topics: Abnormalities, Drug-Induced; Adipose Tissue; Alkaline Phosphatase; Animals; DDT; Dieldrin; Dogs; Female; Fetal Death; Hydrocarbons, Halogenated; Lactation; Male; Naphthalenes; Pesticides; Pregnancy; Reproduction

Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Antifungal Agents; Chickens; Chlordan; Cholinesterase Inhibitors; Cricetinae; DDT; Dieldrin; Dogs; Drug Synergism; Ducks; Eggs; Embryo, Mammalian; Embryo, Nonmammalian; Extraembryonic Membranes; Female; Fetal Death; Fetus; Genetics; Guinea Pigs; Haplorhini; Herbicides; Hydrocarbons, Halogenated; Insecticides; Maternal-Fetal Exchange; Mice; Milk, Human; Neurologic Manifestations; Parathion; Pesticides; Phosphates; Pregnancy; Rabbits; Rats; Teratoma

Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Chromosome Aberrations; Chromosome Disorders; Dieldrin; Disorders of Sex Development; Dogs; Female; Genitalia, Female; Karyotyping; Leukocytes; Male; Methyltestosterone; Pregnancy; Time Factors