didymin has been researched along with Liver-Cirrhosis* in 2 studies
2 other study(ies) available for didymin and Liver-Cirrhosis
| Article | Year |
|---|---|
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Mice were injected with CCl. The pharmacodynamic experiments indicated that didymin significantly attenuated CCl. Our findings demonstrate that didymin can ameliorate liver fibrosis, which is mainly attributed to the inhibition of ERS, inflammation, and glycerophospholipid metabolism. Topics: Animals; Apoptosis; Carbon Tetrachloride; Endoplasmic Reticulum Stress; Flavonoids; Glycerophospholipids; Glycosides; Inflammation; Liver; Liver Cirrhosis; Metabolomics; Mice; Transcriptome | 2022 |
Didymin Alleviates Hepatic Fibrosis Through Inhibiting ERK and PI3K/Akt Pathways via Regulation of Raf Kinase Inhibitor Protein.
Didymin has been reported to have anti-cancer potential. However, the effect of didymin on liver fibrosis remains illdefined.. Hepatic fibrosis was induced by CCl4 in rats. The effects of didymin on liver pathology and collagen accumulation were observed by hematoxylin-eosin and Masson's trichrome staining, respectively. Serum transaminases activities and collagen-related indicators levels were determined by commercially available kits. Moreover, the effects of didymin on hepatic stellate cell apoptosis and cell cycle were analyzed by flow cytometry. Mitochondrial membrane potential was detected by using rhodamine-123 dye. The expression of Raf kinase inhibitor protein (RKIP) and the phosphorylation of the ERK/MAPK and PI3K/Akt pathways were assessed by Western blot.. Didymin significantly ameliorated chronic liver injury and collagen deposition. It strongly inhibited hepatic stellate cells proliferation, induced apoptosis and caused cell cycle arrest in G2/M phase. Moreover, didymin notably attenuated mitochondrial membrane potential, accompanied by release of cytochrome C. Didymin significantly inhibited the ERK/MAPK and PI3K/Akt pathways. The effects of didymin on the collagen accumulation in rats and on the biological behaviors of hepatic stellate cells were largely abolished by the specific RKIP inhibitor locostatin.. Didymin alleviates hepatic fibrosis by inhibiting ERK/MAPK and PI3K/Akt pathways via regulation of RKIP expression. Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Collagen; Cytochromes c; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glycosides; Liver; Liver Cirrhosis; Male; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylethanolamine Binding Protein; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |