didimethylsulfoxide-dichloroplatinum(ii) and Uterine-Neoplasms

The radiosensitivity and radio-chemosensitivity of 3 series of human cancer cell lines were evaluated by human tumor clonogenic assay. The sources of cell lines were gingiva carcinoma (Ca9-22), uterus carcinoma (Hela) and gastric carcinoma (MKN-45). BLM and CDDP were used, and chemosensitivity of gingiva carcinoma tended to be higher than other cell lines. Radiosensitivity was same as MKN-45. Isobologram were employed for quantitation of the interaction between the irradiation and anti-cancer agents. In Ca9-22, the interaction of between gamma-rays, BLM and CDDP was supra-additive. Hela was also supra-additive, but in MKN-45, the interaction of between gamma-rays and BLM was sub-additive.

Topics: Bleomycin; Female; Gingival Neoplasms; Humans; Organoplatinum Compounds; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uterine Neoplasms