didimethylsulfoxide-dichloroplatinum(ii) and Uterine-Cervical-Neoplasms

As one method of multidisciplinary treatment for cancer of the uterine cervix, a combination IAC using CDDP and 5-FU was applied. Six operable and three inoperable, advanced patients were treated with a single 100-120 mg/body IAC bolus of CDDP followed by a continuous IA infusion of 2,500 mg/body of 5-FU. This was combined with surgical therapy in the former group and radiotherapy in the latter group. In operable cases, the extirpated tissues were examined histopathologically for effects of the combination IAC. Microscopic findings included atrophy and swelling of the cancer cell nucleus, plus variable diffused reduction of the cancer cell nest accompanied by vacuolation of the cytoplasm. In inoperable cases, observations carried out by graphical scintigram, and clinical investigation at 10 days after the IAC, indicated improved conditions. Among the adverse reactions, renal dysfunction recovered two weeks after IAC. No evidence of severe myelosuppression was observed. Therefore, IAC with CDDP and 5-FU, plus surgery or radiotherapy, against carcinoma of the cervix had favorable laboratory and clinical results.

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Fluorouracil; Humans; Infusions, Intra-Arterial; Kidney; Middle Aged; Organoplatinum Compounds; Uterine Cervical Neoplasms