didimethylsulfoxide-dichloroplatinum(ii) and Urinary-Bladder-Neoplasms

Traditional approaches for the treatment of locally advanced bladder tumours may not be sufficient enough. Neoadjuvant chemotherapy, a new modality, may be beneficial by enhancing the local and systemic control of the disease. The background of this new modality and early results of various trials are discussed.

Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Organoplatinum Compounds; Survival Rate; Urinary Bladder Neoplasms; Vinblastine

Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Transitional Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Gallium; Humans; Methotrexate; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Prognosis; Survival Rate; Treatment Outcome; Urinary Bladder Neoplasms

Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Models, Biological; Neoplasm Staging; Organoplatinum Compounds; Postoperative Care; Treatment Outcome; Urinary Bladder Neoplasms; Vinblastine

16 patients with invasive bladder cancer were treated primarily "bladder in place", with chemotherapy. (M-VAC, CDDP + MTX). There were 11 with T1 to T4, N+, M0, M+, 5 with T1, T2, N0, M0. The aim of the study was to evaluate the response of bladder lesions to chemotherapy. 2 had complete response (CR), 6 partial response (PR) and 8 no-response (NR). Patients with complete responses and partial responses were found to have complete resection before chemotherapy. Unresectable lesions were associated with NR patients. The results did not show a significant improvement and they question the role of neo-adjuvant chemotherapy.

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Evaluation; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Invasiveness; Organoplatinum Compounds; Urinary Bladder Neoplasms; Vinblastine

The combination effects of CDDP and hyperthermia in mouse bladder tumor (MBT-2) were investigated both in vivo and in vitro. MBT-2 was transplanted into the hind leg of a C3H/He mouse. Then the leg was dipped in a hot water bath immediately after the intraperitoneal administration of CDDP. The antitumor effects were evaluated from tumor volume. The CDDP plus hyperthermia (43 degrees C) group showed remarkable tumor growth retardation. The in vitro colony forming assay showed that MBT-2 cultured cells treated with CDDP at 42 degrees C exhibited great colony forming inhibition in comparison with the CDDP alone cells. The effects of CDDP plus hyperthermia on the cell cycle progression of MBT-2 cultured cells were studied by using flow cytometry. The results showed that the cells treated with CDDP at 42 degrees C exhibited an accumulation of cells in the C2 phase for many hours as compared with the CDDP alone cells, indicating thermal enhancement of DNA damage in MBT-2 cultured cells treated with CDDP.

Topics: Animals; Cell Cycle; Combined Modality Therapy; Female; Hyperthermia, Induced; Mice; Mice, Inbred Strains; Organoplatinum Compounds; Tumor Stem Cell Assay; Urinary Bladder Neoplasms