didimethylsulfoxide-dichloroplatinum(ii) and Neuroblastoma

Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Carmustine; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Etoposide; Female; France; Humans; Infant; Male; Neuroblastoma; Organoplatinum Compounds; Remission Induction; Reoperation; Survival Rate; Teniposide; Vincristine

For the purpose of studying clinical evaluation of A 1 protocol for advanced neuroblastoma, chemotherapy with vincristine, cyclophosphamide, THP-adriamycin and cisplatin was performed in 8 pediatric patients with advanced neuroblastoma undergoing second look operation (4) or delayed primary operation (4). Tumor volume measured on CT, histological finding of tumor obtained at operation, blood and urinary tumor marker level were studied.. 1) The chemotherapy is supposed to be effective for round cell type neuroblastoma. On the other hand, it is ineffective for composite type ganglioneuroblastoma. 2) More than 3 courses of A 1 protocol are necessary to yield a good effect. 3) There is no relationship between the effect of the chemotherapy and the prognosis.

Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Evaluation; Female; Humans; Infant; Male; Neoplasm Staging; Neuroblastoma; Organoplatinum Compounds; Prognosis; Remission Induction; Reoperation; Vincristine