didanosine and Blepharoptosis

To report a case of blepharoptosis in a patient with human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) with biopsy confirmed mitochondrial deletions consistent with HAART related myopathy.. A 51-year-old man with HIV demonstrated visually significant ptosis after being on HAART therapy for over 20 years.. Muscle tissue biopsy following blepharoplasty was analyzed and found to have significant mitochondrial deletions.. This patient represents a case of isolated ptosis consistent with acquired myopathy secondary to mitochondrial dysfunction without systemic manifestations otherwise seen in inherited mitochondrial disorders.

Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Blepharoptosis; Cyclopropanes; Didanosine; Dideoxynucleosides; DNA, Mitochondrial; HIV Infections; Humans; Male; Middle Aged; Mitochondria, Muscle; Mitochondrial Myopathies; Oculomotor Muscles

Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blepharoptosis; Carbamates; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Middle Aged; Oculomotor Muscles; Organophosphates; Organophosphonates; Sulfonamides; Tenofovir

Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blepharoptosis; Didanosine; DNA, Mitochondrial; Genetic Predisposition to Disease; HIV Infections; Humans; Lipodystrophy; Male; Middle Aged; Mitochondria; Mitochondrial Diseases; Muscle, Skeletal; Mutation; Oculomotor Muscles; Ophthalmoplegia; Ophthalmoplegia, Chronic Progressive External; Recovery of Function; Risk Factors; Time