dicyclomine has been researched along with Muscle Contraction in 9 studies
Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dicyclomine was as potent a local anesthetic as lidocaine, as determined by the guinea-pig wheal test." | 1.26 | The mechanism of action of dicyclomine hydrochloride on rabbit detrusor muscle and vas deferens. ( Johns, A; Johnson, CE; Paton, DM; Tasker, JJ; Theman, MA, 1976) |
| "Dicyclomine failed to cause inhibition of the barium chloride-induced contractions in the guinea pig vesicourethral smooth muscle." | 1.26 | In vitro study of antispasmodic effects of dicyclomine hydrochloride on vesicourethral smooth muscle of guinea pig and rabbit. ( Barbieri, EJ; DiGregorio, GJ; Khanna, OP; McMichael, R; Ruch, E, 1979) |
| "Dicyclomine was only about 1/30 as potent as atropine in competitive antimuscarinic activity." | 1.26 | Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle. ( Awad, SA; Downie, JW; Twiddy, DA, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maggi, CA | 2 |
| Meli, A | 2 |
| Downie, JW | 2 |
| McGuire, RP | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Gualtieri, F | 1 |
| Novella Romanelli, M | 1 |
| Bartolini, A | 1 |
| Johns, A | 1 |
| Tasker, JJ | 1 |
| Johnson, CE | 1 |
| Theman, MA | 1 |
| Paton, DM | 1 |
| Khanna, OP | 1 |
| DiGregorio, GJ | 1 |
| Barbieri, EJ | 1 |
| McMichael, R | 1 |
| Ruch, E | 1 |
| Thompson, IM | 1 |
| Lauvetz, R | 1 |
| Twiddy, DA | 1 |
| Awad, SA | 1 |
| Kilbinger, H | 1 |
| Stein, A | 1 |
1 trial available for dicyclomine and Muscle Contraction
| Article | Year |
|---|---|
Oxybutynin in bladder spasm, neurogenic bladder, and enuresis.
Topics: Adult; Amines; Bethanechol Compounds; Child; Clinical Trials as Topic; Dicyclomine; Enuresis; Humans | 1976 |
8 other studies available for dicyclomine and Muscle Contraction
| Article | Year |
|---|---|
Eserine-induced hypertone of guinea pig distal colon in vivo: a new pharmacological procedure for testing smooth muscle relaxants.
Topics: Animals; Atropine; Benzodiazepinones; Colon; Dicyclomine; Dose-Response Relationship, Drug; Guinea P | 1984 |
An in vivo procedure for estimating spasmolytic activity in the rat by measuring smooth muscle contractions to topically applied acetylcholine.
Topics: Acetylcholine; Animals; Butylscopolammonium Bromide; Colon; Dicyclomine; Male; Muscle Contraction; M | 1982 |
Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by dicyclomine hydrochloride and rociverine.
Topics: Animals; Atropine; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Calcium Channel Blockers; Cycl | 1981 |
Antinociception induced by SM 32 depends on a central cholinergic mechanism.
Topics: Analgesics; Animals; Cholinergic Agents; Cholinergic Fibers; Dicyclomine; GABA Antagonists; Guinea P | 1997 |
The mechanism of action of dicyclomine hydrochloride on rabbit detrusor muscle and vas deferens.
Topics: Acetylcholine; Anesthetics, Local; Animals; Atropine; Calcium; Cyclohexanecarboxylic Acids; Dicyclom | 1976 |
In vitro study of antispasmodic effects of dicyclomine hydrochloride on vesicourethral smooth muscle of guinea pig and rabbit.
Topics: Acetylcholine; Animals; Atropine; Barium; Chlorides; Cyclohexanecarboxylic Acids; Dicyclomine; Dose- | 1979 |
Antimuscarinic and noncompetitive antagonist properties of dicyclomine hydrochloride in isolated human and rabbit bladder muscle.
Topics: Animals; Atropine; Carbachol; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship, | 1977 |
Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum.
Topics: Animals; Cyclohexanecarboxylic Acids; Dicyclomine; Electric Stimulation; Guinea Pigs; Ileum; In Vitr | 1988 |