Page last updated: 2024-10-26

dicyclomine and Emesis

dicyclomine has been researched along with Emesis in 32 studies

Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.

Research Excerpts

ExcerptRelevanceReference
"We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy."9.248-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017)
"Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy."9.20Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015)
" The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)."9.16Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012)
"To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy."9.14Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010)
"Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries."7.79Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013)
"We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy."5.248-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017)
"Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy."5.20Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015)
" The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)."5.16Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012)
"To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy."5.14Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010)
" We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations."5.12Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021)
"A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy."5.04Treatment of pregnancy sickness. ( Wheatley, D, 1977)
"Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM."3.91New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019)
"Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries."3.79Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013)
"Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada."3.77Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011)
"Nausea and vomiting are common in early pregnancy."2.50The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014)
" Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined."2.37Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199013 (40.63)18.7374
1990's0 (0.00)18.2507
2000's7 (21.88)29.6817
2010's11 (34.38)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Biffi, A1
Rea, F1
Locatelli, A1
Cetin, I1
Filippelli, A1
Corrao, G1
Bérard, A1
Sheehy, O1
Gorgui, J1
Zhao, JP1
Soares de Moura, C1
Bernatsky, S1
Ashkenazi-Hoffnung, L1
Merlob, P1
Stahl, B1
Klinger, G1
Niebyl, JR1
Briggs, GG1
Madjunkova, S1
Maltepe, C2
Koren, G8
Clark, S3
Hankins, GD3
Caritis, SN2
Umans, JG3
Miodovnik, M3
Mattison, DR2
Matok, I2
Zhang, R1
Persaud, N1
Nulman, I1
Rovet, J1
Barrera, M1
Knittel-Keren, D1
Feldman, BM1
Gill, SK1
Garcia-Bournissen, F2
Costantine, MM1
Chiossi, G1
Caritis, S1
Brent, R2
Kutcher, JS1
Engle, A1
Firth, J1
Lamm, SH1
TOWNE, JE1
GEIGER, CJ1
FAHRENBACH, DM1
HEALEY, FJ1
PIGNONE, M1
FANTINI, ML1
Staroselsky, A1
Huff, PS1
David, TJ1
Mitchell, AA1
Rosenberg, L1
Shapiro, S1
Slone, D1
Harron, DW1
Griffiths, K1
Shanks, RG1
Mazzotta, P1
Navioz, Y1
Magee, LA1
Strong, TH1
Wheatley, D1
Check, WA1
Shiono, PH1
Klebanoff, MA1
Leathem, AM1
Walters, WA1
Elbourne, D1
Mutch, L1
Dauncey, M1
Campbell, H1
Samphier, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192]200 participants (Anticipated)Observational2023-09-30Not yet recruiting
A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445]Phase 3280 participants (Actual)Interventional2008-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Diclectin Versus Placebo for Treatment of Nausea and Vomiting of Pregnancy (NVP) as Measured by the Change in Pregnancy Unique-Quantification of Emesis (PUQE) Overall Score of Symptoms From Baseline (Day 1) to End of Study Visit (Day 15).

The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)

InterventionPUQE Score (Mean)
Diclectin®-4.8
Placebo-3.9

Reviews

8 reviews available for dicyclomine and Emesis

ArticleYear
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
    Pharmacological research, 2021, Volume: 163

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2021
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
    Drug and therapeutics bulletin, 2019, Volume: 57, Issue:3

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines

2019
The pharmacologic management of nausea and vomiting of pregnancy.
    The Journal of family practice, 2014, Volume: 63, Issue:2 Suppl

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N

2014
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
    Paediatric drugs, 2014, Volume: 16, Issue:3

    Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2014
Safety of drug therapy for nausea and vomiting of pregnancy.
    The Journal of family practice, 1980, Volume: 11, Issue:6

    Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female;

1980
Alternative therapies of morning sickness.
    Clinical obstetrics and gynecology, 2001, Volume: 44, Issue:4

    Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal

2001
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:5 Suppl Un

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2002
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
    Clinical pharmacy, 1986, Volume: 5, Issue:8

    Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema

1986

Trials

5 trials available for dicyclomine and Emesis

ArticleYear
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
    BMC pregnancy and childbirth, 2015, Mar-18, Volume: 15

    Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug

2015
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians

2017
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:5

    Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D

2012
Treatment of pregnancy sickness.
    British journal of obstetrics and gynaecology, 1977, Volume: 84, Issue:6

    Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine;

1977

Other Studies

19 other studies available for dicyclomine and Emesis

ArticleYear
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
    Journal of clinical epidemiology, 2019, Volume: 116

    Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi

2019
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
    The Israel Medical Association journal : IMAJ, 2013, Volume: 15, Issue:1

    Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations

2013
Diclegis for nausea and vomiting of pregnancy.
    The Medical letter on drugs and therapeutics, 2013, Aug-05, Volume: 55, Issue:1422

    Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2013
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
    The Journal of pediatrics, 2009, Volume: 155, Issue:1

    Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam

2009
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:1

    Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl

2011
Bendectin and birth defects: hopefully, the final chapter.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C

2003
Bendectin and birth defects. II: Ecological analyses.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems

2003
Nausea and vomiting of pregnancy: treatment with bendectin.
    International record of medicine and general practice clinics, 1958, Volume: 171, Issue:9

    Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau

1958
Bendectin in the treatment of nausea and vomiting in pregnancy.
    Obstetrics and gynecology, 1959, Volume: 14

    Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau

1959
[DICYCLOMINE HYDROCHLORIDE IN VOMITING OF THE INFANT].
    La Clinica pediatrica, 1964, Volume: 46

    Topics: Dicyclomine; Humans; Infant; Parasympatholytics; Vomiting

1964
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
    Gastroenterology, 2007, Volume: 132, Issue:2

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe

2007
Debendox does not cause the Poland anomaly.
    Archives of disease in childhood, 1982, Volume: 57, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com

1982
Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects.
    JAMA, 1981, Jun-12, Volume: 245, Issue:22

    Topics: Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; F

1981
Debendox and congenital malformations in Northern Ireland.
    British medical journal, 1980, Nov-22, Volume: 281, Issue:6252

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1980
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2000, Volume: 70, Issue:3

    Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di

2000
CDC study: no evidence for teratogenicity of Bendectin.
    JAMA, 1979, Dec-07, Volume: 242, Issue:23

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart

1979
Bendectin and human congenital malformations.
    Teratology, 1989, Volume: 40, Issue:2

    Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do

1989
The management of nausea and vomiting during pregnancy.
    The Medical journal of Australia, 1987, Sep-21, Volume: 147, Issue:6

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea;

1987
Debendox revisited.
    British journal of obstetrics and gynaecology, 1985, Volume: 92, Issue:8

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com

1985