Page last updated: 2024-10-26

dicyclomine and Complications, Pregnancy

dicyclomine has been researched along with Complications, Pregnancy in 45 studies

Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.

Research Excerpts

ExcerptRelevanceReference
"We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy."9.248-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017)
"Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy."9.20Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015)
" The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)."9.16Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012)
"To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy."9.14Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010)
"Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries."7.79Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013)
" The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs."7.66Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982)
"We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy."5.248-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017)
"Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy."5.20Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015)
" The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)."5.16Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012)
"To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy."5.14Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010)
"A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy."5.04Treatment of pregnancy sickness. ( Wheatley, D, 1977)
"Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries."3.79Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013)
"Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada."3.77Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011)
" Although no definitive causative factor has been identified in previously reported cases, the affection in our case is possibly related to Debendox (Bendectin) and nitrofurantoin taken in early pregnancy for nausea and renal tract infection, respectively."3.69Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy? ( Dubowitz, V; Muntoni, F; Philpot, J; Skellett, S, 1995)
"The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects."3.67The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984)
" The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs."3.66Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982)
"Nausea and vomiting are common in early pregnancy."2.50The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014)
" Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined."2.37Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986)
"Two hundred cases of verified brain tumors occurring in patients under 15 years of age were studied in relation to possible etiologic, genetic, and environmental risk factors."1.28Potential risk factors for brain tumors in children. An analysis of 200 cases. ( Giuffrè, R; Liccardo, G; Pastore, FS; Spallone, A; Vagnozzi, R, 1990)
" No dose-response relationship was evident."1.27Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy. ( Birch, JM; Cartwright, RA; Hartley, AL; Hopton, PA; Johnston, HE; Mann, JR; McKinney, PA; Stiller, CA; Waterhouse, JA, 1985)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199024 (53.33)18.7374
1990's4 (8.89)18.2507
2000's6 (13.33)29.6817
2010's11 (24.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ashkenazi-Hoffnung, L1
Merlob, P1
Stahl, B1
Klinger, G1
Niebyl, JR2
Briggs, GG1
Madjunkova, S1
Maltepe, C2
Koren, G9
Clark, S3
Hankins, GD3
Caritis, SN2
Umans, JG3
Miodovnik, M3
Mattison, DR2
Matok, I2
Zhang, R1
Persaud, N1
Nulman, I1
Rovet, J1
Barrera, M1
Knittel-Keren, D1
Feldman, BM1
Gill, SK1
Garcia-Bournissen, F2
Costantine, MM1
Chiossi, G1
Caritis, S1
Brent, R2
Kutcher, JS1
Engle, A1
Firth, J1
Lamm, SH1
NULSEN, RO1
GEIGER, CJ1
FAHRENBACH, DM1
HEALEY, FJ1
Staroselsky, A1
Aselton, P1
Jick, H1
Chentow, SJ1
Perera, DR1
Hunter, JR1
Rothman, KJ1
Hays, DP1
Williams, DA1
Weiss, T1
Wade, E1
Dignan, P1
McCredie, J1
Kricker, A1
Elliott, J1
Forrest, J1
Davis, JM1
Huff, PS1
Smith, RJ1
David, TJ1
Donaldson, GL1
Bury, RG1
Harron, DW1
Griffiths, K1
Shanks, RG1
Philpot, J1
Muntoni, F1
Skellett, S1
Dubowitz, V1
Pastuszak, A1
Ito, S1
Mazzotta, P1
Navioz, Y1
Magee, LA1
Wheatley, D1
Smithells, RW1
Sheppard, S1
Giuffrè, R1
Liccardo, G1
Pastore, FS1
Spallone, A1
Vagnozzi, R1
Skolnick, A1
Leathem, AM1
Jick, SS1
Garrison, JM1
Jedd, MB1
Melton, LJ1
Griffin, MR1
Kaufman, B1
Hoffman, AD1
Broughton, D1
O'Brien, PC1
Walters, WA1
Elbourne, D1
Mutch, L1
Dauncey, M1
Campbell, H1
Samphier, M1
McKinney, PA1
Cartwright, RA1
Stiller, CA1
Hopton, PA1
Mann, JR1
Birch, JM1
Hartley, AL1
Waterhouse, JA1
Johnston, HE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192]200 participants (Anticipated)Observational2023-09-30Not yet recruiting
A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445]Phase 3280 participants (Actual)Interventional2008-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Diclectin Versus Placebo for Treatment of Nausea and Vomiting of Pregnancy (NVP) as Measured by the Change in Pregnancy Unique-Quantification of Emesis (PUQE) Overall Score of Symptoms From Baseline (Day 1) to End of Study Visit (Day 15).

The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)

InterventionPUQE Score (Mean)
Diclectin®-4.8
Placebo-3.9

Reviews

8 reviews available for dicyclomine and Complications, Pregnancy

ArticleYear
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
    Drug and therapeutics bulletin, 2019, Volume: 57, Issue:3

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines

2019
The pharmacologic management of nausea and vomiting of pregnancy.
    The Journal of family practice, 2014, Volume: 63, Issue:2 Suppl

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N

2014
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
    Paediatric drugs, 2014, Volume: 16, Issue:3

    Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2014
Clinical practice. Nausea and vomiting in pregnancy.
    The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16

    Topics: Adult; Chorionic Gonadotropin; Complementary Therapies; Diagnosis, Differential; Dicyclomine; Doxyla

2010
Safety of drug therapy for nausea and vomiting of pregnancy.
    The Journal of family practice, 1980, Volume: 11, Issue:6

    Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female;

1980
Drugs in pregnancy.
    The New England journal of medicine, 1998, Apr-16, Volume: 338, Issue:16

    Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E

1998
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:5 Suppl Un

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2002
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
    Clinical pharmacy, 1986, Volume: 5, Issue:8

    Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema

1986

Trials

6 trials available for dicyclomine and Complications, Pregnancy

ArticleYear
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
    BMC pregnancy and childbirth, 2015, Mar-18, Volume: 15

    Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug

2015
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians

2017
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth

2010
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
    Therapeutic drug monitoring, 2012, Volume: 34, Issue:5

    Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D

2012
Studies support Bendectin safety claim.
    Science (New York, N.Y.), 1981, Jun-26, Volume: 212, Issue:4502

    Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; I

1981
Treatment of pregnancy sickness.
    British journal of obstetrics and gynaecology, 1977, Volume: 84, Issue:6

    Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine;

1977

Other Studies

31 other studies available for dicyclomine and Complications, Pregnancy

ArticleYear
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
    The Israel Medical Association journal : IMAJ, 2013, Volume: 15, Issue:1

    Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations

2013
Diclegis for nausea and vomiting of pregnancy.
    The Medical letter on drugs and therapeutics, 2013, Aug-05, Volume: 55, Issue:1422

    Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2013
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
    The Journal of pediatrics, 2009, Volume: 155, Issue:1

    Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam

2009
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
    Therapeutic drug monitoring, 2011, Volume: 33, Issue:1

    Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl

2011
Bendectin and birth defects: hopefully, the final chapter.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C

2003
Bendectin and birth defects. II: Ecological analyses.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems

2003
Bendectin in the treatment of nausea of pregnancy.
    The Ohio State medical journal, 1957, Volume: 53, Issue:6

    Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau

1957
Bendectin in the treatment of nausea and vomiting in pregnancy.
    Obstetrics and gynecology, 1959, Volume: 14

    Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau

1959
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
    Gastroenterology, 2007, Volume: 132, Issue:2

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe

2007
Pyloric stenosis and maternal Bendectin exposure.
    American journal of epidemiology, 1984, Volume: 120, Issue:2

    Topics: Adult; Dicyclomine; Doxylamine; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Hu

1984
Debendox and pregnancy.
    The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre

1984
Nausea and vomiting of pregnancy.
    American family physician, 1983, Volume: 28, Issue:4

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc

1983
Bendectin: a case of mourning sickness.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:11

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc

1983
Prune perineum syndrome: report of a second case.
    Teratology, 1983, Volume: 28, Issue:1

    Topics: Abnormalities, Multiple; Acetaminophen; Adult; Codeine; Dextropropoxyphene; Dicyclomine; Female; Hum

1983
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
    The Medical journal of Australia, 1984, Apr-28, Volume: 140, Issue:9

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine;

1984
Good-bye, Bendectin, old friend.
    Postgraduate medicine, 1984, May-15, Volume: 75, Issue:7

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma

1984
Debendox does not cause the Poland anomaly.
    Archives of disease in childhood, 1982, Volume: 57, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com

1982
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
    Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:2

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine;

1982
Indications for bendectin narrowed.
    FDA drug bulletin, 1981, Volume: 11, Issue:1

    Topics: Antiemetics; Carcinogens; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; Pre

1981
Debendox and congenital malformations in Northern Ireland.
    British medical journal, 1980, Nov-22, Volume: 281, Issue:6252

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1980
Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy?
    Neuromuscular disorders : NMD, 1995, Volume: 5, Issue:1

    Topics: Age of Onset; Antiemetics; Arm; Dermatoglyphics; Diagnosis, Differential; Dicyclomine; Doxylamine; D

1995
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2000, Volume: 70, Issue:3

    Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di

2000
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
    Teratology, 1978, Volume: 17, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam

1978
Congenital deformities associated with Bendectin.
    Canadian Medical Association journal, 1977, Oct-08, Volume: 117, Issue:7

    Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin

1977
Potential risk factors for brain tumors in children. An analysis of 200 cases.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1990, Volume: 6, Issue:1

    Topics: Adolescent; Brain Neoplasms; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; Glioma; Huma

1990
Key witness against morning sickness drug faces scientific fraud charges.
    JAMA, 1990, Mar-16, Volume: 263, Issue:11

    Topics: Animals; Antiemetics; Australia; Biomedical Research; Dicyclomine; Doxylamine; Drug Combinations; Fe

1990
Discontinuation of Bendectin.
    American journal of public health, 1988, Volume: 78, Issue:3

    Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; P

1988
Factors associated with infantile hypertrophic pyloric stenosis.
    American journal of diseases of children (1960), 1988, Volume: 142, Issue:3

    Topics: Birth Order; Breast Feeding; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hypertrophy

1988
The management of nausea and vomiting during pregnancy.
    The Medical journal of Australia, 1987, Sep-21, Volume: 147, Issue:6

    Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea;

1987
Debendox revisited.
    British journal of obstetrics and gynaecology, 1985, Volume: 92, Issue:8

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com

1985
Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy.
    British journal of cancer, 1985, Volume: 52, Issue:6

    Topics: Adolescent; Antiemetics; Child; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship

1985