Page last updated: 2024-10-26

dicyclomine and Abnormalities, Drug-Induced

dicyclomine has been researched along with Abnormalities, Drug-Induced in 91 studies

Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women."7.80Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014)
" The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs."7.66Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982)
"In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy."7.65Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977)
" We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations."5.12Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021)
""Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations."4.79Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. ( Kutcher, JS; Lamm, SH; Linn, S; McKeigue, PM, 1994)
"Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM."3.91New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019)
"Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women."3.80Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014)
"The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects."3.67The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984)
"Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy."3.67Developmental toxicity evaluation of Bendectin in CD rats. ( Kimmel, CA; Marr, MC; Price, CJ; Tyl, RW, 1988)
" The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs."3.66Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982)
"In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy."3.65Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977)
"This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors."1.26Bilateral clinical anophthalmia: drugs as potential factors. ( Golden, SM; Perman, KI, 1980)

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-199067 (73.63)18.7374
1990's15 (16.48)18.2507
2000's4 (4.40)29.6817
2010's4 (4.40)24.3611
2020's1 (1.10)2.80

Authors

AuthorsStudies
Biffi, A1
Rea, F1
Locatelli, A1
Cetin, I1
Filippelli, A1
Corrao, G1
Bérard, A1
Sheehy, O1
Gorgui, J1
Zhao, JP1
Soares de Moura, C1
Bernatsky, S1
Howland, RH1
Persaud, N2
Chin, J1
Walker, M1
Healy, D1
Brent, R2
Kutcher, JS2
Engle, A1
Firth, J1
Lamm, SH2
Brickley, P1
Clarke, M1
Clayton, DG1
Hall, JB1
Smithells, RW2
Sheppard, S2
Kalter, H1
Warkany, J1
Holmes, LB1
Patterson, SP1
Hill, LM1
Kleinberg, F1
Cordero, JF2
Oakley, GP2
Grodofsky, MP1
Wilmott, RW1
Leeder, JS1
Spielberg, SP1
MacLeod, SM1
Mitchell, AA1
Schwingl, PJ1
Rosenberg, L1
Louik, C1
Shapiro, S2
Aselton, PJ1
Jick, H3
McCredie, J1
Kricker, A1
Elliott, J1
Forrest, J1
Davis, JM1
Correy, JF4
Newman, NM4
Shanks, RG2
Griffiths, K2
Harron, DW2
Fleming, DM1
Knox, JD1
Crombie, DL1
Michaelis, J1
Michaelis, H1
Glück, E1
Koller, S1
Brent, RR1
Brown, A1
Leal, J1
Huff, PS1
Kolata, G2
Morelock, S1
Hingson, R1
Kayne, H1
Dooling, E1
Zuckerman, B1
Day, N1
Alpert, JJ1
Flowerdew, G1
Gart, JJ1
Thomas, DG1
David, TJ1
Donaldson, GL1
Bury, RG1
Eskenazi, B1
Bracken, MB1
Greenberg, F1
James, LM1
Gibson, GT1
Colley, DP1
McMichael, AJ1
Hartshorne, JM1
Kolata, GB1
Golden, SM1
Perman, KI1
Korcok, M1
Pearson, RD1
Barinaga, M1
McKeigue, PM1
Linn, S1
Appelbaum, PS1
Bertin, JE1
Henifin, MS1
Brushwood, DB1
McBride, WG2
Mervis, J1
Marwick, C1
Marshall, E1
Koren, G1
Pastuszak, A1
Ito, S1
Check, WA1
Harris, R1
Milkovich, L1
van den Berg, BJ1
Patterson, DC1
Heinonen, OP1
Siskind, V1
Kaufman, DW1
Monson, RR1
Slone, D1
Brannigan, VM1
Bier, VM1
Berg, C1
Collins, JA1
Burrows, EA1
Burrows, RF1
Curran, JT1
Saunders, EJ1
Saunders, JA1
Newman, SA1
Shiono, PH1
Klebanoff, MA1
Kiley, VA1
Lazerson, J1
Tyl, RW1
Price, CJ1
Marr, MC1
Kimmel, CA1
Goldberg, JD1
Golbus, MS1
Elbourne, D2
Mutch, L2
Melnick, M1
Porter, JB1
Hunter-Mitchell, J1
Walker, AM1
Sheffield, LJ1
Batagol, R1
Orme, ML1
Aselton, P1
Milunsky, A1
Hunter, JR1
Stergachis, A1
Brent, RL1
Danks, DM1
Dauncey, M1
Campbell, H1
Samphier, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192]200 participants (Anticipated)Observational2023-09-30Not yet recruiting
A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825]Phase 261 participants (Actual)Interventional2006-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in the Area Under the Concentration vs. Time Curve in the Second and Third Trimesters of Pregnancy.

"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy

Interventionng/ML/day (Mean)
AUC -1AUC - 2
Part 1115136

Reviews

11 reviews available for dicyclomine and Abnormalities, Drug-Induced

ArticleYear
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
    Pharmacological research, 2021, Volume: 163

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2021
Congenital malformations (second of two parts).
    The New England journal of medicine, 1983, Mar-03, Volume: 308, Issue:9

    Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Alcohol Drinking; Anesthetics; Anticoagul

1983
Teratogen update: bendectin.
    Teratology, 1983, Volume: 27, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Dicyclomine; Doxylamine; Drug Combinations; Drug Utilization;

1983
Effects of drugs and chemicals on the fetus and newborn (1).
    Mayo Clinic proceedings, 1984, Volume: 59, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug

1984
Drug exposure during pregnancy: some epidemiologic considerations.
    Clinical obstetrics and gynecology, 1983, Volume: 26, Issue:2

    Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations;

1983
Safety of drug therapy for nausea and vomiting of pregnancy.
    The Journal of family practice, 1980, Volume: 11, Issue:6

    Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female;

1980
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.
    Teratology, 1994, Volume: 50, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Case-Control Studies; Cohort Studies; Dicyclomine; Doxylam

1994
Drugs in pregnancy.
    The New England journal of medicine, 1998, Apr-16, Volume: 338, Issue:16

    Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E

1998
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
    American journal of obstetrics and gynecology, 2002, Volume: 186, Issue:5 Suppl Un

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2002
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
    Health care for women international, 1990, Volume: 11, Issue:4

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat

1990
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
    The Medical journal of Australia, 1985, Aug-19, Volume: 143, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec

1985

Trials

3 trials available for dicyclomine and Abnormalities, Drug-Induced

ArticleYear
FDA to reexamine bendectin data.
    Science (New York, N.Y.), 1982, Jul-23, Volume: 217, Issue:4557

    Topics: Abnormalities, Drug-Induced; Animals; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combin

1982
An evaluation of the teratogenicity of certain antinauseant drugs.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami

1976
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
    The Medical journal of Australia, 1985, Aug-19, Volume: 143, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec

1985

Other Studies

78 other studies available for dicyclomine and Abnormalities, Drug-Induced

ArticleYear
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
    Journal of clinical epidemiology, 2019, Volume: 116

    Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi

2019
Concern for truth: driving defensively when confronting a zombie epidemic.
    Journal of psychosocial nursing and mental health services, 2013, Volume: 51, Issue:11

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor

2013
Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy?
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2014, Volume: 36, Issue:4

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

2014
Epidemiological evidence in forensic pharmacovigilance.
    The International journal of risk & safety in medicine, 2012, Volume: 24, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Breast Implantation; Causality; Connective Tissue Diseases

2012
Bendectin and birth defects: hopefully, the final chapter.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C

2003
Bendectin and birth defects. II: Ecological analyses.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems

2003
Science v. law. A decade-old rule on scientific evidence comes under fire.
    Scientific American, 2003, Volume: 289, Issue:6

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi

2003
Safety of Debendox.
    Lancet (London, England), 1981, Mar-21, Volume: 1, Issue:8221

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetal Death; Humans

1981
Debendox in pregnancy.
    Lancet (London, England), 1981, Jul-18, Volume: 2, Issue:8238

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Humans; Infa

1981
Teratogenicity of debendox and pyrimethamine.
    Lancet (London, England), 1983, Sep-10, Volume: 2, Issue:8350

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy;

1983
Debendox is not thalidomide.
    Lancet (London, England), 1984, Jul-28, Volume: 2, Issue:8396

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

1984
Our bundle of responsibility. Presidential address.
    American journal of obstetrics and gynecology, 1984, Jun-01, Volume: 149, Issue:3

    Topics: Abnormalities, Drug-Induced; Costs and Cost Analysis; Delivery of Health Care; Dicyclomine; Doxylami

1984
Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia.
    The New England journal of medicine, 1984, Sep-13, Volume: 311, Issue:11

    Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female;

1984
Debendox and pregnancy.
    The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre

1984
Bendectin: the wrong way to regulate drug availability.
    Canadian Medical Association journal, 1983, Nov-15, Volume: 129, Issue:10

    Topics: Abnormalities, Drug-Induced; Canada; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Fema

1983
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
    American journal of obstetrics and gynecology, 1983, Dec-01, Volume: 147, Issue:7

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis

1983
Additional follow-up of congenital limb disorders in relation to Bendectin use.
    JAMA, 1983, Jul-01, Volume: 250, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Follow

1983
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
    The Medical journal of Australia, 1984, Apr-28, Volume: 140, Issue:9

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine;

1984
Good-bye, Bendectin, old friend.
    Postgraduate medicine, 1984, May-15, Volume: 75, Issue:7

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma

1984
Debendox withdrawn.
    The Medical journal of Australia, 1984, Jun-23, Volume: 140, Issue:13

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New

1984
Debendox and congenital malformations in Northern Ireland.
    British medical journal (Clinical research ed.), 1981, Jun-13, Volume: 282, Issue:6280

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Northern Ireland; P

1981
Debendox in early pregnancy and fetal malformation.
    British medical journal (Clinical research ed.), 1981, Jul-11, Volume: 283, Issue:6284

    Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations

1981
Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
    Teratology, 1983, Volume: 27, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Estradiol; Fem

1983
Congenital malformations.
    The New England journal of medicine, 1983, Aug-04, Volume: 309, Issue:5

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Combinations; F

1983
The Bendectin Saga: another American tragedy (Brent, '80).
    Teratology, 1983, Volume: 27, Issue:2

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden

1983
Debendox in the dock.
    Nursing mirror, 1980, Feb-21, Volume: 150, Issue:8

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1980
Bendectin use during pregnancy.
    The American journal of nursing, 1982, Volume: 82, Issue:11

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy;

1982
Bendectin and fetal development. A study of Boston City Hospital.
    American journal of obstetrics and gynecology, 1982, Jan-15, Volume: 142, Issue:2

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1982
The performance of three approximate confidence limit methods for the odds ratio.
    American journal of epidemiology, 1982, Volume: 115, Issue:3

    Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Dicyclomine; Doxylamine; Drug Combinations; Epidemiol

1982
Debendox does not cause the Poland anomaly.
    Archives of disease in childhood, 1982, Volume: 57, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com

1982
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
    Acta paediatrica Scandinavica, 1982, Volume: 71, Issue:2

    Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine;

1982
Bendectin (Debendox) as a risk factor for pyloric stenosis.
    American journal of obstetrics and gynecology, 1982, Dec-15, Volume: 144, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart Defect

1982
The law and Bendectin.
    American family physician, 1981, Volume: 23, Issue:4

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden

1981
Is Bendectin a teratogen?
    JAMA, 1981, Jun-12, Volume: 245, Issue:22

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio

1981
Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors: an ongoing prospective study.
    The Medical journal of Australia, 1981, Apr-18, Volume: 1, Issue:8

    Topics: Abnormalities, Drug-Induced; Adult; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combi

1981
Debendox and limb reduction deformities.
    The Medical journal of Australia, 1981, Apr-18, Volume: 1, Issue:8

    Topics: Abnormalities, Drug-Induced; Australia; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug C

1981
Debendox and the media.
    British medical journal, 1980, Feb-16, Volume: 280, Issue:6212

    Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Female; Humans; Infant, Newbo

1980
Debendox in pregnancy.
    The Medical journal of Australia, 1980, Mar-08, Volume: 1, Issue:5

    Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations

1980
How safe is Bendectin?
    Science (New York, N.Y.), 1980, Oct-31, Volume: 210, Issue:4469

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; Female; Hu

1980
Bilateral clinical anophthalmia: drugs as potential factors.
    Southern medical journal, 1980, Volume: 73, Issue:10

    Topics: Abnormalities, Drug-Induced; Adult; Amitriptyline; Anophthalmos; Dicyclomine; Drug Combinations; Dru

1980
Debendox and congenital malformations in Northern Ireland.
    British medical journal, 1980, Nov-22, Volume: 281, Issue:6252

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1980
The Bendectin debate.
    Canadian Medical Association journal, 1980, Nov-08, Volume: 123, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal

1980
Bendectin and fetal malformations.
    Canadian Medical Association journal, 1981, Feb-01, Volume: 124, Issue:3

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

1981
Bendectin case dismissed.
    Science (New York, N.Y.), 1995, Jan-13, Volume: 267, Issue:5195

    Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Drug In

1995
Evaluating the admissibility of expert testimony.
    Hospital & community psychiatry, 1994, Volume: 45, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo

1994
Science, law, and the search for truth in the courtroom: lessons from Daubert v. Merrell Dow.
    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics, 1994,Spring, Volume: 22, Issue:1

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo

1994
Admissibility of scientific testimony into evidence.
    American journal of hospital pharmacy, 1994, Mar-01, Volume: 51, Issue:5

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry;

1994
Study of prescription drugs in the first trimester and congenital malformations.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1993, Volume: 33, Issue:2

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy;

1993
Supreme Court to judges: start thinking like scientists.
    Science (New York, N.Y.), 1993, Jul-02, Volume: 261, Issue:5117

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi

1993
Court ruling on 'junk science' gives judges more say about what expert witness testimony to allow.
    JAMA, 1993, Jul-28, Volume: 270, Issue:4

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry;

1993
Supreme Court to weigh science.
    Science (New York, N.Y.), 1993, Jan-29, Volume: 259, Issue:5095

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo

1993
CDC study: no evidence for teratogenicity of Bendectin.
    JAMA, 1979, Dec-07, Volume: 242, Issue:23

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart

1979
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
    Teratology, 1978, Volume: 17, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam

1978
Unusual fetal malformations after antiemetics in early pregnancy.
    British medical journal, 1978, Mar-18, Volume: 1, Issue:6114

    Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Female; Humans; Pregnancy

1978
Fetal malformation after Debendox treatment in early pregnancy.
    British medical journal, 1978, Apr-22, Volume: 1, Issue:6119

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug

1978
Congenital deformities associated with Benedectin.
    Canadian Medical Association journal, 1977, Jun-18, Volume: 116, Issue:12

    Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations

1977
Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
    American journal of obstetrics and gynecology, 1977, Jul-01, Volume: 128, Issue:5

    Topics: Abnormalities, Drug-Induced; Birth Weight; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Env

1977
Congenital deformities associated with Bendectin.
    Canadian Medical Association journal, 1977, Oct-08, Volume: 117, Issue:7

    Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin

1977
Prescription drugs in the first trimester and congenital malformations.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:4

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Fe

1992
Risk, statistical inference, and the law of evidence: the use of epidemiological data in toxic tort cases.
    Risk analysis : an official publication of the Society for Risk Analysis, 1992, Volume: 12, Issue:3

    Topics: Abnormalities, Drug-Induced; Antiemetics; Confidence Intervals; Data Interpretation, Statistical; Di

1992
Use of prescription drugs in the first trimester and congenital malformations.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1991, Volume: 31, Issue:4

    Topics: Abnormalities, Drug-Induced; Aspirin; Contraceptives, Oral; Dicyclomine; Female; Humans; Infant, New

1991
Bendectin--birth defects controversy.
    JAMA, 1990, Aug-01, Volume: 264, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Extre

1990
Bendectin and human congenital malformations.
    Teratology, 1989, Volume: 40, Issue:2

    Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do

1989
Agenesis of the corpus callosum and neural crest tumors.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:2

    Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho

1986
Developmental toxicity evaluation of Bendectin in CD rats.
    Teratology, 1988, Volume: 37, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam

1988
The value of case reports in human teratology.
    American journal of obstetrics and gynecology, 1986, Volume: 154, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth

1986
Debendox.
    The Medical journal of Australia, 1986, Mar-03, Volume: 144, Issue:5

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com

1986
Limb-reduction deformities and Debendox.
    The Medical journal of Australia, 1987, Oct-05, Volume: 147, Issue:7

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New

1987
The weight of the evidence--or--more likely than not.
    Journal of craniofacial genetics and developmental biology, 1986, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Dicyclomine; District of Columbia; Doxylamine; Drug Combinations; Femal

1986
Drugs and stillbirth.
    American journal of public health, 1986, Volume: 76, Issue:12

    Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Contraceptives, Oral; Dicyclomine; Doxyla

1986
Comments on "Teratogen update:bendectin".
    Teratology, 1985, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Bibliographies as Topic; Dicyclomine; Doxylamine; Drug Combinations; Hu

1985
The debendox saga.
    British medical journal (Clinical research ed.), 1985, Oct-05, Volume: 291, Issue:6500

    Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans

1985
Debendox.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations

1986
Jury clears Bendectin.
    Science (New York, N.Y.), 1985, Mar-29, Volume: 227, Issue:4694

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden

1985
First-trimester drug use and congenital disorders.
    Obstetrics and gynecology, 1985, Volume: 65, Issue:4

    Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru

1985
Editorial comment on comments on "Teratogen update: Bendectin".
    Teratology, 1985, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Methods; Pyridines;

1985
Blame, compensation and birth defects.
    The Medical journal of Australia, 1985, Aug-19, Volume: 143, Issue:4

    Topics: Abnormalities, Drug-Induced; Australia; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Comb

1985
Debendox revisited.
    British journal of obstetrics and gynaecology, 1985, Volume: 92, Issue:8

    Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com

1985