dicyclomine has been researched along with Abnormalities, Drug-Induced in 91 studies
Dicyclomine: A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms.
dicyclomine : The ester resulting from the formal condensation of 1-cyclohexylcyclohexanecarboxylic acid with 2-(diethylamino)ethanol. An anticholinergic, it is used as the hydrochloride to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 7.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy." | 7.65 | Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| ""Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations." | 4.79 | Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. ( Kutcher, JS; Lamm, SH; Linn, S; McKeigue, PM, 1994) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 3.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| "Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy." | 3.67 | Developmental toxicity evaluation of Bendectin in CD rats. ( Kimmel, CA; Marr, MC; Price, CJ; Tyl, RW, 1988) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy." | 3.65 | Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score. ( Heinonen, OP; Kaufman, DW; Monson, RR; Shapiro, S; Siskind, V; Slone, D, 1977) |
| "This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors." | 1.26 | Bilateral clinical anophthalmia: drugs as potential factors. ( Golden, SM; Perman, KI, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 67 (73.63) | 18.7374 |
| 1990's | 15 (16.48) | 18.2507 |
| 2000's | 4 (4.40) | 29.6817 |
| 2010's | 4 (4.40) | 24.3611 |
| 2020's | 1 (1.10) | 2.80 |
| Authors | Studies |
|---|---|
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
| Corrao, G | 1 |
| Bérard, A | 1 |
| Sheehy, O | 1 |
| Gorgui, J | 1 |
| Zhao, JP | 1 |
| Soares de Moura, C | 1 |
| Bernatsky, S | 1 |
| Howland, RH | 1 |
| Persaud, N | 2 |
| Chin, J | 1 |
| Walker, M | 1 |
| Healy, D | 1 |
| Brent, R | 2 |
| Kutcher, JS | 2 |
| Engle, A | 1 |
| Firth, J | 1 |
| Lamm, SH | 2 |
| Brickley, P | 1 |
| Clarke, M | 1 |
| Clayton, DG | 1 |
| Hall, JB | 1 |
| Smithells, RW | 2 |
| Sheppard, S | 2 |
| Kalter, H | 1 |
| Warkany, J | 1 |
| Holmes, LB | 1 |
| Patterson, SP | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Cordero, JF | 2 |
| Oakley, GP | 2 |
| Grodofsky, MP | 1 |
| Wilmott, RW | 1 |
| Leeder, JS | 1 |
| Spielberg, SP | 1 |
| MacLeod, SM | 1 |
| Mitchell, AA | 1 |
| Schwingl, PJ | 1 |
| Rosenberg, L | 1 |
| Louik, C | 1 |
| Shapiro, S | 2 |
| Aselton, PJ | 1 |
| Jick, H | 3 |
| McCredie, J | 1 |
| Kricker, A | 1 |
| Elliott, J | 1 |
| Forrest, J | 1 |
| Davis, JM | 1 |
| Correy, JF | 4 |
| Newman, NM | 4 |
| Shanks, RG | 2 |
| Griffiths, K | 2 |
| Harron, DW | 2 |
| Fleming, DM | 1 |
| Knox, JD | 1 |
| Crombie, DL | 1 |
| Michaelis, J | 1 |
| Michaelis, H | 1 |
| Glück, E | 1 |
| Koller, S | 1 |
| Brent, RR | 1 |
| Brown, A | 1 |
| Leal, J | 1 |
| Huff, PS | 1 |
| Kolata, G | 2 |
| Morelock, S | 1 |
| Hingson, R | 1 |
| Kayne, H | 1 |
| Dooling, E | 1 |
| Zuckerman, B | 1 |
| Day, N | 1 |
| Alpert, JJ | 1 |
| Flowerdew, G | 1 |
| Gart, JJ | 1 |
| Thomas, DG | 1 |
| David, TJ | 1 |
| Donaldson, GL | 1 |
| Bury, RG | 1 |
| Eskenazi, B | 1 |
| Bracken, MB | 1 |
| Greenberg, F | 1 |
| James, LM | 1 |
| Gibson, GT | 1 |
| Colley, DP | 1 |
| McMichael, AJ | 1 |
| Hartshorne, JM | 1 |
| Kolata, GB | 1 |
| Golden, SM | 1 |
| Perman, KI | 1 |
| Korcok, M | 1 |
| Pearson, RD | 1 |
| Barinaga, M | 1 |
| McKeigue, PM | 1 |
| Linn, S | 1 |
| Appelbaum, PS | 1 |
| Bertin, JE | 1 |
| Henifin, MS | 1 |
| Brushwood, DB | 1 |
| McBride, WG | 2 |
| Mervis, J | 1 |
| Marwick, C | 1 |
| Marshall, E | 1 |
| Koren, G | 1 |
| Pastuszak, A | 1 |
| Ito, S | 1 |
| Check, WA | 1 |
| Harris, R | 1 |
| Milkovich, L | 1 |
| van den Berg, BJ | 1 |
| Patterson, DC | 1 |
| Heinonen, OP | 1 |
| Siskind, V | 1 |
| Kaufman, DW | 1 |
| Monson, RR | 1 |
| Slone, D | 1 |
| Brannigan, VM | 1 |
| Bier, VM | 1 |
| Berg, C | 1 |
| Collins, JA | 1 |
| Burrows, EA | 1 |
| Burrows, RF | 1 |
| Curran, JT | 1 |
| Saunders, EJ | 1 |
| Saunders, JA | 1 |
| Newman, SA | 1 |
| Shiono, PH | 1 |
| Klebanoff, MA | 1 |
| Kiley, VA | 1 |
| Lazerson, J | 1 |
| Tyl, RW | 1 |
| Price, CJ | 1 |
| Marr, MC | 1 |
| Kimmel, CA | 1 |
| Goldberg, JD | 1 |
| Golbus, MS | 1 |
| Elbourne, D | 2 |
| Mutch, L | 2 |
| Melnick, M | 1 |
| Porter, JB | 1 |
| Hunter-Mitchell, J | 1 |
| Walker, AM | 1 |
| Sheffield, LJ | 1 |
| Batagol, R | 1 |
| Orme, ML | 1 |
| Aselton, P | 1 |
| Milunsky, A | 1 |
| Hunter, JR | 1 |
| Stergachis, A | 1 |
| Brent, RL | 1 |
| Danks, DM | 1 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
11 reviews available for dicyclomine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Congenital malformations (second of two parts).
Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Alcohol Drinking; Anesthetics; Anticoagul | 1983 |
Teratogen update: bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Dicyclomine; Doxylamine; Drug Combinations; Drug Utilization; | 1983 |
Effects of drugs and chemicals on the fetus and newborn (1).
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug | 1984 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.
Topics: Abnormalities, Drug-Induced; Antiemetics; Case-Control Studies; Cohort Studies; Dicyclomine; Doxylam | 1994 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat | 1990 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
3 trials available for dicyclomine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
FDA to reexamine bendectin data.
Topics: Abnormalities, Drug-Induced; Animals; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combin | 1982 |
An evaluation of the teratogenicity of certain antinauseant drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami | 1976 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
78 other studies available for dicyclomine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Concern for truth: driving defensively when confronting a zombie epidemic.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor | 2013 |
Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Epidemiological evidence in forensic pharmacovigilance.
Topics: Abnormalities, Drug-Induced; Antiemetics; Breast Implantation; Causality; Connective Tissue Diseases | 2012 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
Science v. law. A decade-old rule on scientific evidence comes under fire.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi | 2003 |
Safety of Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetal Death; Humans | 1981 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Humans; Infa | 1981 |
Teratogenicity of debendox and pyrimethamine.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1983 |
Debendox is not thalidomide.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
Our bundle of responsibility. Presidential address.
Topics: Abnormalities, Drug-Induced; Costs and Cost Analysis; Delivery of Health Care; Dicyclomine; Doxylami | 1984 |
Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Bendectin: the wrong way to regulate drug availability.
Topics: Abnormalities, Drug-Induced; Canada; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Fema | 1983 |
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis | 1983 |
Additional follow-up of congenital limb disorders in relation to Bendectin use.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Follow | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Debendox withdrawn.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1984 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Northern Ireland; P | 1981 |
Debendox in early pregnancy and fetal malformation.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1981 |
Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Estradiol; Fem | 1983 |
Congenital malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Combinations; F | 1983 |
The Bendectin Saga: another American tragedy (Brent, '80).
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1983 |
Debendox in the dock.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Bendectin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1982 |
Bendectin and fetal development. A study of Boston City Hospital.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1982 |
The performance of three approximate confidence limit methods for the odds ratio.
Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Dicyclomine; Doxylamine; Drug Combinations; Epidemiol | 1982 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Bendectin (Debendox) as a risk factor for pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Adult; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart Defect | 1982 |
The law and Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1981 |
Is Bendectin a teratogen?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio | 1981 |
Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors: an ongoing prospective study.
Topics: Abnormalities, Drug-Induced; Adult; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combi | 1981 |
Debendox and limb reduction deformities.
Topics: Abnormalities, Drug-Induced; Australia; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug C | 1981 |
Debendox and the media.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Female; Humans; Infant, Newbo | 1980 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1980 |
How safe is Bendectin?
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; Female; Hu | 1980 |
Bilateral clinical anophthalmia: drugs as potential factors.
Topics: Abnormalities, Drug-Induced; Adult; Amitriptyline; Anophthalmos; Dicyclomine; Drug Combinations; Dru | 1980 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
The Bendectin debate.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal | 1980 |
Bendectin and fetal malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1981 |
Bendectin case dismissed.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Drug In | 1995 |
Evaluating the admissibility of expert testimony.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Science, law, and the search for truth in the courtroom: lessons from Daubert v. Merrell Dow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Admissibility of scientific testimony into evidence.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1994 |
Study of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1993 |
Supreme Court to judges: start thinking like scientists.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi | 1993 |
Court ruling on 'junk science' gives judges more say about what expert witness testimony to allow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1993 |
Supreme Court to weigh science.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1993 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1978 |
Unusual fetal malformations after antiemetics in early pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Female; Humans; Pregnancy | 1978 |
Fetal malformation after Debendox treatment in early pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1978 |
Congenital deformities associated with Benedectin.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1977 |
Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
Topics: Abnormalities, Drug-Induced; Birth Weight; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Env | 1977 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Fe | 1992 |
Risk, statistical inference, and the law of evidence: the use of epidemiological data in toxic tort cases.
Topics: Abnormalities, Drug-Induced; Antiemetics; Confidence Intervals; Data Interpretation, Statistical; Di | 1992 |
Use of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Aspirin; Contraceptives, Oral; Dicyclomine; Female; Humans; Infant, New | 1991 |
Bendectin--birth defects controversy.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Extre | 1990 |
Bendectin and human congenital malformations.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do | 1989 |
Agenesis of the corpus callosum and neural crest tumors.
Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho | 1986 |
Developmental toxicity evaluation of Bendectin in CD rats.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1988 |
The value of case reports in human teratology.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1986 |
Limb-reduction deformities and Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1987 |
The weight of the evidence--or--more likely than not.
Topics: Abnormalities, Drug-Induced; Dicyclomine; District of Columbia; Doxylamine; Drug Combinations; Femal | 1986 |
Drugs and stillbirth.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Contraceptives, Oral; Dicyclomine; Doxyla | 1986 |
Comments on "Teratogen update:bendectin".
Topics: Abnormalities, Drug-Induced; Bibliographies as Topic; Dicyclomine; Doxylamine; Drug Combinations; Hu | 1985 |
The debendox saga.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1985 |
Debendox.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1986 |
Jury clears Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1985 |
First-trimester drug use and congenital disorders.
Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru | 1985 |
Editorial comment on comments on "Teratogen update: Bendectin".
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Methods; Pyridines; | 1985 |
Blame, compensation and birth defects.
Topics: Abnormalities, Drug-Induced; Australia; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Comb | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |