dicumarol and Kidney-Diseases

In this first article of a series of papers listing first case reports of animal diseases published since 2000, the following 19 cases of dog diseases are discussed: Blastomycotic granuloma involving the cranial vena cava. Congenital myocardial hamartoma. Discospondylitis: three cases caused respectively by Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus epidermidis. Dystrophin deficient muscular dystrophy in a Labrador Retriever. Emphysematous prostatitis. Erythema multiforme major caused by a Parvovirus infection of keratinocytes. Hemochromatosis due to repeated blood transfusions. Intraspinal synovial cyst. Juvenile nephropathy in the Collie and the Irish Wolfhound. Primary cerebellar cortical degeneration (abiotrophy) in a Scottish terrier. Primary pulmonary artery chondrosarcoma. Renal dysplasia in a Bull Mastiff. Rhabdomyosarcoma (botryoid sarcoma) of the urinary bladder in a Maltese. Spinal mast cell tumor. Spongiform degeneration of the white matter in the central nervous system of Australian Cattle dog. Systemic pasteurellosis caused by Pasteurella canis. Thymic hemorrhage caused by dicumarol intoxication. Undimerized biclonal gammopathy with a single heavy chain class IgA in a dog with multiple myeloma. After a short introduction, the bibliographical data and the abstract of the author(s) and mostly some additional information derived from the article are given. The article will be regularly updated adding overlooked as well as new first reports.

Topics: Animals; Blastomycosis; Chondrosarcoma; Creutzfeldt-Jakob Syndrome; Dicumarol; Dog Diseases; Dogs; Erythema Multiforme; Female; Glomerulonephritis, Membranous; Hemochromatosis; Kidney Diseases; Male; Mastocytosis; Multiple Myeloma; Muscular Dystrophies; Pasteurella Infections; Prostatitis; Rhabdomyosarcoma; Spinocerebellar Degenerations; Spondylitis; Synovial Cyst

Aristolochic acid I (AAI) is the major toxic component of aristolochic acid that causes aristolochic acid nephropathy and Balkan endemic nephropathy. Nitroreduction is an essential metabolic process for AAI rapid clearance in different species including humans. However, which enzyme participates in AAI nitroreduction in vivo and whether this metabolic process contributes to AAI nephrotoxicity are unclear. Here, we showed that NAD(P)H:quinone oxidoreductase 1 (NQO1) was highly expressed in mouse renal tubular epithelial cells. Inhibition of NQO1 activity by dicoumarol pretreatment significantly decreased renal aristolactam I (ALI) levels, a major reductive metabolite of AAI, whereas it increased renal AAI and its major oxidative metabolite 8-hydroxy-aristolochic acid I (AAIa) levels in male C57BL/6 mice. Similar changes in renal ALI, AAI, and AAIa levels were also observed in mice pretreated with another NQO1 inhibitor, phenindione. Consistent with higher levels of renal AAI and AAIa found in dicoumarol-pretreated mice, their serum clearance was much slower compared with vehicle-pretreated mice. The survival rate of mice pretreated with dicoumarol was markedly increased when higher doses of AAI were given. Similarly, pretreatment of mice with phenindione also attenuated AAI-induced nephrotoxicity. These results indicate that NQO1 plays an important role in renal AAI nitroreduction and may thus contribute to AAI-induced nephrotoxicity.

Topics: Animals; Aristolochic Acids; Dicumarol; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); Phenindione; Survival Rate

Topics: Adult; Anticoagulants; Dicumarol; Female; Hematoma; Hematuria; Humans; Hydronephrosis; Kidney Diseases; Middle Aged; Retroperitoneal Space; Urography

Topics: Adult; Aged; Angina Pectoris; Anticoagulants; Diabetes Mellitus; Dicumarol; Follow-Up Studies; Heart Failure; Humans; Hypertension; Interprofessional Relations; Intracranial Embolism and Thrombosis; Kidney Diseases; Male; Middle Aged; Myocardial Infarction; Peptic Ulcer; United States; United States Department of Veterans Affairs

Topics: Anticoagulants; Arrhythmias, Cardiac; Blood Cell Count; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dicumarol; Heart Failure; Heparin; Humans; Hypertension; Kidney Diseases; Liver Diseases; Myocardial Infarction; Peptic Ulcer; Pulmonary Embolism; Shock; Thromboembolism; Thrombophlebitis; Thrombosis; Varicose Veins; Warfarin

Topics: Dicumarol; Hemorrhage; Humans; Kidney; Kidney Diseases

Topics: Coumarins; Dicumarol; Kidney Diseases; Renal Insufficiency