dicumarol and Dementia

The safety of direct oral anticoagulants (DOACs) in oldest old patients with nonvalvular atrial fibrillation (NVAF) in daily clinical practice has not been systematically assessed. This study examined the safety of DOACs and dicumarol (a vitamin K antagonist) in NVAF geriatric patients.. Prospective study from January 2010 through June 2015, with follow-up through January 2016.. Geriatric medicine department at a tertiary hospital.. A total of 554 outpatients, 75 years or older, diagnosed of NVAF and starting oral anticoagulation.. The main outcome was bleeding, which was classified into major (including those life-threatening) and nonmajor episodes. Statistical analyses were performed with Cox regression.. A total of 351 patients received DOACs and 193 dicumarol. Patients on DOACs were older, with more frequent comorbidities, mobility limitation and disability in activities of daily living, as well as higher mortality, than those treated with dicumarol. The incidence of any bleeding was 19.2/100 person-years among patients on DOACs and 13.7/100 person-years on dicumarol; corresponding figures for major bleeding were 5.2 for those on DOACs, and 3.3 for those on dicumarol. In crude analyses, hazard ratios (95% confidence intervals) for any bleeding, and for mayor bleeding in patients on DOACs vs dicumarol were 1.60 (1.04-2.44) and 2.22 (0.88-5.59), respectively. Excess risk of bleeding associated with DOACs vs dicumarol disappeared after adjustment for clinical characteristics, so that corresponding figures were 1.19 (0.68-2.08) and 1.01 (0.35-2.93). Results did not vary across subgroups of high-risk patients.. In very old patients with NVAF, the higher risk of bleeding associated with DOACs vs dicumarol could be mostly explained by the worse clinical profile of patients receiving DOACs. Risk of bleeding was rather high, and warrants close clinical monitoring.

Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Chronic Disease; Comorbidity; Dabigatran; Dementia; Dicumarol; Disabled Persons; Follow-Up Studies; Hemorrhage; Humans; Mobility Limitation; Prospective Studies; Pyrazoles; Pyridones; Rivaroxaban; Vitamin K

Topics: Adult; Aged; Anticoagulants; Anxiety; Atrophy; Brain Diseases; Dementia; Dicumarol; Fear; Female; Haloperidol; Humans; Informed Consent; Intracranial Arteriosclerosis; Male; Middle Aged; Pain, Intractable; Paranoid Disorders; Pneumoencephalography; Postoperative Complications; Prothrombin Time; Psychotherapy

Topics: Aged; Dementia; Dicumarol; Humans; Intracranial Arteriosclerosis; Middle Aged; Prothrombin Time; Psychotherapy

Topics: Aged; Cerebral Arterial Diseases; Dementia; Dicumarol; Humans; Ischemic Attack, Transient; Prothrombin Time

Topics: Aged; Brain Damage, Chronic; Carotid Artery Diseases; Cerebrovascular Circulation; Dementia; Dicumarol; Female; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged; Psychotic Disorders; Vertebral Artery

Topics: Aged; Dementia; Dicumarol; Female; Humans

Topics: Aged; Anticoagulants; Cerebrovascular Circulation; Dementia; Dicumarol; Humans; Middle Aged

Topics: Aged; Dementia; Dicumarol; Humans