dicumarol and Coronary-Disease

Topics: Aged; Anticoagulants; Carbohydrates; Cholesterol; Coronary Disease; Dicumarol; Diet Therapy; Dietary Carbohydrates; Dietary Fats; Humans; Middle Aged; Mortality; Myocardial Infarction; Thrombosis

Topics: Anticoagulants; Coronary Artery Disease; Coronary Disease; Dicumarol; Heparin; Hyperlipidemias; Myocardial Infarction; Oximetry

Topics: Angina Pectoris; Anticoagulants; Coronary Artery Disease; Coronary Disease; Dicumarol; Heparin; Humans; Myocardial Infarction; Phenindione; Toxicology; Warfarin

Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Dicumarol; Female; Humans; Male; Middle Aged; Thrombophlebitis

Topics: Adult; Aged; Blood Coagulation Tests; Clinical Trials as Topic; Coronary Disease; Dicumarol; Humans; Male; Middle Aged; Phenobarbital

During administration of bishydroxycoumarin, hematocrit, viscosity of whole blood, and viscosity of plasma decreased in samples from nine healthy volunteers and 31 patients who had coronary heart disease. The relationships between viscosity of blood and intensity of anticoagulant therapy varied from patient to patient. Discontinuation of the drug was followed by return of viscosities to pretreatment levels in two to four days. The decrease of viscosity of blood by anticoagulant therapy may explain the relief of anginal pain in patients who have coronary heart disease.

Topics: Administration, Oral; Anticoagulants; Blood Viscosity; Coronary Disease; Dicumarol; Hematocrit; Humans; Male

The authors report a series of 22 cases of subdural hematomas in patients submitted to anticoagulant therapy. A review of the literature finds 150 cases. Subdural hematomas occurs in about one third of the patients presenting hemorrhage of central nervous system related to anticoagulant therapy. Among subdural hematomas of any cause, the possible role of a previous anticoagulant therapy is stressed in 4,8 to 14% of cases. In most cases, long term anticoagulants were indicated for arterial or heart (ischemic) lesions (16/22 cases). In 6 cases, anticoagulants were indicated for prevention or treatment of pulmonary embolies. In 18 cases, anticoagulant drug is from the group of dicoumarol or phenylindanedione. In 3 cases, the only anticoagulant given to patient was heparin. Pathogenic study suggests that hypocoagulability might not always be the only factor of bleeding: high blood pressure, other drugs and head trauma (10 cases) are often associated. Clinical features, in our series, are similar to those encountered in cases of subdural hematoma of any cause. According to the existence of a cranial injury and to the chronology of anticoagulant therapy, the authors divide their 22 patients into 3 groups. The use of protamin sulfate or human plasma fraction PPSB provides in few minutes a normal coagulability. Neurosurgical treatment in all our cases evacuated in 11 patients a chronic subdural hematoma, in 2 cases an acute, and in 9 cases a subacute hematoma. Results were fair in 19 patients with no sequelae. 3 patients died during the immediate post-operative period. The authors conclude by stressing several preventive measures.

Topics: Anticoagulants; Cerebral Angiography; Coronary Disease; Craniocerebral Trauma; Dicumarol; Hematoma, Subdural; Heparin; Humans; Phenindione; Pulmonary Embolism

Topics: Coronary Disease; Dicumarol; Humans; Platelet Aggregation

Topics: Adult; Aged; Coronary Disease; Dicumarol; Female; Hemorrhage; Humans; Male; Middle Aged

Topics: Adult; Aged; Coronary Disease; Dicumarol; Follow-Up Studies; Humans; Middle Aged; Myocardial Infarction; Time Factors

Topics: Acute Disease; Adult; Anticoagulants; Arrhythmias, Cardiac; Chronic Disease; Coronary Disease; Dicumarol; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Prothrombin Time; Thrombelastography; Thrombosis; Warfarin

Topics: Anticholesteremic Agents; Anticoagulants; Arteriosclerosis; Cholesterol; Collateral Circulation; Coronary Disease; Dicumarol; Diet Therapy; Digitalis Glycosides; Humans; Manipulation, Orthopedic; Nikethamide; Vasodilator Agents

Topics: Age Factors; Aged; Anticoagulants; Arrhythmias, Cardiac; Cerebrovascular Disorders; Coronary Disease; Death, Sudden; Dicumarol; Female; Humans; Long-Term Care; Male; Myocardial Infarction; Retrospective Studies; Sex Factors; Thromboembolism

Topics: Acenocoumarol; Adult; Aged; Anticoagulants; Blood Coagulation Tests; Coronary Disease; Coumarins; Dicumarol; Female; Humans; Long-Term Care; Male; Middle Aged; Myocardial Infarction; Recurrence

Topics: Adult; Analgesics; Blood Coagulation; Blood Coagulation Factors; Blood Coagulation Tests; Coronary Disease; Coumarins; Depression, Chemical; Dicumarol; Factor V; Factor VII; Factor X; Female; Hemostasis; Humans; Male; Middle Aged; Serotonin Antagonists; Stimulation, Chemical; Thrombophlebitis; Time Factors

Topics: Adult; Aged; Arteriosclerosis; Blood Coagulation; Blood Coagulation Tests; Cerebrovascular Disorders; Coronary Disease; Dicumarol; Female; Femoral Artery; Humans; Male; Middle Aged; Myocardial Infarction; Retinal Vessels; Thrombosis

Topics: Anticoagulants; Coronary Disease; Dicumarol; Female; Humans; Male; Myocardial Infarction; Warfarin

Topics: Aged; Blood Coagulation; Blood Platelets; Coronary Disease; Dicumarol; Fibrinogen; Fibrinolytic Agents; Heparin; Humans; Myocardial Infarction

Topics: Coronary Disease; Dicumarol; Humans; Prothrombin Time

Topics: Angiography; Anticoagulants; Arteriosclerosis Obliterans; Blood Coagulation Tests; Cerebrovascular Disorders; Coronary Disease; Diabetic Angiopathies; Dicumarol; Leg; Mortality; Myocardial Infarction; Prognosis

Topics: Anticoagulants; Coronary Disease; Dicumarol; Heart Defects, Congenital; Heart Valve Diseases; Intracranial Arteriosclerosis; Phlebitis; Pulmonary Emphysema; Thromboembolism; Toxicology; Vascular Diseases; Warfarin

Topics: Arteriosclerosis; Atrial Fibrillation; Cerebrovascular Disorders; Coronary Disease; Dicumarol; Diet; Diet Therapy; Family Practice; General Practice; Humans; Intracranial Embolism; Intracranial Embolism and Thrombosis; Myocardial Infarction; Prothrombin Time; Thrombosis; Vitamin K; Warfarin

Topics: Blood Coagulation Tests; Coronary Disease; Dicumarol; Geriatrics; Intracranial Embolism; Intracranial Embolism and Thrombosis; Leriche Syndrome; Myocardial Infarction; Outpatients; Phenindione; Thrombosis; Toxicology; Warfarin

Topics: Anticoagulants; Coronary Disease; Dicumarol; Embolism; Ethyl Biscoumacetate; Hemorrhage; Humans; Postoperative Complications; Prothrombin Time; Thrombophlebitis; Toxicology; Warfarin

The administration of heparin during the first 48 hours following acute myocardial infarction is widely practised. Heparin treatment is also recommended for acute coronary insufficiency on the grounds that it may prevent development of an impending myocardial infarction. These measures had been accepted without support of a controlled clinical trial. By random selection, 101 patients hospitalized with a provisional diagnosis of acute myocardial infarction received heparin (100 mg. intravenously every eight hours for 48 hours) and 105 patients were assigned to a control group. Both groups of patients received bishydroxycoumarin (Dicumarol). The mortality in the heparin series was 30% and in the control group, 28%. A significantly large number of the heparin-treated patients developed clinical and laboratory proof of recent myocardial infarction. It is concluded that early intermittent intravenous heparin treatment does not lower the mortality in patients with acute myocardial infarction nor does it prevent impending myocardial infarction in patients with acute coronary insufficiency.

Topics: Acute Disease; Anterior Wall Myocardial Infarction; Anticoagulants; Cardiovascular Diseases; Coronary Disease; Dicumarol; Drug Therapy; Heparin; Humans; Myocardial Infarction

Topics: Anticoagulants; Arrhythmias, Cardiac; Blood Cell Count; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus; Dicumarol; Heart Failure; Heparin; Humans; Hypertension; Kidney Diseases; Liver Diseases; Myocardial Infarction; Peptic Ulcer; Pulmonary Embolism; Shock; Thromboembolism; Thrombophlebitis; Thrombosis; Varicose Veins; Warfarin

Topics: Acenocoumarol; Aged; Anticoagulants; Cerebrovascular Disorders; Coronary Disease; Dicumarol; Drug Therapy; Ethyl Biscoumacetate; Geriatrics; Humans; Incidence; Middle Aged; Mortality; Neoplasm Metastasis; Neoplasms; Pathology; Phenindione; Thromboembolism; Warfarin

Topics: Biomedical Research; Biometry; Coronary Artery Disease; Coronary Disease; Dicumarol; Double-Blind Method; Drug Therapy; Geriatrics; Placebos; Preventive Medicine; Statistics as Topic; Toxicology

Topics: 4-Hydroxycoumarins; Anticoagulants; Arteriosclerosis Obliterans; Atrial Fibrillation; Biomedical Research; Coronary Disease; Coumarins; Dicumarol; Hypertension; Thrombosis; Toxicology

Topics: 4-Hydroxycoumarins; Anticoagulants; Arteriosclerosis Obliterans; Atrial Fibrillation; Biomedical Research; Coronary Disease; Dicumarol; Hypertension; Hypertension, Pulmonary; Thrombophlebitis; Toxicology

Topics: Anticoagulants; Arteriosclerosis; Cholesterol; Coronary Disease; Dicumarol; Hyperlipidemias; Iodine Isotopes; Lipids; Trichloroacetic Acid; Triolein; Warfarin

Topics: Blood Coagulation; Coronary Disease; Dextrothyroxine; Dicumarol; Humans; Thyroxine

Topics: Anticoagulants; Coronary Disease; Coumarins; Dicumarol; Humans; Myocardial Infarction; Sodium; Warfarin

Topics: Cardiotonic Agents; Coronary Artery Disease; Coronary Disease; Dicumarol; Enzyme Inhibitors; Humans

Topics: Angina Pectoris; Anticoagulants; Coronary Artery Disease; Coronary Disease; Dicumarol; Humans; Long-Term Care; Myocardial Infarction; Phenindione

Topics: Coronary Artery Disease; Coronary Disease; Coumarins; Dicumarol

Topics: Anti-Arrhythmia Agents; Cardiotonic Agents; Coronary Disease; Coronary Thrombosis; Coumarins; Dicumarol; Enzyme Inhibitors

Topics: Coronary Disease; Coronary Thrombosis; Coumarins; Dicumarol; Embolism; Thromboembolism

Topics: Angina Pectoris; Coronary Disease; Coronary Thrombosis; Coumarins; Dicumarol

Topics: Coronary Disease; Coumarins; Dicumarol; Humans; Myocardial Infarction

Topics: Coronary Disease; Coumarins; Dicumarol; Family Practice; Humans

Topics: Coronary Artery Disease; Coronary Disease; Dicumarol; Disease Management; Heart

Topics: Coronary Artery Disease; Coronary Disease; Coronary Vessels; Coumarins; Dicumarol; Disease

Topics: Coronary Disease; Coronary Vessels; Dicumarol; Disease