dicumarol and Cardiovascular-Diseases

Extended medical care for pregnant women with cardio-angiopathies is discussed in this paper. High-continuity follow-up checks should begin in early childhood and conducted also in adult age, prior to conception. Appropriate medical documentation, including radiographs, should be complied well prior to pregnancy, to avoid X-ray examination during gravidity.--Also discussed is dicumarol treatment of pregnant carriers of artificial cardiac valves. Any treatment of cardio-angiopathy should be best timed to periods before conception to the benefit of better family planning. Extended medical care should be persistently implemented with high continuity as an integral part of medical programmes extended by district centres to pregnant women with cardio-angiopathies.

Topics: Adult; Ambulatory Care; Cardiovascular Diseases; Dicumarol; Female; Heart Valve Prosthesis; Heparin; Humans; Pregnancy; Pregnancy Complications, Cardiovascular

Cardiovascular therapy frequently requires simultaneous administration of several drugs. These drugs may interact pharmacokinetically or pharmacodynamically, and most drug interactions are therapeutically useful. The clinical importance of adverse drug interactions is often overestimated; they are almost always predictable and preventable, if their mechanisms are understood and the drug dosages appropriately modified. Coumarin anticoagulants and cardiac glycosides are involved in the most serious interactions. Diuretics, antiarrhythmic drugs, sympatholytics, sympathomimetics and monoamine oxidase blockers also interact in clinically significant fashion with other drugs.

Topics: Antidepressive Agents; Biological Transport; Biotransformation; Cardiovascular Diseases; Dicumarol; Digoxin; Drug Interactions; Guanethidine; Humans; Intestinal Absorption; Kinetics; Protein Binding; Serum Albumin

Topics: Acid-Base Equilibrium; Anticoagulants; Antithrombins; Blood Platelets; Cardiovascular Diseases; Dicumarol; Factor XI; Factor XII; Fibrinolysin; Hemodynamics; Heparin; Humans; Hydrogen-Ion Concentration; Thrombosis

Topics: Acenocoumarol; Adult; Aged; Anticoagulants; Blood Coagulation Tests; Cardiovascular Diseases; Dicumarol; Female; Hemorrhage; Heparin; Humans; Hypertension; Male; Middle Aged; Phenindione

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Drug Therapy; Geriatrics; Heparin; Myocardial Infarction; Phenindione; Warfarin

Topics: Aged; Anticoagulants; Cardiovascular Diseases; Dicumarol; Drug Therapy; Humans; Myocardial Infarction; Statistics as Topic; Toxicology; United States

Topics: Cardiovascular Diseases; Dicumarol; Geriatrics; Hematologic Tests; Heparin; Middle Aged; Mortality; Myocardial Infarction; Phenindione; Prothrombin; Prothrombin Time

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Geriatrics; Hematoma; Hematoma, Epidural, Cranial; Hematoma, Epidural, Spinal; Humans; Muscles; Myelography; Neurologic Manifestations; Pain; Paraplegia; Prothrombin Time; Radiography; Surgical Procedures, Operative; Toxicology

The administration of heparin during the first 48 hours following acute myocardial infarction is widely practised. Heparin treatment is also recommended for acute coronary insufficiency on the grounds that it may prevent development of an impending myocardial infarction. These measures had been accepted without support of a controlled clinical trial. By random selection, 101 patients hospitalized with a provisional diagnosis of acute myocardial infarction received heparin (100 mg. intravenously every eight hours for 48 hours) and 105 patients were assigned to a control group. Both groups of patients received bishydroxycoumarin (Dicumarol). The mortality in the heparin series was 30% and in the control group, 28%. A significantly large number of the heparin-treated patients developed clinical and laboratory proof of recent myocardial infarction. It is concluded that early intermittent intravenous heparin treatment does not lower the mortality in patients with acute myocardial infarction nor does it prevent impending myocardial infarction in patients with acute coronary insufficiency.

Topics: Acute Disease; Anterior Wall Myocardial Infarction; Anticoagulants; Cardiovascular Diseases; Coronary Disease; Dicumarol; Drug Therapy; Heparin; Humans; Myocardial Infarction

Topics: Anticoagulants; Atrial Fibrillation; Cardiovascular Diseases; Dicumarol; Humans; Quinidine

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Myocardial Infarction

Topics: Acute Disease; Anticoagulants; Cardiovascular Diseases; Dicumarol; Myocardial Infarction; Retrospective Studies

Topics: Acute Disease; Anticoagulants; Cardiovascular Diseases; Dicumarol; Heparin; Myocardial Infarction

Topics: Anterior Wall Myocardial Infarction; Anticoagulants; Cardiovascular Diseases; Dicumarol; Myocardial Infarction

Topics: Cardiovascular Diseases; Dicumarol; Myocardial Infarction

Topics: Acute Disease; Anticoagulants; Cardiovascular Diseases; Dicumarol; Heparin; Humans; Myocardial Infarction; Secondary Prevention

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Heparin; Humans; Myocardial Infarction

Topics: Biomedical Research; Cardiovascular Diseases; Dicumarol; Humans; Myocardial Infarction; Research Design

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Humans; Long-Term Care; Myocardial Infarction

Topics: Blood Coagulation; Cardiovascular Diseases; Coagulants; Coumarins; Dicumarol; Humans; Myocardial Infarction; Rheumatic Heart Disease

Topics: Blood Coagulation; Blood Coagulation Tests; Cardiovascular Diseases; Coumarins; Dicumarol; Hematologic Diseases; Humans; Prothrombin Time

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Hospitals, Private; Myocardial Infarction

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Hemostatics; Myocardial Infarction; Prothrombin; Prothrombin Time

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Heparin; Myocardial Infarction

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Myocardial Infarction

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Heart; Vascular Diseases

Topics: Cardiovascular Diseases; Cardiovascular System; Coumarins; Diagnostic Techniques, Cardiovascular; Dicumarol; Flicker Fusion; Vision, Ocular

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Ethyl Biscoumacetate; Myocardial Infarction

Topics: Blood Sedimentation; Cardiovascular Diseases; Coumarins; Dicumarol; Hematologic Tests; Myocardial Infarction

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Outpatients

Topics: Cardiovascular Diseases; Coumarins; Dicumarol; Myocardial Infarction

Topics: Cardiovascular Diseases; Dicumarol; Hemostatics; Humans; Myocardial Infarction; Prothrombin

Topics: Acute Disease; Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Coumarins; Dicumarol; Myocardial Infarction

Topics: Acute Disease; Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Myocardium

Topics: Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Humans; Myocardium; Pericarditis

Considerable experience by many independent workers with the use of anticoagulants in the treatment of certain types of heart disease has shown that such therapy reduces significantly the incidence of thromboembolic complications and, largely through this effect, the morbidity and mortality rate from heart disease of these types. This is certainly established in acute coronary occlusion with myocardial infarction and in those instances of rheumatic heart disease with auricular fibrillation in which repeated embolic phenomena have occurred. The case for the administration of the anticoagulants in congestive heart failure is less secure, although there is no doubt that the number of thromboembolic complications is reduced by use of them. The administration of the anticoagulants requires considerably more exacting attention than does the administration of the majority of therapeutic agents in use commonly today. Hence, it is suggested that the use of anticoagulants in heart disease be restricted to those instances in which the indications are clear and facilities are compatible with the efficient and safe use of the drug, whether Dicumarol or heparin.

Topics: Anticoagulants; Atrial Fibrillation; Cardiovascular Diseases; Dicumarol; Heart Diseases; Heart Failure; Heparin; Humans; Myocardial Infarction; Rheumatic Heart Disease

Topics: Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Myocardium

Topics: Acute Disease; Cardiovascular Diseases; Dicumarol; Myocardial Infarction; Myocardium

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Heparin; Phenindione

Topics: Anterior Wall Myocardial Infarction; Anticoagulants; Cardiovascular Diseases; Dicumarol; Myocardium

Topics: Anticoagulants; Blood; Cardiovascular Diseases; Dicumarol; Heart; Heparin; Myocardial Infarction; Thrombosis

Topics: Cardiovascular Diseases; Dicumarol; Heart; Myocardial Infarction

Topics: Anticoagulants; Cardiovascular Diseases; Coronary Occlusion; Coronary Vessels; Dicumarol; Heart; Heparin; Myocardial Infarction

Topics: Acute Disease; Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Heart

Topics: Cardiovascular Diseases; Dicumarol; Heart; Humans; Infarction; Myocardial Infarction

Topics: Cardiovascular Diseases; Dicumarol; Heart; Hemorrhage; Infarction; Minnesota; Myocardial Infarction; Pericardial Effusion; Pericardium

Topics: Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Heart; Infarction; Myocardial Infarction

Topics: Anterior Wall Myocardial Infarction; Cardiovascular Diseases; Dicumarol; Heart; Infarction; Myocardial Infarction

Topics: Blood Pressure; Cardiovascular Diseases; Dicumarol; Infarction; Myocardial Infarction; Myocardium

Topics: Anticoagulants; Cardiovascular Diseases; Dicumarol; Heart; Heparin; Humans; Infarction; Myocardial Infarction

Topics: Cardiovascular Diseases; Coronary Thrombosis; Dicumarol; Humans; Myocardial Infarction

Topics: Cardiovascular Diseases; Dicumarol; Myocardial Infarction