dictyostatin and Breast-Neoplasms

dictyostatin has been researched along with Breast-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for dictyostatin and Breast-Neoplasms

Article	Year
Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6- epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6- epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts. Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Macrolides; Mice; Xenograft Model Antitumor Assays	2008
Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation. Organic letters, 2002, Dec-12, Volume: 4, Issue:25 [structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues. Topics: Alkanes; Antineoplastic Agents; Breast Neoplasms; Carbamates; Female; Humans; Lactones; Macrolides; Ovarian Neoplasms; Pyrones; Tumor Cells, Cultured	2002

Article

Year

Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.

Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6- epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6- epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Macrolides; Mice; Xenograft Model Antitumor Assays

2008

Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation.

Organic letters, 2002, Dec-12, Volume: 4, Issue:25

[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.

Topics: Alkanes; Antineoplastic Agents; Breast Neoplasms; Carbamates; Female; Humans; Lactones; Macrolides; Ovarian Neoplasms; Pyrones; Tumor Cells, Cultured

2002