dictyostatin and Body-Weight

dictyostatin has been researched along with Body-Weight* in 1 studies

Other Studies

1 other study(ies) available for dictyostatin and Body-Weight

Article	Year
Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6- epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6- epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts. Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Macrolides; Mice; Xenograft Model Antitumor Assays	2008

Article

Year

Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.

Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6- epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6- epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts.

Topics: Animals; Body Weight; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Female; Humans; Macrolides; Mice; Xenograft Model Antitumor Assays

2008