diclofenac has been researched along with Stomach Ulcer in 110 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 9.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| "Patients who needed high-dose (200 to 300 mg/d) diclofenac for cancer pain and without mucosal lesions at baseline gastroduodenal endoscopy were randomized to receive misoprostol (200 micrograms twice daily; M group) or ranitidine (150 mg twice daily; R group)." | 9.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| " Misoprostol is the only cytoprotective drug found to be effective in the prevention of both gastric and duodenal ulcers associated with NSAIDs." | 8.79 | Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis. ( McKenna, F, 1995) |
| "Ionotropic gelation seems to be a simple, efficient technique to prepare aceclofenac-loaded microspheres with a reduced risk of gastric ulceration." | 8.12 | Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats. ( Abou-Taleb, HA; Ibrahim, MA; Yassin, HA, 2022) |
| "This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU." | 7.85 | Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. ( Goswami, SK; Hammock, BD; Inceoglu, B; Morisseau, C; Rand, AA; Thomas, M; Wan, D; Yang, GY; Yang, J, 2017) |
| "The present study was aimed to evaluate the effect of methanolic extract of Terminalia arjuna (TA) on diclofenac sodium induced gastric ulcer in experimental rats." | 7.74 | Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. ( Devi, RS; Narayan, S; Shyamala Devi, CS; Vani, G, 2007) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 5.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| "Diclofenac sodium (DFNa) was suspended in medium chain triglyceride (MCT) by forming a complex with an edible lipophilic surfactant." | 5.34 | Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. ( Fujii, T; Goto, M; Hirata, A; Ito, S; Kamiya, N; Piao, H; Shimizu, I; Yokoyama, H, 2007) |
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 5.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| "Patients with osteoarthritis (age, >or=50 y) were randomized to receive lumiracoxib 400 mg once daily, naproxen 500 mg twice daily, or ibuprofen 800 mg 3 times daily for 12 months." | 5.12 | Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study. ( Gitton, X; Hawkey, CJ; Krammer, G; Matchaba, P; Mellein, B; Richard, D; Sallstig, P; Smalley, W; Stricker, K; Weinstein, WM, 2007) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 5.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| "Patients who needed high-dose (200 to 300 mg/d) diclofenac for cancer pain and without mucosal lesions at baseline gastroduodenal endoscopy were randomized to receive misoprostol (200 micrograms twice daily; M group) or ranitidine (150 mg twice daily; R group)." | 5.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| "Three randomized, blinded, multicenter studies, including one in general practice, evaluated the efficacy of combination diclofenac/misoprostol versus diclofenac or ibuprofen in a total of 1824 patients with rheumatoid arthritis (RA) or osteoarthritis (OA)." | 5.08 | Diclofenac/misoprostol: the European clinical experience. ( McKenna, F, 1998) |
| " One hundred patients, free from endoscopically detectable lesions of the gastroduodenal mucosa, affected either by rheumatoid arthritis or osteoarthritis, and candidates for NSAID therapy, were randomly allocated either to 200 mg sulglycotide three times daily (n = 50) or to an indistinguishable placebo (n = 50) for 4 weeks, together with standard NSAID administration (50 mg diclofenac three times daily (n = 50); 50 mg indomethacin three times daily (n = 50))." | 5.07 | Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Montrone, F; Petrillo, M, 1993) |
| " Misoprostol is the only cytoprotective drug found to be effective in the prevention of both gastric and duodenal ulcers associated with NSAIDs." | 4.79 | Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis. ( McKenna, F, 1995) |
| "Ionotropic gelation seems to be a simple, efficient technique to prepare aceclofenac-loaded microspheres with a reduced risk of gastric ulceration." | 4.12 | Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats. ( Abou-Taleb, HA; Ibrahim, MA; Yassin, HA, 2022) |
| "We used two well-established mouse models of gastric ulcer (GU) induced by oral administration of EtOH (80% solution in water) or diclofenac (30 mg/kg, p." | 4.02 | AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice. ( Binienda, A; Fichna, J; Kordek, R; Majchrzak, K; Małecka-Panas, E; Salaga, M; Zatorski, H; Zielińska, M, 2021) |
| " platensis on different types of pain and inflammation in comparison to diclofenac sodium." | 3.96 | Effects of Spirulina platensis on pain and inflammation in long Evans rats. ( Akhter, S; Ali, T; Nipa, NS; Rafiq, K, 2020) |
| "Preclinical Research & Development The objective of the present study was to evaluate the tapentadol-diclofenac combination in three dose-ratios in the mouse acetic acid-induced visceral pain and their ulcerogenic activity on the stomachal mucous." | 3.88 | Assessment of the antinociceptive and ulcerogenic activity of the tapentadol-diclofenac combination in rodents. ( Alonso-Castro, ÁJ; Granados-Soto, V; Isiordia-Espinoza, MA; Sánchez-Enriquez, S; Zapata-Morales, JR, 2018) |
| "This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU." | 3.85 | Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. ( Goswami, SK; Hammock, BD; Inceoglu, B; Morisseau, C; Rand, AA; Thomas, M; Wan, D; Yang, GY; Yang, J, 2017) |
| "The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcer." | 3.85 | Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach. ( Basha S, K; Giridharan, R; Lavinya B, U; Peter S, J; Sabina, EP, 2017) |
| " All the compounds were found to cause less gastric ulceration than the standard drug diclofenac." | 3.83 | Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents. ( Kale, MA; Kuberkar, SV; Nawale, RB; Peharkar, MR, 2016) |
| "Aceclofenac, a nonsteroidal anti-inflammatory drug, has a propensity to cause gastric ulcers, while zinc ions are known to possess anti-ulcer and anti-inflammatory activities." | 3.80 | Zinc-aceclofenac complex: synthesis, hydrolysis study and antiinflammatory studies. ( Kale, MA; Nawale, RB; Shelke, R, 2014) |
| "Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats." | 3.80 | Anti-ulcer and wound healing activities of Sida corymbosa in rats. ( Isimi, CY; John-Africa, LB; Yahaya, TA, 2014) |
| " YF476 protection against diclofenac-induced gastric ulcers was compared to esomeprazole and correlated with plasma levels of hormones related to gastric pH (gastrin, ghrelin, and somatostatin), gastric gene expression of these hormones, their receptors, and inducible nitric oxide synthase (iNOS)." | 3.79 | The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression. ( Boyce, M; Campbell, CA; Gillberg, L; Halim, MA; Hellström, PM; Näslund, E; Rudholm-Feldreich, T; Sanger, GJ; Theodorsson, E; Webb, DL, 2013) |
| " dose with respect to standard diclofenac in carrageenan induced rat paw edema model with lessened propensity to cause gastro-intestinal hypermotility and were found to have nil tendencies to generate gastric ulcers." | 3.77 | Aminocarbonyl arylvinylbenzamides as gastric sparing anti-inflammatory agents. ( Agrawal, SS; Khadse, SC; Talele, GS, 2011) |
| " Anti-inflammatory activity screening of some synthesized compounds utilizing in vivo acute carrageenan-induced paw edema standard method in rats exhibited that the prepared heterocycles possess considerable pharmacological properties especially, 4a, 4b, 10a, and 10b which reveal remarkable activities relative to diclofenac sodium (reference standard)." | 3.77 | Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides. ( Barsoum, FF, 2011) |
| " Among the 12 prepared compounds, Compounds 3d, e, i and j exhibited significant anti-inflammatory activity in model of acute inflammation such as carrageenan-induced rat edema paw while compounds 3d and e showed considerable activity in model of chronic inflammation such as adjuvant-induced arthritis and were compared with diclofenac (13." | 3.75 | Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents. ( Aragade, P; Khode, S; Maddi, V; Mamledesai, S; Palkar, M; Ronad, PK; Satyanarayana, D; Thippeswamy, AH, 2009) |
| " The aim of this study was to assess the gastroprotective effects of an aqueous suspension of the ethanolic extract from leaves and flowers of Guazuma ulmifolia in a model of acute gastric ulcer induced by diclofenac as ulcerogenic agent, using the proton pump inhibitor omeprazole as a protection reference." | 3.74 | The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions. ( Berenguer, B; De la Puerta, R; Martín-Calero, MJ; Miño, P; Quílez, A; Sánchez-Fidalgo, S; Trabadela, C, 2007) |
| "The present study was aimed to evaluate the effect of methanolic extract of Terminalia arjuna (TA) on diclofenac sodium induced gastric ulcer in experimental rats." | 3.74 | Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. ( Devi, RS; Narayan, S; Shyamala Devi, CS; Vani, G, 2007) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| "Seven days after induction of gastric ulcer with serosal acetic acid, daily oral treatment with antiinflammatory doses of diclofenac, nitrofenac, or vehicle was started." | 3.69 | A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. ( Cirino, G; Elliott, SN; McKnight, W; Wallace, JL, 1995) |
| " in two antiulcer tests (ethanol induced gastric lesions and diclofenac induced gastric ulcers), were 5-25 times better than those of carbenoxolone." | 3.69 | Synthesis and antiulcer activity of uvaol hemiphthalate derivatives. ( Cristoni, A; Malandrino, S; Nizzola, R; Pifferi, G, 1994) |
| " The diclofenac derivative, 'nitrofenac', was examined in terms of its ability to induce acute gastric erosions and chronic-type gastric ulcers in rats and rabbits, respectively." | 3.69 | A diclofenac derivative without ulcerogenic properties. ( Cicala, C; Cirino, G; Grisham, M; McKnight, W; Reuter, B; Wallace, JL, 1994) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| " When the possibility of poor compliance and the potential adverse effects of misoprostol are considered, rebamipide appears to be a clinically effective and safe alternative." | 2.79 | Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity. ( Cho, CS; Kang, YM; Kim, JH; Kim, SK; Lee, DH; Lee, SK; Lee, ST; Lee, YC; Park, SH; Park, W; Park, YW; Rew, JS; Yoo, WH, 2014) |
| " However, compliance is limited by the different dosing regimens of misoprostol and NSAID and GI symptoms associated with misoprostol at its recommended q." | 2.69 | Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group. ( Ball, JA; Bocanegra, TS; Fort, JG; Geis, GS; Sikes, DH; Tindall, EA; Wallemark, CB; Weaver, AL, 1998) |
| "Diclofenac is a well established nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of a variety of painful inflammatory conditions." | 2.39 | Diclofenac/misoprostol. A review of its pharmacology and therapeutic efficacy in painful inflammatory conditions. ( Davis, R; Goa, KL; Yarker, YE, 1995) |
| "Aceclofenac is a popular analgesic, antipyretic, and nonsteroidal anti-inflammatory drug (NSAID) used for prolonged treatment (at least three months) in musculoskeletal disorders." | 1.48 | Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations. ( Boatto, G; Burrai, L; Chegaev, K; Cristiano, C; De Caro, C; Gazzano, E; Lazzarato, L; Magliocca, S; Marabello, D; Marini, E; Nieddu, M; Riganti, C; Rimoli, MG; Rolando, B; Russo, R; Sodano, F, 2018) |
| " The aim of this work was to compare the pharmacokinetic profiles of diclofenac from DICCIC (7." | 1.38 | Pharmacokinetic profile of a new diclofenac prodrug without gastroulcerogenic effect. ( Baldan-Cimatti, HM; Candido, CD; Davanco, MG; de Campos, ML; Dos Santos, JL; Nogueira, MA; Padilha, EC; Peccinini, RG, 2012) |
| " Preliminary pharmacokinetic studies have shown in vivo bioconversion of prodrug to diclofenac." | 1.38 | Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. ( Barbieri, KP; Bosquesi, PL; Campos, ML; Chelucci, RC; Chin, CM; de Castro Souto, PC; Matsubara, MH; Moreira, V; Peccinini, RG; Santos, JL; Teixeira, C, 2012) |
| "Paroxetine (1-10 mg/kg) was given orally 30 min before indomethacin." | 1.37 | Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats. ( Amagase, K; Gyenge, M; Kojo, A; Nukui, K; Takeuchi, K; Tanaka, A, 2011) |
| " Oral bioavailability of P2026 was estimated from plasma concentration of diclofenac and nitrate/nitrite (NOx)." | 1.36 | Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat. ( Desai, DC; Deshattiwar, JJ; Deshmukh, NJ; Dhiman, M; Gaikwad, PP; Karwa, M; Mali, SV; Nemmani, KV; Pamidiboina, V; Pathan, AR; Satyam, A; Sharma, SD; Thanga Mariappan, T, 2010) |
| ") occurring after the start of rabeprazole treatment were handled as adverse events." | 1.35 | Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan. ( Mizokami, Y, 2009) |
| "Diclofenac sodium (DFNa) was suspended in medium chain triglyceride (MCT) by forming a complex with an edible lipophilic surfactant." | 1.34 | Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. ( Fujii, T; Goto, M; Hirata, A; Ito, S; Kamiya, N; Piao, H; Shimizu, I; Yokoyama, H, 2007) |
| "Misoprostol did not produce any damage to the stomach." | 1.34 | Comparison of antinociceptive efficacy and gastroprotection between celecoxib and diclofenac plus misoprostol in rats. ( Déciga-Campos, M; Granados-Soto, V; Medina-Santillan, R; Reyes-García, G, 2007) |
| " In contrast, the small intestines in old rats of both genders given the 50 mg/kg dosage had >30% fewer ulcers and a fourfold decrease in area of ulceration compared to young rats." | 1.31 | Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy. ( Atchison, CR; Balakumaran, A; Hoffmann, WE; Treinen-Moslen, M; West, AB, 2000) |
| "In the model of adjuvant arthritis VUFB-16066 improves most of disease symptoms including immunopathological disturbances, which indicates possible disease-modifying activity of the drug." | 1.30 | Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. ( Andĕrova, E; Jandera, A; Kuchar, M; Panajotova, V, 1997) |
| "Misoprostol treatment resulted in a significant reduction in the extent of indomethacin-induced antral ulceration, but ranitidine had no effect." | 1.29 | Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer. ( McKnight, GW; Wallace, JL, 1993) |
| "Aceclofenac is a new phenylacetic acid derivative provided with marked antiinflammatory, antiarthritic, analgesic and antipyretic activities in animal experimental models." | 1.28 | The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug. ( Carrasco, E; Felipe, A; Grau, M; Guasch, J; Juliá, S; Montero, JL, 1991) |
| " The degree of gastric or intestinal irritation seen with dosing of other drugs was as follows; indomethacin greater than diclofenac Na greater than ibuprofen greater than aspirin greater than phenylbutazone or indomethacin greater than CH-800 = diclofenac Na greater than ibuprofen greater than phenylbutazone, respectively." | 1.26 | [Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)]. ( Ohtsuki, H; Okabe, S; Tabata, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.73) | 18.7374 |
| 1990's | 28 (25.45) | 18.2507 |
| 2000's | 44 (40.00) | 29.6817 |
| 2010's | 30 (27.27) | 24.3611 |
| 2020's | 5 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Closse, A | 1 |
| Haefliger, W | 1 |
| Hauser, D | 1 |
| Gubler, HU | 1 |
| Dewald, B | 1 |
| Baggiolini, M | 1 |
| Alagarsamy, V | 5 |
| Raja Solomon, V | 1 |
| Dhanabal, K | 2 |
| Khode, S | 1 |
| Maddi, V | 1 |
| Aragade, P | 1 |
| Palkar, M | 1 |
| Ronad, PK | 1 |
| Mamledesai, S | 1 |
| Thippeswamy, AH | 1 |
| Satyanarayana, D | 1 |
| Bansal, S | 1 |
| Bala, M | 1 |
| Suthar, SK | 1 |
| Choudhary, S | 1 |
| Bhattacharya, S | 1 |
| Bhardwaj, V | 1 |
| Singla, S | 1 |
| Joseph, A | 1 |
| Undare, SS | 1 |
| Valekar, NJ | 1 |
| Patravale, AA | 1 |
| Jamale, DK | 1 |
| Vibhute, SS | 1 |
| Walekar, LS | 1 |
| Kolekar, GB | 1 |
| Deshmukh, MB | 1 |
| Anbhule, PV | 1 |
| Yassin, HA | 1 |
| Ibrahim, MA | 1 |
| Abou-Taleb, HA | 1 |
| Khayyal, MT | 1 |
| Wadie, W | 1 |
| Abd El-Haleim, EA | 1 |
| Ahmed, KA | 1 |
| Kelber, O | 1 |
| Ammar, RM | 1 |
| Abdel-Aziz, H | 1 |
| Olivia, NU | 1 |
| Happiness, UC | 1 |
| Obinna, OM | 1 |
| El-Dash, Y | 1 |
| Khalil, NA | 1 |
| Ahmed, EM | 1 |
| Hassan, MSA | 1 |
| Nipa, NS | 1 |
| Ali, T | 1 |
| Akhter, S | 1 |
| Rafiq, K | 1 |
| Zatorski, H | 1 |
| Salaga, M | 1 |
| Zielińska, M | 1 |
| Majchrzak, K | 1 |
| Binienda, A | 1 |
| Kordek, R | 1 |
| Małecka-Panas, E | 1 |
| Fichna, J | 1 |
| Goswami, SK | 1 |
| Rand, AA | 1 |
| Wan, D | 1 |
| Yang, J | 1 |
| Inceoglu, B | 1 |
| Thomas, M | 1 |
| Morisseau, C | 1 |
| Yang, GY | 1 |
| Hammock, BD | 1 |
| Singh, DP | 1 |
| Borse, SP | 1 |
| Rana, R | 1 |
| Nivsarkar, M | 1 |
| Tariq, S | 1 |
| Alam, O | 1 |
| Amir, M | 1 |
| Zapata-Morales, JR | 1 |
| Alonso-Castro, ÁJ | 1 |
| Granados-Soto, V | 2 |
| Sánchez-Enriquez, S | 1 |
| Isiordia-Espinoza, MA | 1 |
| Magliocca, S | 1 |
| De Caro, C | 1 |
| Lazzarato, L | 1 |
| Russo, R | 1 |
| Rolando, B | 1 |
| Chegaev, K | 1 |
| Marini, E | 1 |
| Nieddu, M | 1 |
| Burrai, L | 1 |
| Boatto, G | 1 |
| Cristiano, C | 1 |
| Marabello, D | 1 |
| Gazzano, E | 1 |
| Riganti, C | 1 |
| Sodano, F | 1 |
| Rimoli, MG | 1 |
| Kinsey, SG | 1 |
| Wise, LE | 1 |
| Ramesh, D | 1 |
| Abdullah, R | 1 |
| Selley, DE | 1 |
| Cravatt, BF | 2 |
| Lichtman, AH | 2 |
| de Campos, ML | 1 |
| Baldan-Cimatti, HM | 1 |
| Davanco, MG | 1 |
| Nogueira, MA | 1 |
| Padilha, EC | 1 |
| Candido, CD | 1 |
| Dos Santos, JL | 3 |
| Peccinini, RG | 4 |
| Radulović, NS | 1 |
| Jovanović, I | 1 |
| Ilić, IR | 1 |
| Randjelović, PJ | 1 |
| Stojanović, NM | 1 |
| Miltojević, AB | 1 |
| Kale, MA | 2 |
| Shelke, R | 1 |
| Nawale, RB | 2 |
| John-Africa, LB | 1 |
| Yahaya, TA | 1 |
| Isimi, CY | 1 |
| Kim, JH | 2 |
| Park, SH | 1 |
| Cho, CS | 1 |
| Lee, ST | 1 |
| Yoo, WH | 1 |
| Kim, SK | 1 |
| Kang, YM | 1 |
| Rew, JS | 1 |
| Park, YW | 1 |
| Lee, SK | 1 |
| Lee, YC | 1 |
| Park, W | 1 |
| Lee, DH | 1 |
| Dhokchawle, BV | 1 |
| Bhandari, AB | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Peharkar, MR | 1 |
| Kuberkar, SV | 1 |
| Peter S, J | 1 |
| Basha S, K | 1 |
| Giridharan, R | 1 |
| Lavinya B, U | 1 |
| Sabina, EP | 1 |
| Solomon, VR | 2 |
| Murugesan, S | 1 |
| Reyes-García, G | 1 |
| Déciga-Campos, M | 1 |
| Medina-Santillan, R | 1 |
| Naidu, PS | 1 |
| Booker, L | 1 |
| O'Neill, S | 1 |
| Malik, A | 1 |
| Shankar, D | 2 |
| Sheorey, RV | 1 |
| Parthiban, P | 2 |
| Lazebnik, LB | 1 |
| Drozdov, VN | 1 |
| Kim, VA | 1 |
| Chung, MC | 2 |
| Oliveira, EV | 1 |
| Blau, L | 1 |
| Menegon, RF | 1 |
| Mizokami, Y | 1 |
| Caunedo-Alvarez, A | 1 |
| Gómez-Rodríguez, BJ | 1 |
| Romero-Vázquez, J | 1 |
| Argüelles-Arias, F | 1 |
| Romero-Castro, R | 1 |
| García-Montes, JM | 1 |
| Pellicer-Bautista, FJ | 1 |
| Herrerías-Gutiérrez, JM | 1 |
| Pathan, AR | 1 |
| Karwa, M | 1 |
| Pamidiboina, V | 1 |
| Deshattiwar, JJ | 1 |
| Deshmukh, NJ | 1 |
| Gaikwad, PP | 1 |
| Mali, SV | 1 |
| Desai, DC | 1 |
| Dhiman, M | 1 |
| Thanga Mariappan, T | 1 |
| Sharma, SD | 1 |
| Satyam, A | 1 |
| Nemmani, KV | 1 |
| Yoshimi, E | 1 |
| Kumakura, F | 1 |
| Hatori, C | 1 |
| Hamachi, E | 1 |
| Iwashita, A | 1 |
| Ishii, N | 1 |
| Terasawa, T | 1 |
| Shimizu, Y | 1 |
| Takeshita, N | 1 |
| Chelucci, R | 1 |
| Chiquetto, R | 1 |
| Campos, ML | 2 |
| Barsoum, FF | 1 |
| Bandgar, BP | 1 |
| Sarangdhar, RJ | 1 |
| Ahamed, FA | 1 |
| Viswakarma, S | 1 |
| Khadse, SC | 1 |
| Talele, GS | 1 |
| Agrawal, SS | 1 |
| Takeuchi, K | 1 |
| Tanaka, A | 1 |
| Nukui, K | 1 |
| Kojo, A | 1 |
| Gyenge, M | 1 |
| Amagase, K | 1 |
| Rajasekaran, A | 1 |
| Rajamanickam, V | 1 |
| Darlinquine, S | 1 |
| Ohyama, K | 1 |
| Shiokawa, A | 1 |
| Ito, K | 1 |
| Masuyama, R | 1 |
| Ichibangase, T | 1 |
| Kishikawa, N | 1 |
| Imai, K | 1 |
| Kuroda, N | 1 |
| Webb, DL | 1 |
| Rudholm-Feldreich, T | 1 |
| Gillberg, L | 1 |
| Halim, MA | 1 |
| Theodorsson, E | 1 |
| Sanger, GJ | 1 |
| Campbell, CA | 1 |
| Boyce, M | 1 |
| Näslund, E | 1 |
| Hellström, PM | 1 |
| Santos, JL | 1 |
| Moreira, V | 1 |
| Chelucci, RC | 1 |
| Barbieri, KP | 1 |
| de Castro Souto, PC | 1 |
| Matsubara, MH | 1 |
| Teixeira, C | 1 |
| Bosquesi, PL | 1 |
| Chin, CM | 1 |
| Bonina, F | 1 |
| Puglia, C | 1 |
| Santagati, NA | 1 |
| Saija, A | 1 |
| Tomaino, A | 1 |
| Tita, B | 1 |
| Sánchez, S | 1 |
| Martín, MJ | 2 |
| Ortiz, P | 1 |
| Motilva, V | 1 |
| Herrerías, JM | 1 |
| Alarcón de la Lastra, C | 1 |
| Sikes, DH | 2 |
| Agrawal, NM | 1 |
| Zhao, WW | 1 |
| Kent, JD | 1 |
| Recker, DP | 1 |
| Verburg, KM | 1 |
| Andersson, T | 1 |
| Frösing, R | 1 |
| Chan, FK | 1 |
| Hung, LC | 1 |
| Suen, BY | 1 |
| Wu, JC | 1 |
| Lee, KC | 1 |
| Leung, VK | 1 |
| Hui, AJ | 1 |
| To, KF | 1 |
| Leung, WK | 1 |
| Wong, VW | 1 |
| Chung, SC | 1 |
| Sung, JJ | 1 |
| Shostak, NA | 1 |
| Riabkova, AA | 1 |
| Savel'ev, VS | 1 |
| Maliarova, LP | 1 |
| Santos, LH | 1 |
| Feres, CA | 1 |
| Melo, FH | 1 |
| Coelho, MM | 1 |
| Nothenberg, MS | 1 |
| Oga, S | 1 |
| Tagliati, CA | 1 |
| Summerton, N | 1 |
| Khan, MS | 1 |
| Akhter, M | 1 |
| Doggrell, SA | 1 |
| Rhee, HI | 1 |
| Jung, IH | 1 |
| Ryu, K | 1 |
| Jung, K | 1 |
| Han, CK | 1 |
| Kwak, WJ | 1 |
| Cho, YB | 1 |
| Joo, HJ | 1 |
| Berenguer, B | 2 |
| Sánchez, LM | 1 |
| Quílez, A | 2 |
| López-Barreiro, M | 1 |
| de Haro, O | 1 |
| Gálvez, J | 1 |
| Chi, YM | 1 |
| Nakamura, M | 1 |
| Zhao, XY | 1 |
| Yoshizawa, T | 1 |
| Yan, WM | 1 |
| Hashimoto, F | 1 |
| Kinjo, J | 1 |
| Nohara, T | 1 |
| Sakurada, S | 1 |
| Piao, H | 2 |
| Kamiya, N | 2 |
| Watanabe, J | 1 |
| Yokoyama, H | 2 |
| Hirata, A | 2 |
| Fujii, T | 2 |
| Shimizu, I | 3 |
| Ito, S | 3 |
| Goto, M | 2 |
| Ribeiro, AQ | 1 |
| Sevalho, G | 1 |
| César, CC | 1 |
| Murugan, M | 1 |
| Siddiqui, AA | 1 |
| Rajesh, R | 1 |
| Gambero, A | 1 |
| Maróstica, M | 1 |
| Becker, TL | 1 |
| Pedrazzoli, J | 1 |
| Jansson, EA | 1 |
| Petersson, J | 1 |
| Reinders, C | 1 |
| Sobko, T | 1 |
| Björne, H | 1 |
| Phillipson, M | 1 |
| Weitzberg, E | 1 |
| Holm, L | 1 |
| Lundberg, JO | 1 |
| Devi, RS | 2 |
| Narayan, S | 2 |
| Vani, G | 2 |
| Shyamala Devi, CS | 1 |
| Mythilypriya, R | 1 |
| Shanthi, P | 1 |
| Sachdanandam, P | 1 |
| Srinivasan, P | 1 |
| Mohan, KV | 1 |
| Sabitha, KE | 1 |
| Devi, CS | 1 |
| Anjana, G | 1 |
| Deepa, G | 1 |
| Murugesan, B | 1 |
| Rajkumar, S | 1 |
| Beevi, AJ | 1 |
| Hawkey, CJ | 1 |
| Weinstein, WM | 1 |
| Smalley, W | 1 |
| Gitton, X | 1 |
| Sallstig, P | 1 |
| Stricker, K | 1 |
| Krammer, G | 1 |
| Mellein, B | 1 |
| Richard, D | 1 |
| Matchaba, P | 1 |
| Yanaka, A | 1 |
| Zhang, S | 1 |
| Sato, D | 1 |
| Tauchi, M | 1 |
| Suzuki, H | 1 |
| Shibahara, T | 1 |
| Matsui, H | 1 |
| Nakahara, A | 1 |
| Hyodo, I | 1 |
| Trabadela, C | 1 |
| Sánchez-Fidalgo, S | 1 |
| Miño, P | 1 |
| De la Puerta, R | 1 |
| Martín-Calero, MJ | 1 |
| Bhandari, SV | 1 |
| Bothara, KG | 1 |
| Raut, MK | 1 |
| Patil, AA | 1 |
| Sarkate, AP | 1 |
| Mokale, VJ | 1 |
| Abuznaid, M | 1 |
| Sallam, AS | 1 |
| Hamdan, I | 1 |
| Al-Hussaini, M | 1 |
| Bani-Jaber, A | 1 |
| Zimmerman, J | 1 |
| Siguencia, J | 1 |
| Tsvang, E | 1 |
| Valentini, M | 1 |
| Cannizzaro, R | 1 |
| Poletti, M | 1 |
| Bortolussi, R | 1 |
| Fracasso, A | 1 |
| Testa, V | 1 |
| Sozzi, M | 1 |
| Fornasarig, M | 1 |
| Bortoluzzi, F | 1 |
| Grazioli, I | 1 |
| Elliott, SN | 1 |
| McKnight, W | 2 |
| Cirino, G | 2 |
| Wallace, JL | 3 |
| McKenna, F | 2 |
| Açikgöz, M | 1 |
| Kaş, HS | 1 |
| Hasçelik, Z | 1 |
| Milli, U | 1 |
| Hincal, AA | 1 |
| Abou-Mohamed, G | 1 |
| el-Kashef, HA | 1 |
| Salem, HA | 1 |
| Elmazar, MM | 1 |
| Müller, P | 1 |
| Jackisch, P | 1 |
| Simon, B | 1 |
| Conforti, A | 1 |
| Donini, M | 1 |
| Brocco, G | 1 |
| Del Soldato, P | 1 |
| Benoni, G | 1 |
| Cuzzolin, L | 1 |
| Cristoni, A | 1 |
| Nizzola, R | 1 |
| Malandrino, S | 1 |
| Pifferi, G | 1 |
| Reuter, B | 1 |
| Cicala, C | 1 |
| Grisham, M | 1 |
| McKnight, GW | 1 |
| Bianchi Porro, G | 2 |
| Montrone, F | 2 |
| Petrillo, M | 2 |
| Caruso, I | 1 |
| Ardizzone, S | 2 |
| Futaki, N | 1 |
| Yoshikawa, K | 1 |
| Hamasaka, Y | 1 |
| Arai, I | 1 |
| Higuchi, S | 1 |
| Iizuka, H | 1 |
| Otomo, S | 1 |
| Davis, R | 1 |
| Yarker, YE | 1 |
| Goa, KL | 1 |
| Arañó, A | 1 |
| Zapatero, MI | 1 |
| Basi, N | 1 |
| Duque, A | 1 |
| Gropper, S | 1 |
| Miglioli, M | 1 |
| Vaira, D | 1 |
| Menegatti, M | 1 |
| Brunetti, G | 1 |
| Frizziero, L | 1 |
| Grandinetti, G | 1 |
| Panajotova, V | 1 |
| Andĕrova, E | 1 |
| Jandera, A | 1 |
| Kuchar, M | 1 |
| Newman, L | 1 |
| Kido, H | 1 |
| Murakami, N | 1 |
| Ito, A | 1 |
| Kimura, K | 1 |
| Kodera, N | 1 |
| Doi, T | 1 |
| Naruse, T | 1 |
| Schmassmann, A | 1 |
| Peskar, BM | 1 |
| Stettler, C | 1 |
| Netzer, P | 1 |
| Stroff, T | 1 |
| Flogerzi, B | 1 |
| Halter, F | 1 |
| Bocanegra, TS | 1 |
| Weaver, AL | 1 |
| Tindall, EA | 1 |
| Ball, JA | 1 |
| Wallemark, CB | 1 |
| Geis, GS | 2 |
| Fort, JG | 1 |
| Guslandi, M | 1 |
| Foppa, L | 1 |
| Fanti, L | 1 |
| Sorghi, M | 1 |
| Godessart, N | 1 |
| Salcedo, C | 1 |
| Fernández, AG | 1 |
| Palacios, JM | 1 |
| Medina Santillán, R | 1 |
| Reyes García, G | 1 |
| Mateos García, E | 1 |
| Atchison, CR | 1 |
| Balakumaran, A | 1 |
| West, AB | 1 |
| Hoffmann, WE | 1 |
| Treinen-Moslen, M | 1 |
| Dorta, G | 1 |
| Nicolet, M | 1 |
| Vouillamoz, D | 1 |
| Margalith, D | 1 |
| Saraga, E | 1 |
| Bouzourene, H | 1 |
| Häcki, WH | 1 |
| Stolte, M | 1 |
| Blum, AL | 1 |
| Armstrong, D | 1 |
| Horie, T | 1 |
| Inoue, H | 1 |
| Oshima, T | 1 |
| Fujimoto, M | 1 |
| Ozaki, Y | 1 |
| Yamamoto, K | 1 |
| Iuchi, A | 1 |
| Mosaddik, MA | 1 |
| Alam, KM | 1 |
| Paul, RK | 1 |
| Jabbar, A | 1 |
| Rashid, MA | 1 |
| Chandrasekar, MJ | 1 |
| Ravichandran, M | 1 |
| Nanjan, MJ | 1 |
| Suresh, B | 1 |
| Tabata, K | 1 |
| Ohtsuki, H | 1 |
| Okabe, S | 1 |
| Rainsford, KD | 1 |
| Whitehouse, MW | 1 |
| Verdickt, W | 1 |
| Moran, C | 1 |
| Hantzschel, H | 1 |
| Fraga, AM | 1 |
| Stead, H | 1 |
| Grau, M | 2 |
| Guasch, J | 2 |
| Montero, JL | 2 |
| Felipe, A | 2 |
| Carrasco, E | 2 |
| Juliá, S | 2 |
3 reviews available for diclofenac and Stomach Ulcer
| Article | Year |
|---|---|
The safety of lumiracoxib when used in the treatment of arthritis.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; Humans; Org | 2005 |
Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diclofenac; Drug Combin | 1995 |
Diclofenac/misoprostol. A review of its pharmacology and therapeutic efficacy in painful inflammatory conditions.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; Cost-Ben | 1995 |
15 trials available for diclofenac and Stomach Ulcer
| Article | Year |
|---|---|
Preventive efficacy and safety of rebamipide in nonsteroidal anti-inflammatory drug-induced mucosal toxicity.
Topics: Adult; Aged; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Butanon | 2014 |
[Efficiency of famotidin in prophylaxis of NSAIDs-induced gastropathy: result of multicenter research ZASLON-1 (protection of gastric mucosa from non-steroidal anti-inflammatory drugs].
Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Dic | 2009 |
Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclo | 2002 |
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Celecoxib; Cyclooxygenase 2; | 2002 |
Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study.
Topics: Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Diclof | 2007 |
Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Biopsy; Diclofenac; Di | 2007 |
Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antineop | 1995 |
[Comparison of the protective effects of roxatidine and misoprostol on diclofenac gastroduodenal pathology. An endoscopic, controlled study of volunteers].
Topics: Adult; Anti-Ulcer Agents; Delayed-Action Preparations; Diclofenac; Gastric Acid; Gastroscopy; Histam | 1994 |
Sulglycotide in the prevention of nonsteroidal anti-inflammatory drug-induced gastroduodenal mucosal injury. A controlled double-blind, double-dummy, randomized endoscopic study versus placebo in rheumatic patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheu | 1993 |
Prevention with sucralfate gel of NSAID-induced gastroduodenal damage in arthritic patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Doubl | 1996 |
Diclofenac/misoprostol: the European clinical experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Diclofenac; Doubl | 1998 |
Diclofenac/misoprostol compared with diclofenac in the treatment of osteoarthritis of the knee or hip: a randomized, placebo controlled trial. Arthrotec Osteoarthritis Study Group.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Drug Therapy, | 1998 |
Prevention of gastroduodenal injury induced by NSAIDs with low-dose misoprostol.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Double-Blind Method; | 1999 |
The effects of omeprazole on healing and appearance of small gastric and duodenal lesions during dosing with diclofenac in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cross-Over Studies; Diclofenac; D | 2000 |
A double-blind comparison of the gastroduodenal safety and efficacy of diclofenac and a fixed dose combination of diclofenac and misoprostol in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Diclofenac; Digestive System; Double-Blind Me | 1992 |
92 other studies available for diclofenac and Stomach Ulcer
| Article | Year |
|---|---|
2,3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzofurans; Cattle; Chemical Phenomena; | 1981 |
Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Rela | 2007 |
Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Female; Male; Mic | 2009 |
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Synthetic; Cyclo | 2014 |
Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Carrageenan; Catalytic Domain; | 2016 |
Aceclofenac-Loaded Microspheres Prepared by Vesicular Ionotropic Gelation to Minimize Drug-induced Gastric Ulcers in Rats.
Topics: Alginates; Animals; Capsules; Diclofenac; Male; Microspheres; Polymers; Rats; Rats, Wistar; Stomach | 2022 |
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Duodenal Ulcer | 2019 |
Protective effect of Cnidoscolus aconitifolius leaves against diclofenac-induced gastric mucosal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Euph | 2020 |
Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Binding Sites; Catalytic Domain; Cyclooxygenas | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldeh | 2020 |
AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice.
Topics: Administration, Oral; Animals; Catalase; Diclofenac; Disease Models, Animal; Ethanol; Male; Mice; Om | 2021 |
Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Diclofenac; Dose-Res | 2017 |
Curcumin, a component of turmeric, efficiently prevents diclofenac sodium-induced gastroenteropathic damage in rats: A step towards translational medicine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Curcumin; Diclofenac; Gastrointestinal He | 2017 |
Synthesis, anti-inflammatory, p38α MAP kinase inhibitory activities and molecular docking studies of quinoxaline derivatives containing triazole moiety.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Enzyme Assays; Female; Lipid Peroxidat | 2018 |
Assessment of the antinociceptive and ulcerogenic activity of the tapentadol-diclofenac combination in rodents.
Topics: Acetic Acid; Analgesics; Animals; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Male | 2018 |
Aceclofenac-Galactose Conjugate: Design, Synthesis, Characterization, and Pharmacological and Toxicological Evaluations.
Topics: Acute Pain; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avail | 2018 |
Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arachidonic Acids; | 2013 |
Pharmacokinetic profile of a new diclofenac prodrug without gastroulcerogenic effect.
Topics: Animals; Diclofenac; Indoles; Male; Prodrugs; Rats; Rats, Wistar; Stomach Ulcer | 2012 |
Methyl and isopropyl N-methylanthranilates attenuate diclofenac- and ethanol-induced gastric lesions in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Re | 2013 |
Zinc-aceclofenac complex: synthesis, hydrolysis study and antiinflammatory studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemistry, Pharmaceutical; Computer S | 2014 |
Anti-ulcer and wound healing activities of Sida corymbosa in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Diclofenac; Dose-Response Relationship, Drug; | 2014 |
Synthesis, hydrolysis kinetics and pharmacological evaluation of aceclofenac prodrugs.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2015 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Synthesis and Pharmacological Evaluation of Tetrazolobenzimidazoles as Novel Anti-inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Carrageenan; Diclofenac; Disease Models, Animal; | 2016 |
Suppressive effect of Spirulina fusiformis on diclofenac-induced hepato-renal injury and gastrointestinal ulcer in Wistar albino rats: A biochemical and histological approach.
Topics: Animals; Antioxidants; Biomarkers; Blood Proteins; Diclofenac; Female; Glycogen; Intestinal Mucosa; | 2017 |
Synthesis and pharmacological evaluation of some 3-(2-methylphenyl)-2-substituted amino-quinazolin-4(3H)-ones as analgesic and antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Female; Indicators | 2008 |
Comparison of antinociceptive efficacy and gastroprotection between celecoxib and diclofenac plus misoprostol in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Celecoxib; Cyclooxygenase 2 Inh | 2007 |
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac | 2009 |
Patchy small bowel ischaemia secondary to sepsis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disseminated Intravascular Coagulation; Gastrec | 2009 |
Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Disease Models, Animal; Edema; F | 2009 |
Synthesis, ex vivo and in vitro hydrolysis study of an indoline derivative designed as an anti-inflammatory with reduced gastric ulceration properties.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Diclofenac; Drug Design; Hydrolysis; Indo | 2009 |
Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclo | 2009 |
Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Cyclooxygenase 2 Inhibitors | 2010 |
Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bio | 2010 |
Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflamm | 2010 |
Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Movement; Cyclooxygenase 2 Inhibitors; Diclofena | 2010 |
Synthesis and molecular modeling studies of anti-inflammatory active 1H-pyrrolizine-5-carboxamides.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Disease Models, Animal; Edema; Female; H | 2011 |
Synthesis, characterization, and biological evaluation of novel diclofenac prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Carrageenan; Crystallography, X | 2011 |
Aminocarbonyl arylvinylbenzamides as gastric sparing anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Carrageenan; Diclofenac; Dose-Response | 2011 |
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antidepressive Agents, Tricycli | 2011 |
Synthesis, anti-inflammatory and analgesic evaluation of thioxoquinazolinone derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Lethal Dose 50; Pentazocine; Quinazolinon | 2011 |
Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Cyclooxygenase Inhibitors; | 2012 |
The type 2 CCK/gastrin receptor antagonist YF476 acutely prevents NSAID-induced gastric ulceration while increasing iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzodiazepinones; Diclofenac; | 2013 |
Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 2; Diclofenac; Dinopro | 2012 |
Oligoethylene ester derivatives of ketoprofen, naproxen and diclofenac as oral prodrugs: a pharmacological evaluation.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Ester | 2002 |
Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Diclofenac; Dipyrone; Dose-Response Re | 2002 |
[Pharmacia and Pfizer on the CLASS trial: criticism doesn't give a fair picture of the results].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Controlled Cli | 2002 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno | 2003 |
Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Drug Combinations; Drug Eval | 2004 |
Evidence in practice--number 3: Cox 2 inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Evidence-Based Medic | 2004 |
Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chromatography, High Pressu | 2004 |
SKI306X, an oriental herbal mixture, suppresses gastric leukotriene B4 synthesis without causing mucosal injury and the diclofenac-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenas | 2005 |
Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Diclofenac; Femal | 2006 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Oral delivery of diclofenac sodium using a novel solid-in-oil suspension.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Diclofenac | 2006 |
The use of nonsteroidal anti-inflammatory drugs and the occurrence of gastric lesions among patients undergoing upper endoscopy in a university hospital in Brazil.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Confounding Factors, Epidemiologic; Diclof | 2006 |
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.
Topics: Animals; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytoprotection; D | 2007 |
Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Diclofenac; Diet; DNA Primers; Gast | 2007 |
Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Diclofenac; DNA; Gast | 2007 |
Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation--Kalpaamruthaa.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Arthritis, Rheumatoid; Diclofenac; Dinoprostone; Fema | 2007 |
Ulcer protective effect of Terminalia arjuna on gastric mucosal defensive mechanism in experimental rats.
Topics: Animals; Dexamethasone; Diclofenac; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Gastr | 2007 |
Synthesis and pharmacological investigation of novel 3-(3-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Diclofenac; Disease Models, Ani | 2007 |
Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Oils; Rats; Rats | 2007 |
The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Dinoprostone; Femal | 2007 |
Design, synthesis and evaluation of antiinflammatory, analgesic and ulcerogenicity studies of novel S-substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of diclofenac acid as nonulcerogenic derivatives.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Design; | 2008 |
Diclofenac-bismuth complex: synthesis, physicochemical, and biological evaluation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chemical Precipitation; Diclofenac; Electro | 2008 |
Upper gastrointestinal hemorrhage associated with cutaneous application of diclofenac gel.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cyclooxygenase Inhibitors; Diclofenac | 1995 |
Chitosan microspheres of diclofenac sodium, II: In vitro and in vivo evaluation.
Topics: Animals; Chitin; Chitosan; Delayed-Action Preparations; Diclofenac; Microspheres; Particle Size; Rab | 1995 |
Effect of zinc on the anti-inflammatory and ulcerogenic activities of indometacin and diclofenac.
Topics: Analysis of Variance; Animals; Diclofenac; Drug Interactions; Indomethacin; Male; Rats; Stomach Ulce | 1995 |
Acute anti-inflammatory activity and gastrointestinal tolerability of diclofenac and nitrofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Female; Gastrointe | 1993 |
Synthesis and antiulcer activity of uvaol hemiphthalate derivatives.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Diclofenac; Diuresis; Ethanol; Female; Magnetic Resonance | 1994 |
A diclofenac derivative without ulcerogenic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Diclofenac; Gastric Mucosa; Inflam | 1994 |
Characterization of a simple animal model for nonsteroidal anti-inflammatory drug induced antral ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Dose-Response | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Comparison of the anti-inflammatory effect and gastrointestinal tolerability of aceclofenac and diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Edema; Male; Rats; Rats, | 1996 |
Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid.
Topics: Abdominal Pain; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Art | 1997 |
Upper gastrointestinal bleeding following major maxillofacial surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carcinoma, Squamous Cell; Chemopre | 1997 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Nonsteroidal anti-inflammatory drugs and gastric mucosal blood flow.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Blood Flow Velocity; Diclo | 1999 |
Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 1999 |
Aging enhances susceptibility of diclofenac-treated rats to gastric ulceration, while attenuating enteropathy.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Diclofenac; Female; | 2000 |
Penetration by a giant gastric ulcer induced by a nonsteroidal anti-inflammatory drug.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Follow-Up Studies; Gastroscopy; Humans; Long-Te | 2000 |
The anti-ulcerogenic effect of an alkaloidal fraction from Mikania cordata on diclofenac sodium-induced gastrointestinal lesions in rats.
Topics: Alkaloids; Animals; Anti-Ulcer Agents; Diclofenac; Gastric Acidity Determination; Gastric Mucosa; In | 2000 |
Antiulcer activity of Mikania cordata.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Diclofenac; Disease Models, Animal; Male; Plant Extracts; Pl | 2000 |
Synthesis and evaluation of a nonsteroidal anti-inflammatory polymeric prodrug for sustained and site-specific delivery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Delayed-Action Preparatio | 2001 |
[Irritative activity of a new anti-inflammatory agent 4-(p-chorophenyl)-2-phenyl-5-thiazoleacetic acid (CH-800) on the gastrointestinal tract in rats (author's transl)].
Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Diclofenac; Digestive Sy | 1979 |
Non-steroid anti-inflammatory drugs: combined assay for anti-edemic potency and gastric ulcerogenesis in the same animal.
Topics: Acacia; Adjuvants, Pharmaceutic; Animals; Aspartic Acid; Aspirin; Carrageenan; Diclofenac; Drug Eval | 1977 |
Pharmacology of the potent new non-steroidal anti-inflammatory agent aceclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoquinones; Capillary | 1991 |
The pharmacological profile of aceclofenac, a new nonsteroidal antiinflammatory and analgesic drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dogs; Female; Indomethacin; Male; Mice | 1991 |