diclofenac has been researched along with Stevens-Johnson Syndrome in 12 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 75-year-old woman took aceclofenac (100 mg/day) for 15 days for long-standing arthritis." | 7.72 | [Exudative erythema multiforme with transition to a toxic epidermal necrolysis after taking aceclofenac (Beofenac)]. ( Brinkmeier, T; Frosch, PJ; Ludwig, C, 2003) |
| " As for SCARs, associations of HLA-B*15:02 or HLA-A*31:01 and HLA-B*58:01 have been revealed for carbamazepine- and allopurinol-related Stevens-Johnson syndrome and toxic epidermal neclolysis, respectively." | 4.89 | Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury. ( Kaniwa, N; Saito, Y, 2013) |
| " We report a case of fatal Lyell's syndrome after oral re-administration of diclofenac in a patient with a previous history of diclofenac-related Stevens-Johnson syndrome, four years back." | 3.88 | [Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)]. ( Bi, GI; Kamagate, M; Koffi, N; Kouadio, S; Nda-Koffi, C; Ogondon, B; Pete, Y; Yapo, B, 2018) |
| "A 75-year-old woman took aceclofenac (100 mg/day) for 15 days for long-standing arthritis." | 3.72 | [Exudative erythema multiforme with transition to a toxic epidermal necrolysis after taking aceclofenac (Beofenac)]. ( Brinkmeier, T; Frosch, PJ; Ludwig, C, 2003) |
| "Five patients with severe drug-induced toxic epidermal necrolysis improved rapidly after one to two plasma exchanges." | 1.27 | Plasmapheresis in severe drug-induced toxic epidermal necrolysis. ( Czarnetzki, BM; Kamanabroo, D; Schmitz-Landgraf, W, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bi, GI | 1 |
| Pete, Y | 1 |
| Kamagate, M | 1 |
| Koffi, N | 1 |
| Nda-Koffi, C | 1 |
| Ogondon, B | 1 |
| Kouadio, S | 1 |
| Yapo, B | 1 |
| Kaniwa, N | 1 |
| Saito, Y | 1 |
| Patell, RD | 1 |
| Dosi, RV | 1 |
| Shah, PC | 1 |
| Joshi, HS | 1 |
| Haddad, C | 1 |
| Chosidow, O | 1 |
| Valeyrie-Allanore, L | 1 |
| Ghaleh, B | 1 |
| Legrand, T | 1 |
| Mockenhaupt, M | 1 |
| Barau, C | 1 |
| Khoudour, N | 1 |
| Sekula, P | 1 |
| Wolkenstein, P | 1 |
| Hulin, A | 1 |
| Shetty, SR | 1 |
| Chatra, L | 1 |
| Shenai, P | 1 |
| Rao, PK | 1 |
| Hengge, UR | 1 |
| Jochum, C | 1 |
| Tschakarjan, E | 1 |
| Maschke, J | 1 |
| Erbel, R | 1 |
| Schmid, KW | 1 |
| Otterbach, F | 1 |
| Ludwig, C | 1 |
| Brinkmeier, T | 1 |
| Frosch, PJ | 1 |
| Spornraft-Ragaller, P | 1 |
| Ragaller, M | 1 |
| Meurer, M | 1 |
| Hunger, RE | 1 |
| Hunziker, T | 1 |
| Buettiker, U | 1 |
| Braathen, LR | 1 |
| Yawalkar, N | 1 |
| de Luis, DA | 1 |
| Fortun, J | 1 |
| Pintado, V | 1 |
| Aller de la Fuente, R | 1 |
| Alonso, R | 1 |
| Enrique, E | 1 |
| Cisteró, A | 1 |
| Kamanabroo, D | 1 |
| Schmitz-Landgraf, W | 1 |
| Czarnetzki, BM | 1 |
1 review available for diclofenac and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury.
Topics: Alleles; Allopurinol; Amoxicillin-Potassium Clavulanate Combination; Azetidines; Benzylamines; Carba | 2013 |
11 other studies available for diclofenac and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)].
Topics: Administration, Oral; Cote d'Ivoire; Diclofenac; Fatal Outcome; Female; Hospitals, Teaching; Humans; | 2018 |
Widespread bullous fixed drug eruption.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blister; Diagnosis, Differential; Diclofenac; Drug Eruption | 2014 |
Are Idiopathic Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Related to Drugs in Food? The Example of Phenylbutazone.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Ch | 2017 |
Stevens-Johnson syndrome: a case report.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctival Diseases; Dental Caries; Diclofenac; Female; F | 2010 |
[Purpura fulminans. A fatal consequence of a widely used medication?].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disseminated Intravascular Coagulation; | 2002 |
[Exudative erythema multiforme with transition to a toxic epidermal necrolysis after taking aceclofenac (Beofenac)].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diclofenac; Erythema Multiforme; Female; H | 2003 |
[Toxic epidermal necrolysis induced by NSAID].
Topics: Aged; Back Pain; Biopsy; Diagnosis, Differential; Diclofenac; Female; Humans; Skin; Stevens-Johnson | 2003 |
Rapid resolution of toxic epidermal necrolysis with anti-TNF-alpha treatment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Diclofenac; Female; Humans; I | 2005 |
[HIV infection and Lyell syndrome: a wake-up call concerning anti-inflammatory agents].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory | 1997 |
Positive patch test to diclofenac in Stevens-Johnson syndrome.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Hypersensitivity; Humans; Male; Patc | 2000 |
Plasmapheresis in severe drug-induced toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Diclofenac; Female; Humans; Male; Plasmapheresis; Pyrazoles; Pyrazolones; S | 1985 |