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diclofenac and Sprains

diclofenac has been researched along with Sprains in 21 studies

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Research Excerpts

ExcerptRelevanceReference
"According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol."9.15Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011)
"It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries."9.12The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007)
"A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated."9.12Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). ( Bulitta, M; D'Anchise, R; Giannetti, B, 2007)
"Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs)."6.46Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury. ( Argoff, CE; McCarberg, BH, 2010)
"Diclofenac 4% spray gel rapidly relieves pain and improves mobility in patients with acute, uncomplicated ankle sprain and is well tolerated."5.17A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain. ( Giannetti, B; Menke, G; Novellini, R; Predel, HG; Seigfried, B, 2013)
"According to these results, diclofenac and paracetamol had the same effect on pain reduction of ankle sprains but more acute ankle edema was present in patients who were treated with diclofenac than in patients who were treated with paracetamol."5.15Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. ( Lyrtzis, C; Natsis, K; Noussios, G; Papadopoulos, C; Papathanasiou, E, 2011)
" The efficacy and tolerability of a novel plaster containing both diclofenac epolamine (DHEP) and heparin in the treatment of acute painful ankle sprains with oedema was investigated in a randomized, double-blind, placebo-controlled study."5.14Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study. ( Coudreuse, JM; de Vathaire, F, 2010)
"Celecoxib, a COX-2 selective inhibitor, is as effective as diclofenac SR in treating ankle sprains."5.12Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population. ( Abrahan, L; Fakir-Bolte, C; Hwang, LJ; Lau, FL; Nadarajah, A, 2006)
"It was concluded that diclofenac sodium and paracetamol are effective and well tolerated as a short term treatment alternatives for acute ankle injuries."5.12The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium. ( Agus, H; Kayali, C; Surer, L; Turgut, A, 2007)
"A previously published study comparing the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains is critically re-evaluated."5.12Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). ( Bulitta, M; D'Anchise, R; Giannetti, B, 2007)
" Local adverse events were minimum for both groups."2.67Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries. ( Butrón, F; Galicia, A; Martinez-Zurita, F; Zamora, G, 1994)
"Many types of acute pain have been managed with traditional oral non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase-2 inhibitors (coxibs)."2.46Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury. ( Argoff, CE; McCarberg, BH, 2010)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's3 (14.29)18.2507
2000's6 (28.57)29.6817
2010's10 (47.62)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Predel, HG3
Giannetti, B4
Seigfried, B1
Novellini, R1
Menke, G1
Yanchick, J1
Magelli, M1
Bodie, J1
Sjogren, J1
Rovati, S2
McCarberg, BH1
Argoff, CE1
Klainguti, A1
Forgacs, A1
Berkes, I1
Castellacci, E1
Coudreuse, JM1
de Vathaire, F1
Costantino, C1
Kwarecki, J1
Samokhin, AV1
Mautone, G2
Center, DM1
Migliorino, R1
Lyrtzis, C1
Natsis, K1
Papadopoulos, C1
Noussios, G1
Papathanasiou, E1
Hamelsky, S1
Gold, M1
Mahler, P1
Mahler, F1
Duruz, H1
Ramazzina, M1
Liguori, V1
Solignac, M1
Koll, R1
Bulitta, M2
Staiger, C1
Nadarajah, A1
Abrahan, L1
Lau, FL1
Hwang, LJ1
Fakir-Bolte, C1
Kayali, C1
Agus, H1
Surer, L1
Turgut, A1
D'Anchise, R1
Böhmer, D1
Ambrus, P1
Butrón, F1
Galicia, A1
Zamora, G1
Martinez-Zurita, F1
Morán, M1
Diebschlag, W1
Machtey, I1

Reviews

2 reviews available for diclofenac and Sprains

ArticleYear
Topical diclofenac epolamine patch 1.3% for treatment of acute pain caused by soft tissue injury.
    International journal of clinical practice, 2010, Volume: 64, Issue:11

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Contusions; Diclofenac; Humans; Pain; Soft Tiss

2010
[Assessment of a topical NSAIDs in the treatment of pain and inflammation. The example of Flector Plaster, a local bioadhesive plaster containing diclofenac epolamine].
    Presse medicale (Paris, France : 1983), 2004, Aug-28, Volume: 33, Issue:14 Pt 2

    Topics: Administration, Topical; Animals; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Athletic

2004

Trials

15 trials available for diclofenac and Sprains

ArticleYear
A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain.
    The Journal of international medical research, 2013, Volume: 41, Issue:4

    Topics: Acute Disease; Administration, Topical; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroid

2013
A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma: a double-blind randomized study.
    Current medical research and opinion, 2010, Volume: 26, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants;

2010
Effect of a plaster containing DHEP and heparin in acute ankle sprains with oedema: a randomized, double-blind, placebo-controlled, clinical study.
    Current medical research and opinion, 2010, Volume: 26, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Ster

2010
Diclofenac epolamine plus heparin plaster versus diclofenac epolamine plaster in mild to moderate ankle sprain: a randomized, double-blind, parallel-group, placebo-controlled, multicentre, phase III trial.
    Clinical drug investigation, 2011, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Di

2011
Efficacy of paracetamol versus diclofenac for Grade II ankle sprains.
    Foot & ankle international, 2011, Volume: 32, Issue:6

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents

2011
Efficacy and safety of diclofenac diethylamine 2.32% gel in acute ankle sprain.
    Medicine and science in sports and exercise, 2012, Volume: 44, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Ankle Injuries; Diclofenac; Dou

2012
Double-blind, randomized, controlled study on the efficacy and safety of a novel diclofenac epolamine gel formulated with lecithin for the treatment of sprains, strains and contusions.
    Drugs under experimental and clinical research, 2003, Volume: 29, Issue:1

    Topics: Acetaminophen; Administration, Topical; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Ankle Inj

2003
Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2005, Volume: 12, Issue:10

    Topics: Adolescent; Adult; Ankle Injuries; Area Under Curve; Comfrey; Diclofenac; Female; Gels; Humans; Male

2005
Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population.
    Singapore medical journal, 2006, Volume: 47, Issue:6

    Topics: Acute Disease; Adult; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Asia; Blood Platelets

2006
The efficacy of paracetamol in the treatment of ankle sprains in comparison with diclofenac sodium.
    Saudi medical journal, 2007, Volume: 28, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroi

2007
Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions).
    Arzneimittel-Forschung, 2007, Volume: 57, Issue:11

    Topics: Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under C

2007
[Treatment of muscular injuries with diclofenac-diethylammonium emulsion gel].
    Sportverletzung Sportschaden : Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin, 1995, Volume: 9, Issue:3

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Contusio

1995
Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries.
    Proceedings of the Western Pharmacology Society, 1994, Volume: 37

    Topics: Adult; Contusions; Diclofenac; Edema; Female; Gels; Humans; Male; Middle Aged; Naproxen; Pain Measur

1994
An observer-blind comparison of diclofenac potassium, piroxicam and placebo in the treatment of ankle sprains.
    Current medical research and opinion, 1990, Volume: 12, Issue:4

    Topics: Adult; Ankle Injuries; Diclofenac; Female; Humans; Male; Middle Aged; Pain; Piroxicam; Single-Blind

1990
[Diclofenac in blunt traumatic ankle joint swelling. Volumetric monitoring in a placebo controlled double-blind trial].
    Fortschritte der Medizin, 1986, Jun-05, Volume: 104, Issue:21

    Topics: Adolescent; Adult; Ankle Injuries; Athletic Injuries; Clinical Trials as Topic; Contusions; Diclofen

1986

Other Studies

4 other studies available for diclofenac and Sprains

ArticleYear
Time to significant pain reduction following DETP application vs placebo for acute soft tissue injuries.
    Current medical research and opinion, 2010, Volume: 26, Issue:8

    Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Aged; Ankle Joint; Anti-Inflammatory Agen

2010
Topical diclofenac for sprains? These doctors say No.
    The Journal of family practice, 2011, Volume: 60, Issue:5

    Topics: Administration, Topical; Ankle Injuries; Cyclooxygenase Inhibitors; Diclofenac; Humans; Sprains and

2011
[Naturopathy approaches in sports medicine. Rapid recovery of performance capability].
    MMW Fortschritte der Medizin, 2012, Dec-17, Volume: 154, Issue:22

    Topics: Administration, Topical; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries;

2012
Diclofenac in the treatment of painful joints and traumatic tendinitis (including strains and sprains): a brief review.
    Seminars in arthritis and rheumatism, 1985, Volume: 15, Issue:2 Suppl 1

    Topics: Diclofenac; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; Joint Diseases; Ketoprofen; Naproxen;

1985