diclofenac has been researched along with Spinal Cord Injuries in 3 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diclofenac was not selected as test drug because of its therapeutic properties, but because to its biopharmaceutical properties, that is, intermediate hepatic extraction." | 1.38 | Contrasting effects of cord injury on intravenous and oral pharmacokinetics of diclofenac: a drug with intermediate hepatic extraction. ( Arauz, J; Castañeda-Hernández, G; Cruz-Antonio, L; Franco-Bourland, RE; Guízar-Sahagún, G, 2012) |
| "Spinal cord injury (SCI) has been proposed to reduce drug bioavailability after intramuscular administration owing to an impairment in blood flow to paralyzed limbs." | 1.30 | Bioavailability of diclofenac after intramuscular administration to rats with experimental spinal cord injury. ( García-López, P; Salas, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cruz-Antonio, L | 1 |
| Arauz, J | 1 |
| Franco-Bourland, RE | 1 |
| Guízar-Sahagún, G | 1 |
| Castañeda-Hernández, G | 1 |
| García-López, P | 1 |
| Salas, R | 1 |
| Sharma, S | 1 |
| Vaidyanathan, S | 1 |
| Thind, SK | 1 |
| Nath, R | 1 |
| Sankaranarayanan, A | 1 |
3 other studies available for diclofenac and Spinal Cord Injuries
| Article | Year |
|---|---|
Contrasting effects of cord injury on intravenous and oral pharmacokinetics of diclofenac: a drug with intermediate hepatic extraction.
Topics: Administration, Intravenous; Administration, Oral; Animals; Biological Availability; Diclofenac; Fem | 2012 |
Bioavailability of diclofenac after intramuscular administration to rats with experimental spinal cord injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Diclofenac; Female; Injec | 1999 |
The effect of diclofenac sodium on urinary concentration of calcium, uric acid and glycosaminoglycans in traumatic paraplegics.
Topics: Adult; Calcium; Depression, Chemical; Diclofenac; Female; Glycosaminoglycans; Humans; Male; Middle A | 1991 |