diclofenac has been researched along with Sensitivity and Specificity in 76 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "98 per patient depending on the dosage of diclofenac used." | 5.30 | Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece. ( Diamantopoulos, E; Ifandi, G; Ignatiades, T; Katostaras, F; Liaropoulos, L; Spinthouri, M, 1998) |
| " One trial involving 255 patients with rheumatoid arthritis (RA) was a 12-week, randomized controlled trail of diclofenac, naproxen, and aspirin." | 5.06 | Sensitivity of a health status measure to short-term clinical changes in arthritis. ( Anderson, JJ; Firschein, HE; Meenan, RF, 1989) |
| "Wildtype, COX-2 knockout and COX-2 heterozygous mice were subjected to a model of colonic anastomotic leakage, and were treated with vehicle, diclofenac, or prostaglandin E2 (PGE2), the most important COX-2 product in the intestine." | 3.85 | Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing. ( Boonen, B; Bosmans, JW; Derikx, JP; Grootjans, J; Hulsewé, KW; Poeze, M; Reisinger, KW; Sastrowijoto, P; Schellekens, DH, 2017) |
| " Thus, the developed method can be used for the combined dosage form analysis and its chemical stability studies." | 1.56 | Synchronous UPLC Resolution of Aceclofenac and Diacerin in Their Powdered Forms and Matrix Formulation: Stability Study. ( Abd El-Rahman, MK; Ahmed, DA; Lotfy, HM; Weshahy, SA, 2020) |
| "To develop a simple HPLC-DAD method for simultaneous determination of febuxostat (FEB) and diclofenac (DIC) in biological samples to assess pharmacokinetic outcomes of their coadministration." | 1.51 | A novel HPLC-DAD method for simultaneous determination of febuxostat and diclofenac in biological samples: pharmacokinetic outcomes. ( Amin, OA; El-Kimary, EI; El-Yazbi, AF; El-Yazbi, FA; Elkhatib, MA; Khamis, EF; Younis, SE, 2019) |
| "Leflunomide was found to be completely degraded when subjected to alkaline degradation producing one alkaline product." | 1.51 | Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures. ( El-Bagary, RI; El-Hakeem, MM; Mahrouse, MA; Megally, AB; Mohamed, AA, 2019) |
| "Naproxen was not associated with any increase (adjusted OR 1." | 1.48 | Risk of myocardial infarction with use of selected non-steroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis. ( Choi, HK; Dubreuil, M; Louie-Gao, Q; Neogi, T; Peloquin, CE; Zhang, Y, 2018) |
| "Simvastatin was the most toxic tested compound for zebrafish embryo, followed by diclofenac." | 1.42 | Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays. ( Martins, R; Ribeiro, S; Santos, MM; Torres, T, 2015) |
| " The applicability of this method for pharmacokinetic studies has been established after successful application during a 12-subject bioavailabity study." | 1.38 | A high performance liquid chromatography-tandem mass spectrometric method for the determination of mefenamic acid in human plasma: application to pharmacokinetic study. ( Bhavsar, R; Dhaneshwar, S; Mahadik, M, 2012) |
| "A reproducible, rapid and sensitive method has been developed for the assay of chlorzoxazone (CHL), paracetamol (PCM) and aceclofenac (ACE) in their combined solid dosage forms using packed-column supercritical fluid chromatography (SFC)." | 1.38 | Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms. ( Desai, PP; Mehta, PJ; Patel, NR; Sherikar, OD, 2012) |
| " Also, this assay was applied to determine the pharmacokinetic parameters of diclofenac in healthy Turkish volunteers who had been given 50 mg diclofenac." | 1.37 | HPLC method for determination of diclofenac in human plasma and its application to a pharmacokinetic study in Turkey. ( Asci, A; Palabiyik, SS; Yilmaz, B, 2011) |
| " The proposed method was successfully applied to the preliminarily study of potential pharmacokinetic interaction between Mor and diclofenac." | 1.35 | Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac. ( Kuroda, N; Nakashima, K; Ogata, Y; Wada, M; Yamada, H; Yokota, C, 2008) |
| "Ibuprofen was used as an internal standard (IS)." | 1.34 | High-performance liquid chromatography and pharmacokinetics of aceclofenac in rats. ( Musmade, P; Srinivasan, KK; Subramanian, G, 2007) |
| "Diclofenac sodium was extracted with ethyl acetate from serum samples, spotted on Silica Gel 60 F(254) plates and the plates were developed using the above mentioned mobile phase." | 1.31 | HPTLC determination of diclofenac sodium from serum. ( D'Mello, PM; Lala, LG; Naik, SR, 2002) |
| "98 per patient depending on the dosage of diclofenac used." | 1.30 | Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece. ( Diamantopoulos, E; Ifandi, G; Ignatiades, T; Katostaras, F; Liaropoulos, L; Spinthouri, M, 1998) |
| " In experiment 1, single injections were administered IV to 1 cow and IV and IM to 1 heifer (7 days apart), and pharmacokinetic variables were calculated." | 1.29 | High-performance liquid chromatography method for determination of flunixin in bovine plasma and pharmacokinetics after single and repeated doses of the drug. ( Johansson, IM; Odensvik, K, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.32) | 18.7374 |
| 1990's | 14 (18.42) | 18.2507 |
| 2000's | 40 (52.63) | 29.6817 |
| 2010's | 19 (25.00) | 24.3611 |
| 2020's | 2 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 2 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Sebaiy, MM | 1 |
| El-Adl, SM | 1 |
| Mattar, AA | 1 |
| Abd El-Rahman, MK | 1 |
| Ahmed, DA | 1 |
| Weshahy, SA | 1 |
| Lotfy, HM | 1 |
| Perréard, C | 1 |
| d'Orlyé, F | 1 |
| Griveau, S | 1 |
| Liu, B | 1 |
| Bedioui, F | 1 |
| Varenne, A | 1 |
| Dubreuil, M | 1 |
| Louie-Gao, Q | 1 |
| Peloquin, CE | 1 |
| Choi, HK | 1 |
| Zhang, Y | 3 |
| Neogi, T | 1 |
| Winiczenko, R | 1 |
| Górnicki, K | 1 |
| Kaleta, A | 1 |
| Janaszek-Mańkowska, M | 1 |
| Khan, ZA | 1 |
| Singh, C | 1 |
| Khan, T | 1 |
| Ganguly, M | 1 |
| Bradsher, C | 1 |
| Goodwin, P | 1 |
| Petty, JT | 1 |
| Sandau, C | 1 |
| Bove, DG | 1 |
| Marsaa, K | 1 |
| Bekkelund, CS | 1 |
| Lindholm, MG | 1 |
| Salazar, J | 1 |
| Bermúdez, V | 1 |
| Olivar, LC | 1 |
| Torres, W | 1 |
| Palmar, J | 1 |
| Añez, R | 1 |
| Ordoñez, MG | 1 |
| Rivas, JR | 1 |
| Martínez, MS | 1 |
| Hernández, JD | 1 |
| Graterol, M | 1 |
| Rojas, J | 1 |
| Mubarak, Z | 1 |
| Humaira, A | 1 |
| Gani, BA | 1 |
| Muchlisin, ZA | 1 |
| Gremillet, C | 1 |
| Jakobsson, JG | 1 |
| Gomila, A | 1 |
| Shaw, E | 1 |
| Carratalà, J | 1 |
| Leibovici, L | 1 |
| Tebé, C | 1 |
| Wiegand, I | 1 |
| Vallejo-Torres, L | 1 |
| Vigo, JM | 1 |
| Morris, S | 1 |
| Stoddart, M | 1 |
| Grier, S | 1 |
| Vank, C | 1 |
| Cuperus, N | 1 |
| Van den Heuvel, L | 1 |
| Eliakim-Raz, N | 1 |
| Vuong, C | 1 |
| MacGowan, A | 1 |
| Addy, I | 1 |
| Pujol, M | 1 |
| Cobb, A | 1 |
| Rieger, E | 1 |
| Bell, J | 1 |
| Mallik, S | 1 |
| Zhao, Z | 1 |
| Szécsényi, Á | 1 |
| Li, G | 1 |
| Gascon, J | 1 |
| Pidko, EA | 1 |
| Zhang, GR | 1 |
| Wolker, T | 1 |
| Sandbeck, DJS | 1 |
| Munoz, M | 1 |
| Mayrhofer, KJJ | 1 |
| Cherevko, S | 1 |
| Etzold, BJM | 1 |
| Lukashuk, L | 1 |
| Yigit, N | 1 |
| Rameshan, R | 1 |
| Kolar, E | 1 |
| Teschner, D | 1 |
| Hävecker, M | 1 |
| Knop-Gericke, A | 1 |
| Schlögl, R | 1 |
| Föttinger, K | 1 |
| Rupprechter, G | 1 |
| Franconieri, F | 1 |
| Deshayes, S | 1 |
| de Boysson, H | 1 |
| Trad, S | 1 |
| Martin Silva, N | 1 |
| Terrier, B | 1 |
| Bienvenu, B | 1 |
| Galateau-Sallé, F | 1 |
| Emile, JF | 1 |
| Johnson, AC | 1 |
| Aouba, A | 1 |
| Vogt, TJ | 1 |
| Gevensleben, H | 1 |
| Dietrich, J | 1 |
| Kristiansen, G | 1 |
| Bootz, F | 1 |
| Landsberg, J | 1 |
| Goltz, D | 1 |
| Dietrich, D | 1 |
| Idorn, M | 1 |
| Skadborg, SK | 1 |
| Kellermann, L | 1 |
| Halldórsdóttir, HR | 1 |
| Holmen Olofsson, G | 1 |
| Met, Ö | 1 |
| Thor Straten, P | 1 |
| Johnson, LE | 1 |
| Brockstedt, D | 1 |
| Leong, M | 1 |
| Lauer, P | 1 |
| Theisen, E | 1 |
| Sauer, JD | 1 |
| McNeel, DG | 1 |
| Morandi, F | 1 |
| Marimpietri, D | 1 |
| Horenstein, AL | 1 |
| Bolzoni, M | 1 |
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| Massaia, M | 1 |
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| Malavasi, F | 1 |
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| Farmer, E | 1 |
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| Wu, TC | 1 |
| Modak, S | 1 |
| Le Luduec, JB | 1 |
| Cheung, IY | 1 |
| Goldman, DA | 1 |
| Ostrovnaya, I | 1 |
| Doubrovina, E | 1 |
| Basu, E | 1 |
| Kushner, BH | 1 |
| Kramer, K | 1 |
| Roberts, SS | 1 |
| O'Reilly, RJ | 1 |
| Cheung, NV | 1 |
| Hsu, KC | 1 |
| Salgarello, T | 1 |
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| Tetzlaff, MT | 1 |
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| Watters, AK | 1 |
| Netchiporouk, E | 1 |
| Provost, N | 1 |
| Gilbert, M | 1 |
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| Sasseville, D | 1 |
| Wheeler, DA | 1 |
| Duvic, M | 1 |
| Litvinov, IV | 1 |
| O'Connor, BJ | 1 |
| Fryda, NJ | 1 |
| Ranglack, DH | 1 |
| Yang, Y | 2 |
| Yang, J | 1 |
| Zhang, X | 2 |
| Grün, AL | 1 |
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| Aumeeruddy-Elalfi, Z | 1 |
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| Dotsenko, A | 1 |
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| Rozhkova, A | 1 |
| Sinitsyna, O | 1 |
| Shashkov, I | 1 |
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| Hong, CE | 1 |
| Kim, JU | 1 |
| Lee, JW | 1 |
| Lee, SW | 1 |
| Jo, IH | 1 |
| Pandiyarajan, S | 1 |
| Premasudha, P | 1 |
| Kadirvelu, K | 1 |
| Wang, B | 1 |
| Luo, L | 1 |
| Wang, D | 1 |
| Ding, R | 1 |
| Hong, J | 1 |
| Caviezel, D | 1 |
| Maissen, S | 1 |
| Niess, JH | 1 |
| Kiss, C | 1 |
| Hruz, P | 1 |
| Pockes, S | 1 |
| Wifling, D | 1 |
| Keller, M | 1 |
| Buschauer, A | 1 |
| Elz, S | 1 |
| Santos, AF | 1 |
| Ferreira, IP | 1 |
| Pinheiro, CB | 1 |
| Santos, VG | 1 |
| Lopes, MTP | 1 |
| Teixeira, LR | 2 |
| Rocha, WR | 1 |
| Rodrigues, GLS | 1 |
| Beraldo, H | 1 |
| Lohar, S | 1 |
| Dhara, K | 1 |
| Roy, P | 1 |
| Sinha Babu, SP | 1 |
| Chattopadhyay, P | 1 |
| Sukwong, P | 1 |
| Sunwoo, IY | 1 |
| Lee, MJ | 1 |
| Ra, CH | 1 |
| Jeong, GT | 1 |
| Kim, SK | 2 |
| Huvinen, E | 1 |
| Eriksson, JG | 1 |
| Stach-Lempinen, B | 1 |
| Tiitinen, A | 1 |
| Koivusalo, SB | 1 |
| Malhotra, M | 1 |
| Suresh, S | 1 |
| Garg, A | 1 |
| Wei, L | 1 |
| Jiang, Y | 2 |
| Zhou, W | 1 |
| Liu, S | 1 |
| Liu, Y | 1 |
| Rausch-Fan, X | 1 |
| Liu, Z | 1 |
| Marques, WL | 1 |
| van der Woude, LN | 1 |
| Luttik, MAH | 1 |
| van den Broek, M | 1 |
| Nijenhuis, JM | 1 |
| Pronk, JT | 1 |
| van Maris, AJA | 1 |
| Mans, R | 1 |
| Gombert, AK | 1 |
| Xu, A | 1 |
| Li, J | 1 |
| Chen, W | 2 |
| Zheng, R | 1 |
| Han, Z | 1 |
| Ji, L | 1 |
| Shen, WQ | 1 |
| Bao, LP | 1 |
| Hu, SF | 1 |
| Gao, XJ | 1 |
| Xie, YP | 1 |
| Gao, XF | 1 |
| Huang, WH | 1 |
| Lu, X | 1 |
| Gostin, PF | 1 |
| Addison, O | 1 |
| Morrell, AP | 1 |
| Cook, AJMC | 1 |
| Liens, A | 1 |
| Stoica, M | 1 |
| Ignatyev, K | 1 |
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| Wu, J | 1 |
| Chiu, YL | 1 |
| Davenport, AJ | 1 |
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| Gao, X | 1 |
| Zhang, J | 3 |
| Huang, K | 1 |
| Wai, H | 1 |
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| Kim, WS | 1 |
| Eastman, A | 1 |
| Micalizio, GC | 1 |
| Liang, JH | 1 |
| Huo, XK | 1 |
| Cheng, ZB | 1 |
| Sun, CP | 1 |
| Zhao, JC | 1 |
| Kang, XH | 1 |
| Zhang, TY | 1 |
| Chen, ZJ | 1 |
| Yang, TM | 1 |
| Wu, YY | 1 |
| Deng, XP | 1 |
| Zhang, YX | 1 |
| Salem, HF | 1 |
| Kharshoum, RM | 1 |
| Abou-Taleb, HA | 1 |
| AbouTaleb, HA | 1 |
| AbouElhassan, KM | 1 |
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| Kuwahara, F | 1 |
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| Kobayashi, S | 1 |
| Kashiwagi, T | 1 |
| Kimura, J | 1 |
| Lin, JD | 1 |
| Liou, MJ | 1 |
| Hsu, HL | 1 |
| Leong, KK | 1 |
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| Lee, HY | 1 |
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| Bayraktar, E | 1 |
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| Gocmen, AY | 1 |
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| Huang, S | 2 |
| Adams, E | 1 |
| Van Schepdael, A | 1 |
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| Chung, CY | 1 |
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| Chen, Y | 1 |
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| Bhattacharya, R | 1 |
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| Saeui, CT | 1 |
| Yarema, KJ | 1 |
| Betenbaugh, MJ | 1 |
| Zhang, H | 2 |
| Patik, JC | 1 |
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| Curtis, BM | 1 |
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| Helge, JW | 1 |
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| Gayani, B | 1 |
| Dilhari, A | 1 |
| Wijesinghe, GK | 1 |
| Kumarage, S | 1 |
| Abayaweera, G | 1 |
| Samarakoon, SR | 1 |
| Perera, IC | 1 |
| Kottegoda, N | 1 |
| Weerasekera, MM | 1 |
| Nardi, MV | 1 |
| Timpel, M | 1 |
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| Zorn Morales, N | 1 |
| Chiappini, A | 1 |
| Toccoli, T | 1 |
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| Odobel, F | 1 |
| Coutsolelos, AG | 1 |
| Fuentes, I | 1 |
| García-Mendiola, T | 1 |
| Sato, S | 1 |
| Pita, M | 1 |
| Nakamura, H | 1 |
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| Teixidor, F | 1 |
| Marques, F | 1 |
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| Liu, F | 1 |
| Qi, P | 1 |
| Zhang, L | 2 |
| El-Yazbi, FA | 1 |
| Amin, OA | 1 |
| El-Kimary, EI | 1 |
| Khamis, EF | 1 |
| Younis, SE | 1 |
| Elkhatib, MA | 1 |
| El-Yazbi, AF | 1 |
| El-Bagary, RI | 1 |
| Mahrouse, MA | 1 |
| El-Hakeem, MM | 1 |
| Megally, AB | 1 |
| Mohamed, AA | 1 |
| Arvand, M | 1 |
| Gholizadeh, TM | 1 |
| Zanjanchi, MA | 1 |
| Ribeiro, S | 1 |
| Torres, T | 1 |
| Martins, R | 1 |
| Santos, MM | 1 |
| Reisinger, KW | 1 |
| Schellekens, DH | 1 |
| Bosmans, JW | 1 |
| Boonen, B | 1 |
| Hulsewé, KW | 1 |
| Sastrowijoto, P | 1 |
| Derikx, JP | 1 |
| Grootjans, J | 1 |
| Poeze, M | 1 |
| Youdim, KA | 1 |
| Lyons, R | 1 |
| Payne, L | 1 |
| Jones, BC | 1 |
| Saunders, K | 1 |
| Sparidans, RW | 1 |
| Lagas, JS | 1 |
| Schinkel, AH | 1 |
| Schellens, JH | 1 |
| Beijnen, JH | 1 |
| Shaikh, KA | 1 |
| Devkhile, AB | 1 |
| Elsayed, MM | 1 |
| Vierl, U | 1 |
| Cevc, G | 1 |
| Solangi, AR | 1 |
| Memon, SQ | 1 |
| Mallah, A | 1 |
| Khuhawar, MY | 1 |
| Bhanger, MI | 1 |
| Kittisupamongkol, W | 1 |
| Bavbek, S | 1 |
| Ikincioğullari, A | 1 |
| Dursun, AB | 1 |
| Guloğlu, D | 1 |
| Arikan, M | 1 |
| Elhan, AH | 1 |
| Misirligil, Z | 1 |
| Dowling, G | 1 |
| Gallo, P | 1 |
| Fabbrocino, S | 1 |
| Serpe, L | 1 |
| Regan, L | 1 |
| De Weck, AL | 2 |
| Sanz, ML | 2 |
| Gamboa, PM | 1 |
| Aberer, W | 1 |
| Blanca, M | 1 |
| Correia, S | 1 |
| Erdman, S | 1 |
| Jermann, JM | 1 |
| Kanny, G | 1 |
| Kowalski, M | 1 |
| Mayorga, L | 1 |
| Medrala, W | 1 |
| Merk, A | 1 |
| Sturm, GJ | 1 |
| Sainte-Laudy, J | 1 |
| Schneider, MS | 1 |
| Sczczeklik, A | 1 |
| Weber, JM | 1 |
| Wedi, A | 1 |
| Botello, I | 1 |
| Borrull, F | 1 |
| Aguilar, C | 1 |
| Calull, M | 1 |
| Iwamura, A | 1 |
| Fukami, T | 1 |
| Hosomi, H | 1 |
| Nakajima, M | 1 |
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5 trials available for diclofenac and Sensitivity and Specificity
| Article | Year |
|---|---|
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
Upregulation of CD63 or CD203c alone or in combination is not sensitive in the diagnosis of nonsteroidal anti-inflammatory drug intolerance.
Topics: Administration, Oral; Adult; Antigens, CD; Aspirin; Basophil Degranulation Test; Basophils; Biomarke | 2009 |
Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro diagnosis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Basophils; Diclofenac; Dr | 2009 |
High-performance liquid chromatographic determination of diclofenac in human plasma after solid-phase extraction.
Topics: Administration, Oral; Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-Steroidal; Area U | 2001 |
Sensitivity of a health status measure to short-term clinical changes in arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; D | 1989 |
71 other studies available for diclofenac and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Different techniques for overlapped UV spectra resolution of some co-administered drugs with paracetamol in their combined pharmaceutical dosage forms.
Topics: Acetaminophen; Caffeine; Diclofenac; Linear Models; Models, Chemical; Orphenadrine; Reproducibility | 2020 |
Synchronous UPLC Resolution of Aceclofenac and Diacerin in Their Powdered Forms and Matrix Formulation: Stability Study.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Diclofenac; Drug Stability; Lin | 2020 |
Aptamer entrapment in microfluidic channel using one-step sol-gel process, in view of the integration of a new selective extraction phase for lab-on-a-chip.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aptamers, Nucleotide; Chromatography, Affinity; | 2017 |
Risk of myocardial infarction with use of selected non-steroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclo | 2018 |
A novel HPLC-DAD method for simultaneous determination of febuxostat and diclofenac in biological samples: pharmacokinetic outcomes.
Topics: Adult; Animals; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Cross-Over Stud | 2019 |
Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures.
Topics: Anthraquinones; Calibration; Diclofenac; Drug Combinations; Drug Stability; Leflunomide; Limit of De | 2019 |
MWCNTs/Cu(OH)2 nanoparticles/IL nanocomposite modified glassy carbon electrode as a voltammetric sensor for determination of the non-steroidal anti-inflammatory drug diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biosensing Techniques; Carbon; Copper; Diclofenac; | 2012 |
Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays.
Topics: Animals; Biological Assay; Diclofenac; Ecotoxicology; Embryo, Nonmammalian; Paracentrotus; Propranol | 2015 |
Cyclooxygenase-2 Is Essential for Colorectal Anastomotic Healing.
Topics: Anastomosis, Surgical; Anastomotic Leak; Angiogenesis Inducing Agents; Animals; Chi-Square Distribut | 2017 |
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.
Topics: Aryl Hydrocarbon Hydroxylases; Biological Assay; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cy | 2008 |
Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Diclofenac; Half-Life; Male; Mice; Re | 2008 |
Simultaneous determination of aceclofenac, paracetamol, and chlorzoxazone by RP-HPLC in pharmaceutical dosage form.
Topics: Acetaminophen; Chlorzoxazone; Chromatography, High Pressure Liquid; Diclofenac; Reproducibility of R | 2008 |
Accurate potentiometric determination of lipid membrane-water partition coefficients and apparent dissociation constants of ionizable drugs: electrostatic corrections.
Topics: Bupivacaine; Diclofenac; Ions; Ketoprofen; Membrane Lipids; Naphthalenes; Osmolar Concentration; Pha | 2009 |
Quantitative separation of oxytocin, norfloxacin and diclofenac sodium in milk samples using capillary electrophoresis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Borates; Buffaloes; Diclofenac; Electrophoresis, C | 2009 |
Liver injury from diclofenac or acetaminophen?
Topics: Acetaminophen; Diclofenac; Humans; Liver; Liver Failure; Risk Assessment; Sensitivity and Specificit | 2009 |
Determination of ibuprofen, ketoprofen, diclofenac and phenylbutazone in bovine milk by gas chromatography-tandem mass spectrometry.
Topics: Animals; Cattle; Diclofenac; Drug Residues; Food Analysis; Food Contamination; Gas Chromatography-Ma | 2008 |
Electrokinetic supercharging focusing in capillary zone electrophoresis of weakly ionizable analytes in environmental and biological samples.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Electrophoresis, Capillary; Fenoprofen; Humans; | 2010 |
CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Cyclooxyge | 2011 |
HPLC method for determination of diclofenac in human plasma and its application to a pharmacokinetic study in Turkey.
Topics: Acetonitriles; Adult; Chromatography, High Pressure Liquid; Diclofenac; Drug Stability; Humans; Leas | 2011 |
Simultaneous determination of timolol maleate, rosuvastatin calcium and diclofenac sodium in pharmaceuticals and physiological fluids using HPLC-UV.
Topics: Animals; Aqueous Humor; Cattle; Chromatography, High Pressure Liquid; Diclofenac; Drug Stability; Fl | 2011 |
A high performance liquid chromatography-tandem mass spectrometric method for the determination of mefenamic acid in human plasma: application to pharmacokinetic study.
Topics: Acetates; Anticoagulants; Area Under Curve; Chromatography, High Pressure Liquid; Diclofenac; Drug S | 2012 |
Quantification of active ingredients in suppositories by FT-Raman spectroscopy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Least- | 2013 |
Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Diclofenac; Humans; Least-Squar | 2012 |
Competitive CE-UV binding tests for selective recognition of bisphenol A by molecularly imprinted polymer particles.
Topics: Benzhydryl Compounds; Binding, Competitive; Diclofenac; Electrophoresis, Capillary; Hydrogen-Ion Con | 2012 |
Development and validation of packed column supercritical fluid chromatographic technique for quantification of chlorzoxazone, paracetamol and aceclofenac in their individual and combined dosage forms.
Topics: Acetaminophen; Carbon Dioxide; Chlorzoxazone; Chromatography, Supercritical Fluid; Diclofenac; Drug | 2012 |
Samter's triad and eicosanoid imbalance in children with recurrent nasal polyps.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Diclofenac; Drug Hypersensitivit | 2012 |
High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: application to drug metabolites.
Topics: Diclofenac; Humans; Isotope Labeling; Isotopes; Mass Spectrometry; Microsomes, Liver; Models, Chemic | 2012 |
Liquid chromatographic determination of diclofenac in human synovial fluid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Humans; R | 2003 |
Photoallergic contact dermatitis due to diclofenac.
Topics: Administration, Topical; Adult; Allergens; Arthralgia; Dermatitis, Photoallergic; Diclofenac; Elbow | 2003 |
Analysis of diclofenac and its metabolites by high-performance liquid chromatography: relevance of CYP2C9 genotypes in diclofenac urinary metabolic ratios.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressur | 2003 |
Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements.
Topics: Chemical Phenomena; Chemistry, Physical; Delayed-Action Preparations; Diclofenac; Drug Carriers; Hyp | 2003 |
[Measurement of postoperative pain: analysis of the sensitivity of various self-evaluation instruments].
Topics: Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans | 2003 |
Residue analysis of the pharmaceutical diclofenac in different water types using ELISA and GC-MS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Environmental Monitoring; Enzyme-Linked Immunos | 2003 |
A high-throughput method for enzyme kinetic studies.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP | 2003 |
Polarographic behaviors of diclofenac sodium in the presence of dissolved oxygen and its analytical application.
Topics: Buffers; Calibration; Catalysis; Diclofenac; Electrolytes; Hydrogen; Hydrogen-Ion Concentration; Mol | 2004 |
The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome.
Topics: Acetaminophen; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Basophil Degra | 2004 |
Ultrastructural alterations in renal tissues of rabbits induced by diclofenac sodium (Voltaren).
Topics: Animals; Biopsy, Needle; Diclofenac; Disease Models, Animal; Immunohistochemistry; Kidney Glomerulus | 2004 |
Measuring the mass of an electron by LC/TOF-MS: a study of "twin ions".
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Carbon Dioxide; Chromatography, Liquid; Diclofe | 2005 |
Iron(II)-phthalocyanine as a novel recognition sensor for selective potentiometric determination of diclofenac and warfarin drugs.
Topics: Calibration; Diclofenac; Ferrous Compounds; Hydrogen-Ion Concentration; Indoles; Ions; Pharmaceutica | 2005 |
Electrochemical determination of pharmaceuticals in spiked water samples.
Topics: Clofibric Acid; Diclofenac; Electrochemistry; Environmental Monitoring; Fresh Water; Ofloxacin; Phar | 2005 |
Determinations of fluoroquinolones and nonsteroidal anti-inflammatory drugs in urine by extractive spectrophotometry and photoinduced spectrofluorimetry using multivariate calibration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Analytical; Ciprofloxacin; Diclofenac | 2005 |
Influence of antiinflammatory drugs (methylprednisolone and diclofenac sodium) on experimental pleurodesis induced by silver nitrate or talc.
Topics: Animals; Diclofenac; Disease Models, Animal; Female; Male; Methylprednisolone; Pleural Diseases; Ple | 2005 |
A Friday afternoon case of apparent anti-glomerular basement nephritis.
Topics: Acetaminophen; Acute Kidney Injury; Analgesics; Animals; Anti-Glomerular Basement Membrane Disease; | 2006 |
Potentiometric behaviour of ion selective electrodes based on iron porphyrins: the influence of porphyrin substituents on the response properties and analytical determination of diclofenac in pharmaceutical formulations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ferric Compounds; Hydrogen-Ion Concentration; I | 2006 |
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP | 2007 |
Diclofenac induces basophil degranulation without increasing CD63 expression in sensitive patients.
Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Basophil Degranulation Te | 2007 |
Simultaneous determination of ZLR-8 and its active metabolite diclofenac in dog plasma by high-performance liquid chromatography.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Chromatography, High Pressure Liquid; | 2007 |
Study of recombinant cytochrome P450 2C9 activity with diclofenac by MEKC.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, Micellar Electrokinetic Capillary; Cytochrome P-450 C | 2007 |
High-performance liquid chromatography and pharmacokinetics of aceclofenac in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry Techniques, Analytical; Chromatography, | 2007 |
An economic model of long-term use of celecoxib in patients with osteoarthritis.
Topics: Age Factors; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cost-Benefit | 2007 |
Determination of diclofenac sodium in commercial pharmaceutical formulations and human control serum using a kinetic-spectrophotometric method.
Topics: Amino Acids; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Ions; Kinetics; Ligands; P | 2007 |
Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
Topics: Acetaminophen; Animals; Bile; Carbamazepine; Chromatography, Liquid; Clozapine; Cresols; Diclofenac; | 2007 |
Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Diclofenac; Humans; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac.
Topics: Animals; Benzoates; Brain; Chromatography, High Pressure Liquid; Diclofenac; Drug Interactions; Fluo | 2008 |
Analysis of diclofenac and four of its metabolites in human urine by HPLC.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Calibration; Chromatography, High Pressure L | 1995 |
High-performance liquid chromatography method for determination of flunixin in bovine plasma and pharmacokinetics after single and repeated doses of the drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Specimen Collection; Cattle; Chromatography, | 1995 |
High-performance liquid chromatographic assay for antiinflammatory agents diclofenac and flurbiprofen in ocular fluids.
Topics: Animals; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Diclofenac; Flurb | 1994 |
Sensitive capillary gas chromatographic-mass spectrometric-selected-ion monitoring method for the determination of diclofenac concentrations in human plasma.
Topics: Acetone; Anti-Inflammatory Agents, Non-Steroidal; Calibration; Diclofenac; Drug Monitoring; Gas Chro | 1996 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; En | 1998 |
Simultaneous determination of diclofenac and oxybuprocaine in human aqueous humor with HPLC and electrochemical detection.
Topics: Anesthetics, Local; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Cycloo | 1998 |
Economic evaluation of nimesulide versus diclofenac in the treatment of osteoarthritis in Greece.
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit Analysis; Diclofenac; Greece; | 1998 |
Study of the solid-phase extraction of diclofenac sodium, indomethacin and phenylbutazone for their analysis in human urine by liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Diclofenac; Humans; I | 1999 |
Aceclofenac: is the antiinflammatory effect really due to cyclooxygenase inhibition?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells, Cultured; Chondrocytes; Diclo | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
Determination of cyanocobalamin, betamethasone, and diclofenac sodium in pharmaceutical formulations, by high performance liquid chromatography.
Topics: Acetic Acid; Acetonitriles; Betamethasone; Calibration; Chemistry, Pharmaceutical; Chromatography, H | 1999 |
Spectrofluorometric determination of diclofenac in tablets and ointments.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Betamethasone; Diclofenac; Excipients; Hydro | 1999 |
Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chromatography, High Pressure Liquid; Diclofenac; | 2001 |
HPTLC determination of diclofenac sodium from serum.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Thin Layer; Diclofenac; Sensitivity and Spe | 2002 |
Simplified micromethod for the HPLC measurement of diclofenac in plasma.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Humans; Sensitivity and Specificity; Time Factors | 1992 |
An automated method for the determination of diclofenac sodium in human plasma.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Humans; Robotics; Sensitivity and Specificity | 1991 |