diclofenac has been researched along with Seizures in 14 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy." | 3.85 | Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. ( Ayyıldız, N; Taşdemir, A; Taşkıran, M, 2017) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter." | 3.69 | Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect. ( Makde, SD; Paranjpe, BD; Shrivastava, MP, 1997) |
| "Epilepsy is a disease which affects between 1 and 2% of the population, and a large proportion of these people do not react to currently available anticonvulsant medications, indicating the need for further research into novel pharmacological therapies." | 1.91 | Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. ( Erbas, O; Erdogan, A; Erdogan, MA; Gurgul, S, 2023) |
| "The knowledge of pharmacokinetic and pharmacodynamic properties of antiepileptic drugs is helpful in optimizing drug therapy for epilepsy." | 1.46 | Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence. ( Kumar, B; Medhi, B; Modi, M; Saikia, B, 2017) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i." | 1.38 | Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. ( Mori, T; Shibasaki, M; Shimizu, N; Suzuki, T, 2012) |
| "The clinical risk of convulsion for each combination was estimated using a pharmacodynamic model based on receptor occupancy using the in vitro data set obtained and pharmacokinetic parameters in humans collected from the literature." | 1.35 | Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. ( Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M, 2009) |
| "In contrast, the incidence of seizures was reduced 18 h after LPS injection." | 1.33 | The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. ( Akarsu, ES; Algan, E; Ozdayi, S; Ulupinar, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 4 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Javed, L | 1 |
| Hanif, F | 1 |
| Malhi, SM | 1 |
| Zaman, U | 1 |
| Jahan, N | 1 |
| Amir, Q | 1 |
| Javed, A | 1 |
| Malik, AB | 1 |
| Abrar, H | 1 |
| Erdogan, A | 2 |
| Erdogan, MA | 2 |
| Gurgul, S | 2 |
| Erbas, O | 2 |
| Karami, Z | 1 |
| Zanjani, MS | 1 |
| Andalib, S | 1 |
| Babaie, H | 1 |
| Aminoroaia, P | 1 |
| Elgarhi, R | 1 |
| Shehata, MM | 1 |
| Abdelsameea, AA | 1 |
| Salem, AE | 1 |
| Kumar, B | 1 |
| Modi, M | 1 |
| Saikia, B | 1 |
| Medhi, B | 1 |
| Vieira, V | 1 |
| Glassmann, D | 1 |
| Marafon, P | 1 |
| Pereira, P | 1 |
| Gomez, R | 1 |
| Coitinho, AS | 1 |
| Taşkıran, M | 1 |
| Taşdemir, A | 1 |
| Ayyıldız, N | 1 |
| Kim, J | 1 |
| Ohtani, H | 1 |
| Tsujimoto, M | 1 |
| Sawada, Y | 1 |
| Mori, T | 1 |
| Shimizu, N | 1 |
| Shibasaki, M | 1 |
| Suzuki, T | 1 |
| Dalpiaz, A | 2 |
| Pavan, B | 2 |
| Scaglianti, M | 2 |
| Vitali, F | 1 |
| Bortolotti, F | 1 |
| Biondi, C | 2 |
| Scatturin, A | 2 |
| Tanganelli, S | 2 |
| Ferraro, L | 2 |
| Prasad, P | 2 |
| Manfredini, S | 2 |
| Snyman, T | 1 |
| Stewart, MJ | 1 |
| Grove, A | 1 |
| Steenkamp, V | 1 |
| Akarsu, ES | 1 |
| Ozdayi, S | 1 |
| Algan, E | 1 |
| Ulupinar, F | 1 |
| Shrivastava, MP | 1 |
| Makde, SD | 1 |
| Paranjpe, BD | 1 |
| Vertuani, S | 1 |
| Compagnone, D | 1 |
14 other studies available for diclofenac and Seizures
| Article | Year |
|---|---|
Diclofenac sodium enhances the antiepileptic effect of levetiracetam in pilocarpine induced epileptic mice model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Convulsants; Di | 2021 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions.
Topics: Animals; Anticonvulsants; Diclofenac; Disease Models, Animal; Epilepsy; Myoclonus; Pentylenetetrazol | 2023 |
Influence of Poloxamer 188 on Anti-Inflammatory and Analgesic Effects of Diclofenac-Loaded Nanoemulsion: Formulation, Optimization and in Vitro/in Vivo Evaluation.
Topics: Analgesics; Anti-Inflammatory Agents; Diclofenac; Edema; Emulsions; Humans; Pain; Poloxamer; Seizure | 2023 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence.
Topics: Acetamides; Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Brain; Carbon Tetrachl | 2017 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclooxygenase 2 Inhibitors; Diclofenac; Epilepsy; Male; | 2017 |
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cipr | 2009 |
Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal.
Topics: Animals; Arachidonic Acid; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Diclofenac; Enzyme Inhi | 2012 |
Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.
Topics: Animals; Ascorbic Acid; Brain; Cell Line; Diclofenac; Humans; Male; Mice; Nipecotic Acids; Organic A | 2004 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.
Topics: Animals; Convulsants; Cyclooxygenase Inhibitors; Diclofenac; Escherichia coli; Indomethacin; Lipopol | 2006 |
Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, N | 1997 |
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.
Topics: Animals; Ascorbic Acid; Biological Transport; Cell Line; Central Nervous System Agents; Diclofenac; | 2002 |