diclofenac has been researched along with Precancerous Conditions in 17 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 5.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "Laser therapy appears the best option among nonsurgical approaches for actinic cheilitis, and PDT showed higher efficacy when sequentially combined with 5% imiquimod." | 5.05 | Treatments of actinic cheilitis: A systematic review of the literature. ( Cornacchia, L; Lai, M; Longo, C; Pampena, R; Pellacani, G; Peris, K, 2020) |
| "In the future, the treatment of actinic keratosis can be more often done in primary health care." | 2.52 | [Diagnosis and treatment of actinic keratosis]. ( Isoherranen, K; Koskenmies, S; Overmark, M; Pitkänen, S; Saksela, O; Ylitalo, L, 2015) |
| "Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma." | 2.42 | Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003) |
| "The ability to manage non-melanoma skin cancers and pre-malignant lesions with topical pharmacologic agents is highly compelling." | 2.42 | Topical treatment strategies for non-melanoma skin cancer and precursor lesions. ( Fein, H; McGillis, ST, 2004) |
| "The cost of topical treatments for actinic keratosis (AK) has historically been evaluated in relation to the number of lesions requiring treatment or simply by the price of a single tube/sachet of the drug used." | 1.51 | Evaluation of the treatment costs and duration of topical treatments for multiple actinic keratosis based on the area of the cancerization field and not on the number of lesions. ( Calzavara-Pinton, P; Hamon, P; Tanova, N, 2019) |
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 1.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, M | 1 |
| Pampena, R | 1 |
| Cornacchia, L | 1 |
| Pellacani, G | 1 |
| Peris, K | 1 |
| Longo, C | 1 |
| Calzavara-Pinton, P | 1 |
| Tanova, N | 1 |
| Hamon, P | 1 |
| Samrao, A | 1 |
| Cockerell, CJ | 1 |
| Pommergaard, HC | 1 |
| Burcharth, J | 1 |
| Rosenberg, J | 1 |
| Raskov, H | 1 |
| Mücke, T | 1 |
| Gentz, I | 1 |
| Kanatas, A | 1 |
| Ritschl, LM | 1 |
| Mitchell, DA | 1 |
| Wolff, KD | 1 |
| Deppe, H | 1 |
| Isoherranen, K | 1 |
| Koskenmies, S | 1 |
| Overmark, M | 1 |
| Ylitalo, L | 1 |
| Saksela, O | 1 |
| Pitkänen, S | 1 |
| Dirschka, T | 1 |
| Bierhoff, E | 1 |
| Pflugfelder, A | 1 |
| Garbe, C | 1 |
| Fenske, NA | 1 |
| Spencer, J | 1 |
| Adam, F | 1 |
| Sanyal, SN | 1 |
| Kaur, J | 1 |
| Jadotte, YT | 1 |
| Schwartz, RA | 1 |
| Esmann, S | 1 |
| Jemec, GB | 1 |
| Tutrone, WD | 1 |
| Saini, R | 1 |
| Caglar, S | 1 |
| Weinberg, JM | 1 |
| Crespo, J | 1 |
| Silapunt, S | 1 |
| Goldberg, LH | 1 |
| Alam, M | 1 |
| McGillis, ST | 1 |
| Fein, H | 1 |
| Merk, HF | 1 |
| Rivers, JK | 2 |
| McLean, DI | 1 |
| Arlette, J | 1 |
| Shear, N | 1 |
| Guenther, L | 1 |
| Carey, W | 1 |
| Poulin, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of the Pragmatic Use of Mobile Phone Based Follow up of Actinic Keratoses Treated With Topical 5-fluorouracil[NCT02938715] | 26 participants (Actual) | Interventional | 2016-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for diclofenac and Precancerous Conditions
| Article | Year |
|---|---|
Treatments of actinic cheilitis: A systematic review of the literature.
Topics: Aminolevulinic Acid; Carcinoma, Squamous Cell; Cheilitis; Combined Modality Therapy; Dermabrasion; D | 2020 |
Pharmacotherapeutic management of actinic keratosis: focus on newer topical agents.
Topics: Administration, Topical; Aminoquinolines; Cryotherapy; Diclofenac; Dose-Response Relationship, Drug; | 2013 |
[Diagnosis and treatment of actinic keratosis].
Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2015 |
Actinic keratoses: past, present and future.
Topics: Adjuvants, Immunologic; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamou | 2010 |
Topical therapy for actinic keratoses, II: Diclofenac, colchicine, and retinoids.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Colchicin | 2003 |
Topical and light-based treatments for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Antineoplasti | 2003 |
Topical treatment strategies for non-melanoma skin cancer and precursor lesions.
Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag | 2004 |
Topical diclofenac in the treatment of actinic keratoses.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Diclofen | 2007 |
4 trials available for diclofenac and Precancerous Conditions
| Article | Year |
|---|---|
Clinical trial analyzing the impact of continuous defocused CO2 laser vaporisation on the malignant transformation of erosive oral lichen planus.
Topics: Adult; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; Cell T | 2015 |
Topical 3.0% diclofenac in 2.5% hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aged; Aged, 80 and over; Anti-Inflammatory Agents, | 2010 |
An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratoses.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Irritant; Der | 1997 |
Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel.
Topics: Adjuvants, Immunologic; Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents, | 2002 |
5 other studies available for diclofenac and Precancerous Conditions
| Article | Year |
|---|---|
Evaluation of the treatment costs and duration of topical treatments for multiple actinic keratosis based on the area of the cancerization field and not on the number of lesions.
Topics: Administration, Topical; Aminolevulinic Acid; Cohort Studies; Cost of Illness; Diclofenac; Diterpene | 2019 |
Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Calcitriol; Chemoprevention; D | 2013 |
Induction of apoptosis as a potential chemopreventive effect of dual cycloxygenase inhibitor, diclofenac, in early colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Chemoprevention; Colon; Co | 2010 |
Solar cheilosis: an ominous precursor part II. Therapeutic perspectives.
Topics: Administration, Topical; Aminoquinolines; Biopsy; Carcinoma, Squamous Cell; Cheilitis; Combined Moda | 2012 |
Patients' perceptions of topical treatments of actinic keratosis.
Topics: Administration, Topical; Aged; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Diclofenac | 2014 |