diclofenac has been researched along with Orthopedic Disorders in 7 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the efficacy and safety of the COX-2 inhibitor lumiracoxib 400 mg once daily (qd) and naproxen 500 mg twice daily (bid) in patients with acute musculoskeletal pain caused by uncomplicated soft tissue injury." | 9.13 | A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain. ( Adekunle, F; Andrews, C; Ellis, G; Kinch, H; Kyle, C; Zachariah, J, 2008) |
| "To compare the efficacy and safety of the COX-2 inhibitor lumiracoxib 400 mg once daily (qd) and naproxen 500 mg twice daily (bid) in patients with acute musculoskeletal pain caused by uncomplicated soft tissue injury." | 5.13 | A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain. ( Adekunle, F; Andrews, C; Ellis, G; Kinch, H; Kyle, C; Zachariah, J, 2008) |
| "There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone." | 5.11 | Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005) |
| "Pain treatment with acetaminophen was not inferior to that with diclofenac or the combination of acetaminophen and diclofenac in acute minor musculoskeletal extremity trauma, both in rest and with movement." | 2.87 | Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial. ( Goddijn, H; Goslings, JC; Hollmann, MW; Kemper, EM; Lirk, P; Ridderikhof, ML; Schinkel, E; Van Dieren, S; Vandewalle, E, 2018) |
| "To evaluate the risk of adverse events (AEs) associated with topical diclofenac for the treatment of acute and chronic musculoskeletal conditions." | 2.47 | Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions. ( Fotopoulos, G; Maibach, H; Taylor, RS, 2011) |
| " The bioavailability in terms of systemic exposure from the patch compared with oral intake (75 mg/day) is in the order of 1%." | 2.45 | Diclofenac epolamine (Flector) patch: evidence for topical activity. ( Petersen, B; Rovati, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ridderikhof, ML | 1 |
| Lirk, P | 1 |
| Goddijn, H | 1 |
| Vandewalle, E | 1 |
| Schinkel, E | 1 |
| Van Dieren, S | 1 |
| Kemper, EM | 1 |
| Hollmann, MW | 1 |
| Goslings, JC | 1 |
| Qureshi, I | 1 |
| Pathan, SA | 1 |
| Qureshi, RS | 1 |
| Thomas, SH | 1 |
| Petersen, B | 1 |
| Rovati, S | 1 |
| Kyle, C | 1 |
| Zachariah, J | 1 |
| Kinch, H | 1 |
| Ellis, G | 1 |
| Andrews, C | 1 |
| Adekunle, F | 1 |
| Taylor, RS | 1 |
| Fotopoulos, G | 1 |
| Maibach, H | 1 |
| Woo, WW | 1 |
| Man, SY | 1 |
| Lam, PK | 1 |
| Rainer, TH | 1 |
| Gøtzsche, PC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 7-Day Multicenter Randomized Double-Blind, Double-Dummy Parallel Group Trial to Assess the Safety and Efficacy of 400 mg Lumiracoxib Once Daily Versus 500 mg Naproxen Twice Daily in Patients With Acute Musculoskeletal Pain Due to Uncomplicated Soft Tiss[NCT00170898] | Phase 4 | 419 participants | Interventional | 2004-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diclofenac and Orthopedic Disorders
| Article | Year |
|---|---|
Diclofenac epolamine (Flector) patch: evidence for topical activity.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Musculoskeleta | 2009 |
Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions.
Topics: Administration, Topical; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Bli | 2011 |
4 trials available for diclofenac and Orthopedic Disorders
| Article | Year |
|---|---|
Acetaminophen or Nonsteroidal Anti-Inflammatory Drugs in Acute Musculoskeletal Trauma: A Multicenter, Double-Blind, Randomized, Clinical Trial.
Topics: Acetaminophen; Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroid | 2018 |
Intramuscular versus oral diclofenac for acute pain in adults with acute musculoskeletal injuries presenting to the ED setting: a prospective, double-blind, double-dummy, randomised controlled trial.
Topics: Acute Pain; Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; | 2019 |
A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain.
Topics: Acute Disease; Adult; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Dou | 2008 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans | 2005 |
1 other study available for diclofenac and Orthopedic Disorders
| Article | Year |
|---|---|
[Paracetamol has the same effect as non-steroidal anti-inflammatory agents in acute musculoskeletal injuries].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans | 2006 |