diclofenac has been researched along with Neuralgia in 23 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Before treatment, the concentrations of interleukin-8 in the cerebrospinal fluid were inversely related to the duration of neuralgia in all the patients (r=-0." | 9.09 | Intrathecal methylprednisolone for intractable postherpetic neuralgia. ( Asai, M; Hashimoto, H; Kimura, F; Kotani, N; Kushikata, T; Matsuki, A; Muraoka, M; Yodono, M, 2000) |
| "The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al." | 9.08 | Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study. ( De Benedittis, G; Lorenzetti, A, 1996) |
| "Topical aspirin/diethyl ether (ADE) mixture was used to treat 45 consecutive patients with acute herpetic neuralgia (AHN) (n = 28) and with post-herpetic neuralgia (PHN) (n = 17) in an open-label study." | 9.07 | A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial. ( Besana, F; De Benedittis, G; Lorenzetti, A, 1992) |
| "The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat." | 7.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| " Before treatment, the concentrations of interleukin-8 in the cerebrospinal fluid were inversely related to the duration of neuralgia in all the patients (r=-0." | 5.09 | Intrathecal methylprednisolone for intractable postherpetic neuralgia. ( Asai, M; Hashimoto, H; Kimura, F; Kotani, N; Kushikata, T; Matsuki, A; Muraoka, M; Yodono, M, 2000) |
| "The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al." | 5.08 | Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study. ( De Benedittis, G; Lorenzetti, A, 1996) |
| "Topical aspirin/diethyl ether (ADE) mixture was used to treat 45 consecutive patients with acute herpetic neuralgia (AHN) (n = 28) and with post-herpetic neuralgia (PHN) (n = 17) in an open-label study." | 5.07 | A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial. ( Besana, F; De Benedittis, G; Lorenzetti, A, 1992) |
| "In acute musculoskeletal pain (strains and sprains) with assessment at about seven days, therapies were diclofenac Emulgel (78% Emulgel, 20% placebo; 2 studies, 314 participants, NNT 1." | 4.95 | Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews. ( Aldington, D; Bell, RF; Derry, S; Gaskell, H; Kalso, EA; Moore, RA; Phillips, T; Wiffen, PJ, 2017) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| "Mice subjected to chronic constriction injury (CCI) were tested for mechanical and cold allodynia after administration of the MAGL inhibitor, JZL184, or the non-selective COX inhibitor diclofenac." | 3.81 | Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Gujjar, R; Kinsey, SG; Leishman, E; Mahadevan, A, 2015) |
| "The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat." | 3.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| "Postoperative pain was assessed at first day, at discharge and after one month using visual analogue scale." | 2.84 | Elective Division of Ilioinguinal Nerve in Inguinal Hernioplasty: Remedy for the Morbid Postoperative Inguinal Pain. ( Baig, MAN; Muneeb, MD, 2017) |
| "Neuropathic pain is a condition resulting from injury to the peripheral and/or central nervous system." | 2.80 | Effect of 1.5% Topical Diclofenac on Clinical Neuropathic Pain. ( Ahmed, SU; Chen, L; Cohen, A; Houghton, M; Mao, J; St Hillary, K; Vo, T; Zhang, Y, 2015) |
| "Reduction or elimination of postoperative pain is therefore possible." | 2.68 | Has postoperative pain been eradicated? ( Sabanathan, S, 1995) |
| "This drug can be used to relieve neuropathic pain." | 2.58 | Peripheral nerve and diclofenac sodium: Molecular and clinical approaches. ( Altun, G; Deniz, ÖG; Kaplan, AA; Yurt, KK, 2018) |
| "Understanding mechanisms of neuropathic orofacial pain, targets of treatment, and basic pharmacology and working with informed compounding pharmacists may result in significant benefit for patients." | 2.49 | Topical medications as treatment of neuropathic orofacial pain. ( Heir, GM; Khan, J; Nasri-Heir, C, 2013) |
| "OBJECTIVE: Neuropathic pain is regulated by several metabolites of the kynurenine pathway (KYNA-kynurenic acid, and QA-quinolinic acid)." | 1.91 | Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation. ( Debbag, S; Saricaoglu, F; Yalcinkaya, A, 2023) |
| "Left sciatic nerve ligation was used as neuropathic pain model." | 1.48 | Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. ( Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR, 2018) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, Y | 1 |
| Zhang, Q | 1 |
| Welsh, WJ | 1 |
| Khan, J | 3 |
| Wang, Q | 1 |
| Korczeniewska, OA | 1 |
| McNeil, R | 1 |
| Ren, Y | 1 |
| Benoliel, R | 2 |
| Eliav, E | 2 |
| Debbag, S | 1 |
| Yalcinkaya, A | 1 |
| Saricaoglu, F | 1 |
| Derry, S | 1 |
| Wiffen, PJ | 1 |
| Kalso, EA | 1 |
| Bell, RF | 1 |
| Aldington, D | 1 |
| Phillips, T | 1 |
| Gaskell, H | 1 |
| Moore, RA | 1 |
| Kaplan, AA | 1 |
| Yurt, KK | 1 |
| Deniz, ÖG | 1 |
| Altun, G | 1 |
| Muneeb, MD | 1 |
| Baig, MAN | 1 |
| Ibrahim, MA | 1 |
| Abdelzaher, WY | 1 |
| Rofaeil, RR | 1 |
| Abdelwahab, S | 1 |
| Eker, HE | 1 |
| Yalçın Çok, O | 1 |
| Bozdoğan Özyılkan, N | 1 |
| Arıboğan, A | 1 |
| Chien, GC | 1 |
| Mathur, S | 1 |
| Harvey, RL | 1 |
| Harden, RN | 1 |
| Nasri-Heir, C | 1 |
| Heir, GM | 1 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Crowe, MS | 1 |
| Leishman, E | 1 |
| Banks, ML | 1 |
| Gujjar, R | 1 |
| Mahadevan, A | 1 |
| Bradshaw, HB | 1 |
| Kinsey, SG | 1 |
| Ahmed, SU | 1 |
| Zhang, Y | 1 |
| Chen, L | 1 |
| Cohen, A | 1 |
| St Hillary, K | 1 |
| Vo, T | 1 |
| Houghton, M | 1 |
| Mao, J | 1 |
| Plaza-Villegas, F | 1 |
| Heir, G | 1 |
| Markman, S | 1 |
| Noma, N | 1 |
| Patel, J | 1 |
| Daud, A | 1 |
| Habib, N | 1 |
| Riera, AS | 1 |
| Wernicke, JF | 1 |
| Wang, F | 1 |
| Pritchett, YL | 1 |
| Smith, TR | 1 |
| Raskin, J | 1 |
| D'Souza, DN | 1 |
| Iyengar, S | 1 |
| Chappell, AS | 1 |
| Sabanathan, S | 1 |
| De Benedittis, G | 2 |
| Lorenzetti, A | 2 |
| Takasaki, I | 1 |
| Andoh, T | 1 |
| Nitta, M | 1 |
| Takahata, H | 1 |
| Nemoto, H | 1 |
| Shiraki, K | 1 |
| Nojima, H | 1 |
| Kuraishi, Y | 1 |
| Kotani, N | 1 |
| Kushikata, T | 1 |
| Hashimoto, H | 1 |
| Kimura, F | 1 |
| Muraoka, M | 1 |
| Yodono, M | 1 |
| Asai, M | 1 |
| Matsuki, A | 1 |
| James, JS | 1 |
| Volle, L | 1 |
| Domenach, M | 1 |
| Besana, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| Does Repetitive Peripheral Nerve Blocks Vs Single Peripheral Nerve Block Vs Standard Medical Treatment Provide a Better Pain Relief on Zoster Pain at the Acute Phase and Reduce the Risk of Post Herpetic Neuralgia?[NCT04133142] | 0 participants (Actual) | Interventional | 2020-05-15 | Withdrawn (stopped due to No enrollement and covid) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for diclofenac and Neuralgia
| Article | Year |
|---|---|
Topical analgesics for acute and chronic pain in adults - an overview of Cochrane Reviews.
Topics: Acute Pain; Adult; Analgesics; Arthritis, Rheumatoid; Capsaicin; Chronic Pain; Diclofenac; Humans; K | 2017 |
Peripheral nerve and diclofenac sodium: Molecular and clinical approaches.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Nerve Regeneration; Neuralgia; | 2018 |
Topical medications as treatment of neuropathic orofacial pain.
Topics: Administration, Cutaneous; Capsaicin; Cyclooxygenase Inhibitors; Diclofenac; Facial Pain; Humans; Li | 2013 |
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
7 trials available for diclofenac and Neuralgia
| Article | Year |
|---|---|
Elective Division of Ilioinguinal Nerve in Inguinal Hernioplasty: Remedy for the Morbid Postoperative Inguinal Pain.
Topics: Adult; Diclofenac; Elective Surgical Procedures; Female; Hernia, Inguinal; Herniorrhaphy; Humans; Il | 2017 |
Effect of 1.5% Topical Diclofenac on Clinical Neuropathic Pain.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceut | 2015 |
An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.
Topics: Acetaminophen; Amitriptyline; Analgesics; Carbamazepine; Diabetes Complications; Diabetic Neuropathi | 2007 |
Has postoperative pain been eradicated?
Topics: Acute Disease; Analgesia; Diclofenac; Female; Forced Expiratory Volume; Humans; Male; Morphine; Nerv | 1995 |
Topical aspirin/diethyl ether mixture versus indomethacin and diclofenac/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study.
Topics: Acute Disease; Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Di | 1996 |
Intrathecal methylprednisolone for intractable postherpetic neuralgia.
Topics: Aged; Anesthetics, Local; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofe | 2000 |
A new topical treatment for acute herpetic neuralgia and post-herpetic neuralgia: the aspirin/diethyl ether mixture. An open-label study plus a double-blind controlled clinical trial.
Topics: Acute Disease; Administration, Topical; Adult; Aged; Aspirin; Diclofenac; Double-Blind Method; Drug | 1992 |
12 other studies available for diclofenac and Neuralgia
| Article | Year |
|---|---|
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes | 2021 |
Response profile in a rat model of exercise-induced hypoalgesia is associated with duloxetine, pregabalin and diclofenac effect on constriction-induced neuropathy.
Topics: Analgesics; Animals; Constriction, Pathologic; Diclofenac; Duloxetine Hydrochloride; Neuralgia; Pain | 2023 |
Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation.
Topics: Animals; Diclofenac; Hyperalgesia; Kynurenine; Neuralgia; Nociception; Rats; Rats, Sprague-Dawley; S | 2023 |
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; D | 2018 |
An add-on therapy for neuropathic pain: Infiltration block with diclofenac sodium and lidocaine through the hypertrophic scar tissue.
Topics: Adult; Aged; Anesthetics, Local; Cicatrix, Hypertrophic; Diclofenac; Female; Humans; Injections; Lid | 2019 |
Topical diclofenac treatment for post-incisional neuropathic pain.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Craniotomy; Diclofenac; Humans; Ma | 2013 |
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.
Topics: Analgesics; Animals; Benzodioxoles; Cannabinoid Receptor Antagonists; Cyclooxygenase Inhibitors; Dic | 2015 |
Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats.
Topics: Administration, Topical; Analysis of Variance; Animals; Diclofenac; Facial Pain; gamma-Aminobutyric | 2012 |
Anti-inflammatory, anti-nociceptive and antipyretic effects of extracts of Phrygilanthus acutifolius flowers.
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2006 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Neuropathy: call for info. on Voltaren Emulgel (topical diclofenac sodium).
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal | 1999 |
[Clinical trial of a new anti-inflammatory agent: Voltarene].
Topics: Adult; Aged; Anti-Inflammatory Agents; Diclofenac; Drug Evaluation; Female; Humans; Male; Middle Age | 1977 |