diclofenac has been researched along with Neoplasms in 27 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The efficacy of misoprostol and ranitidine in the prevention of gastroduodenal damage in patients taking diclofenac for their cancer pain has been compared in this study." | 9.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 9.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| " as additive treatment to parenteral patient-controlled administration therapy (PCAT) with morphine in cancer pain has been investigated in a double-blind study." | 9.07 | Morphine-sparing effect of diclofenac in cancer pain. ( Björkman, R; Hedner, J; Ullman, A, 1993) |
| "In a multicentric, interindividual, double-blind study, the analgesic action, duration of effect, tolerability and side effects of the new combination preparation, Combaren (diclofenac-Na 50 mg+codeine phosphate 50 mg), were compared with those of diclofenac-Na 50 mg (Voltaren 50) in 184 patients with severe tumor-related pain." | 9.07 | [Drug therapy in severe tumor pain. Comparative study of a new combination preparation versus diclofenac-Na]. ( Strobel, E, 1992) |
| " After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)." | 6.68 | Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997) |
| " The efficacy of misoprostol and ranitidine in the prevention of gastroduodenal damage in patients taking diclofenac for their cancer pain has been compared in this study." | 5.08 | Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage. ( Bortolussi, R; Bortoluzzi, F; Cannizzaro, R; Fornasarig, M; Fracasso, A; Grazioli, I; Poletti, M; Sozzi, M; Testa, V; Valentini, M, 1995) |
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 5.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| " as additive treatment to parenteral patient-controlled administration therapy (PCAT) with morphine in cancer pain has been investigated in a double-blind study." | 5.07 | Morphine-sparing effect of diclofenac in cancer pain. ( Björkman, R; Hedner, J; Ullman, A, 1993) |
| "In a multicentric, interindividual, double-blind study, the analgesic action, duration of effect, tolerability and side effects of the new combination preparation, Combaren (diclofenac-Na 50 mg+codeine phosphate 50 mg), were compared with those of diclofenac-Na 50 mg (Voltaren 50) in 184 patients with severe tumor-related pain." | 5.07 | [Drug therapy in severe tumor pain. Comparative study of a new combination preparation versus diclofenac-Na]. ( Strobel, E, 1992) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| "This investigation evaluates the pro-apoptotic and anti-inflammatory effects of β-D-mannuronic acid [M2000] compared to diclofenac, based on gene expression involved in apoptosis and inflammation process [including Bcl2, NFκB, IL-8 and Cd49d] in Peripheral Blood Mononuclear Cells [PBMCs] of healthy donors under exvivo conditions." | 3.96 | Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC. ( Afraei, S; Aghazadeh, Z; Ghaderi, A; Jafarnezhad, F; Khalatbari, A; Mahdavi, M; Mirshafiey, A; Zavareh, FT, 2020) |
| "Although it is necessary to treat the cause of fever, if possible, symptomatic fever management is also important." | 2.70 | Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol. ( Korístek, Z; Mayer, J; Oborilová, A; Pospísil, Z, 2002) |
| " After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)." | 2.68 | Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997) |
| " The administered dosage was 10 mg every 6 h for ketorolac and 50 mg every 8 h for diclofenac sodium." | 2.67 | Ketorolac versus diclofenac sodium in cancer pain. ( Corli, O; De Conno, F; Gallucci, M; Piva, L; Speranza, R; Tamburini, M; Toscani, F; Ventafridda, V, 1994) |
| "Paraneoplastic fever is well known, and is not an uncommon problem in daily practice." | 2.67 | A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever. ( Bacojanis, C; Beldecos, D; Karabelis, A; Karvounis, N; Kosmidis, P; Milonacis, N; Tsavaris, N; Zinelis, A, 1990) |
| "NSAIDs may prevent Alzheimer's disease (AD) but have failed as a treatment, possibly because only 1-2% of an oral NSAID dose reaches the brain." | 2.61 | Transspinal delivery of drugs by transdermal patch back-of-neck for Alzheimer's disease: a new route of administration. ( Lehrer, S; Rheinstein, PH, 2019) |
| "Diclofenac is a potent NSAID of clinical choice, which is widely used for containing inflammation." | 1.51 | Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics. ( Goel, Y; Pandey, SK; Singh, SM; Singh, VK; Temre, MK; Yadav, S, 2019) |
| "Valdecoxib has highest similarity to analogs 8, 19, 21, 22, 23, 26, 27, and 28." | 1.40 | Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization. ( Bartzatt, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 5 (18.52) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, JJ | 1 |
| Yu, WW | 1 |
| Hu, LL | 1 |
| Liu, WJ | 1 |
| Lin, XH | 1 |
| Wang, W | 1 |
| Zhang, Q | 1 |
| Wang, PL | 1 |
| Tang, SW | 1 |
| Wang, X | 2 |
| Liu, M | 1 |
| Lu, W | 1 |
| Zhang, HK | 1 |
| Raaijmakers, TK | 1 |
| van den Bijgaart, RJE | 1 |
| Scheffer, GJ | 1 |
| Ansems, M | 1 |
| Adema, GJ | 1 |
| Kostrhunova, H | 1 |
| McGhie, BS | 1 |
| Markova, L | 1 |
| Novakova, O | 1 |
| Kasparkova, J | 1 |
| Aldrich-Wright, JR | 1 |
| Brabec, V | 1 |
| Altay, A | 1 |
| Caglar, S | 1 |
| Caglar, B | 1 |
| Khalatbari, A | 1 |
| Mahdavi, M | 1 |
| Jafarnezhad, F | 1 |
| Afraei, S | 1 |
| Zavareh, FT | 1 |
| Aghazadeh, Z | 1 |
| Ghaderi, A | 1 |
| Mirshafiey, A | 1 |
| Pandey, SK | 1 |
| Yadav, S | 1 |
| Goel, Y | 1 |
| Temre, MK | 1 |
| Singh, VK | 1 |
| Singh, SM | 1 |
| Lehrer, S | 1 |
| Rheinstein, PH | 1 |
| Huang, R | 1 |
| Jiang, L | 1 |
| Cao, Y | 1 |
| Liu, H | 1 |
| Ping, M | 1 |
| Li, W | 1 |
| Xu, Y | 1 |
| Ning, J | 1 |
| Chen, Y | 1 |
| Gottfried, E | 1 |
| Lang, SA | 1 |
| Renner, K | 1 |
| Bosserhoff, A | 1 |
| Gronwald, W | 1 |
| Rehli, M | 1 |
| Einhell, S | 1 |
| Gedig, I | 1 |
| Singer, K | 1 |
| Seilbeck, A | 1 |
| Mackensen, A | 1 |
| Grauer, O | 1 |
| Hau, P | 1 |
| Dettmer, K | 1 |
| Andreesen, R | 1 |
| Oefner, PJ | 1 |
| Kreutz, M | 1 |
| Bartzatt, R | 1 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Oborilová, A | 1 |
| Mayer, J | 1 |
| Pospísil, Z | 1 |
| Korístek, Z | 1 |
| Tsuda, H | 1 |
| Naito, A | 1 |
| Kim, CK | 1 |
| Fukamachi, K | 1 |
| Nomoto, H | 1 |
| Moore, MA | 1 |
| Corli, O | 3 |
| Cozzolino, A | 1 |
| Scaricabarozzi, I | 1 |
| Valentini, M | 1 |
| Cannizzaro, R | 1 |
| Poletti, M | 1 |
| Bortolussi, R | 1 |
| Fracasso, A | 1 |
| Testa, V | 1 |
| Sozzi, M | 1 |
| Fornasarig, M | 1 |
| Bortoluzzi, F | 1 |
| Grazioli, I | 1 |
| Toscani, F | 2 |
| Piva, L | 1 |
| Gallucci, M | 2 |
| Speranza, R | 2 |
| Tamburini, M | 2 |
| De Conno, F | 3 |
| Ventafridda, V | 3 |
| Björkman, R | 1 |
| Ullman, A | 1 |
| Hedner, J | 1 |
| Freemantle, C | 1 |
| Alam, CA | 1 |
| Brown, JR | 1 |
| Seed, MP | 1 |
| Willoughby, DA | 1 |
| Mercadante, S | 2 |
| Sapio, M | 1 |
| Caligara, M | 1 |
| Serretta, R | 1 |
| Dardanoni, G | 1 |
| Barresi, L | 1 |
| Minotti, V | 2 |
| De Angelis, V | 1 |
| Righetti, E | 1 |
| Celani, MG | 1 |
| Rossetti, R | 1 |
| Lupatelli, M | 1 |
| Tonato, M | 2 |
| Pisati, R | 1 |
| Monza, G | 1 |
| Fumi, G | 1 |
| Del Favero, A | 2 |
| Bianchi, M | 2 |
| Clavenna, A | 1 |
| Groff, L | 1 |
| Zecca, E | 1 |
| Ripamonti, C | 2 |
| Strobel, E | 1 |
| Maddaloni, S | 1 |
| Roccella, S | 1 |
| Salvaggio, L | 1 |
| Panerai, AE | 1 |
| Tsavaris, N | 1 |
| Zinelis, A | 1 |
| Karabelis, A | 1 |
| Beldecos, D | 1 |
| Bacojanis, C | 1 |
| Milonacis, N | 1 |
| Karvounis, N | 1 |
| Kosmidis, P | 1 |
| Gottlieb, A | 1 |
| Patoia, L | 1 |
| Roila, F | 1 |
| Basurto, C | 1 |
| Pasqualucci, V | 1 |
| Maresca, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for diclofenac and Neoplasms
| Article | Year |
|---|---|
Transspinal delivery of drugs by transdermal patch back-of-neck for Alzheimer's disease: a new route of administration.
Topics: Administration, Cutaneous; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antineoplasti | 2019 |
Comparative Efficacy of Therapeutics for Chronic Cancer Pain: A Bayesian Network Meta-Analysis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bayes Theorem; Bridged Bicyclo Compou | 2019 |
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
Carcinogenesis and its modification by environmental endocrine disruptors: in vivo experimental and epidemiological findings.
Topics: Animals; Breast Neoplasms; DDT; Diclofenac; Endocrine System; Environmental Pollutants; Epidemiologi | 2003 |
The modulation of granulomatous tissue and tumour angiogenesis by diclofenac in combination with hyaluronan (HYAL EX-0001).
Topics: Animals; Diclofenac; Drug Delivery Systems; Granuloma; Humans; Hyaluronic Acid; Neoplasms; Neovascul | 1995 |
12 trials available for diclofenac and Neoplasms
| Article | Year |
|---|---|
Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammato | 2002 |
Nimesulide and diclofenac in the control of cancer-related pain. Comparison between oral and rectal administration.
Topics: Administration, Oral; Administration, Rectal; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofe | 1993 |
Nonsteroidal antiinflammatory drugs for cancer pain: comparison between misoprostol and ranitidine in prevention of upper gastrointestinal damage.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antineop | 1995 |
Ketorolac versus diclofenac sodium in cancer pain.
Topics: Adolescent; Adult; Aged; Analgesics; Diclofenac; Female; Humans; Ketorolac Tromethamine; Male; Middl | 1994 |
Morphine-sparing effect of diclofenac in cancer pain.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Diclofenac; Double-Blind Method; Drug Therapy, Combinati | 1993 |
Opioid-sparing effect of diclofenac in cancer pain.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Di | 1997 |
Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1998 |
Diclofenac does not modify methadone bioavailability in cancer patients.
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Diclofen | 1999 |
[Drug therapy in severe tumor pain. Comparative study of a new combination preparation versus diclofenac-Na].
Topics: Adult; Aged; Aged, 80 and over; Codeine; Diclofenac; Double-Blind Method; Drug Combinations; Female; | 1992 |
A randomized trial of the effect of three non-steroid anti-inflammatory agents in ameliorating cancer-induced fever.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Fever; Humans; Indomethacin; Male; Napr | 1990 |
Sodium naproxen versus sodium diclofenac in cancer pain control.
Topics: Aged; Diclofenac; Female; Humans; Male; Naproxen; Neoplasms; Pain, Intractable; Random Allocation; S | 1990 |
Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Aspirin; Chronic Disea | 1989 |
10 other studies available for diclofenac and Neoplasms
| Article | Year |
|---|---|
Discovery and Characterization of 1
Topics: Animals; Calcium; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Drug Disc | 2020 |
NSAIDs affect dendritic cell cytokine production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Ce | 2022 |
Platinum(IV) Derivatives of [Pt(1
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Diclofenac; Ligand | 2023 |
Silver(I) complexes containing diclofenac and niflumic acid induce apoptosis in human-derived cancer cell lines.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diclofenac; Humans; MCF-7 C | 2022 |
Efficacy of β-D-Mannuronic Acid [M2000] on the Pro-Apoptotic Process and Inflammatory-Related Molecules NFκB, IL-8 and Cd49d using Healthy Donor PBMC.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Diclofenac; Gene Expression Profiling; Ge | 2020 |
Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cy | 2019 |
New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Carcinoma; Cell Line, Tumor; | 2013 |
Drug analogs of COX-2 selective inhibitors lumiracoxib and valdecoxib derived from in silico search and optimization.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Computer Simulation; Cyclooxygenase | 2014 |
Predictive factors in advanced cancer pain treated only by analgesics.
Topics: Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Male; Middle | 1992 |
Diclofenac does not modify morphine bioavailability in cancer patients.
Topics: Aged; Biological Availability; Chromatography, High Pressure Liquid; Diclofenac; Drug Interactions; | 1992 |