diclofenac has been researched along with Nausea in 23 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine." | 9.24 | Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy. ( Diener, HC; Lipton, RB; Schmidt, P, 2017) |
| " This study compared two postoperative oral analgesic protocols after day case inguinal hernia repair; 30 mg morphine sulphate (MST) and 10 mg metoclopramide every 8 h for 48 h or 75 mg diclofenac twice daily for 48 h." | 9.08 | Comparison of diclofenac sodium and morphine sulphate for postoperative analgesia after day case inguinal hernia surgery. ( Cahill, CJ; Livingstone, JI; McEvoy, A, 1996) |
| "Forty children undergoing strabismus surgery as day patients were randomly allocated to receive oxybuprocaine 0." | 9.08 | Diclofenac vs oxybuprocaine eyedrops for analgesia in paediatric strabismus surgery. ( Benham, SW; Lawson, RA; McNicol, LR; Morton, NS, 1997) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 9.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "Postoperative pain was assessed by a blinded observer using an objective pain scale (OPS)." | 6.68 | Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery. ( Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M, 1997) |
| " We recorded patients' visual analog scale scores preoperatively and at 4, 8, 16, 24, and 48 hours postoperatively; the number of patients using postoperative diclofenac suppositories and buprenorphine hydrochloride; the number of patients experiencing nausea; the number of patients with infection and delayed wound healing as adverse effects; the surgery time; the retear rate; and passive shoulder range of motion." | 5.34 | Effect of cocktail therapy after arthroscopic rotator cuff repair: a randomized, double-blind trial. ( Teratani, T, 2020) |
| "To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine." | 5.24 | Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy. ( Diener, HC; Lipton, RB; Schmidt, P, 2017) |
| "There was no statistical difference in the mean reduction in pain score between any of the combinations at any point, although combination therapy was the first to reach a clinically significant reduction in pain score (<13 mm), and diclofenac-paracetamol combinations consistently produced a greater reduction in mean pain score than either nonsteroidal antiinflammatory drugs or paracetamol alone." | 5.11 | Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury. ( Lam, PK; Man, SY; Rainer, TH; Woo, WW, 2005) |
| " This study compared two postoperative oral analgesic protocols after day case inguinal hernia repair; 30 mg morphine sulphate (MST) and 10 mg metoclopramide every 8 h for 48 h or 75 mg diclofenac twice daily for 48 h." | 5.08 | Comparison of diclofenac sodium and morphine sulphate for postoperative analgesia after day case inguinal hernia surgery. ( Cahill, CJ; Livingstone, JI; McEvoy, A, 1996) |
| "Forty children undergoing strabismus surgery as day patients were randomly allocated to receive oxybuprocaine 0." | 5.08 | Diclofenac vs oxybuprocaine eyedrops for analgesia in paediatric strabismus surgery. ( Benham, SW; Lawson, RA; McNicol, LR; Morton, NS, 1997) |
| " In this study, a very small dose of intrathecal morphine, in association with intramuscular diclofenac, proved effective for controlling pain after cesarean delivery, with a low incidence of morphine-induced pruritus." | 5.08 | Small doses of intrathecal morphine combined with systemic diclofenac for postoperative pain control after cesarean delivery. ( Amaro, AR; Cappelli, EL; Cardoso, MM; Carvalho, JC; Prado, AA, 1998) |
| "At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy." | 5.07 | Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy. ( Hovorka, J; Kallela, H; Korttila, K, 1993) |
| "In treatment of refractory migraine headache, CAMBIA® may provide similar benefits as IM ketorolac without increasing the risk of treatment failure, major bleeding, or cardiovascular events." | 2.94 | IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial. ( Cheng, J; Engel, ER, 2020) |
| "Active disease was defined by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) for more than 3 at randomization." | 2.78 | Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis. ( Chang, IC; Chang, JK; Lee, MY; Tsou, HK; Wei, JC; Yeo, K; Yu, CT, 2013) |
| "Tramadol was found to provide adequate analgesia after maxillofacial surgery without risk of respiratory depression." | 2.69 | Efficacy and side effects of tramadol versus oxycodone for patient-controlled analgesia after maxillofacial surgery. ( Rosenberg, PH; Silvasti, M; Svartling, N; Tarkkila, P; Tuominen, M, 1999) |
| "Pelvic pain was assessed, with a 100 mm visual analogue scale, at 1 hour, at hospital discharge, and time of first analgesia or any other time analgesia was demanded." | 2.68 | Local anaesthetic on Filshie clips for pain relief after tubal sterilisation: a randomised double-blind controlled trial. ( Breeson, AJ; Ezeh, UO; Lamb, MD; Martin, JL; Shoulder, VS; Vellacott, ID, 1995) |
| "Postoperative pain was assessed by a blinded observer using an objective pain scale (OPS)." | 2.68 | Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery. ( Maekawa, N; Mikawa, K; Nishina, K; Obara, H; Shiga, M, 1997) |
| "Diclofenac is an established analgesic, and new formulations using the potassium or epolamine salts, which can be dissolved in water, have been developed for rapid absorption, which may be beneficial in acute migraine." | 2.49 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2013) |
| "Diclofenac is an established analgesic, and new formulations using the potassium or epolamine salts, which can be dissolved in water, have been developed for rapid absorption, which may be beneficial in acute migraine." | 2.48 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2012) |
| "Diclofenac-potassium was developed as an immediate-release tablet with the aim of providing rapid onset of action after oral administration." | 2.40 | Diclofenac-potassium in migraine: a review. ( Goa, KL; McNeely, W, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 12 (52.17) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, ER | 1 |
| Cheng, J | 1 |
| Teratani, T | 1 |
| Lipton, RB | 1 |
| Schmidt, P | 1 |
| Diener, HC | 1 |
| Derry, S | 2 |
| Rabbie, R | 2 |
| Moore, RA | 2 |
| Ihedioha, U | 1 |
| Vaughan, S | 1 |
| Mastermann, J | 1 |
| Singh, B | 1 |
| Chaudhri, S | 1 |
| Zuniga, JR | 1 |
| Malmström, H | 1 |
| Noveck, RJ | 1 |
| Campbell, JH | 1 |
| Christensen, S | 1 |
| Glickman, RS | 1 |
| Tomasetti, BJ | 1 |
| Boesing, SE | 1 |
| Ault, J | 1 |
| Chang, JK | 1 |
| Yu, CT | 1 |
| Lee, MY | 1 |
| Yeo, K | 1 |
| Chang, IC | 1 |
| Tsou, HK | 1 |
| Wei, JC | 1 |
| Woo, WW | 1 |
| Man, SY | 1 |
| Lam, PK | 1 |
| Rainer, TH | 1 |
| Burdeĭnyĭ, AP | 1 |
| Ezeh, UO | 1 |
| Shoulder, VS | 1 |
| Martin, JL | 1 |
| Breeson, AJ | 1 |
| Lamb, MD | 1 |
| Vellacott, ID | 1 |
| Wilson, YG | 1 |
| Rhodes, M | 1 |
| Ahmed, R | 1 |
| Daugherty, M | 1 |
| Cawthorn, SJ | 1 |
| Armstrong, CP | 1 |
| Hovorka, J | 1 |
| Kallela, H | 1 |
| Korttila, K | 1 |
| McEvoy, A | 1 |
| Livingstone, JI | 1 |
| Cahill, CJ | 1 |
| Stein, A | 1 |
| Ben Dov, D | 1 |
| Finkel, B | 1 |
| Mecz, Y | 1 |
| Kitzes, R | 1 |
| Lurie, A | 1 |
| Mendham, JE | 1 |
| Mather, SJ | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Maekawa, N | 1 |
| Shiga, M | 1 |
| Obara, H | 1 |
| Morton, NS | 1 |
| Benham, SW | 1 |
| Lawson, RA | 1 |
| McNicol, LR | 1 |
| Moriarty, A | 1 |
| Cardoso, MM | 1 |
| Carvalho, JC | 1 |
| Amaro, AR | 1 |
| Prado, AA | 1 |
| Cappelli, EL | 1 |
| McNeely, W | 1 |
| Goa, KL | 1 |
| Silvasti, M | 1 |
| Tarkkila, P | 1 |
| Tuominen, M | 1 |
| Svartling, N | 1 |
| Rosenberg, PH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine[NCT02664116] | Phase 4 | 40 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| The Postoperative Analgesic Efficacy of Varied Concentrations of Ropivacaine Used for the Transverse Abdominis Plane (TAP) Block After Cesarean Delivery[NCT01170702] | Phase 4 | 120 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total dose of morphine equivalents (IV equivalent of morphine) taken by the participant 0-24 hours after completion of the TAP block. (NCT01170702)
Timeframe: 24 hours
| Intervention | Morphine equivalents (mg) (Median) |
|---|---|
| Group 1 | 54 |
| Group 2 | 38 |
| Group 3 | 32 |
| Group 4 | 45 |
Total dose of morphine equivalents (IV equivalent of morphine) taken by the participant 24-72 hours after completion of the TAP block. (NCT01170702)
Timeframe: 24-72 hours
| Intervention | Morphine equivalents (mgs) (Median) |
|---|---|
| Group 1 | 67 |
| Group 2 | 60 |
| Group 3 | 67 |
| Group 4 | 67 |
Total dose of morphine equivalents (IV equivalent of morphine) taken by the participant 0-72 hours after completion of the TAP block. (NCT01170702)
Timeframe: 72 hours
| Intervention | Morphine equivalents (mgs) (Median) |
|---|---|
| Group 1 | 120 |
| Group 2 | 96 |
| Group 3 | 98 |
| Group 4 | 112 |
Pain burden at rest calculated as area under the pain score * time (hr) curve 0-72 hours. (NCT01170702)
Timeframe: 72 hours
| Intervention | score on scale * (hr) (Median) |
|---|---|
| Group 1 | 129 |
| Group 2 | 79 |
| Group 3 | 79 |
| Group 4 | 151 |
Pain burden with movement calculated as area under the pain score * time (hr) curve 0-72 hours. (NCT01170702)
Timeframe: 72 hours
| Intervention | pain score * time (hr) curve 72 hours (Median) |
|---|---|
| Group 1 | 265 |
| Group 2 | 202 |
| Group 3 | 233 |
| Group 4 | 327 |
The elapsed time in minutes of the first PCA (patient controlled analgesia) request in time (minutes) from the end of the TAP block. (NCT01170702)
Timeframe: Elapsed time in minutes
| Intervention | Minutes (Mean) |
|---|---|
| Group 1 | 90 |
| Group 2 | 118 |
| Group 3 | 126 |
| Group 4 | 83 |
Pain scores at rest ( 0 low 10 high) using an 11 point VRS (verbal pain scale) at the following hour time points, at the first request for patient controlled analgesia (PCA) then at 2,6,24,and 74 hours after the first request for PCA (patient controlled analgesia). (NCT01170702)
Timeframe: Request for first patient controlled analgesia then at 2,6,24,72 hours after initial PCA request
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| At first PCA request | 2 hous after first PCA request | 6 hours after first PCA request | 24 hours after first PCA request | 72 hours after first PCA reqest | |
| Group 1 | 3 | 3 | 3 | 2 | 1 |
| Group 2 | 3 | 1 | 2 | 1 | .5 |
| Group 3 | 2 | 0 | 2 | 1 | 1 |
| Group 4 | 2 | 2 | 2 | 3 | 1 |
Pain scores with movement ( 0 low 10 high) using an 11 point VRS (verbal pain scale) at the first request for patient controlled analgesia (PCA) then at 2,6,24,and 74 hours after the first request for PCA (patient controlled analgesia). (NCT01170702)
Timeframe: First PCA request then at 2,6,24,72 hours after first PCA request.
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| At first PCA request | 2 hous after first PCA request | 6 hours after first PCA request | 24 hours after first PCA request | 72 hours after first PCA reqest | |
| Group 1 | 5 | 4 | 4 | 4 | 3.5 |
| Group 2 | 3.5 | 2 | 4 | 3 | 2 |
| Group 3 | 3.5 | 3 | 5 | 4 | 3 |
| Group 4 | 4 | 3 | 4 | 5 | 4 |
3 reviews available for diclofenac and Nausea
| Article | Year |
|---|---|
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Female; Humans | 2013 |
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Humans; Hypera | 2012 |
Diclofenac-potassium in migraine: a review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Humans; Migraine Diso | 1999 |
18 trials available for diclofenac and Nausea
| Article | Year |
|---|---|
IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Meth | 2020 |
Effect of cocktail therapy after arthroscopic rotator cuff repair: a randomized, double-blind trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, No | 2020 |
Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy.
Topics: Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged | 2017 |
Patient education videos for elective colorectal surgery: results of a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-St | 2013 |
Controlled phase III clinical trial of diclofenac potassium liquid-filled soft gelatin capsule for treatment of postoperative dental pain.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Stero | 2010 |
Tramadol/acetaminophen combination as add-on therapy in the treatment of patients with ankylosing spondylitis.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2013 |
Randomized double-blind trial comparing oral paracetamol and oral nonsteroidal antiinflammatory drugs for treating pain after musculoskeletal injury.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dizziness; Female; Humans | 2005 |
[Double-blind trial of the therapeutic efficacy of voltaren and indomethacin in Bechterew's disease].
Topics: Adult; Clinical Trials as Topic; Dermatitis, Atopic; Diclofenac; Dizziness; Double-Blind Method; Fem | 1981 |
Local anaesthetic on Filshie clips for pain relief after tubal sterilisation: a randomised double-blind controlled trial.
Topics: Adult; Cyclizine; Diclofenac; Double-Blind Method; Female; Gels; Humans; Laparoscopy; Lidocaine; Mef | 1995 |
Intramuscular diclofenac sodium for postoperative analgesia after laparoscopic cholecystectomy: a randomised, controlled trial.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Analgesia; Cholecystectomy, Laparoscopic; D | 1994 |
Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.
Topics: Acetaminophen; Adult; Ambulatory Care; Diclofenac; Double-Blind Method; Female; Fentanyl; Humans; In | 1993 |
Comparison of diclofenac sodium and morphine sulphate for postoperative analgesia after day case inguinal hernia surgery.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analgesi | 1996 |
Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Double-Blind Method; Female | 1996 |
Comparison of diclofenac and tenoxicam for postoperative analgesia with and without fentanyl in children undergoing adenotonsillectomy or tonsillectomy.
Topics: Adenoidectomy; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Blood Loss, Surgical; Ch | 1996 |
Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery.
Topics: Analgesics; Anesthesia, Inhalation; Anesthetics, Inhalation; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
Diclofenac vs oxybuprocaine eyedrops for analgesia in paediatric strabismus surgery.
Topics: Ambulatory Surgical Procedures; Analgesia; Anesthesia, General; Anesthetics, Local; Anti-Inflammator | 1997 |
Small doses of intrathecal morphine combined with systemic diclofenac for postoperative pain control after cesarean delivery.
Topics: Cesarean Section; Diclofenac; Female; Humans; Injections, Spinal; Morphine; Nausea; Pain, Postoperat | 1998 |
Efficacy and side effects of tramadol versus oxycodone for patient-controlled analgesia after maxillofacial surgery.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents; Anti | 1999 |
2 other studies available for diclofenac and Nausea
| Article | Year |
|---|---|
Teaching case: migraine and pupil dilation.
Topics: Adult; Anticonvulsants; Comorbidity; Cyclooxygenase Inhibitors; Diclofenac; Female; Fructose; Humans | 2011 |
Use of Ropivacaine in postoperative infusions.
Topics: Abdomen; Amides; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agen | 1997 |