diclofenac has been researched along with Migraine Disorders in 40 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine." | 9.24 | Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy. ( Diener, HC; Lipton, RB; Schmidt, P, 2017) |
| "A randomized, controlled, cross-over trial compared single doses of 50 mg diclofenac potassium sachets and tablets with placebo in 328 patients with migraine pain, treating 888 attacks." | 9.12 | Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo. ( Diener, HC; Edson, K; Gács, G; Lyczak, P; Montagna, P; Mulder, LJ; Schumann, G; Siegel, J; Zöller, B, 2006) |
| "To determine whether baseline nausea or prior triptan treatment for migraine impact the effectiveness of diclofenac potassium for oral solution in treating acute migraine." | 5.24 | Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy. ( Diener, HC; Lipton, RB; Schmidt, P, 2017) |
| "This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
| "A randomized, controlled, cross-over trial compared single doses of 50 mg diclofenac potassium sachets and tablets with placebo in 328 patients with migraine pain, treating 888 attacks." | 5.12 | Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo. ( Diener, HC; Edson, K; Gács, G; Lyczak, P; Montagna, P; Mulder, LJ; Schumann, G; Siegel, J; Zöller, B, 2006) |
| " However, long-term use of NSAIDs is associated with side-effects, mainly involving the gastrointestinal tract." | 3.77 | [Migraine and non-steroidal anti-inflammatory agents]. ( Pradalier, A; Vincent, D, 1992) |
| "In treatment of refractory migraine headache, CAMBIA® may provide similar benefits as IM ketorolac without increasing the risk of treatment failure, major bleeding, or cardiovascular events." | 2.94 | IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial. ( Cheng, J; Engel, ER, 2020) |
| "Adult sufferers with an established migraine diagnosis according to the International Classification of Headache Disorders, second edition (ICHD-II), treated one moderate or severe attack with 50 mg diclofenac potassium for oral solution (dissolved in approximately 2 ounces of water; N=343) or matching placebo (N=347)." | 2.75 | Efficacy and tolerability of a new powdered formulation of diclofenac potassium for oral solution for the acute treatment of migraine: results from the International Migraine Pain Assessment Clinical Trial (IMPACT). ( Grosberg, B; Lipton, RB; Pearlman, SH; Quiring, JN; Saper, JR; Singer, RP; Sorrentino, JV, 2010) |
| "5 mg combined with either aceclofenac 100 mg or placebo." | 2.73 | Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia. ( De Klippel, N; Giurgea, S; Herroelen, L; Jacquy, J; Louis, P; Monseu, G; Schoenen, J; Vandenheede, M, 2008) |
| "Sumatriptan is a specific migraine treatment which has recently become among the most widely prescribed acute migraine therapies." | 2.69 | Acute treatment of migraine attacks: efficacy and safety of a nonsteroidal anti-inflammatory drug, diclofenac-potassium, in comparison to oral sumatriptan and placebo. The Diclofenac-K/Sumatriptan Migraine Study Group. ( , 1999) |
| "Forty-six patients with acute migraine attacks were treated with intramuscular injection of 75 mg diclofenac sodium, and another group of forty patients with intramuscular injection of paracetamol." | 2.67 | Treatment of acute migraine attack with diclofenac sodium: a double-blind study. ( Chrisikos, N; Fotiadou, A; Karabetsos, A; Karachalios, GN; Kehagioglou, K, 1992) |
| "Diclofenac was significantly more effective than placebo (p less than 0." | 2.67 | Effectiveness of oral diclofenac in the acute treatment of common migraine attacks: a double-blind study versus placebo. ( Bousser, MG; Lasserre, O; Massiou, H; Serrurier, D, 1991) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.49 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2013) |
| "Migraine is a common, disabling condition and a burden for the individual, health services and society." | 2.48 | Diclofenac with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2012) |
| "Migraineurs often do not use acute migraine-specific medications." | 2.46 | Meeting acute migraine treatment needs through novel treatment formulations. ( Silberstein, SD, 2010) |
| "Diclofenac-potassium was developed as an immediate-release tablet with the aim of providing rapid onset of action after oral administration." | 2.40 | Diclofenac-potassium in migraine: a review. ( Goa, KL; McNeely, W, 1999) |
| "These drugs can be categorized into migraine-specific and migraine-non-specific." | 1.72 | 2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022) |
| "Among migraine patients, 80% had used NSAIDs in the past year." | 1.46 | Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache. ( Affaitati, G; Cipollone, F; Costantini, R; Giamberardino, MA; Lapenna, D; Lopopolo, M; Martelletti, P; Massimini, F; Tana, C, 2017) |
| " A microemulsion-based technology has various advantages over other technically complex dosage forms." | 1.40 | Duel-acting subcutaneous microemulsion formulation for improved migraine treatment with zolmitriptan and diclofenac: formulation and in vitro-in vivo characterization. ( Christie, M; Dubey, R; Martini, LG, 2014) |
| "Of the patients with migraine, 83." | 1.30 | [Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil]. ( Bigal, ME; Bordini, CA; Speciali, JG, 1999) |
| "In case of migraine associated with dysmenorrhoea and/or premenstrual tension the management with triphasic hormone proved to be of therapeutic value." | 1.28 | The relation between atypical migraine and multiphasic oral contraceptives. ( Dienes, L; Szigethy, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.50) | 18.7374 |
| 1990's | 10 (25.00) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 14 (35.00) | 24.3611 |
| 2020's | 4 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nurathirah, MN | 1 |
| Yazid, MB | 1 |
| Norhayati, MN | 1 |
| Baharuddin, KA | 1 |
| Abu Bakar, MA | 1 |
| Geppetti, P | 1 |
| De Cesaris, F | 1 |
| Benemei, S | 1 |
| Cortelli, P | 1 |
| Cevoli, S | 1 |
| Pierangeli, G | 1 |
| Favoni, V | 1 |
| Lisotto, C | 1 |
| Usai, S | 1 |
| Frediani, F | 1 |
| Di Fiore, P | 1 |
| D'Arrigo, G | 1 |
| Tassorelli, C | 1 |
| Sances, G | 1 |
| Cainazzo, MM | 1 |
| Baraldi, C | 1 |
| Sarchielli, P | 1 |
| Corbelli, I | 1 |
| De Vanna, G | 1 |
| Tedeschi, G | 1 |
| Russo, A | 1 |
| Lau, CI | 1 |
| Wang, YF | 1 |
| Bérczi, B | 1 |
| Sneath, P | 1 |
| Engel, ER | 1 |
| Cheng, J | 1 |
| Lipton, RB | 2 |
| Schmidt, P | 1 |
| Diener, HC | 2 |
| Diener, H- | 1 |
| Tepper, DE | 1 |
| Derry, S | 2 |
| Rabbie, R | 2 |
| Moore, RA | 2 |
| Dubey, R | 1 |
| Martini, LG | 1 |
| Christie, M | 1 |
| Garnock-Jones, KP | 1 |
| Affaitati, G | 1 |
| Martelletti, P | 1 |
| Lopopolo, M | 1 |
| Tana, C | 1 |
| Massimini, F | 1 |
| Cipollone, F | 1 |
| Lapenna, D | 1 |
| Giamberardino, MA | 1 |
| Costantini, R | 1 |
| Gulseren, D | 1 |
| Sahin, EB | 1 |
| Bozdogan, O | 1 |
| Artuz, F | 1 |
| Buettner, C | 1 |
| Melo-Carrillo, A | 1 |
| Burstein, R | 2 |
| Schoenen, J | 1 |
| De Klippel, N | 1 |
| Giurgea, S | 1 |
| Herroelen, L | 1 |
| Jacquy, J | 1 |
| Louis, P | 1 |
| Monseu, G | 1 |
| Vandenheede, M | 1 |
| Jakubowski, M | 1 |
| Haag, G | 1 |
| Silberstein, SD | 1 |
| Comoglu, T | 1 |
| Dogan, A | 1 |
| Comoglu, S | 1 |
| Basci, N | 1 |
| Grosberg, B | 1 |
| Singer, RP | 1 |
| Pearlman, SH | 1 |
| Sorrentino, JV | 1 |
| Quiring, JN | 1 |
| Saper, JR | 1 |
| Morillo, LE | 2 |
| Engindeniz, Z | 1 |
| Demircan, C | 1 |
| Karli, N | 1 |
| Armagan, E | 1 |
| Bulut, M | 1 |
| Aydin, T | 1 |
| Zarifoglu, M | 1 |
| Montagna, P | 1 |
| Gács, G | 1 |
| Lyczak, P | 1 |
| Schumann, G | 1 |
| Zöller, B | 1 |
| Mulder, LJ | 1 |
| Siegel, J | 1 |
| Edson, K | 1 |
| Vécsei, L | 1 |
| Gallacchi, G | 1 |
| Sági, I | 1 |
| Semjén, J | 1 |
| Tajti, J | 1 |
| Szok, D | 1 |
| Müller, M | 1 |
| Vadass, P | 1 |
| Kerékgyártó, M | 1 |
| Orssaud, C | 1 |
| Roche, O | 1 |
| El Dirani, H | 1 |
| Allali, J | 1 |
| Dufier, JL | 1 |
| Dahlöf, C | 1 |
| Björkman, R | 1 |
| Hering, R | 1 |
| Couturier, EG | 1 |
| Steiner, TJ | 1 |
| McNeely, W | 1 |
| Goa, KL | 1 |
| Bigal, ME | 1 |
| Bordini, CA | 1 |
| Speciali, JG | 1 |
| Polliack, J | 1 |
| Szigethy, A | 1 |
| Dienes, L | 1 |
| Pradalier, A | 1 |
| Vincent, D | 1 |
| Karachalios, GN | 1 |
| Fotiadou, A | 1 |
| Chrisikos, N | 1 |
| Karabetsos, A | 1 |
| Kehagioglou, K | 1 |
| Messinger, HB | 1 |
| Massiou, H | 1 |
| Serrurier, D | 1 |
| Lasserre, O | 1 |
| Bousser, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine[NCT02664116] | Phase 4 | 40 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| The Utility of Adding 1 L Intravenous Normal Saline to Standard 75 mg Intramuscular Diclofenac Potassium Injection in Patients Presented to the Emergency Department With an Acute Migraine Attack[NCT04287140] | 120 participants (Anticipated) | Interventional | 2020-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for diclofenac and Migraine Disorders
| Article | Year |
|---|---|
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
BET 2: Treating migraines with diclofenac instead of a triptan.
Topics: Adult; Diclofenac; Evidence-Based Emergency Medicine; Female; Humans; Migraine Disorders; Treatment | 2019 |
Topics: Analgesics; Aspirin; Diclofenac; Humans; Ibuprofen; Migraine Disorders; Pyrrolidines; Randomized Con | 2017 |
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Female; Humans | 2013 |
Diclofenac potassium powder for oral solution: a review of its use in patients with acute migraine.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Controlled Clinical Trials as Topic; | 2014 |
[Self-medication of primary headaches].
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diclof | 2009 |
Meeting acute migraine treatment needs through novel treatment formulations.
Topics: Analgesics, Non-Narcotic; Diclofenac; Dihydroergotamine; Drug Administration Routes; Drug Delivery S | 2010 |
Diclofenac with or without an antiemetic for acute migraine headaches in adults.
Topics: Acute Disease; Adult; Analgesics; Antiemetics; Diclofenac; Drug Therapy, Combination; Humans; Hypera | 2012 |
Migraine headache.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Dicl | 2003 |
Migraine headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ergotamine; Humans; Ibuprofen; Indoles; Migrain | 2004 |
Diclofenac-potassium in migraine: a review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Diclofenac; Humans; Migraine Diso | 1999 |
[Migraine and non-steroidal anti-inflammatory agents].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Ergotamine; Flufenamic | 1992 |
14 trials available for diclofenac and Migraine Disorders
| Article | Year |
|---|---|
Self-administered subcutaneous diclofenac sodium in acute migraine attack: A randomized, double-blind, placebo-controlled dose-finding pilot study.
Topics: Diclofenac; Double-Blind Method; Humans; Infusions, Intravenous; Migraine Disorders; Pilot Projects | 2022 |
IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Meth | 2020 |
Post Hoc Subanalysis of Two Randomized, Controlled Phase 3 Trials Evaluating Diclofenac Potassium for Oral Solution: Impact of Migraine-Associated Nausea and Prior Triptan Use on Efficacy.
Topics: Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged | 2017 |
Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Therapy, Combination; Female; Human | 2008 |
Formulation and evaluation of diclofenac potassium fast-disintegrating tablets and their clinical application in migraine patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Dosage Forms; Drug C | 2011 |
Efficacy and tolerability of a new powdered formulation of diclofenac potassium for oral solution for the acute treatment of migraine: results from the International Migraine Pain Assessment Clinical Trial (IMPACT).
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; | 2010 |
Intramuscular tramadol vs. diclofenac sodium for the treatment of acute migraine attacks in emergency department: a prospective, randomised, double-blind study.
Topics: Acute Disease; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Data Collection; | 2005 |
Efficacy and tolerability of diclofenac potassium sachets in migraine: a randomized, double-blind, cross-over study in comparison with diclofenac potassium tablets and placebo.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac | 2006 |
Diclofenac epolamine is effective in the treatment of acute migraine attacks. A randomized, crossover, double blind, placebo-controlled, clinical study.
Topics: Adult; Analgesics; Diclofenac; Double-Blind Method; Europe; Female; Humans; Male; Middle Aged; Migra | 2007 |
Diclofenac-K (50 and 100 mg) and placebo in the acute treatment of migraine.
Topics: Adolescent; Adult; Aged; Diclofenac; Dose-Response Relationship, Drug; Double-Blind Method; Female; | 1993 |
Acute treatment of migraine attacks: efficacy and safety of a nonsteroidal anti-inflammatory drug, diclofenac-potassium, in comparison to oral sumatriptan and placebo. The Diclofenac-K/Sumatriptan Migraine Study Group.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dicl | 1999 |
[Migraine and non-steroidal anti-inflammatory agents].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Ergotamine; Flufenamic | 1992 |
Treatment of acute migraine attack with diclofenac sodium: a double-blind study.
Topics: Acetaminophen; Acute Disease; Adolescent; Adult; Aged; Diclofenac; Double-Blind Method; Female; Huma | 1992 |
Effectiveness of oral diclofenac in the acute treatment of common migraine attacks: a double-blind study versus placebo.
Topics: Administration, Oral; Adult; Diclofenac; Double-Blind Method; Female; Humans; Male; Middle Aged; Mig | 1991 |
15 other studies available for diclofenac and Migraine Disorders
| Article | Year |
|---|---|
2022 Taiwan Guidelines for Acute Treatment of Migraine.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G | 2022 |
Non-steroidal anti-inflammatories for the acute treatment of migraine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Migraine Disorders | 2013 |
Duel-acting subcutaneous microemulsion formulation for improved migraine treatment with zolmitriptan and diclofenac: formulation and in vitro-in vivo characterization.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Emulsions; In Vitro Techniques; Male; | 2014 |
Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Follow-Up Studies; H | 2017 |
An avoidable adverse drug reaction: Nicolau syndrome.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dopamine D2 Receptor Antagonists; Female | 2017 |
Terminating Migraine-Associated Allodynia Using Oral Suspension Diclofenac: A Prospective Non-Randomized Drug Trial.
Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Hyperalgesia; Middle Aged; | 2017 |
Almotriptan efficacy in migraine with allodynia: a critique of Schoenen et al.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Therapy, Combination; Female; Human | 2009 |
[Painful ophthalmoplegia in children: Tolosa-Hunt syndrome or ophthalmoplegic migraine?].
Topics: Adolescent; Adrenal Cortex Hormones; Child, Preschool; Diclofenac; Female; Humans; Male; Migraine Di | 2007 |
Intramuscular diclofenac in late treatment of migraine.
Topics: Adult; Diclofenac; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Male; Mi | 1996 |
[Headache treatment in an emergency unit of the city of Ribeirão Preto, Brazil].
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroida | 1999 |
[Migraine therapy. NSAID are included as first choice].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Double-Blind Method; Humans; Migraine Disorders | 2001 |
[Non-steroidal anti-inflammatory drugs with new characteristics. Rapid help in migraine].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Clinical Trials as Topic; Diclofen | 2002 |
Chronic recurrent headaches.
Topics: Diclofenac; Drug Therapy, Combination; Humans; Migraine Disorders; Phenylacetates; Trifluoperazine | 1979 |
The relation between atypical migraine and multiphasic oral contraceptives.
Topics: Adult; Contraceptives, Oral; Diclofenac; Domperidone; Drug Evaluation; Female; Humans; Menstruation; | 1992 |
Trial of oral diclofenac for the acute treatment of common migraine attacks.
Topics: Diclofenac; Humans; Migraine Disorders; Research Design | 1992 |